임신부 체중증가와 신생아 체중과의 관계

정효지,김은정,최봉순,최경호,신정자,윤성도 동아시아식생활학회 2000 동아시아식생활학회지 Vol.10 No.6

This study was carried out to find the factors which are related to the weight gain during pregnancy of women and infant birth weight. The information of the general characteristics and pregnancy outcomes of the 506 women who had a delivery during Jan to Dec. 1997 in a hospital at Taegu area were collected from the medical records. The results are as follows. The mean age of the subjects was 29 years old and the average prepregnancy weight was 52.75㎏. They gained 13.51㎏ of weight during the pregnancy. The weight gain during pregnancy was higher in prepregnancy BMI <20kg/m^(2), the infant weight was heavier in groups that had over 14kg of weight gain during the pregnancy than other groups. The prepregnancy BMI was negatively correlated to weight gain during pregnancy (r=0.2825), and positively correlated to number of pregnancy (r=0.2146), number of living delivery (r=0.1409), and infant weight (r=0.1250). The baby weight was positively correlated to weight gain during pregnancy (r=0.1392) and Apgar score(r=0.1627). The results showed that the prepregnancy BMI and weight gain during pregnancy may be the influential factors on the infant weight, thus we need to develop the specific nutritional management program according to the status of prepregnancy weight.

鐵筋 콘크리트 有孔보의 거동에 관한 실험적 연구(Ⅱ)

최종만,이화직,하영철,곽윤근 國立金烏工科大學校附設生産技術硏究所 1994 産業技術開發硏究 Vol.10 No.-

Openings through beams are required for the passage of utility ducts and pipes, and they are freqently encountered in the design of modern buildings. They are particularly important in multistory buildings where the use of openings in beams can mean lower story heights, leading in turn to a multiplicity of savings. Therefore, the designers are often faced with the necessity of providing adequate openings in the buildings. However, provision of openings may cause problems of excessive cracking and deflection, and may severly affect the strength of a beam. An experimental investigation is carried out on twelve reinforced concrete beams with square openings. The size of opening, and it's location are considered as major variables. The specimens were tested under two point loading. Loads were usually applied in steps of 0.5 ton up to failure to observe the crack initiation and propagation, initial diagonal cracking, midspan deflection, concrete strain and reinforcement strain.

고분자 재료의 계장화 충격실험에 관한 연구

최선웅,우창기,윤종희 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.6

Impact behavior of polycarbonate in various defect state was investigated using an instrumented impact tester. A method of analyzing raw impact data was developed and successfully demonstrated the impact behavior in terms of load-displacement and energy-displacement curves. This technique was shown to be capable of separating defect, no-defect initiated fractures as well as their propagation behaviors.

鐵筋 콘크리트 有孔보의 擧動에 관한 실험적 연구

이화직,최종만,하영철,곽윤근 金烏工科大學校 1993 論文集 Vol.14 No.-

Openings through beams are required for the passage of utility ducts and pipes, and they are frequently encountered in the design of modern buildings. They are particularly important in multistory buildings where the use of openings in beams can mean lower story heights, leading in turn to a multiplicity of savings. Therefore, the designers are often faced with the necessity of providing adequate openings in the buildings. However, provision of openings may cause problems of excessive cracking and deflection, and may severely affect the strength of a beam. An experimental investigation is carried out on ten reinforced concrete beams with rectangular openings. The size of opening and it's location are considered as major variables. The specimens were tested under two point loading. Loads were usually applied in steps of 0.5 ton up to failure to observe the crack initiation and propagation, initial diagonal cracking midspan deflection, concrete strain and reinforcement strain.

Effect of Calcium and Boron on Black Leg Infection of Rhizome in Wasabi (Wasabia Japonica Matsum.)

