Clinical Usefulness of Korean Red Ginseng in Postmenopausal Women with Severe Climacteric Disturbance

Yoshihiro Kikuchi(Yoshihiro Kikuchi),Takehiko Tode(Takehiko Tode),Junko Hirata(Junko Hirata),Hideyuki Nakata(Hideyuki Nakata),Tsunekazu Kita(Tsunekazu Kita) 고려인삼학회 2003 Journal of Ginseng Research Vol.27 No.3

The aim of this study is to evaluate clinical usefulness of Korean red ginseng (RG) on various postmenopausal syndromes. Total plasminogen inhibitor-1 (tPAI-1) in peripheral blood from 9 postmenopausal women with climacteric syndromes (CS) was measured before and 3 months after treatment with daily oral administrat i on of 6g RG and that from 8 postmenopausal women without any CS was also measured as healthy controls. Blood samples were collected in the early morning on the bed-rest. Psychological conditions of postmenopausal women with CS were measured before and 3 months after treatment with RG using simplified menopausal index (SMI). In addition, OKETSU (blood stagnation) syndrome scores and KI deficiency (generalized energy stagnation) scores proposed by Terasawa et al., were recorded before and 3months after treatment with RG in postmenopausal women with CS and in healthy postmenopausal women. OKETSU syndrome scores and tPAI-1 levels in postmenopausal patients with CS were significantly (P<0.001 and<br/> P<0.01) higher than those in healthy postmenopausal women without CS. Similarly, SMI scores and KI deficiency scores in postmenopausal patients with CS were about three-fold higher than those without any CS. When RG was administered for 3 months, KI deficiency scores and OKETSU scores as well as SMI scores declined around the levels of healthy postmenopausal women. Although tPAI-1 levels significantly (P<0.05) decreased after treatment with RG, those did not reach the levels of healthy postmenopausal women. Clinical usefulness of administration of RG to postmenopausal women with CS was confirmed from evaluation not only by modern medicine but also by traditional KAMPO medicine.

Goniotrichopsis reniformis (Kajimura) Kikuchi comb. nov. (Stylonematales, Rhodophyta) from Japan

신종암,Kikuchi, Norio,West, John A.,Kajimura, Mitsuo,Shin, Jong-Ahm 한국조류학회(藻類) 2006 ALGAE Vol.21 No.2

The morphology and life history of Stylonema reniforme Kajimura (Stylonematales, Rhodophyta) from Japan were investigated and its taxonomic placement was discussed. This species has 6-30 discoid chloroplasts devoid of a pyrenoid in each cell. This is a typical feature of the genus Goniotrichopsis. The species reproduced only by monospores, which were formed by the direct transformation of the vegetative cells similar to the type species Goniotrichopsis sublittoralis Smith. Goniotrichopsis reniformis (Kajimura) Kikuchi comb. nov. was proposed. The asexual life history of the present species was completed in 3-10 weeks at 15-20°C in culture.

A Damage Model for Void Configuration and Failure under Different Constrained Deformation Regions in Ductile Matrix

Kikuchi, M .,Geni, M . 대한금속재료학회(대한금속학회) 2001 METALS AND MATERIALS International Vol.7 No.4

The constraint effects of SiC particle volume fractions and their specimen geometry are analyzed by conducting tensile tests while changing the SiC particle volume fraction 0%, 2% and 10% and the tensile specimen notch radius 0.5, 1.0, 2.0, 4.0, 8.0 and 16.0 ㎜. The effect of constraint on the void configuration and coalescence are investigated experimentally using 3-dimensional SEM fracture surface observations and 3-dimensional image analysis. It was found that the final void volume fraction and void shape were greatly affected by stress triaxiality and deformation constraint.

Future landscape visualization using a city digital twin: integration of augmented reality and drones with implementation of 3D model-based occlusion handling

Kikuchi Naoki,Fukuda Tomohiro,Yabuki Nobuyoshi 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.2

The integration of augmented reality and drones allows past and future landscapes to be visualized from an aerial perspective. However, these visualizations still suffer from the occlusion problem, where the three-dimensional (3D) virtual model displayed in the real world is in front of a real-world object. Currently, city digital twins are essential for the sustainable development of cities and the development of detailed 3D models of cities. By visualizing the city digital twin, augmented reality can facilitate the participation of nonexpert citizens in the decision-making process of urban design, but research examples are limited. Here, using detailed city 3D models, we develop a digital-twin approach to outdoor augmented reality with occlusion handling for both first-person and bird’s-eye views. In a verification experiment, the occlusion handling accuracy of the prototype system was measured to be about 0.8 using intersection over union. The frame rate of the entire prototype system was about 30 fps, and the delay between the controller and the augmented reality device was about 3 s. The internet-based system architecture was developed to integrate augmented reality and drone systems. Our system allows multiple stakeholders involved in building construction projects to observe aerial perspectives of those projects, both on-site and off-site via an internet browser, using augmented reality with occlusion handling.

