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NMR Study of Magnetic Properties of Eu1−xSrxMnO3 (0 ≤ x ≤ 0.5)
Kenji Shimizu,Masanori Yamaguchi,Shujuan Yuan,Shixun Cao 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.3
The perovskite manganite EuMnO3 is known to be a compound with a narrow eg-band width due to small ionic radius of Eu3+ compared to La3+. The Eu1−xSrxMnO3 compounds show complex magnetic properties, depending on the Sr concentration x. We have carried out 55Mn spin-echo nuclear magnetic resonance (NMR) measurements on polycrystalline Eu1−xSrxMnO3 (0 ≤ x≤ 0.5) compounds at 4.2 or 1.4 K in order to clarify the microscopic local magnetic state of the Mn ions. NMR spectra have been observed in the frequency range from 250 MHz to 400 MHz. For the A-type antiferromagnetic EuMnO3, the resonance frequency is about 260 MHz, which is much lower than that observed for Mn3+ in La1−xSrxMnO3. For 0.1 ≤ x ≤ 0.4, the resonance lines corresponding to Mn4+ and Mn3+ have been observed at about 315 MHz and 390 MHz, respectively. Furthermore, the spectra originating from Mn2+ have been observed around 590 MHz for 0.1 ≤ x ≤ 0.4. For Eu0.5Sr0.5MnO3, the NMR spectrum spreads widely with several distinct peaks in the frequency range from 250 MHz to 410 MHz, which shows that the compound is in an inhomogeneous state due to competition between the antiferromagnetic and the ferromagnetic states.
Shimizu, Hirotaka,Arai, Katsuhiro,Takeuchi, Ichiro,Minowa, Kei,Hosoi, Kenji,Sato, Masamichi,Oka, Itsuhiro,Kaburaki, Yoichiro,Shimizu, Toshiaki The Korean Society of Pediatric Gastroenterology 2021 Pediatric gastroenterology, hepatology & nutrition Vol.24 No.1
Purpose: The long-term efficacy and safety of infliximab (IFX) in children with ulcerative colitis (UC) have not been well-evaluated. Here, we reviewed the long-term durability and safety of IFX in our single center pediatric cohort with UC. Methods: This retrospective study included 20 children with UC who were administered IFX. Results: For induction, 5 mg/kg IFX was administered at weeks 0, 2, and 6, followed by every 8 weeks for maintenance. The dose and interval of IFX were adjusted depending on clinical decisions. Corticosteroid (CS)-free remission without dose escalation (DE) occurred in 30% and 25% of patients at weeks 30 and 54, respectively. Patients who achieved CS-free remission without DE at week 30 sustained long-term IFX treatment without colectomy. However, one-third of the patients discontinued IFX treatment because of a primary nonresponse, and one-third experienced secondary loss of response (sLOR). IFX durability was higher in patients administered IFX plus azathioprine for >6 months. Four of five patients with very early onset UC had a primary nonresponse. Infusion reactions (IRs) occurred in 10 patients, resulting in discontinuation of IFX in four of these patients. No severe opportunistic infections occurred, except in one patient who developed acute focal bacterial nephritis. Three patients developed psoriasis-like lesions. Conclusion: IFX is relatively safe and effective for children with UC. Clinical remission at week 30 was associated with long-term durability of colectomy-free IFX treatment. However, approximately two-thirds of the patients were unable to continue IFX therapy because of primary nonresponse, sLOR, IRs, and other side effects.
Review : EUS-Guided Biliary Drainage
( Kenji Yamao ),( Kazuo Hara ),( Nobumasa Mizuno ),( Akira Sawaki ),( Susumu Hijioka ),( Yasumasa Niwa ),( Masahiro Tajika ),( Hiroki Kawai ),( Shinya Kondo ),( Yasuhiro Shimizu ),( Vikram Bhatia ) The Editorial Office of Gut and Liver 2010 Gut and Liver Vol.4 No.s1
Endoscopic ultrasonography (EUS) combines endoscopy and intraluminal ultrasonography, and allows imaging with a high-frequency transducer over a short distance to generate high-resolution ultrasonographic images. EUS is now a widely accepted modality for diagnosing pancreatobiliary diseases. EUS-guided fineneedle aspiration (EUS-FNA) using a curved linear- array echoendoscope was initially described more than 20 years ago, and since then many researchers have expanded its indications to sample diverse lesions and have also used it for various therapeutic purposes. EUS-guided biliary drainage (EUS-BD) is one of the therapeutic procedures that has been developed using a curved linear-array echoendoscope. Technically, EUS-BD includes rendezvous techniques via transesophageal, transgastric, and transduodenal routes, EUS-guided choledochoduodenostomy (EUS-CDS), and EUS-guided hepaticogastrostomy (EUS-HGS). Published data have demonstrated a high success rate, albeit with a comparatively high rate of nonfatal complications for EUS-CDS and EUS-HGS, and a comparatively low success rate with a low complication rate for the rendezvous technique. At present, these procedures represent an alternative to surgery or percutaneous transhepatic biliary drainage (PTBD) for patients with obstructive jaundice when endoscopic biliary drainage (EBD) has failed. However, these procedures should be performed in centers with extensive experience in linear EUS and therapeutic biliary ERCP. Large prospective studies are needed in the near future to establish standardized EUS-BD procedures as well as to perform controlled comparative trials between EUS-BD and PTBD, between rendezvous techniques and direct-access techniques (EUS-CDS and EUS-HGS), and between EBD and EUS-BD. (Gut Liver 2010;4(Suppl. 1):S67-75)
A Note on Unavoidable Sets for a Spherical Curve of Reductivity Four
Kashiwabara, Kenji,Shimizu, Ayaka Department of Mathematics 2019 Kyungpook mathematical journal Vol.59 No.4
The reductivity of a spherical curve is the minimal number of times a particular local transformation called an inverse-half-twisted splice is required to obtain a reducible spherical curve from the initial spherical curve. It is unknown if there exists a spherical curve whose reductivity is four. In this paper, an unavoidable set of configurations for a spherical curve with reductivity four is given by focusing on 5-gons. It has also been unknown if there exists a reduced spherical curve which has no 2-gons and 3-gons of type A, B and C. This paper gives the answer to this question by constructing such a spherical curve.
