Application of Terahertz Spectroscopy and Imaging in the Diagnosis of Prostate Cancer

Zhang, Ping,Zhong, Shuncong,Zhang, Junxi,Ding, Jian,Liu, Zhenxiang,Huang, Yi,Zhou, Ning,Nsengiyumva, Walter,Zhang, Tianfu Optical Society of Korea 2020 Current Optics and Photonics Vol.4 No.1

The feasibility of the application of terahertz electromagnetic waves in the diagnosis of prostate cancer was examined. Four samples of incomplete cancerous prostatic paraffin-embedded tissues were examined using terahertz spectral imaging (TPI) system and the results obtained by comparing the absorption coefficient and refractive index of prostate tumor, normal prostate tissue and smooth muscle from one of the paraffin tissue masses examined were reported. Three hundred and sixty cases of absorption coefficients from one of the paraffin tissues examined were used as raw data to classify these three tissues using the Principal Component Analysis (PCA) and Least Squares Support Vector Machine (LS-SVM). An excellent classification with an accuracy of 92.22% in the prediction set was achieved. Using the distribution information of THz reflection signal intensity from sample surface and absorption coefficient of the sample, an attempt was made to use the TPI system to identify the boundaries of the different tissues involved (prostate tumors, normal and smooth muscles). The location of three identified regions in the terahertz images (frequency domain slice absorption coefficient imaging, 1.2 THz) were compared with those obtained from the histopathologic examination. The tissue tumor region had a distinctively visible color and could well be distinguished from other tissue regions in terahertz images. Results indicate that a THz spectroscopy imaging system can be efficiently used in conjunction with the proposed advanced computer-based mathematical analysis method to identify tumor regions in the paraffin tissue mass of prostate cancer.

Application of Terahertz Spectroscopy and Imaging in the Diagnosis of Prostate Cancer

Ping Zhang,Shuncong Zhong,Junxi Zhang,Jian Ding,Zhenxiang Liu,Yi Huang,Ning Zhou,Walter Nsengiyumva,Tianfu Zhang 한국광학회 2020 Current Optics and Photonics Vol.4 No.1

The feasibility of the application of terahertz electromagnetic waves in the diagnosis of prostate cancer was examined. Four samples of incomplete cancerous prostatic paraffin-embedded tissues were examined using terahertz spectral imaging (TPI) system and the results obtained by comparing the absorption coefficient and refractive index of prostate tumor, normal prostate tissue and smooth muscle from one of the paraffin tissue masses examined were reported. Three hundred and sixty cases of absorption coefficients from one of the paraffin tissues examined were used as raw data to classify these three tissues using the Principal Component Analysis (PCA) and Least Squares Support Vector Machine (LS-SVM). An excellent classification with an accuracy of 92.22% in the prediction set was achieved. Using the distribution information of THz reflection signal intensity from sample surface and absorption coefficient of the sample, an attempt was made to use the TPI system to identify the boundaries of the different tissues involved (prostate tumors, normal and smooth muscles). The location of three identified regions in the terahertz images (frequency domain slice absorption coefficient imaging, 1.2 THz) were compared with those obtained from the histopathologic examination. The tissue tumor region had a distinctively visible color and could well be distinguished from other tissue regions in terahertz images. Results indicate that a THz spectroscopy imaging system can be efficiently used in conjunction with the proposed advanced computer-based mathematical analysis method to identify tumor regions in the paraffin tissue mass of prostate cancer.

Magnetic alignment of MnBi crystals and magnetic properties of MnBi-Bi composites

Yongsheng Liu,Jincang Zhang,Zhongming Ren,Shixun Cao,Xiaoyong Zhang,Guangqiang Jia,Kang Deng,Xi Li,Junxi Zhang 한국물리학회 2007 Current Applied Physics Vol.7 No.5

Below Curie temperatureTC, MnBi crystals are aligned alongc-axis in a Bi matrix under a fabrication eldHfof 0.5 T. AboveTC,this alignment is also accomplished by quenching under a highHfof 10 T. Such a method has a prominent feature that MnBi crystalsgrow preferentially and congregate along theHfdirection. Magnetic testing shows a pronounced anisotropy in magnetization in direc-tions normal and parallel toHf, resulting from the alignment. In the case of the alignment belowTC,Hfincreases the transition temper-ature of spin-reorientation and the change in magnetization.

The Identification of Six Novel Proteins with Fibronectin or Collagen Type І Binding Activity from Streptococcus suis Serotype 2

Hui Zhang,Junxi Zheng,Li Yi,Yue Li,Zhe Ma,Hongjie Fan,Chengping Lu 한국미생물학회 2014 The journal of microbiology Vol.52 No.11

Streptococcus suis, a major swine pathogen, is an emergingzoonotic agent that causes meningitis and septic shock. Bacterialcell wall and secreted proteins are often involved ininteractions with extracellular matrix proteins (ECMs), whichplay important roles in the initial steps of pathogenesis. Inthis study, 2D SDS-PAGE, western blotting-based bindingaffinity measurements, and microtiter plate binding assayswere used to identify cell wall and secreted proteins from S. suis that interact with fibronectin and collagen type І. Weidentified six proteins from S. suis, including three proteins(translation elongation factor G, oligopeptide-binding proteinOppA precursor, and phosphoglycerate mutase) thatshow both fibronectin and collagen type І binding activity. To the best of our knowledge, these three newly identifiedproteins had no previously reported fibronectin or collagentype І binding activity. Overall, the aim in this study was toidentify proteins with ECM binding activity from S. suis andit represents the first report of six new proteins from S. suisthat interact with fibronectin or collagen type І.

