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Effective Diagnosis and Monitoring of Heart Disease
Ahmed Fawzi Otoom,Emad E. Abdallah,Yousef Kilani,Ahmed Kefaye,Mohammad Ashour 보안공학연구지원센터 2015 International Journal of Software Engineering and Vol.9 No.1
Wearable sensor mobile technologies and machine learning techniques are considered as two of the key research areas in the computer science and healthcare application industries. Our main aim is to build a simple yet accurate mobile application that is capable of real-time diagnosis and monitoring of patients with Coronary Artery Disease (CAD) or heart disease which is a major cause of death worldwide. Most available mobile healthcare systems focus on the data acquisition and monitoring component with little attention paid to real-time diagnosis. In this work, we build an intelligent classifier that is capable of predicting a heart disease problem based on clinical data entered by the user or the doctor and by using machine learning algorithms. This diagnosis component is integrated in the mobile application with a real-time monitoring component that continuously monitors the patient and raises an alarm whenever an emergency occurs. Our results show that the proposed diagnosis component has proved successful with a classification performance accuracy of more than 85% with the cross-validation test. Moreover, the monitoring algorithm provided a 100% detection rate.
Ilef Limem,Ines Bouhlel,Meriem Bouchemi,Soumaya Kilani,Jihed Boubaker,Mohamed Ben-Sghaier,Ines Skandrani,Wissem Behouri,Aicha Neffati,Kamel Ghedira,Leila Chekir-Ghedira 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3
Four extracts were prepared from the leaves of Phlomis mauritanica: lyophilized infusion, total oligomer flavonoids, methanol, and ethyl acetate extracts. The antimutagenic properties of these extracts were investigated by assessing the inhibition of the mutagenic effects of direct-acting mutagens such as sodium azide and 4-nitrophenylenediamine and indirect-acting mutagens like aflatoxin B1 (AFB1) using the Ames assay. The four extracts prepared from P. mauritanica strongly inhibit the mutagenicity induced by AFB1 in both Salmonella typhimurium TA 100 and TA 98 assay systems. Lyophilized infusion and methanol extracts at the dose of 250μg per plate reduced AFB1 mutagenicity by 93% and 91%, respectively, in S. typhymurium strain TA 100. We examined also the antioxidant effect of these extracts by the enzymatic xanthine/xanthine oxidase assay. Result indicated that total oligomer flavonoids and ethyl acetate and methanol extracts were potent inhibitors of xanthine oxidase activity. In contrast, lyophilized infusion, total oligomer flavonoids, and methanol extracts exhibited a high degree of superoxide anion scavenging. Our findings emphasize the potential of P. mauritanica extracts to prevent mutations and oxidant effects. Furthermore, the results presented here could be an additional argument to support the use of this species as a medicinal and dietary plant.
Sherif Hamdy El-Gohary,Mohamed Kilany Metwally,Seyoung Eom,전승현,변경민,김태성 대한의용생체공학회 2014 Biomedical Engineering Letters (BMEL) Vol.4 No.3
Purpose In this work, we propose an alternative photoacousticprobe based on transurethral laser illumination to a conventionaltransrectal photoacoustic imaging system suffering from ahigh optical absorption at a rectal wall and its surroundingtissues. Methods We validate improved performance of the proposedscheme using 3-dimensional prostate model and analyticalcalculations such as Monte Carlo simulation and finiteelement method (FEM). Monte Carlo simulation and FEMare used to find the absorption profiles of photons and theaccompanying temperature elevation and pressure signalgeneration. Results It is found that light source inside the urethra andultrasound transducer on the rectal wall is an optimalcombination to produce a high amplitude in pressure signaland a high signal-to-noise ratio in the reconstructed image. Design study on light source geometry such as beam shape,beam size and gap distance between two light sources is alsoperformed to improve an absorption efficiency at the prostatecancer. Conclusions Our study will be helpful in determining anoptimized probe design of photoacoustic imaging system foradvancing the detection of prostate cancer.
Ines Bouhlel Chatti,Ilef Limem,Jihed Boubaker,Ines Skandrani,Soumaya Kilani,Wissem Bhouri,Mohamed Ben Sghaier,Aicha Nefatti,Hedi Ben Mansour,Kamel Ghedira,Leila Chekir-Ghedira 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.3
The extract enriched in total oligomer flavonoids (TOF), and the aqueous, methanol, and ethyl acetate extracts of Acacia salicina were investigated for their polyphenolic compound content, antioxidative activity in the nitro blue tetrazolium/riboflavin assay system, antibacterial activity against Gram-positive and Gram-negative bacterial reference strains, antigenotoxic activity tested with the Ames assay, and cytotoxic activity against the K562 human chronic myelogenous leukemia cell line and L1210 leukemia murine cells. TOF extract was effective at inhibiting nitro blue tetrazolium reduction by superoxide radical in a nonenzymatic O2•−-generating system. Significant activity against bacterial reference strains Staphylococcus aureus, Enterococcus faecalis, Salmonella enteritidis, and Salmonella typhimurium was shown with all the tested extracts. These extracts significantly decreased the genotoxicity induced by sodium azide and 4-nitro-o-phenylenediamine. A pronounced cytotoxic effect on both leukemia cell lines was detected in TOF, methanolic and ethyl acetate extracts. The antioxidant, antimicrobial, antigenotoxic, and cytotoxic activities exhibited by A. salicina depended on the chemical composition of the tested extracts.
Chatti, Ines Bouhlel,Limem, Ilef,Boubaker, Jihed,Skandrani, Ines,Kilani, Soumaya,Bhouri, Wissem,Sghaier, Mohamed Ben,Nefatti, Aicha,Mansour, Hedi Ben,Ghedira, Kamel,Chekir-Ghedira, Leila The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
The extract enriched in total oligomer flavonoids (TOF), and the aqueous, methanol, and ethyl acetate extracts of Acacia salicina were investigated for their polyphenolic compound content, antioxidative activity in the nitro blue tetrazolium/riboflavin assay system, antibacterial activity against Gram-positive and Gram-negative bacterial reference strains, antigenotoxic activity tested with the Ames assay, and cytotoxic activity against the K562 human chronic myelogenous leukemia cell line and L1210 leukemia murine cells. TOF extract was effective at inhibiting nitro blue tetrazolium reduction by superoxide radical in a nonenzymatic $O_2^{\cdot-}$-generating system. Significant activity against bacterial reference strains Staphylococcus aureus, Enterococcus faecalis, Salmonella enteritidis, and Salmonella typhimurium was shown with all the tested extracts. These extracts significantly decreased the genotoxicity induced by sodium azide and 4-nitro-o-phenylenediamine. A pronounced cytotoxic effect on both leukemia cell lines was detected in TOF, methanolic and ethyl acetate extracts. The antioxidant, antimicrobial, antigenotoxic, and cytotoxic activities exhibited by A. salicina depended on the chemical composition of the tested extracts.