A Clinical Study on the Anti-hypertensive Effect of Barnidipine HCl in Hypertensive Patients with Renal Disease

Kwon, K. H 大韓臨床藥理學會 1996 臨床藥理學會誌 Vol.4 No.2

에너지 절감형 화염확산 억제 알루미늄 다겹 스크린의 난방 특성

김현정 ( H. J. Kim ),노현권 ( H. K. Noh ),박범순 ( B. S. Park ),한충수 ( C. S. Han ),강태환 ( T. H. Kang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.2

알루미늄 차광 보온 스크린은 국내의 시설 온실에서 반드시 사용해야 하는 시설 원예용 자재로서 원예작물의 경우 적절한 차광을 통해 고품질의 농산물을 생산할 수 있다. 또한 보온성 향상으로 에너지 절감효율을 높여 유류비 절감효과 및 이산화탄소는 배출량을 절감시킬 수 있는 친환경 제품으로 각광을 받고 있다. 그러나 해외로 수출하기 위해서는 준불연 이상의 난연 특성을 지니고 있어야 한다. 따라서 알루미늄 차광 보온 스크린의 수출경쟁력을 강화하고, 국내 농업용 및 원예용 하우스의 화재피해 경감을 위하여 화염의 확산을 억제할 수 있는 농업용 알루미늄 스크린을 이용하여 난방효과를 분석하고자 한다. 본 연구에 사용된 공시재료는 대조구로서 (주) 부전에서 1차 년도에 개발한 화염확산 억제 알루미늄 스크린을 이용하였다. 실험구 1은 1차 년도에 개발한 화염확산 억제 알루미늄 스크린과 부직포 및 합성모노 필라먼트의 보온재 3겹을 설치하였다. 실험구 2는 2차년도에 보완 개발한 화염확산 억제 알루미늄 스크린과 천 및 합성 모노필라먼트 3겹을 설치하여 난방특성 실험을 수행하였다. 온실 난방시스템의 구성은 하우스 내부의 온도를 측정하여 내부 온도를 조절에 사용되는 온도 센서(K-Type)와 등유용 온풍 난방기를 온실에 설치하였다. 하우스 내부 온도 센서는 20°C로 설정했고, 등유 온풍 난방기의 정격 난방 능력은 20.000Kcal/h, 정격 전압 220~280V로 사용, 연료는 등유를 사용했다. 일정기간 천정부 1중과 2중 하우스 사이 온도는 18시 이후 야간에서 실험구 1 온실이 대조구 온실과 비교하여 -2.9°C, 실험구 2 온실은 대조구 온실과 비교하여 -3.4°C 낮은 것으로 나타났다. 일정기간 천정부 2중과 3중 하우스 사이 온도는 대조구와 비교하여 18시 이후 실험구 1 온실이 대조구 온실과 비교하여 -3.8°C 낮은 것으로 나타났고, 실험구 2 온실은 -4.6°C 낮은 것으로 나타났다. 등유 온풍 난방기를 통해 공급된 누적 공급열량은 1월 22일부터 2월 6일까지 15일간을 기준으로 실험기간 동안 대조구 온실과 실험구 1, 2 온실에서 각각 711,157 KJ/h, 365,455 KJ/h, 227,175 KJ/h로 나타나 대조구보다 실험구 1, 2 온실이 345,701 KJ/h 및 483,982 KJ/h 공급열량이 적은 것으로 나타났다. 또한 실험구 2 온실이 실험구 1과 비교하여 138,280 KJ/h 공급열량이 적은 것으로 나타났다. 이상의 결과로 부터 실험구 온실이 대조구 온실보다 보온성이 높고, 난방 에너지가 절감되는 것으로 판단된다.

