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- 저자 : Jun-De Lee (검색결과 25 건)
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당뇨병성 케톤산증을 동반한 십이지장소마토스타틴종 1 예
정현주,이홍우,정준근,허갑범,이현철,이은직,김경래,조재화,남문석,이희대,김기황 대한내과학회 1995 대한내과학회지 Vol.48 No.6
The syndrome induced by excessive somatostatin secretion in somatostatinoma is characterized by steatorrhea, hypochlorhydria, cholelithiasis, and mild non-ketotic hyperglycemia. Since the first case of pancreatic somatostatinoma reported by Larsson et al in 1977, approximately 25 cases of pancreatic somatostatinama have been reported. Extrapancreatic somatostatinoma(mainly gastrointestinal somatostatinoma) was relatively rare, and first described by Kaneko et al in 1979. Gastrointestinal somatostatinomas are somewhat different from pancreatic somatostatinomas. Somatostatinoma syndrome is rarely seen in gastrointestinal somatostatinoma because of its low level of somatostatin. Due to the fact that somatostatin inhibits the secretion of insulin and glucagon simultaneously, the absence of diabetic ketoacidosis has been regarded. Jackson et al first described the diabetic ketoacidosis in the patient with malignant extrapancreatic somatostatinoma originated from the lung. As far as we can determine, intestinal somatostatinoma presenting with diabetic ketoacidosis has not been reported previously. In our case, the increased circulating level of somatostatin was detected and fasting insulin and C-peptide levels were suppressed, but plasma glucagon was not suppressed below normal level. Diabetic ketoacidosis was promptly corrected with insulin replacement and supportive fluid therapies, and after operation, the hyperglycemia was disappeared without insulin replacement. The mass was located at the second portion of duodenum and oval shaped, solid mass was seperated from the head of pancreas by a thick fibrous capsule. Light microscopic examination revealed that each tumor cells were polygonal shaped and had plenty of finely granular cytoplasm. The immunohistochemical stainings of tumor cells showed positive immunoreactivity for chromogranin and somatostatin but insulin, glucagon, calcitonin, and serotonin were negatively stained. The electronicroscopy of tumor cells showed electron-dense secretory granules and tonofilament bundles in cytoplasm. We presented a case of duodenal somatostatinoma in whom the diagnosis was recognized after presentation with diabetic ketoacidosis.
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이드보라 ( De Bo Rah Lee ),홍순권 ( Soon Kwon Hong ),전지승 ( Ji Sung Chun ),최준희 ( Jun Hee Choi ),성호석 ( Ho Suk Sung ),황선욱 ( Seon Wook Hwang ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.4
Benign symmetric lipomatosis is a very rare disease that`s characterized by a symmetric accumulation of excessive amounts of adipocytes. The lesions are located mainly on the neck, trunk and proximal extremities. Although its etiology is unknown, it has been described to be associated with a heavy alcohol intake. A 51-year-old woman presented with a two year history of ill-defined soft masses on both mandibular areas. We made the diagnosis of benign symmetric lipomatosis according to the histopathologic examination. As a difference from other reports of benign symmetric lipomatosis, our patient was non-drinker for her past history. We present here a case of benign symmetric lipomatosis at an unusual predilection site and this developed in a non-drinker. (Korean J Dermatol 2009;47(4):456~458)
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Sun, De Jun,Liu, Ying,Lu, Dong Cheng,Kim, Woonbong,Lee, Je Ho,Maynard, Jonathan,Deisseroth, Albert Elsevier 2007 Human pathology Vol.38 No.7
<P><B>Summary</B></P> <P>We used cDNA microarray analysis of RNA extracted from normal, dysplastic, and cancerous cervical tissues to identify the changes in gene expression during the procession from normal to cancerous cervical epithelial cells. We found the expression of 5 genes in cancerous cervical epithelial cells that were not found in normal cervical epithelial cells, among which were lymphoid-restricted membrane protein, protease serine 2, WD repeat domain 59, thyrotropin-releasing hormone degrading enzyme, and the endothelin-3 growth factor. We then analyzed the expression levels of endothelin growth factors 1, 2, and 3 (ET-1, ET-2, and ET-3) and their receptors A and B (ETR-A and ETR-B) by reverse transcriptase-polymerase chain reaction in 3 cervical cancer cell lines