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Periyar Selvam Sellamuthu,,Palanisamy Arulselvan,Balu Periamallipatti Muniappan,Sharida Fakurazi,Murugesan Kandasamy 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.8
Oxidative stress in diabetic tissues is a consequence of free radical accumulation with concurrently impaired natural antioxidants status and results in oxidative tissue damage. The present study investigated the protective effects of mangiferin against pancreatic β-cell damage and on the antioxidant defense systems in streptozotocin (STZ)-induced diabetic rats. Diabetes was experimentally induced by a single intraperitoneal injection of STZ. Oxidative stress biomarkers such as tissue malondialdehyde, hydroperoxides, reduced glutathione (GSH) content, and nonenzymatic antioxidants were measured. Biochemical observations were further substantiated with histological examination and ultrastructural studies in the pancreas of diabetic, glibenclamide and mangiferin-treated diabetic rats (dosage of 40 mg/kg body weight daily for 30 days). Oral administration of mangiferin and glibenclamide to diabetic rats significantly decreased the level of blood glucose and increased levels of insulin. Additionally, mangiferin treatment significantly modulated the pancreatic nonenzymatic antioxidants status (vitamin C, vitamin E, ceruloplasmin, and reduced GSH content) and other oxidative stress biomarkers. The histoarchitecture of diabetic rats showed degenerated pancreas with lower β-cell counts, but mangiferin treatment effectively regenerated insulin secreting islet cells. The electron microscopic study revealed damaged nuclear envelope and mitochondria and fewer secretory granules in pancreas of diabetic rats; however, mangiferin treatment nearly normalized pancreatic architecture. The present findings suggest that mangiferin treatment exerts a therapeutic protective nature in diabetes by decreasing oxidative stress and protecting against pancreatic β-cell damage, which may be attributable to its antioxidative properties.
Aravinthan, Adithan,Govarthanan, Muthusamy,Selvam, Kandasamy,Praburaman, Loganathan,Selvankumar, Thangasamy,Balamurugan, Rangachari,Kamala-Kannan, Seralathan,Kim, Jong-Hoon Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P>A rapid, green phytosynthesis of silver nanoparticles (AgNPs) using the aqueous extract of <I>Helianthus tuberosus</I> (sunroot tuber) was reported in this study. The morphology of the AgNPs was determined by transmission electron microscopy (TEM). Scanning electron microscopy–energy-dispersive spectroscopy (SEM–EDS) and X-ray powder diffraction (XRD) analysis confirmed the presence of AgNPs. Fourier transform infrared spectroscopy (FTIR) analysis revealed that biomolecules in the tuber extract were involved in the reduction and capping of AgNPs. The energy-dispersive spectroscopy (EDS) analysis of the AgNPs, using an energy range of 2–4 keV, confirmed the presence of elemental silver without any contamination. Further, the synthesized AgNPs were evaluated against phytopathogens such as <I>Ralstonia solanacearum</I> and <I>Xanthomonas axonopodis</I>. The AgNPs (1–4 mM) extensively reduced the growth rate of the phytopathogens. In addition, the cytotoxic effect of the synthesized AgNPs was analyzed using rat splenocytes. The cell viability was decreased according to the increasing concentration of AgNPs and 67% of cell death was observed at 100 μg/mL.</P>
Muthusamy Govarthanan,카말라칸,Thangasamy Selvankumar,Kandasamy Selvam,Chinnappan Sudhakar,Vincent Aroulmoji 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.27 No.-
A native feather-degrading keratinolytic bacterium, Bacillus sp. MG-MASC-BT was isolated from featherdumping soil in Mallasamudram, Tamil Nadu, India and screened for keratinase production using alkalitreated horn waste (HW) and feather waste (FW). The study factors influencing keratinase productionwas optimized by Box–Behnken design (BBD). The maximum enzyme production (1075 U/ml) wasobserved at pH 7.0, temperature 55 8C and growth period of 60 h. The media supplemented with 6% ofHW and FW enhanced keratinase production. Statistics based contour plots were generated to evaluatethe changes in the response surface and to understand the relationship between the enzyme yield andthe culture conditions.
Phase transition kinetics and surface binding states of methylammonium lead iodide perovskite
Rajendra Kumar, G.,Dennyson Savariraj, A.,Karthick, S. N.,Selvam, S.,Balamuralitharan, B.,Kim, Hee-Je,Viswanathan, K. K.,Vijaykumar, M.,Prabakar, Kandasamy The Royal Society of Chemistry 2016 Physical chemistry chemical physics Vol.18 No.10
<P>We have presented a detailed analysis of the phase transition kinetics and binding energy states of solution processed methylammonium lead iodide (MAPbI(3)) thin films prepared at ambient conditions and annealed at different elevated temperatures. It is the processing temperature and environmental conditions that predominantly control the crystal structure and surface morphology of MAPbI3 thin films. The structural transformation from tetragonal to cubic occurs at 60 degrees C with a 30 minute annealing time while the 10 minute annealed films posses a tetragonal crystal structure. The transformed phase is greatly intact even at the higher annealing temperature of 150 degrees C and after a time of 2 hours. The charge transfer interaction between the Pb 4f and I 3d oxidation states is quantified using XPS.</P>