Small molecule inhibition of Epstein-Barr virus nuclear antigen-1 DNA binding activity interferes with replication and persistence of the viral genome

Lee, E.K.,Kim, S.Y.,Noh, K.W.,Joo, E.H.,Zhao, B.,Kieff, E.,Kang, M.S. Elsevier/North-Holland 2014 ANTIVIRAL RESEARCH Vol.104 No.-

The replication and persistence of extra chromosomal Epstein-Barr virus (EBV) episome in latently infected cells are primarily dependent on the binding of EBV-encoded nuclear antigen 1 (EBNA1) to the cognate EBV oriP element. In continuation of the previous study, herein we characterized EBNA1 small molecule inhibitors (H20, H31) and their underlying inhibitory mechanisms. In silico docking analyses predicted that H20 fits into a pocket in the EBNA1 DNA binding domain (DBD). However, H20 did not significantly affect EBNA1 binding to its cognate sequence. A limited structure-relationship study of H20 identified a hydrophobic compound H31, as an EBNA1 inhibitor. An in vitro EBNA1 EMSA and in vivo EGFP-EBNA1 confocal microscopy analysis showed that H31 inhibited EBNA1-dependent oriP sequence-specific DNA binding activity, but not sequence-nonspecific chromosomal association. Consistent with this, H31 repressed the EBNA1-dependent transcription, replication, and persistence of an EBV oriP plasmid. Furthermore, H31 induced progressive loss of EBV episome. In addition, H31 selectively retarded the growth of EBV-infected LCL or Burkitt's lymphoma cells. These data indicate that H31 inhibition of EBNA1-dependent DNA binding decreases transcription from and persistence of EBV episome in EBV-infected cells. These new compounds might be useful probes for dissecting EBNA1 functions in vitro and in vivo.

Supplementation of oil-based inactivated H9N2 vaccine with M2e antigen enhances resistance against heterologous H9N2 avian influenza virus infection

Park, J.K.,Lee, D.H.,Cho, C.H.,Yuk, S.S.,To, E.O.,Kwon, J.H.,Noh, J.Y.,Kim, B.Y.,Choi, S.W.,Shim, B.S.,Song, M.K.,Lee, J.B.,Park, S.Y.,Choi, I.S.,Song, C.S. Elsevier Scientific Pub. Co 2014 Veterinary microbiology Vol.169 No.3

Avian influenza virus (AIV) subtype H9N2 has been evolving rapidly and vaccine escape variants have been reported to cause circulation of infections and economic losses. In the present study, we developed and evaluated ectodomain of the AIV matrix 2 (M2e) protein as a supplementing antigen for oil-based inactivated H9N2 vaccine to increase resistance against vaccine escape variants. AIV H9N2 M2e antigen was expressed in Escherichia coli and supplemented to inactivated H9N2 oil emulsion vaccine. Specific pathogen-free chickens received a single injection of inactivated H9N2 oil emulsion vaccines with or without M2e supplementation. At three weeks post vaccination, hemagglutination inhibition tests and enzyme-linked immunosorbent assays were performed to determine serological immune responses. Challenge study using a vaccine escape H9N2 variant was performed to evaluate the efficacy of M2e supplementation. M2e antigen supplemented in oil emulsion vaccine was highly immunogenic, and a single M2e-supplemented vaccination reduced challenge virus replication and shedding more effectively than non-supplemented vaccination.

Genetic identification of a novel locus, ACCELERATED FLOWERING 1 that controls chromatin modification associated with histone H3 lysine 27 trimethylation in Arabidopsis thaliana

Lee, S.,Shin, K.,Lee, I.,Song, H.R.,Noh, Y.S.,Lee, R.A.,Lee, S.,Kim, S.Y.,Park, S.K.,Lee, S.,Soh, M.S. Elsevier Scientific Publishers Ireland Ltd 2013 Plant science Vol.208 No.-

