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전성주(Seoung Ju Chun),전정수(Jung Su Chun),김재하(Jae Ha Kim),최두혁(Do Hyok Choi) 대한내과학회 1987 대한내과학회지 Vol.33 No.5
N/A Korean hemorrhagic fever which was recognized for the first time in Korea near the Demilitarized Zone between North and South Korea in 1951 during Korea War have spread to the southern part of the Korean peninsula and several hundreds of cases are clinically and serologically diagnosed each year. However the Northern Part of Kyoung Ki Do is still remained as epidemic area. In recent years, we experienced 55 cases of Korean Hemorrhagic Fever in the northern part of Kyoung Ki Do during the period, 1984-1986, and we found different clinical patterns of Korean hemorrhagic fever from those reported earlier. Here we report the epidemiological and clinical observations with laboratory findings. 1) The disease was prevalent in adult male farmers and the epidemic seasons were fall and early winter. The epidemic areas of the disease are mainly Yang Ju, Yeoncheon and Pocheon. 2) Clinical pictures of Korean Hemorrhagic Fever were characterized by headache (76%), abdominal pain (69%), nausea & vomiting (67%), fever (56%) and myalgia & general aching (49%). 3) On physical examination, fever (56%), abdominal tenderness (36%), tachycardia (35%), hypotension (27%), petechia (24%), conjunctival injection (22%) and facial flushing and edema (16%) were found. 4) On laboratory examination, leukocytosis, thrombocytopenia, left shift of leukocyte, toxic granule, proteinuria, microscopic hematuria and increased specific gravity were found. Blood chemistry findings were characterized by increased BUN & creatinine, increased SGOT & SGPT, hyponatremia, increased LDH & FDP and hyperkalemia. 5) Clinical forms of typical hemorrhagic fever were as follows: Typical oliguric type 49%, typical nonoliguric type 21% and atypical type 29%. 6) Double infection to Leptospirosia was found in 8 cases.
Gene Cloning and Characterization of MdeA, a Novel Multidrug Efflux Pump in Streptococcus mutans
( Do Kyun Kim ),( Kyoung Hoon Kim ),( Eun Ji Cho ),( Seoung Je Joo ),( Jung Min Chung ),( Byoung Yil Son ),( Jong Hwa Yum ),( Young Man Kim ),( Hyun Ju Kwon ),( Byung Woo Kim ),( Tae Hoon Kim ),( Eun 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.3
Multidrug resistance, especially multidrug efflux mechanisms that extrude structurally unrelated cytotoxic compounds from the cell by multidrug transporters, is a serious problem and one of the main reasons for the failure of therapeutic treatment of infections by pathogenic microorganisms as well as of cancer cells. Streptococcus mutans is considered one of the primary causative agents of dental caries and periodontal disease, which comprise the most common oral diseases. A fragment of chromosomal DNA from S. mutans KCTC3065 was cloned using Escherichia coli KAM32 as host cells lacking major multidrug efflux pumps. Although E. coli KAM32 cells were very sensitive to many antimicrobial agents, the transformed cells harboring a recombinant plasmid became resistant to several structurally unrelated antimicrobial agents such as tetracycline, kanamycin, rhodamin 6G, ampicillin, acriflavine, ethidium bromide, and tetraphenylphosphonium chloride. This suggested that the cloned DNA fragment carries a gene encoding a multidrug efflux pump. Among 49 of the multidrug-resistant transformants, we report the functional gene cloning and characterization of the function of one multidrug efflux pump, namely MdeA from S. mutans, which was expressed in E. coli KAM32. Judging from the structural and biochemical properties, we concluded that MdeA is the first cloned and characterized multidrug efflux pump using the proton motive force as the energy for efflux drugs.
