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- 저자 : Keon Hyon Jo (검색결과 16 건)
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흰쥐의 파라쿼트 중독모델에서 폐손상에 대한 N-acetylcysteine과 Methylprednisolone의 효과
최태환,조건현,오동렬,김세경 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3
Background: This study evaluated the inhibitory effects of N-acetylcysteine(NAC) and methylprednisolone on lung injury in the paraquat-poisoned rat model. Methods: Sixty rats were divided into four groups(n=15 in each group) accordingly to the drug administered : group I, only intraperitoneally injected paraquat (20 mg/kg); group II, intraperitoneally injected paraquat and NAC(300 mg/kg); group III, intraperitoneally injected paraquat and methylprednisolone(60 mg/kg); and group IV, intraperitoneally injected paraquat, NAC(300 mg/kg), and methylprednisolone(60 mg/kg). On the 7th day after injection, the survival rate of experimental rats and the positive area of collagen fiber in the injured lung stained by Masson's trichroms were evaluated. Results: 1. There were no differences in the 7-day survival rates for the four groups. 2, The percent of collagen fiber for group II(6.3 ± 4.7%) was significantly decreased in comparison with that for group I (14.4±9.7%). 3. The percent of collagen fiber for Group III(13.2±5.9%) was not significantly different from that for group I(14.4±9.7%). 4. The percent of collagen fiber for Group IV(6.9±4.6%) was significantly decreased in comparison with that for group I, but was not different from that for group II. Conclusion: These results suggest that NAC protects against pulmonary fibrosis in paraquat-poisoned rats whereas methylprednisolone does not protect against pulmonary fibrosis.
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폐암환자의 Dinitrochlorobenzene (DNCB) 접촉성 감작에 대한 고찰
조건현,이홍균,Jo, Keon-Hyon,Lee, Hong-Kyun 대한흉부심장혈관외과학회 1979 Journal of Chest Surgery (J Chest Surg) Vol.12 No.1
Clinical evaluation of contact sensitization to 2, 4-dinitro-chlorobenzene [DNCB] was performed in 2 groups: group A [30 patients with non-malignant disease] and group B [30 patients with bronchogenic carcinoma]. Initial sensitization was elicited out by applying 2, 000 ug of DNCB to skin surface of the both group A and B. Subsequently a relatively weak challenge dose, 200 ug of DNCB, was applied 14 days later, showing the satisfactory results of sensitization with minimizing non-specific irritative inflammatory skin response. Delayed cutaneous hypersensitivity reactions shown by spontaneous flare phenomena appeared at the challenge site, and they were assessed 48 hours later. The reaction were graded from +1 to +4 according to the degree of flare or vesicular reaction. The results were as follows: 1. 28 cases [93%] of group A, however, only 18 cases [67%] of group B exhibited delayed cutaneous hypersensitivity reaction to DNCB contact sensitization [P<0.02]. 2. Of group A, the delayed cutaneous hypersensitivity reactions above +2 of DNCB score were 25 cases [83%], meanwhile 11 cases [37%] in group B [P<0.001]. 3. Undifferentiated carcinomas showed highest incidence of anergy to DNCB contact sensitization in the all histologic types of group B. 4. In group B, 8 [42%] of 19 cases who react to DNCB were resectable, whereas only 2 [18 %] of 11 cases who failed to react to DNCB were resectable for curative cancer surgery. These study suggests that cellular immune reaction of group B was depressed remarkably comparing with that of group A.
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Valve Replacement with St. Jude Medical Valve
Wang, young-Pil,Jo, Keon-Hyon,Kwack, Moon-Sub,Lee, Sun-Hee,Cho, Kyu-Do,Kim, Chi-Kyung,Kim, Se-Wha 가톨릭 의과학연구원 1997 가톨릭 의과학연구원 국제학술대회 Vol.1 No.-
Consequently, overall mortality was 10.3%(37/357) during follow-up period. Actuarial survival rates after 6 yrs were 94.6% for MVR. 96.8% for AVR. 95.8% for DVR and 100% for TVR. In conclusion, the st. Jude Medical prosthesis can be considered to be an effective valve with a low rate of valve-related complication when there is correct anticoagulant therapy. Our group continues to use the St. Jude Medical Valve in all patients requiring Valve replacement except in those who can not take warfarin anticoagulation.