Flowering on time is a critically important for successful reproduction of plants. Here we report an early-flowering mutant in Arabidopsis thaliana, accelerated flowering 1-1D (afl1-1D) that exhibited pleiotropic developmental defects including semi-dwarfism, curly leaf, and increased branching. Genetic analysis showed that afl1-1D mutant is a single, dominant mutant. Chromosomal mapping indicates that AFL1 resides at the middle of chromosome 4, around which no known flowering-related genes have been characterized. Expression analysis and double mutant studies with late flowering mutants in various floral pathways indicated that elevated FT is responsible for the early-flowering of afl1-1D mutant. Interestingly, not only flowering-related genes, but also several floral homeotic genes were ectopically overexpressed in the afl1-1D mutants in both FT-dependent and -independent manner. The degree of histone H3 Lys27-trimethylation (H3K27me3) was reduced in several chromatin including FT, FLC, AG and SEP3 in the afl1-1D, suggesting that afl1-1D might be involved in chromatin modification. In support, double mutant analysis of afl1-1D and lhp1-4 revealed epistatic interaction between afl1-1D and lhp1-4 in regard to flowering control. Taken together, we propose that AFL1 regulate various aspect of development through chromatin modification, particularly associated with H3K27me3 in A. thaliana.

Si film electrodes with surface-modified Cu current collectors for micro Li batteries

Lee, M.j.,Chae, M.r.,Jeong, J.s.,Noh, J.p.,Ahn, H.j.,Cho, K.k.,Choi, H.k.,Nam, T.h.,Kim, K.w.,Cho, G.b. Pergamon Press 2016 Materials research bulletin Vol.82 No.-

<P>Si film electrodes were fabricated onsurface-modified Cu current collectors using an oxidation-reduction process. Flower-like nanostructures (FLNSs) with diameters of 2-3 mu m and plate-like nanostructures (PLNSs) with lengths of 1 m were formed on the Cu foil oxidized at 423 K for 0.5 h, but only the PLNSs remained after sonication. Reduction of the preoxidized Cu foil at 673 K resulted in the formation of platelike and coral -like nanostructures on the Cu foils reduced for 1 and 3 h and a smooth surface without specific structures on the Cu foil reduced for 6 h. The best electrochemical properties in terms of the first columbic efficiency (85.4%) and the cycle performance (67.3% at 50 cycles) were obtained from the Si film electrode fabricated on the Cu foil that had been reduced for 3 h because the coral -like nanostructures on the Cu foil enhanced the adhesion of the Si film and improved the structural stability of the Si film electrode during the electrochemical reactions. (C) 2016 Elsevier Ltd: All rights reserved.</P>

InAs 양자점의 크기에 따른 분광학적 특성

권영수(Y. S. Kwon),임재영(J. Y. Leem),이철로(C. R. Lee),노삼규(S. K. Noh),유연희(Y. H. Ryu),최정우(J. W. Choe),김성만(S. M. Kim),이욱현(U. H. Lee),류동현(D. H. Ryu),이동한(D. H. Lee),박장환(Jang-Hwan Park) 한국진공학회(ASCT) 1999 Applied Science and Convergence Technology Vol.8 No.4(1)

MBE(Molecular Beam Epitaxy) 방법으로 InAS 양자점의 크기를 달리하여 성장한 lnAs 양자점의 구조적 특성과 분광학적 특성을 조사하였다. 구조적 특성은 AFM(Atomic Force Microscopy)으로 하였으며, 광학적 특성은 PL(Photoluminescence)로 수행하였다. AFM 측정결과 양자점의 밀도는 2 ML에서 최대 값인 1.1×10¹¹/㎠이다. 양자점의 크기가 증가함에 따라 PL 피크는 적색편이를 하고 있었다. 발광피크의 온도의존성을 조사한 결과 온도의 증가에 따라 발광피크는 낮은 에너지로 이동하였으며, 20 K에서 180 K 구간에서는 발광피크의 FWHM(Full Width at Half Maximum) 값은 감소하였으며, 180 K 이상의 온도에서는 온도의 증가에 따라 FWHM도 증가하였다. 한편 Arrehenius-type function으로 구한 활성화 에너지는 InAs 양자점의 크기가 증가함에 따라 증가하였다. We present Photoluminescence (PL) and Atomic Force Microscopy (AFM) image on InAs quantum dots (QDs) having different size which grown by Molecular Beam Epitaxy (MBE). For different size QDs, analysis of the AFM profiles show that the density of QDs was the maximum value (1.1×10¹¹/㎠) at 2.0 ML. In the PL spectra of QDs, it is found that the peak energy decreases with increasing dot size due to the effect of quantum confinement. Temperature dependence of PL intensities show that the PL is quenching and Red shift as the temperature increase. The FWHM range of 20 K~80 K is narrowing with increasing temperature. When temperature is over 180 K, the line-width starts to increase with increasing temperature. At last, temperature dependence of the integrated intensities were fit using the Arrehenius-type function for the activation energy. Fit value of the activation energy was increased with increasing QDs-size.

