척추 전방 전위증 환자의 자기공명 영상 소견에서 보이는 추체종판의 변화

안재성,이준규,황득수,이원석 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

We reviewed the 156 magnetic resonance of lumbar spine with spondylolisthesis in simple X-ray and analysed relationship of the type of spondylolisthesis with bone marrow change in lumbar MRI and low back pain, instability of lumbar spine and prognosis. The patients with no bone marrow change were excluded in our study. Bone marrow changes were classified into 3 types by Moddic methods. Type I is low signal in T1 image and high signal in T2 image, type Ⅱ is high signal in T1 image and isodense or slight increased signal in T2 and type 2Ⅲ is decreased signal in both T1 and T2 image. Displacement over 3㎜ in motion view is defined as instability. Pain was scored by JOA scoring system. 22(14.1%) of 156 patients had local bone marrow change of vertebral end-plate. Of 22 patients, levels of lesion were 28 levels. 14 levels were isthmic type, 6 levels were degenerative type and 8 levels were retrolisthesis, respectively. Isthmic type had type Ⅰ or Ⅲ In 8(57.1%) levels, instability in 7(50.0%) levels and significant pain(0 of 1 point) in 9(69.2%) patients. Degenerative or retrolisthesis had type Ⅱ in 10(71.4%) levels, instability in 1(7.1%) level and significant pain in 4(44.4%) patients. Unstable and more symptomatic type of spondylolisthesis was associated with type Ⅰ or Ⅲ change of bone marrow in MRIm and may be teated more aggressively. Type Ⅰ or Ⅲ of bone marrow change is associated with segmental instability and low back pain and has a poor prognosis, but type Ⅱ are present in more stable and chronic disease. We concluded that isthmic type was more associated with pain, instability and type Ⅰor Ⅲ change, while degenerative or retrolisthesis type were more stable and painful and associated with type Ⅱ change.

Effects of Regular Exercise and L-Arginine Intake on Abdominal Fat, GH/IGF-1 Axis, and Circulating Inflammatory Markers in the High Fat Diet-Induced Obese Aged Rat

Sok Park(박석),Ki Woon Sung(성기운),Jin Lee(이진),Cheon Ho Lee(이천호),Young Jun Lee(이영준),Young June Yoo(유영준),Kyoung Shil Park(박경실),Byung Jin Min(민병진),Yong Sub Shin(신용업),Jung Suk Kim(김정석),Hun Jung(정훈) 한국생명과학회 2012 생명과학회지 Vol.22 No.4

본 연구는 비만과 노화가 동시에 유발된 흰쥐에서 12주간의 트레드밀 운동과 L-arginine의 투여가 복부지방량, GH, IGF-Ⅰ, somatostatin, fibrinogen, PAI-1에 미치는 영향을 관찰하고 이를 개선하는데 더욱 효과적인 방법을 제시하는데 그 목적이 있다. 이를 위해 단독 처치 군과 복합 처치 군으로 나누어 실험하여 그 효과를 비교, 분석한 결과 다음과 같은 결론을 얻었다. 1. 복부지방량은 통제집단에 비해 모든 집단에서 유의하게 감소하였다(p<0.01). 2. AG+EX, AG+LA+EX집단에서 통제집단에 비해 GH의 혈중 농도가 유의하게 높게 나타났다(p<0.1). 3. AG+EX, AG+LA+EX집단에서 통제집단에 비해 IGF-Ⅰ의 혈중 농도가 유의하게 증가하였다(p<0.01). The purpose of this study was to investigate the effect of exercise and/or L-arginine on abdominal fat, IGF-1 on GH/IGF-1 axis, fibrinogen, and PAI-1 in aged and obese rats. Male Sprague-Dawley rats were treated with a D-galactose aging inducing agent (50 mg/kg) given intraperitoneally for 12 weeks. Thirty-two male Sprague-Dawley rats were treated and divided into four groups: aging-high fat diet group (AG+HF), AG+HF with L-arginine intake group (AG+LA), AG+HF with exercise group (AG+EX), and AG+EX with L-arginine intake group (AG+LA+EX). The experimental rats underwent treadmill training (60 min/day, 6 days/week at 0% gradient) for 12 weeks. L-arginine was given orally (150 mg/kg/day) for 12 weeks. After the experiment, blood was collected from the left ventricle and abdominal fat was extracted. The results showed that GH was significantly increased in AG+EX and AG+AL+EX. IGF-1 was significantly increased in both the AG+AL+EX and AG+EX group (p<0.05), while fibrinogen and PAI-1 were not significantly different among the groups. Abdominal fat was significantly decreased in the AG+LA, AG+EX, and AG+LA+EX groups (p<0.05) compared with the AG+HF group. In conclusion, this study suggests that exercise alone or L-arginine alone or a combination not only increases the GH and IGF-1 concentration, but also decreases the abdominal fat mass.