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Lee, Hong Kyun,Jo, Keon Hyon CATHOLIC MEDICAL CENTER 1986 Bulletin of the Clinical Research Institute Vol.14 No.1
Systemic hypotension and bradyarrhythmia are observed occasionally when protamine is administered through the intravenous route to neutralize the effects of circulating heparin following cardiopulmonary bypass. To elucidate the mechanism responsible for hemodynamic changes and hemodynamic differences between the arterial and venous route of administration, we studied hemodynamic responses and quantitative changes of vasoactive substances, histamine and prostacyclin, in experimental dogs. Healthy mongrel dogs, weighing 8-10 ㎏, received heparin (3 ㎎/㎏) initially and then divided into 2 groups according to the route of protamine (3 ㎎/㎏) administration; in group A (n-10), through the ascending aorta and in group B (n=10), through the central vein. Hemodynamic parameters, the plasma level of histamine and 6-keto-prostaglandin F_1α as a stable metabolite of prostacyclin were measured before and after protamine injection in both groups. The results were as follows; 1. The mean systemic arterial pressure decreased significantly from 118±20 mmHg to 76±20 mmHg at 1 minute after protamine administration (P<0.01) and lasted for 8 minutes in group B, whereas it decreased from 118±15 mmHg to 107±22 mmHg at 1 minute after protamine (P<0.05) and soon returned to normal in group A. 2. The systemic vascular resistance decreased from 52±12 unit to 39±16 unit (P<0.05), 35±13 unit (P<0.01) and 40±15 unit (P<0.01) at 1 minute, 3 minutes and 5 minutes after protamine injection in group B, whereas no significant changes in group A. 3. The mean concentration of plasma histamine increased significantly from 49.87±12.22 ng/ml to 65.18±32.60 ng/ml at 1 minute after protamine injection in group B (P H 0.05), whereas it did not increase in group A. 4. The mean concentration of plasma 6-keto-prostaglandin F_1α increased significantly from 0.28±0.07ng/ml to 0.58±0.24ng/ml(P<0.01), 0.50±0.21ng/ml(P>0.01) and 0.38±0.14ng/ml (P<0.05) at 1 minute, 3 minutes and 5 minutes respectively after protamine injection in group B, whereas no significant changes in group A. Based on the above results, protamine induced circulatory changes and hemodyamic stability of intra-aortic administration may be related to the decrease of systemic vascular resistance which was mediated by vasodilatory action of histamine and prostacyclin from the lung when administred through the central vein.