Diminished reality using semantic segmentation and generative adversarial network for landscape assessment: evaluation of image inpainting according to colour vision

Kikuchi Takuya,Fukuda Tomohiro,Yabuki Nobuyoshi 한국CDE학회 2022 Journal of computational design and engineering Vol.9 No.5

The objective of this research is to develop a method to detect and virtually remove representations of existing buildings from a video stream in real-time for the purpose of visualizing a future scenario without these buildings. This is done by using semantic segmentation, which eliminates the need to create three-dimensional models of the buildings and the surrounding scenery, and a generative adversarial network (GAN), a deep learning method for generating images. Real-time communication between devices enables users to utilize only portable devices equipped with a camera to visualize the future landscape onsite. As verification of the proposed method’s usefulness, we evaluated the complementation accuracy of the GAN and real-time performance of the entire method. The results indicated that the process is completed accurately when the area to be complemented is less than 15% of the view and that the process runs at 5.71 fps. The proposed method enables users to understand intuitively the future landscape and contributes to reducing the time and cost for building consensus.

Carbon Stable Isotope Ratios of Phytoplankton and Benthic Diatoms in Lake Katanuma with Reference to Those of Other Lakes

Kikuchi, Eisuke,Takagi, Shigeto,Shikano, Shuichi,Hideyuki, Doi The Korean Society of Limnology 2005 생태와 환경 Vol.38 No.S

Carbon stable isotope ratios of producers varied in lake ecosystems. In tile present study, we tried to estimate the seasonal variations of carbon isotope ratios of phytoplankton and benthic diatoms in a strongly acidic lake ecosystem. Lake Katanuma is a volcanic, strongly acidic lake (average pH of 2.2), located in Miyagi, Japan. Only two algal species dominate in Lake Katanuma; Pinnularia acidojaponica as a benthic diatom, and Chlamydomonas acidophila as a green alga. Carbon isotope values of P. acidojaponica varied seasonally, while those of particulate organic matter, which were mainly composed of C. acidophila remained fairly stable. The differences suggested that $CO_2$ gas was more frequently limited for P. acidojaponica than C. acidophila, since high density patches of benthic diatoms were sometimes observed on the lake sediment. Generally, carbon concentration mechanisms (CCMs)of microalgae can fix bicarbonate in lakes, and affect the carbon isotope values of microalgae. While, in Lake Katanuma, CCMs of the microalgae may scarcely function because of high $CO_2$ gas concentration and low pH. This is the reason for low seasonal amplitude of carbon isotope values of phytoplankton relative to those in other lakes.

Morphology and Life History of Stylonema cornu-cervi Reinsch (Goniotrichales, Rhodophyta) from Japan

Kikuchi, Norio,Shin, Jong-Ahm The Korean Society of Phycology 2005 ALGAE Vol.20 No.1

The morhology and life history of Stylonema cornu-cervi Reinsch from Japan were investigated. The species had multiseriate erect thalli from a basal cell. The thalli usually branched dichotomously, occasionally trichotomously near the base, and non-branched thalli were sometimes observed. A dichotomous branch on the upper portion near the base occurred only one time on each erect branch. Cells contained a stellate chloroplast, which was composed of a central rounded part with an obscure pyrenoid and 5-8 cup-like lobes connected to the central part by a small thin stipe. The biseriate part was observed on the six-celled stage in culture, and the grown thalli were multiseriate except for base and apices. Monospores forming from the immediate transformation of vegetative cells were observed. Thalli grew at 15-25$^{\circ}C$ and died at 10 and 30$^{\circ}C$. The fastest growth and maturation were observed under 25$^{\circ}C$ and 14L:10D. Although S. alsidii (Zanardini) Drew usually had uniseriate thalli, irregularly branched multiseriate thalli had been reported in cultures. It is possible that in the previous report the thalli were confused with S. cornu-cervi. In this report, S. cornu-cervi were distinguished from S. alsidii in that the branches were few, the multiseriate portions were observed on the early stage (six-celled stage), and the grown thalli were multiseriate except at the base and apices.