Kurokawa, Kenji,Ryu, Kyoung-Hwa,Ichikawa, Rie,Masuda, Akiko,Kim, Min-Su,Lee, Hanna,Chae, Jun-Ho,Shimizu, Takashi,Saitoh, Tatsuya,Kuwano, Koichi,Akira, Shizuo,Dohmae, Naoshi,Nakayama, Hiroshi,Lee, Bok American Society for Biochemistry and Molecular Bi 2012 The Journal of biological chemistry Vol.287 No.16
Jung, Jihyang,Shimizu, Yo,Omasa, Kenji,Kim, Sungsu,Lee, Sangdon The Korean Society for Integrative Biology 2016 Animal cells and systems Vol.20 No.4
Geographic information system (GIS) and landscape-level data offer a new opportunity for modeling and evaluating the quality of wildlife habitats. Models of habitat quality have not been developed for some species, and existing models could be improved by incorporating updated information on wildlife-habitat relationships and habitat variables. We developed a GIS-based habitat suitability index (HSI) model for the Korean water deer (Hydropotes inermis argyropus), which often causes human-wildlife conflicts in the Chungnam Province of Korea because of industrialization and urbanization. The model is based on logistic regression analysis, which addresses the impact of multiple habitat variables, such as habitat components, topographic characteristics, and human disturbances. The model yielded a p-value of .289 (<TEX>${\chi}^2=9.672$</TEX>) and 65.4% correct prediction level with the overall observation-prediction comparison data. The model demonstrated that a large portion of the province (61.6%) could be regarded as a poor habitat (mean HSI value of the province = 0.22), while the current habitats of the province could be considered of moderate quality (mean HSI value = 0.31). In addition, the chance of observation of the deer increases as the HSI level increases, which means that the model yields a good predictive power. Lastly, we used the model to produce a habitat suitability map. Our HSI model enabled us to quantify habitat preferences, which could be the basis for decision-making on habitat protection, mitigation, and enhancement of the Korean water deer. The proposed model is also applicable for improving and enhancing the existing management practices, as well as for establishing an effective wildlife protection policy.
Shiratsuchi, Akiko,Shimizu, Kaori,Watanabe, Ikuko,Hashimoto, Yumi,Kurokawa, Kenji,Razanajatovo, Iony M.,Park, Keun H.,Park, Hae K.,Lee, Bok L.,Sekimizu, Kazuhisa,Nakanishi, Yoshinobu Blackwell Publishing Ltd 2010 Immunology Vol.129 No.2
<P>Summary</P><P>We previously reported that <I>Staphylococcus aureus</I> avoids killing within macrophages by exploiting the action of Toll-like receptor 2 (TLR2), which leads to the c-Jun N-terminal kinase (JNK)-mediated inhibition of superoxide production. To search for bacterial components responsible for this event, a series of <I>S. aureus</I> mutants, in which the synthesis of the cell wall was interrupted, were screened for the level of JNK activation in macrophages. In addition to a mutant lacking the lipoproteins that have been suggested to act as a TLR2 ligand, two mutant strains were found to activate the phosphorylation of JNK to a lesser extent than the parental strain, and this defect was recovered by acquisition of the corresponding wild-type genes. Macrophages that had phagocytosed the mutant strains produced more superoxide than those engulfing the parental strain, and the mutant bacteria were more efficiently killed in macrophages than the parent. The genes mutated, <I>dltA</I> and <I>tagO</I>, encoded proteins involved in the synthesis of <SMALL>D</SMALL>-alanylated wall teichoic acid. Unlike a cell wall fraction rich in lipoproteins, <SMALL>D</SMALL>-alanine-bound wall teichoic acid purified from the parent strain by itself did not activate JNK phosphorylation in macrophages. These results suggest that the <SMALL>D</SMALL>-alanylated wall teichoic acid of <I>S. aureus</I> modulates the cell wall milieu for lipoproteins so that they effectively serve as a ligand for TLR2.</P>
Myxopapillary Ependymoma of the Cauda Equina in a 5-Year-Old Boy
Masashi Uehara,Jun Takahashi,Keijiro Mukaiyama,Shugo Kuraishi,Masayuki Shimizu,Shota Ikegami,Toshimasa Futatsugi,Kenji Sano,Kazuhiro Hongo,Hiroyuki Kato 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.6
Myxopapillary ependymoma in childhood typically occurs in the central nervous system. There are few surgical cases of myxopapillary ependymoma of the cauda equina in children. We report a case of myxopapillary ependymoma of the cauda equina in a 5-yearold boy, who presented with leg pain and abnormal gait. Subtotal resection surgery was performed. Following the subtotal tumor resection, follow-up magnetic resonance imaging evaluation showed a recurrent tumor. As a result, we performed a second subtotal tumor resection and followed with postoperative radiation therapy. No further evidence of the disease has been noted elsewhere in the patient in over ten years of follow-up. Myxopapillary ependymoma of the cauda equina in a young boy was improved by subtotal tumor resection and postoperative radiation therapy.