요추 핵자기 공명 영상 소견에서 보이는 추체종판 인접 추체골의 변화

이준규,안재성,권순태,안철세,이원석 대한척추외과학회 1996 대한척추외과학회지 Vol.3 No.2

Study design. 254 magnetic resonance imaging of lumbar spine with degenerative disc disease and chronic low back pain were assessed on vertebral endplate signal change. Objective. This study was undertaken to retrospectively analyzed the relationship of vertebral endplate signal change in lumbar magnetic resonance imaging with low back pain, radiating pain and hypermobility of lumbar spine. Summary of Background Data. Vertebral endplate signal change may result from edema, inflammation or vascular change, but exact pathophysiology and relationshop with clinical finding was uncertain. Methods. We reviewed the 254 magnetic resonance imaging of lumbar spine. We excluded patients who had had previous lumbar disc surgery including LASER discectomy, chemonucleolysis and those with vertebral endplate lesions, such as ostemoyelitis or tumorous condition. Abnormalties on endplate were classified into type A with decreased signal intensities on T1 weighted spin echo image, and type B with increased signal intensities on vertebral endplates. Results. 31(12%) of 254 patients had focal alternations in the endplates and bone marrow adjacent to degenerative disc. Of 31 patients, Sixteen was type A, fifteen was type B. Fourteen(87%) patients in type A had low back pain, while ten(67%) patients in type B. Lateral motion views of lumbar spine showed hepermobility over 3mm in ten patients(63%) with type A, and in six patients(40%) with type B. Spondyloithesis was most common disease associated with endplate and bone marrow changes. 15 cases were spondylolisthesis, of these, 10 cases were type A, and 5 cases were type B. Conclusions. We concluded that type A is associated with segmental hypermobility and low back pain, while type B were more common in patients with stable degenerative disc disease.

Orignal Paper : Inhibitory effect of clonidine on kainic acid-induced seizure activity in regularly exercised mice

박석 ( Sok Park ),김희재 ( Hee Jae Kim ),김정석 ( Jung Suk Kim ),유영준 ( Young June Yoo ),이진 ( Jin Lee ) 한국운동영양학회 2011 Physical Activity and Nutrition (Phys Act Nutr) Vol.15 No.2

Regular exercise and clonidine have been shown to affect epilepsy. After 6 weeks of training involving swimming, the total body weight of trained mice was significantly lower than that of sedentary mice. Further, the blood lactate concentrations of these mice were statistically more stable than those of sedentary mice. These results indicate that the training program increased aerobic resistance in mice. Systemic kainic acid (KA) injection (30 mg/kg) evoked seizure activity in mice within 10 min. Further, clonidine (α2-adrenoreceptor agonist, 4 mg/kg) was injected 30 min before KA. Both the clonidine-treated group and exercised group experienced decreased seizure activity 10 min after KA injection and maintained seizure activity rating scores of 3-3.5 for 2 h afterwards. To examine whether or not clonidine and exercise had synergistic effects, we exercised animals and then treated with clonidine 30 min before KA administration. The clonidine and exercise group experienced decreases in seizure activity by 2 rating scores, and the regimen did not lead to death. Further, the clonidine and exercise group experienced decreased rates of mortality as well as motor impairment. These results suggest that the combination of regular exercise and therapy with an anticonvulsant agent such as clonidine could be a more efficient method for the prevention and/or treatment of epilepsy than exercise alone.

은나노 입자의 항균작용과 작용기작

황인석 ( In Sok Hwang ),조재용 ( Jae Yong Cho ),황지홍 ( Ji Hong Hwang ),황보미 ( Bo Mi Hwang ),최혜민 ( Hye Min Choi ),이준영 ( June Young Lee ),이동건 ( Dong Gun Lee ) 한국미생물생명공학회(구 한국산업미생물학회) 2011 한국미생물·생명공학회지 Vol.39 No.1

The antimicrobial effects of silver (Ag) ion or salts are well known. Recently, silver nanoparticle is attracting an interest in a wide ariety of fields since it has been known to be safe and effective as an antimicrobial agent against a broad spectrum of microorganisms. Although silver nanoparticle has been applied to various kinds of products owing to its potent antimicrobial activity, the effects of silver nanoparticle on microorganisms and antimicrobial mechanism have not been revealed clearly. In this paper, we summarized the characteristics, antimicrobial activities and mechanisms, cytotoxicity and applicability of silver nanoparticle.