Clinical Usefulness of Korean Red Ginseng in Postmenopausal Women with Severe Climacteric Disturbance

Kikuchi, Yoshihiro,Tode, Takehiko,Hirata, Junko,Nakataand, Hideyui,Kita, Tsunekazu The Korean Society of Ginseng 2003 Journal of Ginseng Research Vol.27 No.3

The aim of this study is to evaluate clinical usefulness of Korean red ginseng (RG) on various postmenopausal syndromes. Total plasminogen inhibitor-l (tPAI-l) in peripheral blood from 9 postmenopausal women with climacteric syndromes (CS) was measured before and 3 months after treatment with daily oral administration of 6 g RG and that from 8 postmenopausal women without any CS was also measured as healthy controls. Blood samples were collected in the early morning on the bed-rest. Psychological conditions of postmenopausal women with CS were measured before and 3 months after treatment with RG using simplified menopausal index (SMI). In addition, OKETSU (blood stagnation) syndrome scores and KI deficiency (generalized energy stagnation) scores proposed by Terasawa et al., were recorded before and 3 months after treatment with RG in postmenopausal women with CS and in healthy postmenopausal women. OKETSU syndrome scores and tPAI-l levels in postmenopausal patients with CS were significantly (P<0.001 and P<0.01) higher than those in healthy postmenopausal women without CS. Similarly, SMI scores and KI deficiency scores in postmenopausal patients with CS were about three-fold higher than those without any CS. When RG was administered for 3 months, KI deficiency scores and OKETSU scores as well as SMI scores declined around the levels of healthy postmenopausal women. Although tPAI-1 levels significantly (P<0.05) decreased after treatment with RG, those did not reach the levels of healthy postmenopausal women. Clinical usefulness of administration of RG to postmenopausal women with CS was confirmed from evaluation not only by modem medicine but also by traditional KAMPO medicine.

Signal Recovery from Wavelet Threshold Crossings

Kikuchi, Hisakazu,Nakashizuka, Makoto,Ishii, Ikuo,Makino, Hideo 대한전자공학회 1994 ISPACS:Intelligent Signal Processing and Communica Vol.1 No.1

This paper presents signal reconstruction from wavelet threshold-crossings by using convex projection. We define the wavelet threshold crossings as the irregular sampling of a discrete dyadic wavelet transform. The reconstruction is done by the projection between a convex which characterized by the threshold-crossings and a linear space of all possible wavelet transform. The wavelet threshold-crossings convey the same information as the quantized wavelet transform. The reconstruction precision of the threshold-crossing is superior to the inverse wavelet transform of the quantized wavelet transform. Image reconstruction from the wavelet threshold crossings is demonstrated.

Recent trends of healthcare information and communication technologies in pediatrics: a systematic review

Kikuchi Toru,Lee Keehyuck,Hwang Hee 대한소아청소년과학회 2022 Clinical and Experimental Pediatrics (CEP) Vol.65 No.6

As information communication technology (ICT) has advanced, the healthcare industry has embraced it to reduce medical costs, improve health outcomes, and increase patient satisfaction. Healthcare ICT revolutionizes pediatric healthcare. This study aimed to categorize and synthesize findings from the literature regarding the application of ICT in pediatric patients. This systematic review is based on a comprehensive search of Embase, MEDLINE, and Google Scholar. Study selection and coding were performed independently by 2 researchers, followed by narrative categorization. To reflect current trends in ICT for pediatrics, we adopted the Hype cycle technology classification developed by the advisory and information technology firm, Gartner, and the classification of digital health interventions by the World Health Organization. This study included a total of 135 studies. The analysis revealed 7 main types of ICT for pediatrics: (1) telehealth (39 papers), (2) precision medicine (2 papers), (3) automated decision support systems (17 papers), (4) electronic health records (7 papers), (5) patient portals (7 papers), (6) artificial intelligence (AI) (39 papers), and (7) mobile and wearable technologies (20 papers). In particular, we consistently found references to ICT for pediatrics as well as changing and improving healthcare for children. Further studies are required to determine how we can improve ICT productivity for pediatrics, particularly through AI. This study’s results will help healthcare delivery organizations and technology companies consider the future direction of pediatric healthcare.