여중생의 외모만족도와 정신건강의 관계

노희경,문소현,박세은,서재은,이수현,이현영,임영신,정유리,황유리 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47

Purpose: The purpose of this study was to identify the relationship between satisfaction toward appearance and the level of mental health among female middle school students. Methods: The total study sample was 432 consisting of 3rd year female students who attended co-educational or girls’ middle schools in Korea. Data were collected from August 8 to August 16, 2012. Statistical analyses were conducted using t-test and Pearson’s Correlation Coefficient with SPSS18.0Windows software. Results: There was correlation between appearance satisfaction and mental health, especially with personal sensitivity (r= -.447, p= .000) and depression (r= -.350, p= .000). The level of mental health significantly differed according to type of school (t= -2.668, p= .008). However, appearance satisfaction did not differ according to type of school. Conclusion: The results of this study implied the importance of appropriate education and nursing intervention which would improve satisfaction toward the appearance of female middle school students.

Low temperature synthesis and luminescence investigations of YAG:Ce, Eu nanocomposite powder for warm white light-emitting diode

Yang, H.K.,Noh, H.M.,Jeong, J.H. Elsevier 2014 SOLID STATE SCIENCES Vol.27 No.-

The preparation of the cerium and europium co-doped YAG materials as well as the study for their synthesis and emitting mechanism of the energy transfer between Ce<SUP>3+</SUP> and Eu<SUP>3+</SUP> were investigated in the present study. YAG:Ce<SUP>3+</SUP>, Eu<SUP>3+</SUP> powders were synthesized using a high-energy ball milling method in different sintering temperature and atmosphere: air and H<SUB>2</SUB>/N<SUB>2</SUB>. The effects of the synthesis procedure on the crystallinity, morphology, structure, and luminescence spectra were examined by X-ray diffraction, field emission-scanning electron microscopy, and photoluminescence spectroscopy. The europium co-doped YAG:Ce<SUP>3+</SUP> phosphors is improved the chromaticity coordinates.

Two S-wave gap symmetry for single crystals of the superconductor BaFe_1.8Co_0.2As₂

Choi, K.Y.,Kim, S.H.,Choi, C.,Jung, M.H.,Wang, X.F.,Chen, X.H.,Noh, J.D.,Lee, S.I. North-Holland 2010 Physica. C, Superconductivity Vol.470 No.suppl1

To clarify the gap structure of the iron-pnictide superconductors, we synthesized optimally doped single crystals of BaFe<SUB>1.8</SUB>Co<SUB>0.2</SUB>As<SUB>2</SUB>, which had a critical temperature, T<SUB>c</SUB>, of 23.6K. The initial M-H curve was used to find the lower critical field, H<SUB>c1</SUB>. The full range of the temperature dependence of H<SUB>c1</SUB> was explained by using a two S-wave gap symmetry. We estimate the two gap as Δ<SUB>1</SUB>(0)=1.64+/-0.2meV for the small gap and Δ<SUB>2</SUB>(0)=6.20+/-0.2meV for the large gap.