Effects of L-Arginine Supplementation and Regular Exercise in D-Galactose Induced Aging Rat Aorta

이진(Jin Lee),곽이섭(Yi Sub Kwak),유영준(Young June Yoo),박석(Sok Park) 한국생명과학회 2011 생명과학회지 Vol.21 No.10

이 연구는 L-arginine과 규칙적인 운동이 D-galctose (D-all)투여로 유발된 노화흰쥐의 대동맥에서 발현되는 NF-κB, TNF-a, iNOS, Cav-1, eNOS, Ang Ⅱ의 변화양상을 관찰하는데 그 목적을 두고 있다. 노화유도 모델 쥐는 D-gal (50 mg/kg)를 숫컷 Strague-Dawley (SD)계 흰쥐의 복강에 1일 1회 총 12주간 투여하여 생산하였으며, 이 실험의 집단은 젊은 대조군(Y-con, n=8), 노화 대조군(A-con, n=8), 노화 운동군(A-Ex, n=8), 노화 운동+아르기닌군(A-Ex+A, n=8), 노화 아르기닌군(A-A, n=8)의 5군으로 분류하여 실시하였다. L-arginine은 1일 150 mg/kg씩 총 12주간 경구투여 하였다. 운동방법은 트레이드운동으로 1일 60분씩 20 m/min 속도에서 훈련하였다. 분석결과 1) 유도된 노화군에서 NF-κB, TNF-a, iNOS, Cav-1, 그리고 Ang Ⅱ 단백질의 발현은 젊은 대조군에 비해 유의하게 증가하였다. 그러나 규칙적인 운동과 L-아르기닌군에서 NF-κB, TNF-a, iNOS, Cav-1, 그리고 Ang Ⅱ 단백질의 발현은 노화 대조군에 비해 유의하게 감소하였다. 2) 유도된 노화군에서의 eNOS 단백질 발현은 젊은 대조군에 비해 유의하게 감소하였다. 그러나 규칙적인 운동과 L-아르기닌군은 eNOS 단백질의 발현을 더욱 증가시킨 것으로 나타났다. 이상의 결과를 종합하면 12주간 L-아르기닌 투여와 규칙적인 운동 그리고 복합처치는 염증인자와 관련된 단백질인 NF-κB, TNF-a, iNOS 단백질들의 발현을 억제시켜 항염증 효과를 보여주었으며, 혈관내피의 기능향상과 관련된 eNOS의 발현을 증가시키는데 긍정적인 역할을 수행할 것으로 기대된다. The purpose of this study was to identify the effects of an L-arginine supplementation and regular exercise training on NF-κB, TNF-α, iNOS, Cav-1, eNOS and Ang Ⅱ in the aortas of D-galactose (D-gal) induced aging rats. The male Strague-Dawley rats were treated with a D-galactose aging inducing agent; the D-gal injection (50 mg/kg) was given intraperitoneally for 12 wk. Experimental groups were divided into five groups: (1) Young control group (Y-Con, n=8), (2) Aging control group (A-Con, n=8), (3) Aging exercise group (A-Ex, n=8), (4) Aging exercise group with L-arginine supplementation group (A-Ex+A , n=8), and (5) Aging with L-arginine supplementation group (A-A, n=8). The exercise consisted of running on a treadmill for 60 min/day at 20 m/min for 6 day/wk, at 0% gradient for 12 wk. The L-arginine supplementation was given orally at a dose of 150 mg/kg/day for 12 wk. The findings of this study were as follows: 1. NF-κB, TNF-α, iNOS, Cav-1 and Ang Ⅱ proteins in the aortas of D-gal induced rats were significantly increased, however, L-argi-nine supplementation and regular exercise resulted in a significant inhibition in the expression of NF-κB, TNF-α, iNOS, Cav-1 and Ang Ⅱ proteins. 2. eNOS protein in the aortas of D-gal induced rats was significantly decreased, however, L-arginine supplementation and regular exercise resulted in a significant increase in the expression of eNOS proteins. In conclusion, the findings of the present study reveal that L-arginine supplementation alone or regular exercise alone or in combination with L-arginine supplementation for 12 wk increases anti-inflammatory effects by decreasing NF-κB, TNF-α, and iNOS protein expressions within the aortic tissue. In addition, L-arginine supplementation alone or regular exercise alone or in combination with L-arginine supplementation may prevent endothelial function by up-regulation of eNOS protein in the aortas of D-gal induced aging rats.

