A Comparison between Mechanical Thrombectomy and Intra-arterial Fibrinolysis in Acute Basilar Artery Occlusion: Single Center Experiences

Seunguk Jung,Cheolkyu Jung,배윤정,최병세,Sang-Wha Lee,Jun Young Chang,Beom Joon Kim,Moon-Ku Han,Hee-Joon Bae,Bae Ju Kwon,Sang-Hoon Cha 대한뇌졸중학회 2016 Journal of stroke Vol.18 No.2

Background and Purpose Recent advances in intra-arterial techniques and thrombectomy devices lead to high rate of recanalization. However, little is known regarding the effect of the evolvement of endovascular revascularization therapy (ERT) in acute basilar artery occlusion (BAO). We compared the outcome of endovascular mechanical thrombectomy (EMT) versus intra-arterial fibrinolysis (IAF)-based ERT in patients with acute BAO. Methods After retrospectively reviewed a registry of consecutive patients with acute ischemic stroke who underwent ERT from September 2003 to February 2015, 57 patients with acute BAO within 12 hours from stroke onset were enrolled. They were categorized as an IAF group (n=24) and EMT group (n=33) according to the primary technical option. We compared the procedural and clinical outcomes between the groups. Results The time from groin puncture to recanalization was significantly shorter in the EMT group than in the IAF group (48.5 [25.3 to 87.8] vs. 92 [44 to 179] minutes; P=0.02) The rate of complete recanalization was significantly higher in the EMT group than in the IAF group (87.9% vs 41.7%; P<0.01). The good outcome of the modified Rankin Scale score≤2 at 3 months was more frequent in the EMT group than in the IAF group, but it was not statistically significant (39.4% vs 16.7%; P=0.06). Conclusions EMT-based ERT in patients with acute BAO is superior to IAF-based ERT in terms of the reduction of time from groin puncture to recanalization and the improvement of the rate of complete recanalization.

Dichotomizing Level of Pial Collaterals on Multiphase CT Angiography for Endovascular Treatment in Acute Ischemic Stroke: Should It Be Refined for 6-Hour Time Window?

Woo Ho Geol,Jung Cheolkyu,Sunwoo Leonard,Bae Yun Jung,최병세,Kim Jae Hyoung,Kim Beom Joon,Han Moon-Ku,Bae Hee-Joon,Jung Seunguk,차상훈 대한신경중재치료의학회 2019 Neurointervention Vol.14 No.2

Purpose: Although endovascular treatment is currently thought to only be suitable for patients who have pial arterial filling scores >3 as determined by multiphase computed tomography angiography (mpCTA), a cut-off score of 3 was determined by a study, including patients within 12 hours after symptom onset. We aimed to investigate whether a cut-off score of 3 for endovascular treatment within 6 hours of symptom onset is an appropriate predictor of good functional outcome at 3 months. Materials and Methods: From April 2015 to January 2016, acute ischemic stroke patients treated with mechanical thrombectomy within 6 hours of symptom onset were enrolled into this study. Pial arterial filling scores were semi-quantitatively assessed using mpCTA, and clinical and radiological parameters were compared between patients with favorable and unfavorable outcomes. Multivariate logistic regression analysis was then performed to investigate the independent association between clinical outcome and pial collateral score, with the predictive power of the latter assessed using C-statistics. Results: Of the 38 patients enrolled, 20 (52.6%) had a favorable outcome and 18 had an unfavorable outcome, with the latter group showing a lower mean pial arterial filling score (3.6±0.8 vs. 2.4±1.2, P=0.002). After adjusting for variables with a P-value of <0.1 in univariate analysis (i.e., age and National Institutes of Health Stroke Scale score at admission), pial arterial filling scores higher than a cut-off of 2 were found to be independently associated with favorable clinical outcomes (P=0.012). C-statistic analysis confirmed that our model had the highest prediction power when pial arterial filling scores were dichotomized at >2 vs. ≤2. Conclusion: A pial arterial filling cut-off score of 2 as determined by mpCTA appears to be more suitable for predicting clinical outcomes following endovascular treatment within 6 hours of symptom onset than the cut-off of 3 that had been previously suggested.

