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유방암 조직에서 ATP를 이용한 항암제 반응성 검사의 유용성
이희대,최석경,정준,이승아,황승현,안성귀,정우희 한국유방암학회 2010 Journal of breast cancer Vol.13 No.2
Purpose: Breast cancer is heterogeneous disease and the response to chemotherapeutic agents is also heterogeneous from patient to patient. Chemotherapy response assay is in vitro test that is performed to evaluate the degree of tumor growth inhibition by chemotherapy drugs. In this study, we performed the chemotherapy response assay using adenosine triphosphate (ATP-CRA) in breast cancer patients and assessed the clinical availability. Methods: Sixty five breast cancer patients were enrolled in this study. Cancer cells were evenly divided and treated with commonly used chemotherapeutic drugs in breast cancer (doxorubicin, epirubicin, 5-fluorouracil, paclitaxel, docetaxel, vinorelbine, and gemcitabine). To verify in vitro ATP-CRA indirectly, we analyzed the correlation between cell death rate (CDR) of doxorubicin and epirubicin, and between doxorubicin and paclitaxel. We also analyzed the mean CDR of doxorubicin, epirubicin and paclitaxel by HER2 status. Results: We could successfully perform the ATP-CRA in 60 patients (95.2%). In all cases, we can get the results within 7 days. The range of CDR was very wide, from 0 to more than 50%, except gemcitabine. Epirubicin showed the highest mean CDR (39.9%) and doxorubicin, paclitaxel in order. According to the chemosensitivity index, paclitaxel is the most frequently first-ranked and doxorubicin, epirubicin in order. Correlation coefficient between the cell death rate of doxorubicin and epirubicin is 0.4210 and 0.1299 between paclitaxel and doxorubicin. In HER2 positive group, mean CDR of paclitaxel, epirubicin and doxorubicin was higher than in HER2 negative group, even though epirubicin and doxorubicin were not statistically significant (p=0.018, p=0.114, p=0.311, respectively). Conclusion: ATP-CRA showed heterogeneous results in individual patients. ATP-CRA was successful and can be performed within short time period. According to our in vitro study, it showed similar results with in vivo study but for the clinical use, the prospective randomized controlled trial should be preceded.
자연기반 도보관광객의 지각된 회복환경이 행동의도에 미치는 영향: 계획행동이론을 중심으로
이희대,이승곤 한국관광진흥학회 2023 관광진흥연구 Vol.11 No.3
This study is to analyze the role of the perceived restoration environment in the decisionmaking process of nature-based walking tourists. This study augments perceived restoration environment with four sub-dimensions in the theory of planned behavior(TPB) and develops an extended TPB to predict nature-based trekkers’ behavioral intention. Data was collected from visitors who experienced trekking on the waterside trail in Cheorwon-gun in South Korea. As a result of the analysis, first, the multi-dimension of the perceived restoration environment was confirmed in four sub-dimensions such as Fascination, Being away, Extent, and Compatibility. Second, the perceived restoration environment had a significant effect on attitude, and attitude, subjective norms, and perceived behavioral control had a significant effect on behavioral intentions, and subjective norms had a great influence. Third, the perceived restoration environment has an indirect effect on behavioral intention through attitudes, subjective norms, and perceived behavioral control of the planned behavior theory. Therefore, destination marketers or policy makers should recognize that subjective norms have a great influence on enhancing the behavioral intention of tourists for revisit. Therefore, it is necessary to strengthen positive word-of-mouth activities so that you can visit with your walking tour companions and important acquaintances. In addition, it is important to manage the destination for natural scenery so that the perceived recovery environment can be experienced during the walking tour activity 본 연구는 자연기반 도보관광객의 의사결정과정에서 지각된 회복환경의 역할를 분석하는 것이다. 이를 위하여, 지각된 회복환경을 4가지 하위 차원으로 구성하고, 계획행동이론의 확장 모델을 통하여, 자연기반 도보관광객의 행동의도를 예측하였다. 데이터는 철원군의 물윗길 트레킹을 경험한 방문객들로부터 수집되었다. 분석 결과는 첫째, 벗어남, 매력성, 공간성 및 적합성 등의 네 가지 하위 차원으로 지각된 회복환경의 다차원성을 확인했다. 둘째, 지각된 회복환경은 태도에 유의한 영향을 미치며, 태도, 주관적 규범, 지각된 행동통제 등은 행동의도에 유의한 영향을 미치며, 주관적 규범의 영향력이 크게 나타났다. 셋째, 지각된 회복환경은 계획행동이론의 태도, 주관적 규범, 지각된 행동통제 등을 통해 행동 의도에 간접 효과를 미치는 것으로 분석되었다. 따라서 목적지 마케팅 담당자나 정책입안자는 재방문을 위한 관광객의 행동의도를 제고시키기 위하여 주관적 규범에 대한 영향이 크다는 점을 인식하여, 도보관광의 동반자와 중요한 지인과 함께 방문할 수 있도록 긍정적인 구전 활동을 강화하는 것이 필요하다. 또한 도보관광 활동을 하는 동안 지각된 회복환경을 경험할 수 있도록 자연경관에 대한 목적지 관리가 중요하다.