<i>GSTT1</i> as a Prognosticator for Recurrence and Progression in Patients with Non-Muscle-Invasive Bladder Cancer

Ha, Yun-Sok,Yan, Chunri,Lym, Min Su,Jeong, Pildu,Kim, Won Tae,Kim, Yong-June,Yun, Seok-Joong,Lee, Sang-Cheol,Moon, Sung-Kwon,Choi, Yung Hyun,Kim, Wun-Jae IOS Press 2010 Disease markers Vol.29 No.2

<P>Although polymorphisms in glutathione S-transferase (GST) have been associated with the risk of bladder cancer (BC), few reports provide information about the development of BC. The aim of the present study was to investigate the effect of homozygous glutathione S-transferase-μ (GSTM1) and glutathione S-transferase-&phis; (GSTT1) deletions as prognostic markers in non-muscle-invasive bladder cancer (NMIBC). A total of 241 patients with primary NMIBC were enrolled in this study. GSTM1 and GSTT1 polymorphisms were analyzed by multiplex polymerase chain reaction (PCR) using blood genomic DNA. The results were compared with clinicopathological parameters. The prognostic significance of the GSTs was evaluated by Kaplan-Meier and multivariate Cox regression model. A statistically significant association between genotype and histopathological parameter was not observed. The patients with the GSTT1-positive genotype had significantly reduced recurrence- and progression-free survival than those with the GSTT1-null genotype (log-rank test, <I>p</I> < 0.05, respectively). Recurrenceand progressionfree survival were not related to the GSTM1 genotypes. In multivariate regression analysis, the GSTT1positive genotype was the independent predictor for recurrence [hazard ratio (HR), 1.631; <I>p</I> = 0.043] and progression (HR, 3.418; <I>p</I> = 0.006). These results suggested that the GSTT1 genotype could be a useful prognostic marker for recurrence and progression in NMIBC. </P>

Alpha-Methylacyl-Coenzyme A Racemase-Expressing Urachal Adenocarcinoma of the Abdominal Wall

Ha, Yun-Sok,Kim, Young-Won,Min, Byung-Dal,Lee, Ok-Jun,Kim, Yong-June,Yun, Seok-Joong,Lee, Sang-Cheol,Kim, Wun-Jae The Korean Urological Association 2010 Korean Journal of Urology Vol.51 No.7

<P>Urachal adenocarcinomas are very rare and about one third of these neoplasms arise in urachal remnants. To demonstrate the origin of the urachal adenocarcinoma is not easy, but it is very important for managing patient care. We report on a 35-year-old man who complained of a palpable mass in the periumbilical area. The mass was incidentally identified 10 days earlier. Computed tomography revealed a well-defined enhancing mass with internal calcification and septation abutting on the dome of the urinary bladder. The clinical diagnosis was urachal cancer, which seemed to invade the urinary bladder. Thus, we performed mass excision and partial resection of the bladder. Histopathologically, the mass was diagnosed as mucinous cystadenocarcinoma originating from urachal remnants that showed an unusual expression of alpha-methylacyl-coenzyme A racemase (AMACR). To our knowledge, this report is the first case of AMACR-expressing urachal adenocarcinoma arising in the abdominal wall.</P>

Multi-Institutional Analysis of Localized Renal Cell Carcinoma that Demonstrates the Impact of Diabetic Status on Prognosis After Nephrectomy

Ha, Yun-Sok,Kim, Won Tae,Yun, Seok-Joong,Lee, Sang-Cheol,Kim, Wun-Jae,Park, Yong Hyun,Kang, Seok Ho,Hong, Sung-Hoo,Byun, Seok-Soo,Kim, Yong-June Springer - Society of Surgical Oncology 2013 Annals of surgical oncology Vol.20 No.11

Noise-Robust Modulation Identification Method for Adaptive Receiver Based on Software Defined Radio

Goo-Rak Kwon,June-Sok Lee,Jae-Do Jin,Sung-Jea Ko IEEE 2007 IEEE transactions on consumer electronics Vol.53 No.3

<P>In this paper, we propose an effective noise- robust modulation identification algorithm for adaptive receiver based on software defined radio. The proposed method can estimate the carrier frequency, symbol rate, and modulation scheme of the received signal without the use of the handshaking process requiring supplementary information such as the training sequence. Experimental results show that the proposed algorithm demodulates the signal with a low probability of error at the noisy channel conditions.</P>