Won, Seoung Youn,Kim, Cha Yeon,Kim, Doyoun,Ko, Jaewon,Um, Ji Won,Lee, Sung Bae,Buck, Matthias,Kim, Eunjoon,Heo, Won Do,Lee, Jie-Oh,Kim, Ho Min Frontiers Media S.A. 2017 Frontiers in molecular neuroscience Vol.10 No.-
<P>The leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are cellular receptors of heparan sulfate (HS) and chondroitin sulfate (CS) proteoglycans that direct axonal growth and neuronal regeneration. LAR-RPTPs are also synaptic adhesion molecules that form <I>trans</I>-synaptic adhesion complexes by binding to various postsynaptic adhesion ligands, such as Slit- and Trk-like family of proteins (Slitrks), IL-1 receptor accessory protein-like 1 (IL1RAPL1), interleukin-1 receptor accessory protein (IL-1RAcP) and neurotrophin receptor tyrosine kinase C (TrkC), to regulate synaptogenesis. Here, we determined the crystal structure of the human LAR-RPTP/IL1RAPL1 complex and found that lateral interactions between neighboring LAR-RPTP/IL1RAPL1 complexes in crystal lattices are critical for the higher-order assembly and synaptogenic activity of these complexes. Moreover, we found that LAR-RPTP binding to the postsynaptic adhesion ligands, Slitrk3, IL1RAPL1 and IL-1RAcP, but not TrkC, induces reciprocal higher-order clustering of <I>trans</I>-synaptic adhesion complexes. Although LAR-RPTP clustering was induced by either HS or postsynaptic adhesion ligands, the dominant binding of HS to the LAR-RPTP was capable of dismantling pre-established LAR-RPTP-mediated <I>trans</I>-synaptic adhesion complexes. These findings collectively suggest that LAR-RPTP clustering for synaptogenesis is modulated by a complex synapse-organizing protein network.</P>
Yoon, Hyonok,Kim, Do-Sung,Lee, Geum-Hwa,Kim, Ji Ye,Kim, Diana H,Kim, Kee-Won,Chae, Soo-Wan,You, Wan-Hee,Lee, Yong Chul,Park, Seoung Ju,Kim, Hyung-Ryong,Chae, Han-Jung Pharmaceutical Society of Great Britain 2009 Journal of pharmacy and pharmacology Vol.61 No.11
<P>OBJECTIVES: This study tested whether sodium para-amino salicylic dihydrate, an antibacterial drug for tuberculosis, could block manganese-induced apoptosis in SK-N-MC neurons. METHODS: Cell viability, Hoechst staining, dichlorofluorescin diacetate analysis for reactive oxygen species measurement, and immunoblotting were performed. KEY FINDINGS: In vitro, manganese chloride significantly decreased the viability of SK-N-MC cells, accompanied by apoptotic features such as changes in nuclear morphology. Sodium para-amino salicylic dihydrate inhibited these apoptotic characteristics through reducing intracellular reactive oxygen species generation, protecting mitochondrial membrane potential and caspase-3 activation. CONCLUSIONS: Sodium para-amino salicylic dihydrate inhibits manganese-induced apoptosis in neurons and may reduce manganese-mediated neurodegeneration.</P>
Interleukin-33 stimulates formation of functional osteoclasts from human CD14(+) monocytes.
Mun, Se Hwan,Ko, Na Young,Kim, Hyuk Soon,Kim, Jie Wan,Kim, Do Kyun,Kim, A-Ram,Lee, Seung Hyun,Kim, Yong-Gil,Lee, Chang Keun,Lee, Seoung Hoon,Kim, Bo Kyung,Beaven, Michael A,Kim, Young Mi,Choi, Wahn So Birkhäuser ; Springer 2010 Cellular and molecular life sciences Vol.67 No.22
<P>Interleukin (IL)-33 is a recently described pro-inflammatory cytokine. Here we demonstrate IL-33 as a regulator of functional osteoclasts (OCs) from human CD14(+) monocytes. IL-33 stimulates formation of tartrate-resistant acid phosphatase (TRAP)(+) multinuclear OCs from monocytes. This action was suppressed by anti-ST2 antibody, suggesting that IL-33 acts through its receptor ST2, but not by the receptor activator of NF-κB ligand (RANKL) decoy, osteoprotegerin, or anti-RANKL antibody. IL-33 stimulated activating phosphorylations of signaling molecules in monocytes that are critical for OC development. These included Syk, phospholipase Cγ2, Gab2, MAP kinases, TAK-1, and NF-κB. IL-33 also enhanced expression of OC differentiation factors including TNF-α receptor-associated factor 6 (TRAF6), nuclear factor of activated T cells cytoplasmic 1, c-Fos, c-Src, cathepsin K, and calcitonin receptor. IL-33 eventually induced bone resorption. This study suggests that the osteoclastogenic property of IL-33 is mediated through TRAF6 as well as the immunoreceptor tyrosine-based activation motif-dependent Syk/PLCγ pathway in human CD14(+) monocytes.</P>
A radiographic evaluation of graft height changes after maxillary sinus augmentation
Kim, Do-Hyung,Ko, Min-Jeong,Lee, Jae-Hong,Jeong, Seoung-Nyum Korean Academy of Periodontology 2018 Journal of Periodontal & Implant Science Vol.48 No.3
Purpose: The aims of the present study were to quantitatively assess graft height changes after sinus lift procedures and to analyze the factors that influenced graft height changes, including the residual bone height before surgery, surgical approach, and tooth type. Methods: A total of 39 maxillary posterior implants placed during a simultaneous sinus lift procedure were evaluated. Panoramic radiographs of all patients were taken immediately after implant installation and at 3 months, 6 months, 1 year, 2 years, and 3 years. To analyze graft height changes over time, we measured the distance between the implant platform and the base of the grafted sinus floor at 3 locations. The radiographs were analyzed by a single examiner. Results: Graft height tended to decrease over time, and a statistically significant difference was observed at 2 years compared to baseline (P<0.05). There was no statistically significant difference in graft height change according to the surgical approach or tooth type. For residual bone height, a statistically significant difference in graft height change was found between those with 4-7 mm of residual bone height and those with ${\geq}7mm$ (P<0.05). Conclusions: Graft height after sinus lift procedures significantly decreased at 2 years compared to baseline after sinus augmentation. Further studies should be done with controlled variables, and prospective studies with 3-dimensional images are needed to clarify the factors that influence graft height changes.