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Genome-Wide Association Study of Lung Cancer in Korean Non-Smoking Women
Kim, Jin Hee,Park, Kyunghee,Yim, Seon-Hee,Choi, Jin Eun,Sung, Jae Sook,Park, Ju-Yeon,Choi, Yi Young,Jeon, Hyo-Sung,Park, Jae Yong,Yoon, Hyoung Kyu,Kim, Yeul Hong,Yoo, Byung Su,Kim, Young Tae,Hu, Hae-J The Korean Academy of Medical Sciences 2013 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.28 No.6
<P>Lung cancer in never-smokers ranks as the seventh most common cause of cancer death worldwide, and the incidence of lung cancer in non-smoking Korean women appears to be steadily increasing. To identify the effect of genetic polymorphisms on lung cancer risk in non-smoking Korean women, we conducted a genome-wide association study of Korean female non-smokers with lung cancer. We analyzed 440,794 genotype data of 285 cases and 1,455 controls, and nineteen SNPs were associated with lung cancer development (<I>P</I> < 0.001). For external validation, nineteen SNPs were replicated in another sample set composed of 293 cases and 495 controls, and only rs10187911 on 2p16.3 was significantly associated with lung cancer development (dominant model, OR of TG or GG, 1.58, <I>P</I> = 0.025). We confirmed this SNP again in another replication set composed of 546 cases and 744 controls (recessive model, OR of GG, 1.32, <I>P</I> = 0.027). OR and <I>P</I> value in combined set were 1.37 and < 0.001 in additive model, 1.51 and < 0.001 in dominant model, and 1.54 and < 0.001 in recessive model. The effect of this SNP was found to be consistent only in adenocarcinoma patients (1.36 and < 0.001 in additive model, 1.49 and < 0.001 in dominant model, and 1.54 and < 0.001 in recessive model). Furthermore, after imputation with HapMap data, we found regional significance near rs10187911, and five SNPs showed <I>P</I> value less than that of rs10187911 (rs12478012, rs4377361, rs13005521, rs12475464, and rs7564130). Therefore, we concluded that a region on chromosome 2 is significantly associated with lung cancer risk in Korean non-smoking women.</P>
Kim, Ju Ho,Choi, Dae Seob,Park, Sung Eun,Choi, Ho Cheol,Kim, Seong Hu Korean Society of Magnetic Resonance in Medicine 2017 Investigative Magnetic Resonance Imaging Vol.21 No.2
Purpose: To describe technical methods for functional magnetic resonance imaging (fMRI) study with arterial spin labeling (ASL) compared to blood oxygenation level-dependent (BOLD) technique and discuss the potential of ASL for research and clinical practice. Materials and Methods: Task-based (n = 1) and resting-state fMRI (rs-fMRI) (n = 20) were performed using ASL and BOLD techniques. Results of both techniques were compared. Results: For task-based fMRI with finger-tapping, the primary motor cortex of the contralateral frontal lobe and the ipsilateral cerebellum were activated by both BOLD and ASL fMRI. For rs-fMRI of sensorimotor network, functional connectivity showed similar results between BOLD and ASL. Conclusion: ASL technique has potential application in clinical and research fields because all brain perfusion imaging, CBF measurement, and rs-fMRI study can be performed in a single acquisition.
( Hu Li ),( Seung-woon Rha ),( Byoung Geol Choi ),( Min Suk Shim ),( Se Yeon Choi ),( Cheol Ung Choi ),( Eung Ju Kim ),( Dong Joo Oh ),( Byung Ryul Cho ),( Moo Hyun Kim ),( Doo-il Kim ),( Myung-ho Jeo 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.4
Background/Aims: Transradial intervention (TRI) is becoming the preferred method over transfemoral intervention (TFI) because TRI is associated with lower incidence of major bleeding and vascular complications. However, there has been limited published data regarding the clinical outcomes of TRI versus TFI in Korean patients with ST-elevation myocardial infarction (STEMI). Methods: A total of 689 consecutive STEMI patients who underwent primary percutaneous coronary intervention (PCI) with drug-eluting stents (DESs) from January to December of 2009 at nine university hospitals were enrolled in this study. Mid-term angiographic and 12-month cumulative clinical outcomes of the TRI group (n = 220, 31.9%) were compared to those of the TFI group (n = 469, 28.1%). Results: After propensity score matching, in-hospital complications and the 12-month major clinical outcomes during follow-up in the two groups were similar to each other. However, the incidence rates of repeat revascularization (6.4% vs. 0.5%, p = 0.003), target vessel revascularization (6.4% vs. 0.5%, p = 0.003), and major adverse cardiac events (MACE; 11.6% vs. 4.6%, p = 0.018) in the TFI group were higher than those in the TRI group during the 12-month of follow-up. Conclusions: In our study, TRI in STEMI patients undergoing primary PCI with DESs was associated with lower incidence of access site hematoma, 12-month repeat revascularization, and MACE compared to TFI. Therefore, TRI might play an important role in reducing bleeding complications while improving major clinical outcomes in STEMI patients undergoing primary PCI with DESs.
