Latex Modified Concsdrete 교면공법을 이용한 포장공법의 Life Cycle Cost 분석

조효남,최현호,정평기,이상윤 漢陽大學校 工學技術硏究所 2001 工學技術論文集 Vol.10 No.-

라텍스 개질 콘크리트(Latex Modified Concrete : 이하 LMC라 약칭함)는 방수성, 동결성 등에서 뛰어난 재료이기 때문에 과거 35년 전부터 전 세계적으로 널리 이용되고 있는 포장재료이다. 그러나 아직 국내에서는 고가의 초기공사비 부담으로 인하여 시공실적이 전무한 실정이다. 따라서, 본 연구에서는 현재 우리나라에서 초기도입단계에 있는 라텍스 개질 콘크리트 교면 포장공법을 위한 LCC 분석 절차 및 사용자비용 모델을 제안하고자 하였고, 이러한 절차 및 모델에 기초하여 실제 대상교량의 포장공사에 적용하여 LMC의 LCC 측면에서의 비용 절감효과를 정량적으로 조사하고자 한다. Latex Modified Concrete(LMC) has been widely used for the pavement of highway bridges over the past 35years around the world since it is more resistant to the intrusion of chloride ions, has higher tensile, compressive, and flexural strength, and has greater freeze-thaw resistance. However, in Korea, it has not been introduced to fields due to higher initial construction cost for its overlay than conventional pavement materials. Due to durable characteristics, it should be noted that the LMC may be more cost-effective than conventional pavements such as asphalt pavement considering life-cycle cost(LCC) concept. The objective of this study is intended to suggest a practical LCC analysis model for pavement projects and to demonstrate relative cost-effectiveness of the LMC overlays in comparison with conventional pavement techniques. It may be stated that the procedure proposed in this study may be utilized for making optimal decision on cost-effective pavement design.

연마 다듬질 가공면의 표면 미세형상 평가에 관한 연구

조남규,김현국,권기환,한창수,안유민,이성환,박균명 한국공작기계학회 2000 한국공작기계학회 추계학술대회논문집 Vol.2000 No.-

This paper describes the statistical analysis techniques for the surface roughness assessment of polished surfaces. In experiments, the polishing process of the sample surfaces which are manufactured by ball end mill is consist of two steps; the cusp removal process and the surface finishing process. For the cusp removal process, the criterion of cusp removal was established from the power spectrum analysis to assess the change of the cusp removal rate. For the finishing process, the surface was polished by the rotational CBN tool and vibration wood tool. And the surface quality of polished surface was assessed using the functional parameters based on the statistical values of surface profiles. Consequently, the surface finish performance of the polished surface using the vibration wood tool was improved.

Silibinin Inhibits Tumor Growth through Downregulation of Extracellular Signal-Regulated Kinase and Akt <i>in Vitro</i> and <i>in Vivo</i> in Human Ovarian Cancer Cells

Cho, Hyun Jin,Suh, Dong Soo,Moon, Soo Hyeon,Song, Yong Jung,Yoon, Man Soo,Park, Do Yoon,Choi, Kyung Un,Kim, Yong Keun,Kim, Ki Hyung American Chemical Society 2013 Journal of agricultural and food chemistry Vol.61 No.17

<P>Anticancer activity of silibinin, a flavonoid, has been demonstrated in various cancer cell types. However, the underlying mechanisms were not elucidated in human ovarian cancer cells. The present study was undertaken to examine the effect of silibinin <I>in vitro</I> and <I>in vivo</I> on tumor growth in human ovarian cancer cells. Silibinin decreased cell viability in a dose- and time-dependent manner. Silibinin caused an increase in reactive oxygen species (ROS) generation, and the silibinin-induced cell death was prevented by the antioxidant <I>N</I>-acetylcysteine (NAC). Western blot analysis showed silibinin-induced downregulation of extracellular signal-regulated kinase (ERK) and Akt. Transfection of constitutively active forms of MEK and Akt prevented the silibinin-induced cell death. Oral administration of silibinin in animals with subcutaneous A2780 cells reduced tumor volume. Subsequent tumor tissue analysis showed that silibinin treatment induced a decrease in Ki-67-positive cells, an increase in transferase-mediated dUTP nick end labeling (TUNEL)-positive cells, activation of caspase-3, and inhibition of p-ERK and p-Akt. These results indicate that silibinin reduces tumor growth through inhibition of ERK and Akt in human ovarian cancer cells. These data suggest that silibinin may serve as a potential therapeutic agent for human ovarian cancers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jafcau/2013/jafcau.2013.61.issue-17/jf400192v/production/images/medium/jf-2013-00192v_0008.gif'></P>

