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Kenichi Nagaoka,Akihiro Shimizu,Katsumi Ida,Katsunori Ikeda,Katsuyoshi Tsumori,Kazuo Toi,Keisuke Matsuoka,Kiyomasa Watanabe,Masaki Osakabe,Mikiro Yoshinuma,Mitsutaka Isobe,Osamu Kaneko,Shoichi Okamura 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
The characteristics of neutral beam driven current have been investigated in helical devices, which do not need ohmic current to produce a magnetic field configuration. The neutral beam current drive experiments have been performed in a wide range of Zb/Zeff in LHD and CHS. The Z dependence of neutral beam driven current in the region of Zb/Zeff < 1 obtained by neon discharges in LHD agrees with the Ohkawa model. On the other hand, the current driven by neon beam injection in CHS cannot be explained by the Ohkawa model.
Enami Kaneko,Naoki Sato,Tae Sugawara,Aya Noto,Kazue Takahashi,Kenichi Makino,Yukihiro Terada 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.6
Objective: The antitumor effects of anti-PD-1 antibody against mismatch repair deficiency (MMR-D)-associated cancers have been reported. MMR-D is found in approximately20%–30% of endometrial carcinomas (ECs) and frequently occurs due to promoter hypermethylation ( -PHM). ECs with -PHM are classified according to the molecular screening of Lynch syndrome (LS), but few detailed reports are available. The purpose of this study was to clarify the clinical features of EC with -PHM. Methods: Immunohistochemistry of MMR proteins (MLH1, MSH2, MSH6, and PMS2) was performed on specimens from 527 ECs treated at our university hospital from 2003 to 2018. methylation analysis was added to cases with MLH1/PMS2 loss. ECs were classified as follows: cases that retained MMR proteins as “MMR-proficient;” cases with MLH1/PMS2 loss and -PHM as “met-EC;” and cases with other MMR protein loss and MLH1/PMS2 loss without -PHM as “suspected-LS.” The clinical features, including long-term prognosis, of each group, were analyzed. Results: Accordingly, 419 (79.5%), 65 (12.3%), and 43 (8.2%) cases were categorized as “MMR-proficient,” “suspected-LS,” and “met-EC,” respectively. Significantly, “met-EC” had a lower proportion of grade 1 tumors (37.5%) and a higher proportion of stage III/IV tumors (37.2%) than the other groups. The overall and progression-free survival of “met-EC” were significantly worse than those of “suspected-LS” in all cases. Conclusion: In ECs with MMR-D, “met-ECs” were a subgroup with a poorer prognosis than “suspected-LS.” “Met-ECs” would be the main target for anti-PD-1 antibody treatment, and its clinical susceptibility should be verified individually.
Novel Pathogenetic Mechanism in a Clinical Isolate ofYersinia enterocolitica KU14
Matsuhisa Inoue,Kenichi Kaneko,Takeshi Sasahara,Yoshinori Sato 한국미생물학회 2006 The journal of microbiology Vol.44 No.1
Yersinia enterocolitica induces a broad range of gastrointestinal syndromes, including acute enteritis. We previously reported that the clinical isolate, Y. enterocolitica KU14, which lacks pYV, was still capable of causing clinical infection. The present study demonstrated that KU14 did not trigger the death of macrophages in vitro, unlike WA-314 (ATCC51871, which harbors the pYV virulence plasmid). However, the intracellular growth of KU14 in the macrophages was greater than that of WA-C (ATCC51872, a non-plasmid harboring the derivative pYV plasmid). Treatment with a cholesterol-binding drug (β-cyclodextrin) that affected lipid rafts resulted in a dramatic reduction in the intracellular growth of KU14. These data clearly indicate that the enhanced intracellular growth of KU14 is related to lipid raft-mediated infection.
Novel Pathogenetic Mechanism in a Clinical Isolate of Yersinia enterocolitica KU14
Sato Yoshinori,Kaneko Kenichi,Sasahara Takeshi,Inoue Matsuhisa The Microbiological Society of Korea 2006 The journal of microbiology Vol.44 No.1
Yersinia enterocolitica induces a broad range of gastrointestinal syndromes, including acute enteritis. We previously reported that the clinical isolate, Y. enterocolitica KU14, which lacks pYV, was still capable of causing clinical infection. The present study demonstrated that KU14 did not trigger the death of macrophages in vitro, unlike WA-314 (ATCC51871, which harbors the pYV virulence plasmid). However, the intracellular growth of KU14 in the macrophages was greater than that of WA-C (ATCC51872, a non-plasmid harboring the derivative pYV plasmid). Treatment with a cholesterol-binding drug $(\beta-cyclodextrin)$ that affected lipid rafts resulted in a dramatic reduction in the inracellular growth of KU14. These data clearly indicate that the enhanced inracellular growth of KU14 is related to lipid raft-mediated infection.
The Effect of Stroop Task on Stride Interval of Gait in Elderly People
( Hitoshi Makabe ),( Takuhiro Ikeda ),( Kenichi Kaneko ) 한국감성과학회 2019 한국감성과학회 국제학술대회(ICES) Vol.2019 No.-
Aims: The aim of this study was to examine the effects of Stroop task on stride interval of gait while walking in young and elderly people. Methods: Subjects were 20 healthy young adult men and 20 healthy elderly men. The subjects walked around a 20-m path shaped like a figure 8, at a comfortable walking speed for 12 minutes with Stroop task and without Stroop task. Stride intervals were recorded by tri-axial accelerometer attached to the heel. Scaling exponent (SE) and approximate entropy (ApEn) were calculated from the time series of stride interval. Results: In walking without Stroop task, the elderly showed significantly lower SE than younger, and ApEn showed no significant difference. In walking with Stroop task, the elderly showed significantly lower SE than younger, and the elderly showed significantly larger than younger. Discussion: The SE indicates the long-term correlation of the stride interval, and the ApEn indicates the regularity of the variation of the stride interval. The results revealed that long-term correlation decreased with age. And by giving the Stroop task, the regularity of the stride interval decreased. These results were caused by the decline of brain-motor network function with age.