http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Junhua Huang (검색결과 6 건)
- 무료
- 기관 내 무료
- 유료
-
Junhua Huang,Liding Chen,Xuhuan Xie,Mufeng Wang,Bugong Xu 제어·로봇·시스템학회 2019 International Journal of Control, Automation, and Vol.17 No.8
This paper investigates the distributed consensus problem for heterogeneous multi-agent systems via event-triggered scheme. To alleviate the communication burden, a distributed event-triggered consensus algorithm using an open-loo estimate and neighboring information is proposed. In the proposed event-triggered scheme, the control input of each agent is dependent on the estimate and information at discrete instants. Firstly, the novel event-triggered consensus algorithm is proposed for fixed topology, which involves the discrete communication between neighboring agents. Then, for the switching topology, the triggering condition is proposed by virtue of a topology-dependent dwell time approach. Further, the corresponding consensus procedures are given. Finally, the effectiveness of the proposed scheme is illustrated by numerical results.
-
Junhua Guo,Zhijun Feng,Zhi’ang Huang,Hongyan Wang,Wujie Lu 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.9
MiR-217 can function as an oncogene or a tumour suppressor gene depending on cell type. However, the function of miR-217 in lung cancer remains unclear to date. This study aims to evaluate the function of miR-217 in lung cancer and investigate its effect on the sensitivity of lung cancer cells to cisplatin. The expression of miR-217 was detected in 100 patients by real-time PCR. The effects of miR-217 overexpression on the proliferation, apoptosis, migration and invasion of SPC-A-1 and A549 cells were investigated. The target gene of miR-217 was predicted by Targetscan online software, screened by dual luciferase reporter gene assay and demonstrated by Western blot. Finally, the effects of miR-217 up-regulation on the sensitivity of A549 cells to cisplatin were determined. The expression of miR-217 was significantly lower in lung cancer tissues than in noncancerous tissues (p < 0.001). The overexpression of miR-217 significantly inhibited the proliferation, migration and invasion as well as promoted the apoptosis of lung cancer cells by targeting KRAS. The up-regulation of miR-217 enhanced the sensitivity of SPC-A-1 and A549 cells to cisplatin. In conclusion, miR-217 suppresses tumour development in lung cancer by targeting KRAS and enhances cell sensitivity to cisplatin. Our results encourage researchers to use cisplatin in combination with miR-217 to treat lung cancer. This regime might lead to low-dose cisplatin application and cisplatin side-effect reduction.
-
Guo, Junhua,Feng, Zhijun,Huang, Zhi'ang,Wang, Hongyan,Lu, Wujie Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.9
MiR-217 can function as an oncogene or a tumour suppressor gene depending on cell type. However, the function of miR-217 in lung cancer remains unclear to date. This study aims to evaluate the function of miR-217 in lung cancer and investigate its effect on the sensitivity of lung cancer cells to cisplatin. The expression of miR-217 was detected in 100 patients by real-time PCR. The effects of miR-217 overexpression on the proliferation, apoptosis, migration and invasion of SPC-A-1 and A549 cells were investigated. The target gene of miR-217 was predicted by Targetscan online software, screened by dual luciferase reporter gene assay and demonstrated by Western blot. Finally, the effects of miR-217 up-regulation on the sensitivity of A549 cells to cisplatin were determined. The expression of miR-217 was significantly lower in lung cancer tissues than in noncancerous tissues (p < 0.001). The overexpression of miR-217 significantly inhibited the proliferation, migration and invasion as well as promoted the apoptosis of lung cancer cells by targeting KRAS. The up-regulation of miR-217 enhanced the sensitivity of SPC-A-1 and A549 cells to cisplatin. In conclusion, miR-217 suppresses tumour development in lung cancer by targeting KRAS and enhances cell sensitivity to cisplatin. Our results encourage researchers to use cisplatin in combination with miR-217 to treat lung cancer. This regime might lead to low-dose cisplatin application and cisplatin side-effect reduction.
-
Structural performance of novel SCARC column under axial and eccentric loads
Chunheng Zhou,Zongping Chen,Junhua Li,Liping Cai,Zhenhua Huang 국제구조공학회 2020 Steel and Composite Structures, An International J Vol.37 No.5
A novel spiral confined angle-steel reinforced concrete (SCARC) column was developed in this study. A total of 16 specimens were prepared and tested (eight of them were tested under axial loading, the other eight were tested under eccentric loading). The failure processes and load-displacement relationships of specimens under axial and eccentric loads were examined, respectively. The load-carrying capacity and ductility were evaluated by parametric analysis. A calculation approach was developed to predict the axial and eccentric load-carrying capacity of these novel columns. Results showed that the spiral reinforcement provided enough confinement in SCARC columns under axial and low eccentric loads, but was not effective in that under high eccentric loads. The axial load-carrying capacity and ductility of SCARC columns were improved significantly due to the satisfactory confinement from spirals. The outer reinforcement and other construction measures were necessary for SCARC columns to prevent premature spalling of the concrete cover. The proposed calculation approach provided a reliable prediction of the load-carrying capacity of SCARC columns.
-
Yuan, Gu,Xiao, Junhua,Huang, Weiqiang,Tang, Feili,Zhou, Yawei The Pharmaceutical Society of Korea 2002 Archives of Pharmacal Research Vol.25 No.5
Three hairpin polyamides were designed and synthesized by a haloform reaction and DCC/HOBt coupling reaction without amino protection and deprotection. Their anticancer activity were investigated with three kinds of cell lines-hepatic carcinoma, lung carcinoma and gastric carcinoma, and the values of $IC_{50}$ were at range of $10^{-7}~10^{-8}M$.
-
Zhang Wentao,Zheng Zongtai,Wang Keyi,Mao Weipu,Li Xue,Wang Guangchun,Zhang Yuanyuan,Huang Jianhua,Zhang Ning,Wu Pengfei,Liu Ji,Zhang Haimin,Che Jianping,Peng Bo,Zheng Junhua,Li Wei,Yao Xudong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal tissues and performed a series of in vivo and in vitro experiments to explore piRNAs associated with RCC progression and investigate their functional mechanisms. We found that piR-1742 was highly expressed in RCC tumors and that patients with high piR-1742 expression had a poor prognosis. Inhibition of piR-1742 significantly reduced tumor growth in RCC xenograft and organoid models. Mechanistically, piRNA-1742 regulates the stability of USP8 mRNA by binding directly to hnRNPU, which acts as a deubiquitinating enzyme that inhibits the ubiquitination of MUC12 and promotes the development of malignant RCC. Subsequently, nanotherapeutic systems loaded with piRNA-1742 inhibitors were found to effectively inhibit the metastasis and growth of RCC in vivo. Therefore, this study highlights the functional importance of piRNA-related ubiquitination in RCC and demonstrates the development of a related nanotherapeutic system, possibly contributing to the development of therapeutic approaches for RCC.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