급성충수돌기염으로 발현된 방선균증 2예

조진원,송진영,김창억,민영훈,최창순,우흥정,현인규,김종현,유기철,채승완,손진희 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

The Actinomyces species are normal flora of oral cavity and upper intestine characterized as gram-positive, non-spore-forming anaerobic or mjcroaerophilic rods. Actinomycosis is a chronic suppurative and granulomatous disease characterized by abscess, sinus, abundant granulation and mass. The appendix is the commonly involved site among abdominal actinomycosis. Abdominal actinomycosis is often difficult to diagnose before operation because of no reliable clinical features and infrequency of the disease. We report two cases of abdominal actinomycosis which were manifested as acute appendicitis. Those were detected Incidentally tv the pathologist after routine appendectomy. Both patients were successfully treated with appendectomy followed by proper antibiotics use.

산발성 장형 위선암 환자의 Microsatellite Instability와 병리학적 양상

조창희,홍유찬,안지현,최경현,이상호,신영명,윤기영,정민정,장희경 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background : Through many researches, microsatellite is expected to be a good diagnositic and prognostic factor in colorectal cancer, endometrial cancer, gastric cancer, and the others. The prevalence of microsatellite instability (MSI) in gastric carcinoma has reported variously, 13~44%. Purpose : We aimed to determine the prevalence of MSI-high and the relationship between MSI and pathological characteristics of sporadic intestinal type adenocarcinoma of stomach. Material and Methods : We analyzed 106 sporadic intestinal type adenocarcinoma specimens excised from patients who were over thirty-five years old to determine the statue of microsatellite by DNA sequencing. The tissues were formalin-fixed and paraffin embedded. DNA were extracted and amplified by polymerase chain reaction (PCR). MSI was determined using five markers recommended by National Cancer Institute (NCI). Specimens were also studied with five patholical factors-differenciation of tumor cells, depth of invasion, lymph node metastasis, vessel invasion, and perineural invasion- to determine pathological state. Result : The microsatellite statue was determined as MSI-High in 5 cases (4.7%), no MSI-low, and MSS (microsatellite stable) in 101 cases (95.3%). Within the frequency, there was no large gap in the distinction of gender in MSI cases, but in MSS cases, there was three-times more cases in male. MSI cases had moderate-to-poor differenciation and trend to invade toward serosa. All MSI cases showed no perineural invasion. But we could not find any statistical significance between MSI and pathological characteristics of sporadic intestinal type adenocarcinoma. Conclusion : Results suggest that MSI can not make any certain pathological significance in sporadic intestinal type adenocarcinoma. Even though less than 5% of sporadic intestinal type adenocarcinoma patients showed MSI, it can be used as a influential prediagnostic factor of gastric cancer. Further study with large scale of cases will be followed to verify these results.