Joung Sik Choi,Yeong Geun Choi,Yoon Ki Hong,Jung Seob Moon,Young Jik Jang,Nam Ki Oh 한국육종학회 2002 한국육종학회 학술발표회 발표요지 Vol.34 No.1

Characterization of the thioredoxin peroxidase from <i>Cryptosporidium parvum</i>

Joung, Migyo,Yoon, Sejoung,Choi, Kyungmi,Kim, Joung-Yeon,Park, Woo-Yoon,Yu, Jae-Ran Elsevier 2011 Experimental parasitology Vol.129 No.4

<P><B>Graphical abstract</B></P><P><ce:figure id='f0050'></ce:figure></P><P><B>Highlights</B></P><P>► Recombinant thioredoxin peroxidase of <I>Cryptosporidium parvum</I> (CpTPx) was expressed. ► CpTPx is a two-cysteine peroxiredoxin containing cysteines at positions 49 and 170. ► CpTPx exhibited substantial thiol-dependent peroxidase activity. ► CpTPx protected plasmid DNA from damage by metal-catalyzed oxidation <I>in vitro</I>. ► CpTPx was expressed mainly in the cytoplasm of <I>C. parvum</I>.</P> <P><B>Abstract</B></P><P><I>Cryptosporidium parvum</I> can survive exposure to harsh environmental conditions, various disinfectants, and high doses of γ-radiation. Recently, it was found that the expression of thioredoxin peroxidase (CpTPx) in <I>C. parvum</I> increased after a high dose of γ-irradiation to the parasite. CpTPx is a two-cysteine peroxiredoxin that contains cysteines at positions 49 and 170. Recombinant CpTPx fused to an N-terminal hexahistidine sequence, (His)<SUB>6</SUB>-CpTPx, exhibited substantial thiol-dependent peroxidase activity that protected plasmid DNA from damage by metal-catalyzed oxidation <I>in vitro</I>. (His)<SUB>6</SUB>-CpTPx was used to screen sera from <I>C. parvum</I>-infected mice and humans for antibodies against CpTPx. In Western blots, 10% of the mouse sera and 20% of the human sera reacted with (His)<SUB>6</SUB>-CpTPx, suggesting that after infection by <I>C. parvum</I> CpTPx can induce a host-immune reaction but is not a major antigen. Immunolocalization studies revealed that CpTPx is expressed mainly in the cytoplasm of <I>C. parvum</I> at various developmental stages.</P>

Pediatric Extracorporeal Membrane Oxygenation in Korea: A Multicenter Retrospective Study on Utilization and Outcomes Spanning Over a Decade

Choi Yu Hyeon,Jhang Won Kyoung,Park Seong Jong,Choi Hee Joung,Oh Min-su,Kwon Jung Eun,Kim Beom Joon,Shin Ju Ae,Lee In Kyung,Park June Dong,Lee Bongjin,Chung Hyun,Na Jae Yoon,Choi Ah Young,Cho Joongbum 대한의학회 2024 Journal of Korean medical science Vol.39 No.3

Background: Over the last decade, extracorporeal membrane oxygenation (ECMO) use in critically ill children has increased and is associated with favorable outcomes. Our study aims to evaluate the current status of pediatric ECMO in Korea, with a specific focus on its volume and changes in survival rates based on diagnostic indications. Methods: This multicenter study retrospectively analyzed the indications and outcomes of pediatric ECMO over 10 years in patients at 14 hospitals in Korea from January 2012 to December 2021. Four diagnostic categories (neonatal respiratory, pediatric respiratory, postcardiotomy, and cardiac-medical) and trends were compared between periods 1 (2012–2016) and 2 (2017–2021). Results: Overall, 1065 ECMO runs were performed on 1032 patients, with the annual number of cases remaining unchanged over the 10 years. ECMO was most frequently used for post-cardiotomy (42.4%), cardiac-medical (31.8%), pediatric respiratory (17.5%), and neonatal respiratory (8.2%) cases. A 3.7% increase and 6.1% decrease in pediatric respiratory and post-cardiotomy cases, respectively, were noted between periods 1 and 2. Among the four groups, the cardiac-medical group had the highest survival rate (51.2%), followed by the pediatric respiratory (46.4%), post-cardiotomy (36.5%), and neonatal respiratory (29.4%) groups. A consistent improvement was noted in patient survival over the 10 years, with a significant increase between the two periods from 38.2% to 47.1% (P = 0.004). Improvement in survival was evident in post-cardiotomy cases (30–45%, P = 0.002). Significant associations with mortality were observed in neonates, patients requiring dialysis, and those treated with extracorporeal cardiopulmonary resuscitation (P < 0.001). In pediatric respiratory ECMO, immunocompromised patients also showed a significant correlation with mortality (P < 0.001). Conclusion: Pediatric ECMO demonstrated a steady increase in overall survival in Korea; however, further efforts are needed since the outcomes remain suboptimal compared with global outcomes.