Rapid Microwave-Assisted Copper-Catalyzed Nitration of Aromatic Halides with Nitrite Salts

Seunguk Paik,Myoung Geun Jung 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.2

Effect of Nanoscale SubPc Interfacial Layer on the Performance of Inverted Polymer Solar Cells Based on P3HT/PC₇₁BM

Kim, Jung Yong,Noh, Seunguk,Nam, Young Min,Kim, Jun Young,Roh, Jeongkyun,Park, Myeongjin,Amsden, Jason J.,Yoon, Do Y.,Lee, Changhee,Jo, Won Ho American Chemical Society 2011 ACS APPLIED MATERIALS & INTERFACES Vol.3 No.11

<P>The effect of a nanoscale boron subphthalocyanine chloride (SubPc) interfacial layer on the performance of inverted polymer solar cells based on poly (3-hexyl thiophene) (P3HT) and [6,6]-phenyl-C<SUB>71</SUB>-butyric acid methyl ester (PC<SUB>71</SUB>BM) was studied. When a 1 nm SubPc layer was introduced between the active layer (P3HT:PC<SUB>71</SUB>BM) and MoO<SUB><I>x</I></SUB> in the device with ITO/ZnO/P3HT:PC<SUB>71</SUB>BM/SubPc/MoO<SUB><I>x</I></SUB>/Al configuration, the power conversion efficiency (PCE) was increased from 3.42 (without SubPc) to 3.59%. This improvement is mainly attributed to the enhanced open-circuit voltage from 0.62 to 0.64 V. When the Flory–Huggins interaction parameters were estimated from the solubility parameters through the contact angle measurement, it revealed that the interaction between SubPc and PC<SUB>71</SUB>BM is more attractive than that between SubPc and P3HT at the interface of P3HT:PC<SUB>71</SUB>BM/SubPc, through which charges are well transported from the active layer to the anode. This is supported by a decrease of the contact resistance from 5.49 (SubPc 0 nm) to 0.94 MΩ cm (SubPc 1 nm). The photoelectron spectra provide another evidence for the enhanced PCE, exhibiting that the 1 nm thick SubPc layer extracts more photoelectrons from the active layer than other thicknesses.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2011/aamick.2011.3.issue-11/am2009458/production/images/medium/am-2011-009458_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am2009458'>ACS Electronic Supporting Info</A></P>

Charge transport in amorphous low bandgap conjugated polymer/fullerene films

Kim, Jung Yong,Cho, Hyunduck,Noh, Seunguk,Lee, Yoonkyoo,Nam, Young Min,Lee, Changhee,Jo, Won Ho American Institute of Physics 2012 JOURNAL OF APPLIED PHYSICS - Vol.111 No.4

Evaluation of Angle Dependence on Positional Radioisotope Source Detector using Monte Carlo Simulation in NDT

Moojae Han,Seunguk Heo,Yohan Shin,Jaehoon Jung,Kyotae Kim,Yeji Heo,Deukhee Lee,Heunglae Cho,Sungkwang Park 한국방사선학회 2019 한국방사선학회 논문지 Vol.13 No.1

산업 비파괴 분야에서 사용되는 방사선원은 장비의 노후화 및 작업자의 부주의로 인해 선원이 노출되는 사고가 발생되어 왔다. 이에 선원의 위치를 실시간으로 추적할 수 있는 안전관리 시스템의 필요성이 부곽 되고 있다. 이에 본 연구에서는 방사선원의 위치 추적을 위한 line-array 선량계를 구성하는 unit-cell 선량계 단위의 각도의존성을 분석하기 위해 Monte Carlo Simulation을 수행하였다. 그 결과 각 기울기에서 상위 1 0% 수치에 대한 오차율은 0°에서 5.90%, 30°에서 8.08%, 60°에서 20.90%의 오차율을 보였다. 총 흡수선량의 비율은 0°(100%)를 기준으로 30°에서 83.77%, 60°에서 53.36%로 나타났으며 기울기가 증가함에 따라 낮아지는 경향성을 보였다. 모든 기울기에서 최대 수치는 30°의 No. 9에서 나타났으며, No. 10에서는 7.24% 낮아지는 경향성을 보였다. 본 연구 결과 각도의존성은 크게 발생되는 것으로 나타났으며, 이를 낮추기 위해서는 선원과 line-array 선량계의 적정거리는 1 cm 이상의 거리에서 유지해야 하는 것으로 사료된다. Radiation sources used in the field of industrial non-destructive pose a risk of exposure due to ageing equipment and operator carelessness. Thus, the need for a safety management system to trace the location of the source is being added. In this study, Monte Carlo Simulation was performed to analyse the angle dependence of the unit-cell comprising the line-array dosimeter for tracking the location of radiation sources. As a result, the margin of error for the top 10% of each slope was 5.90% at 0°, 8.08% at 30°, and 20.90% at 60°. The ratio of the total absorbed dose was 83.77% at 30 ° and 53.36% at 60 ° based on 0 °(100%) and showed a tendency to decrease with increasing slope. For all gradients, the maximum number was shown at 30° No. 9 pixels, and for No. 10, there was a tendency to drop 7.24 percent. This study has shown a large amount of angle dependence, and it is estimated that the proper distance between the source and line-array dosimeters should be maintained at a distance of not less than 1 cm to reduce them.