등속성 운동에 따른 투기종목 선수들의 대퇴근 기능과 혈중 효소수준의 변화

조현철,권양기 又石大學校 1998 論文集 Vol.20 No.-

The purpose of this study was to analyze for changes of muscle function and enzyme level of match athletics according to maximum muscle endurance exercise Subjects were 5 Judo player, 5 tae kwon do player and 5 wrestling player of P.E high school. They were measured and evaluated the strength and the muscular power of 60°/sec work speed and muscular endurance of 240°/sec work speed after 75time(extension/flexion exercise) between each set. The finding of this study were as follows: 1. Peak torque strength and balance ratio at the lower work speed 60o/sec was no significant difference among the group. 2. Mean power during extension exercise at work speed of 240°/sec showed significantly(p〈.05) high(67.6watts) at Judo group after two set. Flexion exercise showed significantly(p〈.05) high(77.0watts) at Judo group after one set. Total work during extension exercise showed significantly(p〈.01) high(2535.7Jo ules) at wrestling group after two set, flexion exercise showed significantly(p〈.05) high during one set(3229.8 Joules) and two set(1996.0 Joules) at Judo group. Muscular fatigue ratio showed significantly(p〈.01) low(34.1%) at one set during extension exercise in Tae kwon do group. During flexion exercise showed signif icantly (p〈.05) low(60.6%) after one set in wrestling group. 3. Variation of serum CPK, LDH level of wrestling group was no significant diff among the group. However, Variation of GOT level showed significantly(p〈.05) low in judo group. Within the scope of this study, for the advancement of ability to compete: First, the training of athletes to develope muscular strength, power, and endurance should be aimed at the peak torque improvement and balanced development of muscular strength for hamstring strength power in match players: second, anaerobic power improvement through the interval training should be preceded for the de-velopment of muscular endurance.

正常家兎의 總輸膽管內 揷管을 通해 投與한 Ethyl Alcohol과 Ethyl Ether가 肝實質에 미치는 影響

趙顯默,孫基燮 충남대학교 의과대학 지역사회의학연구소 1982 충남의대잡지 Vol.9 No.1

The retained stones and flukes in the biliary system are still vexing to mcst surgeons because of its considerable morbidity and mortality. For the purpose of removing the retained stones and flukes in the biliary system nonsurgically, many authors have performed T-tube irrigations with physiochemical solutions such as ethyl alcohol, ethyl etherethyl alcohol(2:1), ethyl ether, heparin, 0.01% benzalkonium chloride solution and other solutions. This study was undertaken to investigate the effects of physiochemical agents 〔0.9% NaCl solution, ethyl alcohol (25% & 50%), ethyl ether-ethyl alcohol, ethyl ether solution〕 on liver tissues of healthy rabbits. The capacity of the bile duct system of normal rabbits(weight: 2.8±0.5kg) was estimated by infusion of Biligrafin(75%) through catheters in common bile duct. A polyethylene catheter of gauge No. 20 was inserted into the common bile duct of each rabbit, then 2 ㏄ of 0.9% physiologic saline solution, ethyl alcohol solution(25% & 50%), ethyl ether-ethyl alcohol solution, ethyl ether solution were infused through the catheter in each group. From six days after the operation, physiochemical agents were infused through catheter in common bile duct once a day (total number of infusion in each group: 2,5,10,15,30 times). The rabbits were sacrificed for the study of the histopathological findings of the liver, and the following results were obtained:1. In the control group which was administered ten times of 2cc of 0.9% sodium chloride solution, the histopathological changes appeared for the first time in the form of mild focal necrosis in hepatic cells and mild fibrosis in bile duct system. Moderate to severe necrosis and fibrosis in hepatic cells and bile duct system appeared in the group of thirty times of administrations. 2. In the 25% ethyl alcohol administered group which was given five times of 2cc., the histopathological changes appeared for the first time in the form of mild focal necrosis in hepatic cells and mild fibrosis in bile duct system. The degree of histopathological changes of the hepatic cells and bile duct system generally was proportional to the number of drug administrations. The centrilobular necrosis was similar to carbon tetrachloride intoxication appeared in the subgroup of the ten times of administrations. 3. In the 50% ethyl alcohol administered group which was given two times of 2cc. , the histopathological changes appeared for the first time in the form of mild focal necrosis in hepatic cells and mild fibrosis in bile duct system. The tissue damage generally was proportional to the times of drug administraton. 4. In the 2:1 ethyl ether-ethyl alcohol administered group which was given two times of 2cc. , the histopathological changes appeared for the first time in the form of mild focal necrosis in hepatic cells and bile duct system. In this group diffuse hepatic cell necrosis, generally proportional to times of drug administrations, was more prominant than focal hepatic cell necrosis. 5. In the pure ethyl ether administered group, rabbits died from once or twice administration of ethyl ether 2cc with convulsive seizure. tachypnea, cardiac arrest. Ethyl ether was very toxic when it was infused through common bile duct in rabbits. Diffuse hemorrhagic necrosis in hepatic cells was shown with once or twice administration. 6. It is to be inferred that diluted ethyl alcohol, e.g. 25% ethyl alcohol solution, could several times be used for the purpose of removing the flukes in the bilary system.