and by immunohistochemical staining in cervical normal, dysplastic, and cancer tissues. ET-1, ET-2, and ET-3 growth factor levels were detectable in the maturing layer of cervical epithelium but not in the germinal layer. All 3 growth factors (ET-1, ET-2, and ET-3) were detected in the cytoplasm of the maturing normal cervical epithelial cells. In addition, there were decreased levels of ET-3 and increased levels of ET-1, ET-2, ETR-A, and ETR-B in cancerous cervical epithelial cells compared with normal cervical epithelial cells. These results suggest that the reduction of ET-3 growth factor levels may be important in the transition from normal to cancerous cervical epithelium.</P>
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Botanas, Chrislean Jun,Yoon, Seong Shoon,de la Pena, June Bryan,dela Pena, Irene Joy,Kim, Mikyung,Woo, Taeseon,Seo, Joung-Wook,Jang, Choon-Gon,Park, Kyung-Tae,Lee, Young Hun,Lee, Yong Sup,Kim, Hee Jin The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.2
A diversity of synthetic cathinones has flooded the recreational drug marketplace worldwide. This variety is often a response to legal control actions for one specific compound (e.g. methcathinone) which has resulted in the emergence of closely related replacement. Based on recent trends, the nitrogen atom is one of the sites in the cathinone molecule being explored by designer type modifications. In this study, we designed and synthesized two new synthetic cathinones, (1) ${\alpha}-piperidinopropiophenone$ (PIPP) and (2) ${\alpha}-piperidinopentiothiophenone$ (PIVT), which have piperidine ring substituent on their nitrogen atom. Thereafter, we evaluated whether these two compounds have an abuse potential through the conditioned place preference (CPP) in mice and self-administration (SA) in rats. We also investigated whether the substances can induce locomotor sensitization in mice following 7 days daily injection and challenge. qRT-PCR analyses were conducted to determine their effects on dopamine-related genes in the striatum. PIPP (10 and 30 mg/kg) induced CPP in mice, but not PIVT. However, both synthetic cathinones were not self-administered by the rats and did not induce locomotor sensitization in mice. qRT-PCR analyses showed that PIPP, but not PIVT, reduced dopamine transporter gene expression in the striatum. These data indicate that PIPP, but not PIVT, has rewarding effects, which may be attributed to its ability to affect dopamine transporter gene expression. Altogether, this study suggests that PIPP may have abuse potential. Careful monitoring of this type of cathinone and related drugs are advocated.
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Methoxetamine: A foe or friend?
Botanas, Chrislean Jun,de la Peñ,a, June Bryan,Kim, Hee Jin,Lee, Yong Sup,Cheong, Jae Hoon Elsevier 2019 Neurochemistry International Vol.122 No.-
<P><B>Abstract</B></P> <P>Methoxetamine (MXE) is an <I>N</I>-methyl-D-aspartate (NMDA) receptor antagonist that is chemically and pharmacologically similar to other dissociative substances, such as ketamine and phencyclidine. There are reports on the misuse of MXE, which sometimes resulted in adverse consequences and death. Studies have also shown that MXE has abuse liability and stimulates dopamine neurotransmission in the mesolimbic reward pathway in the brain. These findings have contributed to the negative impression on MXE. However, recent preclinical studies have identified the antidepressant properties of MXE, which are attributed to its ability to affect the glutamatergic and serotonergic systems. MXE is also reported to have analgesic effects. These findings show some of the “redeeming qualities” of MXE and indicate its possible therapeutic uses. In this paper, we have reviewed the findings that provide insights into the adverse and potential therapeutic effects of MXE. We compiled studies on the toxicity, psychotomimetic effects, and abuse liability of MXE, as well as its promising antidepressant and analgesic properties. We also have discussed the mechanism of action that might mediate the somewhat paradoxical effects observed. Importantly, this review provides valuable information on MXE for future research and will enable a better understanding of its psychopharmacological properties and the mechanisms responsible for its unique effects.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We review the adverse and potential therapeutic effects of methoxetamine (MXE). </LI> <LI> MXE, a structural analogue of ketamine, is an NMDA receptor antagonist. </LI> <LI> MXE produces toxic and dissociative effects and has abuse liability. </LI> <LI> MXE also has antidepressant and analgesic properties like ketamine. </LI> <LI> MXE can affect the dopaminergic, glutamatergic, and serotonergic system. </LI> </UL> </P>