Brain Oxygen Monitoring via Jugular Venous Oxygen Saturation in a Patient with Fulminant Hepatic Failure

김예림,김치경,Seunguk Jung,Sang-Bae Ko 대한중환자의학회 2016 Acute and Critical Care Vol.31 No.3

Fulminant hepatic failure (FHF) is often accompanied by a myriad of neurologic complications, which are associated with high morbidity and mortality. Although appropriate neuromonitoring is recommended for early diagnosis and to minimize secondary brain injury, individuals with FHF usually have a high chance of coagulopathy, which limits the ability to use invasive neuromonitoring. Jugular bulb venous oxygen saturation (JvO2) monitoring is well known as a surrogate direct measures of global brain oxygen use. We report the case of a patient with increased intracranial pressure due to FHF, in which JvO2 was used for appropriate brain oxygen monitoring.

몬테카를로 시뮬레이션을 이용한 방사선원 위치 검출기의 각도의존성 연구

한무재 ( Moojae Han ),허승욱 ( Seunguk Heo ),신요한 ( Yohan Shin ),정재훈 ( Jaehoon Jung ),김교태 ( Kyotae Kim ),허예지 ( Yeji Heo ),이득희 ( Deukhee Lee ),조흥래 ( Heunglae Cho ),박성광 ( Sungkwang Park ) 한국방사선학회 2019 한국방사선학회 논문지 Vol.13 No.1

산업 비파괴 분야에서 사용되는 방사선원은 장비의 노후화 및 작업자의 부주의로 인해 선원이 노출되는 사고가 발생되어 왔다. 이에 선원의 위치를 실시간으로 추적할 수 있는 안전관리 시스템의 필요성이 부곽되고 있다. 이에 본 연구에서는 방사선원의 위치 추적을 위한 line-array 선량계를 구성하는 unit-cell 선량계 단위의 각도의존성을 분석하기 위해 Monte Carlo Simulation을 수행하였다. 그 결과 각 기울기에서 상위 10% 수치에 대한 오차율은 0°에서 5.90%, 30°에서 8.08%, 60°에서 20.90%의 오차율을 보였다. 총 흡수선량의 비율은 0°(100%)를 기준으로 30°에서 83.77%, 60°에서 53.36%로 나타났으며 기울기가 증가함에 따라 낮아지는 경향성을 보였다. 모든 기울기에서 최대 수치는 30°의 No. 9에서 나타났으며, No. 10에서는 7.24% 낮아지는 경향성을 보였다. 본 연구 결과 각도의존성은 크게 발생되는 것으로 나타났으며, 이를 낮추기 위해서는 선원과 line-array 선량계의 적정거리는 1 cm 이상의 거리에서 유지해야 하는 것으로 사료된다. Radiation sources used in the field of industrial non-destructive pose a risk of exposure due to ageing equipment and operator carelessness. Thus, the need for a safety management system to trace the location of the source is being added. In this study, Monte Carlo Simulation was performed to analyse the angle dependence of the unit-cell comprising the line-array dosimeter for tracking the location of radiation sources. As a result, the margin of error for the top 10% of each slope was 5.90% at 0°, 8.08% at 30°, and 20.90% at 60°. The ratio of the total absorbed dose was 83.77% at 30 ° and 53.36% at 60 ° based on 0 °(100%) and showed a tendency to decrease with increasing slope. For all gradients, the maximum number was shown at 30° No. 9 pixels, and for No. 10, there was a tendency to drop 7.24 percent. This study has shown a large amount of angle dependence, and it is estimated that the proper distance between the source and line-array dosimeters should be maintained at a distance of not less than 1 cm to reduce them.