세침 흡인술을 이용한 종창된 림프절의 세포학적 평가

백강현,윤기영,최호정,정성목,이영원,조성환,박성준 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

Fine needle aspiration(FNA) cytology is considered as the diagnostic technique of choice in the assessment of swellen lymph nodes. The aim of this study is to determine the indication and diagnostic method of FNA of lymph node lesions performed at Veterinary Medicine Teaching Hospital of Chungnam National University. The records of 16 patients which had undergone FNA during the study period were retrieved. The cytological results were classified as lymphadenitis, lymphoid hyperplasia and lymphoma. Lymphoma cases were classified as B-cell origin and T-cell by immunophenotyping. The result of the FNA cytological diagnosis showed that nine (56%) of the patients were lymphoma, five (31%) of the patients were lymphoid hyperplasia and two (13%) of the patients were lymphadenitis.

스마트폰 부재와 분실을 대비한 어플리케이션

조시현;문상수;김기환;도민균;서재현;김태공 인제대학교 2012 仁濟論叢 Vol.27 No.1

Recently, as the Smart Phone is rapidly disseminated worldwide, it is emerging as an important digital communication media changing the communication types of users. We use the Smart Phone in all aspect of daily life besides communication. The Smart Phone is indispensible tool that has a great ripple effect on our daily life. Therefore, if the Smart Phone users lose or do not bring their phones, they were troubled. In this paper, we make users available to use the Smart Phone, even if they lose or do not bring their phones. To do this end, we develop features that search the phone in case of not knowing where it is, that contact another phone in case of not bringing their phone, that lock the phone in case of losing it. We expect these features promote a expansion and a vitality of the Smart Phone market.

날록손으로 유발된 비아편계 통각감소 : 중뇌수도 주변 회백질 배측 (dorsal-PAG) 전해질 손상효과 Effect of Dorsal-Periaqueductal Gray Lesion

조소현,서미숙,김기석 한국심리학회 한국심리학회지 생물 및 생리 Vol.5 No.1

날록손과 열자극을 배쌍지어 제시하면 통증에 대한 민감성이 감소한다. 날록손으로 유발된 통각감소는 날록손이 사전에 처치되었음에도 불구하고 발생되었다는 점에서 특성상 비아편계가 매개하는 통각감소라 할 수 있다. 본 연구에서는 날록손과 열자극의 배쌍에 의해 유발된 비아편계 통각감소에 책임이 있는 뇌영역이 어디인지를 알아보고자 하였다. 실험장치로서는 열판 장치를 사용하였고 열자극은 53±0.5℃로 하였다. 통증에 대한 민감성 지표로서는 뒷발을 핥기까지의 잠재기를 측정하였다. 실험결과, 모의시술집단은 훈련시에 발생된 통각감소율이 검사시에도 계속 유지된 반면 중뇌수도 주변 회백질 배측부분이 손상된 실험집단은 훈련시 발생된 통각감소율이 훈련전의 기저선 수준으로 환원되었다. 이러한 결과는 중뇌수도 주변 회백질 배측부분이 날록손과 열자극의 배쌍으로 유발된 비아편계 통각감소에 책임이 있는 뇌 부위임을 시사해준다고 하겠다. Animals exposed to the naloxone-heat pairings reduced their sensitivity to the pain. Naloxone-induced analgesia may be, in nature, non-opioid in that was found in the rat pretreated with naloxone. The present study was conducted to examine the area which is the responsible for the analesia induced by naloxone-heat pairings. Hot-plate apparatus which was thermoregulated automatically at 53±0.5℃ was used for heat stimulus. The latencies for hind-paw lick was recorded as an index of pain sensitivity. The result of present experiment was as follows. Sham operated rats were maintained analgesia which developed in the training phase but, analgesia developed in the rats which belongs to the experimental group in the training phase was reduced to the baseline level after dorsal periaqueductal lesion. This result suggest that dorsal-periaqueductal gray is responsible for the analgesia induced by naloxone.