Evaluation of nausea and vomiting in pregnancy using the Pregnancy-Unique Quantification of Emesis and Nausea scale in Korea

( Hyun Joung Choi ),( Yoon Joo Bae ),( June Seek Choi ),( Hun Kyong Ahn ),( Hyun Sook An ),( Dal Soo Hong ),( Jeong-Sup Yun ),( Jung Yeol Han ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.1

Objective Severity of nausea and vomiting of pregnancy (NVP) is associated with adverse pregnancy outcomes and poorer quality of life (QOL). The aim of this study was to evaluate the severity of NVP and maternal well-being status using the Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) scale in a Korean population. Methods A total of 527 pregnant women who were receiving prenatal care at 4 hospitals were asked to participate in the study between January 2015 and June 2015. The severity of NVP was evaluated by the PUQE scale and maternal well-being status was evaluated using the visual analogue scale (VAS). Statistical analyses were performed to determine the risk factors associated with NVP and the associations between the severity of NVP and QOL. Results Among the 472 eligible pregnant women, 381 (80.7%) were suffering from NVP during pregnancy. No significant differences (P>0.05) were observed in any of the variables between the 2 study groups, with the exception of smoking, alcohol consumption, and history of NVP. NVP history was found to be the most powerful risk factor (adjusted odds ratio, 11.6; 95% confidence interval, 4.7-28.7). The correlation coefficient (r) between the VAS scores of maternal well-being status and PUQE severity was -0.25 (r²=0.062; P-<0.001). Conclusion In this study, an explicit decline in maternal well-being status was observed according to severity of NVP. The PUQE scale may be of help to clinicians, healthcare providers, and researchers because of its simplicity and usefulness as a tool for NVP evaluation.

피트모쓰 혼합상토를 이용한 잎들깨의 플러그 육묘 시 용탈률 및 시비농도가 생육 및 무기원소 흡수에 미치는 영향

박종윤(Joung Yoon Park),최종명(Jong Myung Choi),윤화모(Wha Mo Yoon) 한국원예학회 2002 한국원예학회 학술발표요지 Vol.2002 No.3

The Cofactors Role on Chemical Mechanism of Recombinant Acetohydroxy Acid Synthase from Tobacco

Kim, Joung-Mok,Kim, Jung-Rim,Kim, Young-Tae,Choi, Jung-Do,Yoon, Moon-Young Korean Chemical Society 2004 Bulletin of the Korean Chemical Society Vol.25 No.5

Acetohydroxy acid synthase (AHAS) is one of several enzymes that require thiamine diphosphate and a divalent cation as essential cofactors. The active site contains several conserved ionizable groups and all of these appear to be important as judged by the fact that mutation diminishes or abolishes catalytic activity. Recently, we have shown [Yoon, M.-Y., Hwang, J.-H., Choi, M.-K., Baek, D.-K., Kim, J., Kim, Y.-T., Choi, J.-D. FEBS Letters 555 (2003), 185-191] that the activity is pH-dependent due to changes in $V_{max}$ and V/$K_m$. Data were consistent with a mechanism in which substrate was selectively catalyzed by the enzyme with an unprotonated base having a pK 6.48, and a protonated group having a pK of 8.25 for catalysis. Here, we have in detail studied the pH dependence of the kinetic parameters of the cofactors (ThDP, FAD, $Mg^{2+}$) in order to obtain information about the chemical mechanism in the active site. The $V_{max}$ of kinetic parameters for all cofactors was pH-dependent on the basic side. The pK of ThDP, FAD and $Mg^{2+}$ was 9.5, 9.3 and 10.1, respectively. The V/$K_m$ of kinetic parameters for all cofactors was pH-dependent on the acidic and on the basic side. The pK of ThDP, FAD and $Mg^{2+}$ was 6.2-6.4 on the acidic side and 9.0-9.1 on the basic side. The well-conserved histidine mutant (H392) did not affect the pH-dependence of the kinetic parameters. The data are discussed in terms of the acid-base chemical mechanism.