Comparison of Intracardiac Echocardiography Versus Transesophageal Echocardiography for Guidance During Transcatheter Aortic Valve Replacement

Sang-Hyup Lee,Seunguk Oh,Young-Guk Ko,Yong-Joon Lee,Seung-Jun Lee,Sung-Jin Hong,Chul-Min Ahn,Jung-Sun Kim,Byeong-Keuk Kim,Kyu-Yong Ko,Iksung Cho,Chi Young Shim,Geu-Ru Hong,Donghoon Choi,Myeong-Ki Hong 대한심장학회 2024 Korean Circulation Journal Vol.54 No.2

Background and Objectives: Evidence regarding the efficacy and safety of intracardiac echocardiography (ICE) for guidance during transcatheter aortic valve replacement (TAVR) is limited. This study aimed to compare the clinical efficacy and safety of ICE versus transesophageal echocardiography (TEE) for guiding TAVR. Methods: This prospective cohort study included patients who underwent TAVR from August 18, 2015, to June 31, 2021. Eligible patients were stratified by echocardiographic modality (ICE or TEE) and anesthesia mode (monitored anesthesia care [MAC] or general anesthesia [GA]). Primary outcome was the 1-year composite of all-cause mortality, rehospitalization for cardiovascular cause, or stroke, according to the Valve Academic Research Consortium-3 (VARC-3) definition. Propensity score matching was performed, and study outcomes were analyzed for the matched cohorts. Results: Of the 359 eligible patients, 120 patients were matched for the ICE-MAC and TEE-GA groups, respectively. The incidence of primary outcome was similar between matched groups (18.3% vs. 20.0%; adjusted hazard ratio, 0.94; 95% confidence interval [CI], 0.53–1.68; p=0.843). ICE-MAC and TEE-GA also had similar incidences of moderate-to-severe paravalvular regurgitation (PVR) (4.2% vs. 5.0%; adjusted odds ratio, 0.83; 95% CI, 0.23–2.82; p=0.758), new permanent pacemaker implantation, and VARC-3 types 2–4 bleeding. Conclusions: ICE was comparable to TEE for guidance during TAVR for the composite clinical efficacy outcome, with similar incidences of moderate-to-severe PVR, new permanent pacemaker implantation, and major bleeding. These results suggest that ICE could be a safe and effective alternative echocardiographic modality to TEE for guiding TAVR.

Relationship between Single Nucleotide Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Gene and Fatty Acid Composition in Korean Native Cattle

Lee, Jea-young,Ha, Jae-jung,Park, Yong-soo,Yi, Jun-koo,Lee, Seunguk,Mun, Seyoung,Han, Kyudong,Kim, J.-J.,Kim, Hyun-Ji,Oh, Dong-yep Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.2

The peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$) gene plays an important role in the biosynthesis process controlled by a number of fatty acid transcription factors. This study investigates the relationships between 130 single-nucleotide polymorphisms (SNPs) in the $PPAR{\gamma}$ gene and the fatty acid composition of muscle fat in the commercial population of Korean native cattle. We identified 38 SNPs and verified relationships between 3 SNPs (g.1159-71208 A>G, g.42555-29812 G>A, and g.72362 G>T) and the fatty acid composition of commercial Korean native cattle (n = 513). Cattle with the AA genotype of g.1159-71208 A>G and the GG genotype of g.42555-29812 G>A and g.72362 G>T had higher levels of monounsaturated fatty acids and carcass traits (p<0.05). The results revealed that the 3 identified SNPs in the $PPAR{\gamma}$ gene affected fatty acid composition and carcass traits, suggesting that these 3 SNPs may improve the flavor and quality of beef in commercial Korean native cattle.