An Empirical Study on the Validity of Corporate Coaching in China

LI Zhiguo,ZHANG Chunyu,ZHANG Junxi 인하대학교 정석물류통상연구원 2009 인하대학교 정석물류통상연구원 학술대회 Vol.2009 No.10

corporate coaching brought profound influence on numberiess individuals and organizations since it was introduced into Chinese in 1995, this paper focus on the validity of corporate coaching in China based on the outcome of 2000 questionnaires which come from all of 31 provinces of China and more than 18 industries; nearly 90 percents of the coaching clients undertake the responsibility for managerial effect; 73.6 percents of the coaching clients" age distribution lie in 26-40 years old. The data told us that the clients" personal ability, the relationship with others, and organizational performance can get improvement in different ways. We also found that Chinese traditional excellent culture and managerial intelligences can provide abundant nourishment for the long-term healthy development of corporate coaching in China.

Are the U.S. Exports to and Imports form Japan Cointgrated?

Wu, Yangru,Zhang, Junxi 세종대학교 국제경제연구소 1998 Journal of Economic Integration Vol.13 No.4

The size and duration of the U.S. bilateral trade deficit with Japan has raised concern from both politicians and the general public. This paper seeks to investigate the behavior of this deficit by conducting stationarity tests on the deficit and tests for long-run relationships between U.S. exports to and imports from Japan. We show that, if an endogenously searched break is properly accounted for, exports and imports are cointegrated with a coefficient of one, and the deficit appears to be stationary. Thus, in contrast to the public's perception, we conclude that the U.S.-Japan trade deficit may not be "too large." (JEL Classifications: F14, C22)

ROS-activated CXCR2+ neutrophils recruited by CXCL1 delay denervated skeletal muscle atrophy and undergo P53-mediated apoptosis

Xiang Yaoxian,Dai Junxi,Li Yao,You Zongqi,Zhang Junpeng,Huang Xinying,Nie Shuqi,Chen Yujie,Xu Lei,Liu Fengming,Jiang Junjian,Xu Jianguang 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-

Neutrophils are the earliest master inflammatory regulator cells recruited to target tissues after direct infection or injury. Although inflammatory factors are present in muscle that has been indirectly disturbed by peripheral nerve injury, whether neutrophils are present and play a role in the associated inflammatory process remains unclear. Here, intravital imaging analysis using spinning-disk confocal intravital microscopy was employed to dynamically identify neutrophils in denervated muscle. Slice digital scanning and 3D-view reconstruction analyses demonstrated that neutrophils escape from vessels and migrate into denervated muscle tissue. Analyses using reactive oxygen species (ROS) inhibitors and flow cytometry demonstrated that enhanced ROS activate neutrophils after denervation. Transcriptome analysis revealed that the vast majority of neutrophils in denervated muscle were of the CXCR2 subtype and were recruited by CXCL1. Most of these cells gradually disappeared within 1 week via P53-mediated apoptosis. Experiments using specific blockers confirmed that neutrophils slow the process of denervated muscle atrophy. Collectively, these results indicate that activated neutrophils are recruited via chemotaxis to muscle tissue that has been indirectly damaged by denervation, where they function in delaying atrophy.

The Effect of External DC Electric Field on the Atmospheric Corrosion Behaviour of Zinc under a Thin Electrolyte Layer

( Qinqin Liang ),( Yanyang ),( Junxi Zhang ),( Xujie Yuan ),( Qimeng Chen ) 한국부식방식학회(구 한국부식학회) 2018 Corrosion Science and Technology Vol.17 No.2

The effect of external DC electric field on atmospheric corrosion behavior of zinc under a thin electrolyte layer (TEL) was investigated by measuring open circuit potential (OCP), cathodic polarization curve, and electrochemical impedance spectroscopy (EIS). Results of OCP vs. time curves indicated that the application of external DC electric field resulted in a negative shift of OCP of zinc. Results of cathodic polarization curves measurement and EIS measurement showed that the reduction current of oxygen increased while charge transfer resistance (R_ct) decreased under the external DC electric field. Variation of OCP negative shift, reduction current of oxygen, and R_ct increase with increasing of external DC electric field strength as well as the effect of external DC electric field on double-layer structure in the electrode/electrolyte interface and ions distribution in thin electrolyte layer were analyzed. All results showed that the external DC electric field could accelerate the corrosion of zinc under a thin electrolyte layer.