Kim, Dong Hyeok,Lim, Jeong Ju,Lee, Jin Ju,Kim, Dae Geun,Lee, Hu Jang,Min, Wongi,Kim, Kwang Dong,Chang, Hong Hee,Rhee, Man Hee,Watarai, Masahisa,Kim, Suk Elsevier 2012 Veterinary microbiology Vol.158 No.3
<P><B>Abstract</B></P><P><I>Brucella abortus</I>, the causative agent of brucellosis, can survive and replicate within host cells. Understanding bacterial virulence factors and bacteria–host cell interactions is critical for controlling brucellosis, yet very little is known about the virulence strategies and signaling pathways activated in phagocytes during infection to ensure their growth and survival. <I>B. abortus</I> was mutagenized by mini-Tn5Km2 transposon mutagenesis to identify virulence genes related to the internalization and intracellular replication of the bacteria. Of the total 2300 mutants used to infect HeLa cells, 23 mutants defective for intercellular growth and the mutated genes were identified. Sequence analysis of DNA flanking the transposon showed various insertion sites in bacterial genes that might be associated with virulence, including genes associated with lipoproteins, amino acid metabolism, translation, transcription, carbohydrate transport, coenzyme transport, inorganic ion transport, energy metabolism, membrane transport, and cell wall/membrane biogenesis. Moreover, mutants were classified into class I, class II and class III as higher, similar, and lower internalization, respectively, into HeLa cells. Furthermore, defective mutants for intracellular growth in HeLa cells were found to be defective in RAW 264.7 cells. Taken together, we suggest that the identified virulence associated genes might contribute to the intracellular growth and survival of <I>B. abortus</I> in phagocytes.</P>
Clinical analysis and review of literature on pilomatrixoma in pediatric patients
Hu, Ju Long,Yoo, Hyokyung,Kwon, Sung Tack,Kim, Sukwha,Chung, Jee Hyeok,Kim, Hyeonwoo,Kim, Jinhyun,Yu, Na Hee,Kim, Byung Jun Korean Cleft Palate-Craniofacial Association 2020 Archives of Craniofacial Surgery Vol.21 No.5
Background: Pilomatrixoma is a benign tumor that originates from the hair follicle matrix. It usually presents as a hard, slow growing, solitary mass that can be easily misdiagnosed as other skin masses. The aim of this study was to clinically analyze a case series of pilomatrixoma in pediatric patients from Korea. Methods: A total of 165 pediatric patients from 2011 to 2018 with a histological diagnosis of pilomatrixoma were included. A retrospective review was performed using the electronic medical records, including patient demographics, number and location of the mass, clinical and imaging presentation, and postoperative outcomes. Results: There were 61 male and 104 female patients with 152 solitary and 13 multiple pilomatrixomas. Among solitary pilomatrixomas, the lesion commonly occurred in the head and neck (84.2%), followed by upper limbs (11.2%), lower limbs (3.3%), and trunk (1.3%). The pilomatrixoma lesion presented as the following types based on our clinical classification: mass (56.02%), pigmentation (25.31%), mixed (12.65%), ulceration (4.82%), and keloid-like (1.2%). Ultrasonography showed a high positive predictive value (95.56%). There were no specific complications observed except for two cases of recurrence. Conclusion: Pilomatrixoma has various clinical feature presentations and commonly occurs in the head and neck. Ultrasonography is a helpful diagnostic tool. Surgical removal of the lesion is the main treatment method with a low recurrence rate.
Stenotrophomonas ginsengisoli sp. nov., isolated from a ginseng field
Kim, Ho-Bin,Srinivasan, Sathiyaraj,Sathiyaraj, Gayathri,Quan, Lin-Hu,Kim, Se-Hwa,Bui, Thi Phuong Nam,Liang, Zhi-qi,Kim, Yeon-Ju,Yang, Deok-Chun Microbiology Society 2010 International journal of systematic and evolutiona Vol.60 No.7
<P>A Gram-negative, non-spore-forming, rod-shaped bacterium, designated strain DCY01<SUP>T</SUP>, was isolated from soil from a ginseng field in South Korea and was characterized in order to determine its taxonomic position. 16S rRNA gene sequence analysis revealed that strain DCY01<SUP>T</SUP> belonged to the <I>Gammaproteobacteria</I> and was most closely related to <I>Stenotrophomonas koreensis</I> KCTC 12211<SUP>T</SUP> (98.4 % similarity), <I>Stenotrophomonas humi</I> R-32729<SUP>T</SUP> (97.2 %), <I>Stenotrophomonas terrae</I> R-32768 (97.1 %), <I>Stenotrophomonas maltophilia</I> DSM 50170<SUP>T</SUP> (96.9 %) and <I>Stenotrophomonas nitritireducens</I> DSM 12575<SUP>T</SUP> (96.8 %). Chemotaxonomic analyses revealed that strain DCY01<SUP>T</SUP> possessed a quinone system with Q-8 as the predominant compound, and iso-C15 : 0 (28.2 %), C16 : 0 10<I>-</I>methyl (13.2 %), iso-C15 : 1 F (10.8 %) and C15 : 0 (7.5 %) as major fatty acids, corroborating assignment of strain DCY01<SUP>T</SUP> to the genus <I>Stenotrophomonas</I>. The major polar lipids were phosphatidylethanolamine, phosphatidylglycerol and diphosphatidylglycerol. The results of DNA-DNA hybridization and physiological and biochemical tests clearly demonstrated that strain DCY01<SUP>T</SUP> represents a species distinct from recognized <I>Stenotrophomonas</I> species. Based on these data, DCY01<SUP>T</SUP> (=KCTC 12539<SUP>T</SUP>=NBRC 101154<SUP>T</SUP>) should be classified as the type strain of a novel species of the genus <I>Stenotrophomonas</I>, for which the name <I>Stenotrophomonas ginsengisoli</I> sp. nov. is proposed.</P>