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Rha, Suk Joo,Wang, Young Pil,Jo, Keon Hyon,Kim, Se Wha,Kwack, Moon Sub CATHOLIC MEDICAL CENTER 1992 Bulletin of the Clinical Research Institute Vol.20 No.2
Bleomycin and cyclophosphamide are wiely used effective anti-cancer agents for treatment of various forms of cancer. Bleomycin has no myelotoxicity but because of potential risk of pulmonary complications including interstitial pneumonitis and idiopathic interstitial pulmonary fibrosis, it has been limited in use. Some investigator has suggested that cyclophosphamide also can induce pulmonary toxicity like bleomycin. Recently, the combination chemotherapy including bleomycin and cyclophosphamide has been adopted effectively in some types of cancer. But there are no available literature for synergistic effect on pulmonary toxicity in combination chemothrapy including these two drugs. We tried this study to observe synergism of these two drugs on pumonary toxicity in rats. Ninty rats were divided Into five groups: group 1 received intra-peritoneal injection of saline, group 2-a received only 0.1 mg of bleomycin (0.4 mg/kg) by intraperitoneal injection twice a week, group 2-b received only 0.5 mg of bleomycin (2 mg/kg) by intraperitoneal injection twice a week, group 3-a received 0.1 mg of bleomycin (0.4 mg/kg) twice a week with 5 mg of cyclophosphamide (20 mg/kg) two weeks interval by intraperitoneal injection, group 3-b received 0.5 mg of bleomycin (2 mg/kg) twice a week with 5 mg of cyclophosphmide (20 mg/kg) two weeks interval by intraperitoneal injection. the animals were sacrificed at 2 and 4 weeks later. Lung tissue were obtaind and observed by light microscope. The results are as follows: 1. There was no differences between group 2-a and group 3-a at 2 weeks later, However, group 3-a (grade Ⅱ; 7, grade Ⅲ; 3) revealed more severe change in lung tissue at 4 weeks later compared with group 2-a (normal; 3, grade Ⅰ; 4, grade Ⅱ; 3). 2. There was more severe pulmonary injury in group 3-b (grade Ⅱ; 6, grade Ⅲ; 4 at two weeks later, and grade Ⅱ; 2, grade Ⅲ; 8 at 4 weeks later) compared with group 2-b (normal; 3, grade Ⅰ; 3 grade Ⅱ; 4 at 2 weeks later and grade Ⅱ; 4 at 2 weeks later and grade Ⅱ; 5, grade Ⅲ; 5 at 4 weeks later) 3t 2 and 4 weeks later. It seems that the combined administration of bleomycin and cyclophosphmide induce more severe pulmonary toxic effect than bleomycin adminstration alone, and the combination chem otherapy of these two drugs will require special attention on the dose of each drug.
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Adventitial Fibroblast Abormality in Thoracic Aortic Aneurysms and Aortic Dissections
Jong Hui Suh,Jeong-Seob Yoon,Hwan Wook Kim,Keon Hyon Jo 대한흉부외과학회 2011 Journal of Chest Surgery (J Chest Surg) Vol.44 No.6
Development of thoracic aortic aneurysms and aortic dissections (TAAD) is attributed to unbearable wall tension superimposed on defective aortic wall integrity and impaired aortic repair mechanisms. Central to this repair mechanisms are well-balanced and adequately functional cellular components of the aortic wall, including endothelial cells, smooth muscle cells (SMCs), inflammatory cells, and adventitial fibroblasts. Adventitial fibroblasts naturally produce aortic extracellular matrix (ECM), and, when aortic wall is injured, they can be transformed into SMCs, which in turn are involved in aortic remodeling. We postulated the hypothesis that adventitial fibroblasts in patients with TAAD may have defects in ECM production and SMC transformation. Materials and Methods: Adventitial fibroblasts were procured from the adventitial layer of fresh aortic tissues of patients with TAAD (Group I) and of multi-organ donors (Group II), and 4-passage cell culture was performed prior to the experiment. To assess ECM production, cells were treated with TNF-α (50 pM) and the expression of MMP-2 / MMP-3 was analyzed using western blot technique. To assess SMC transformation capacity, cells were treated with TGF-β1 and expression of SM α-actin, SM-MHC, Ki-67 and SM calponin was evaluated using western blot technique. Fibroblasts were then treated with TGF-β1 (10 pM) for up to 10 days with TGF-β1 supplementation every 2 days, and the proportion of transformed SMC in the cell line was measured using immunofluorescence assay for fibroblast surface antigen every 2 days. Results: MMP-3 expression was significantly lower in group I than in group II. TGF-β1-stimulated adventitial fibroblasts in group I expressed less SM α-actin, SM-MHC, and Ki-67 than in group II. SM-calponin expression was not different between the two groups. Presence of fibroblast was observed on immunofluorescence assay after more than 6 days of TGF-β1 treatment in group I, while most fibroblasts were transformed to SMC within 4 days in group II. Conclusion: ECM production and SMC transformation are compromised in adventitial fibroblasts from patients with TAAD. This result suggests that functional restoration of adventitial fibroblasts could well be a novel approach for the prevention and treatment of TAAD.
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