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Liu, Xian De,Jayasena, Dinesh D.,Jung, Yeon-Kuk,Jung, Samooel,Kang, Bo-Seok,Heo, Kang-Nyeong,Lee, Jun-Heon,Jo, Cheo-Run Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.6
The Korean native chickens (Woorimotdak$^{TM}$, KNC) and commercial broilers (Ross, CB) show obvious differences in meat flavor after cooking. To understand the contribution of protein and peptide for meat flavor, 2-dimensional (2-D) gel electrophoresis and matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry was performed. A total of 16 protein spots were differentially expressed in the breast and thigh meat between the two breeds. A total of seven protein spots were represented by different levels between KNC and CB for breast meat. Among them three protein spots (TU39149, TU40162 and TU39598) showed increases in their expressions in KNC while other four protein spots (BU40125, BU40119, BU40029 and BU39904) showed increases in CB. All nine protein spots that were represented by different levels between KNC and CB for thigh meat showed increases in their expression in KNC. Phosphoglucomutase 1 (PGM 1), myosin heavy chain (MyHC), heat shock protein B1 (HSP27), cytochrome c reductase (Enzyme Q), Glyoxylase 1, DNA methyltransferase 3B (DNA MTase 3) were identified as the main protein spots by MALDI-TOF mass spectrometry. These results can provide valuable basic information for understanding the molecular mechanism responsible for breed specific differences in meat quality, especially the meat flavour.
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Botanas, Chrislean Jun,Bryan de la Peñ,a, June,Custodio, Raly James,Joy dela Peñ,a, Irene,Kim, Mikyung,Woo, Taeseon,Kim, Hee Jin,Kim, Hye In,Chang Cho, Min,Lee, Yong Sup,Cheong, Jae Hoon Pergamon Press 2017 Neuropharmacology Vol.126 No.-
<P><B>Abstract</B></P> <P>Depression afflicts around 16% of the world's population, making it one of the leading causes of disease burden worldwide. Despite a number of antidepressants available today, the delayed onset time and low remission rate of these treatments are still a major challenge. The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has shown to produce rapid and sustained antidepressant effects and has paved the way for a new generation of glutamate-based antidepressants. Methoxetamine (MXE) is a ketamine analogue that acts as an NMDA receptor antagonist and a serotonin reuptake inhibitor. However, no studies have evaluated the antidepressant effects of MXE. Here, we assessed whether MXE produces antidepressant effects and explored possible mechanisms underlying its effects. Mice were treated with MXE (2.5, 5, or 10 mg/kg) and their behavior was evaluated 30 min and 24 h later in an array of behavioral experiments used for screening antidepressant drugs. A separate group of mice were treated with NBQX, an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist, or ketanserin, a 5HT2 receptor antagonist, before MXE (5 mg/kg) administration in the forced swimming test (FST). We also investigated the effect of MXE on glutamatergic- and serotonergic-related genes in the mouse hippocampus using quantitative real-time PCR. MXE produced antidepressant effects 30 min after treatment that persisted for 24 h. Both NBQX and ketanserin blocked the antidepressant effects of MXE in the FST. MXE also altered hippocampal glutamatergic- and serotonergic gene expressions. These results suggest that MXE has rapid and sustained antidepressant effects, possibly mediated by the glutamatergic and serotonergic system.</P> <P><B>Highlights</B></P> <P> <UL> <LI> MXE produced rapid and sustained antidepressant effects. </LI> <LI> Antidepressant effects MXE were blocked by NBQX, an AMPA receptor antagonist. </LI> <LI> Ketanserin, a 5HT2 receptor antagonist, attenuated antidepressant effects of MXE. </LI> <LI> MXE altered hippocampal glutamatergic and serotonergic-related gene expression. </LI> <LI> MXE's effects likely mediated by glutamertergic and serotonergic systems. </LI> </UL> </P>
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