Interleukin-2를 이용한 진행성 위장관암의 비장을 경유한 자가 LAK Cell의 면역학적 반응

안우섭,강중신,김인호,전석길,손수상 啓明大學校 醫科大學 1993 계명의대학술지 Vol.12 No.3

To elucidate the anticancer effect by observing the effect of LAK cells after infusion of IL-2 through splenic artery for the advanced gastrointestinal cancer, randomized study was performed for the 8 patients who had liver metastasis from gastic and rectal cancer. 4 patients were performed subtotal gastrectomy for stomach cancer and the others were done abdominoperineal resections for rectal cancer. The liver metastasis were noted all of the cases after surgery between October 1989 and December 1992 at the Department of Surgery, Keimyung University School of Medicine. After confirmation of the hepatic metastasis from gastorintestinal cancer, we performed selective splenic arterial infusin of IL-2 with the dosage of 20,000 units/kg B.W. We checked the immune function pre-and post-IL2 infusion therapy, such as total lymphocyte count, T-cell percentage and CMI multitest with blood count and hepatorenal function. There was no difference between the pre-and post IL-2 infusion in the hemoglobin, serum protein, albumin, BUN and creatinin. The total lymphocyte counts of pre-and post IL-2 infusion were 1641.2 and 1727.4, respectively. The T cell percentage of pre-and infusion were 62.51% and 64.27%, respectively and had the tendency to increase in comparison with pre-IL-2 infusion, but there were not stastical differences. The results of CML muiltitest of pre-and post IL-2 infusion were not definite differences. From the above results, it could be suggested that LAK cell after infusion of IL-2 via selective splenc artery had the slightly positive effect of the immune function of advanced gastrointestinal cancer patient, with hepatic metastasis.

모발염색에 있어서 우위잔여색소(DRP:Dominant Remaining Pigment)개념의 중요성

이중섭 한국미용학회 2002 한국미용학회지 Vol.8 No.2

Recently, we are facing so many changes in hairstyle such as evolutional haircut and fantastic haircoloring. In haircoloring, specially, there are many things changed. First of all, haircoloring services have become general services in a beauty salon, Not only people who want to cover gray hair but people who want to change their hair color also become great part of clients. Second, most clients want to express and style their hair in various manners. Third, as the portion of haircoloring services in a beauty salon has been increased, hairdressers have developed numerous coloring techniques and styles. And last, beauty product manufacturers have launched various professional coloring products, As the business of haircoloring become biggest part of beauty services, most hairdressers, salon owners, educators, and students have recognized the importance of scientific theory and technique of haircoloring, The purpose of this study is to explain the concept of the DRP(Dominant Remaining Pigment) and apply the concept to haircoloring practices. In natural hair color, there is a dominant tone. That means there is one dominant undertone on each natural hair color and bleached hair color. That is the DRP(Donminant Remaining Pigment) and it means the amount of natural pigment remaining in the hair at target level. The reason why the DRP is so important in haircoloring is very simple. Because coloring result is the combination of natural hair color and artificial pigments. The concept of the DRP can be applied in haircoloring: First, in double process, to achieve target hair color, hair must be lightened one level lighter than target level. If not, the result will have unwanted tone, Second, when covering gray hair, it is better way to use warm tone color because gray hair needs undertone to support haircoloring. That is a kind of prepigmentation. Third, to color an extremely overporous hair, it is common way to use filler. Filler compensate deficient underlying pigment and it is always warm tone(The DRP is always warm tone), In this case, it is important to use filler which is one level lighter Third, to color an extremely overporous hair, it is common way to use filler. Filler compensate deficient underlying pigment and it is always warm tone(The DRP is always warm tone), In this case, it is important to use filler which is one level lighter than target level.

미용실의 쿠폰촉진이 소비자의 쿠폰상환 행동에 미치는 영향 : The Influences of Beauty Salon's Coupon Promotions on Consumers'Coupon Redemption Behavior

이중섭 한국미용학회 1999 한국미용학회지 Vol.5 No.2

본 연구에서는 20세기 이후의 시대사조라고 할 수 있는 포스트모더니즘을 파악하고 포스트모더니즘의 특성이 현대 메이크업에서 어떠한 양상으로 나타나는지를 파악하는데 그 목적을 둔다. 포스트모더니즘이란 모더니즘이후에 나타나는 시대사조로서, 단어 자체에서 아이러니 현상을 가진다. '포스트'와 '모더니즘'이라는 어휘자체는 동시에 사용할 수 없는 시제들을 함께 사용했다는 점에서 상당히 모순점을 가진다. 이러한 포스트모더니즘은 모더니즘에 대한 반동으로 시작되었지만, 상당부분에 있어서는 모더니즘의 논리를 연장시키며, 보다 극단적으로 발전시킨다. 즉 모더니즘의 한계를 바탕으로 상호보완된 논리라고 보는 절충주의적인 입장이 타당하다. '다원주의'와 '불확실성'을 가장 큰 특징으로 가지는 포스트모더니즘이 현대 메이크업에서 어떠한 양상으로 나타나는지를 파악하면 아래와 같다. l. 패러디란 포스트모더니즘의 특성인 비역사성에 일견 모순되는 단어처럼 보인다. 그러나 포스트모더니즘에서의 패러디란 단순한 모방이 아닌 역사에 대한 주관적 재해석이라고 보는 것이 타당하다. 인간은 지나온 과거로의 회귀본능을 가진다. 이러한 특성에서 나타난 패러디를 '에스닉'과 "레트로'로 나누어 살펴보았다. 2. 그로데스크란 15 세기 말의 아라베스크 무늬를 지칭하는 말이지만, 현대에 와서는 극도로 부자연스럽고 기괴한 장면에 종종 사용되는 말이다. 현대 사회는 갈수록 각박해져 가고, 사람들은 이제 작은 충격에는 꿈적도 하지 않는다. 따라서 보다 강력한 충격을 원하는 것이다. 따라서 이제는 미의 영역에 추한 것도 받아들여지고 있다. 이러한 맥락에서 전위적인 실험성과 마술적 신비주의를 포스트모더니즘과 관련한 현대 메이크업의 특색으로 파악하였다 3. 유희성이란 현대 문화는 이제 더 이상 고급스러운 고상한 취미에서 벗어나기를 희망한다. '진지함'이란 개념에서 보다 '가벼움'이란 개념으로 사람들의 취향이 바뀌어가고 있다. 무미건조해지는 일상에서 탈출을 위해 '유머'를 절대적으로 필요로 한다. 이러한 맥락에서 유치하고 싸구려의 키치(kitsh) 문화와 신종 중요 마케팅 대상인 키덜트 (kidult) 문화에 대해 살펴 보았다. 4. 탈장르화란 현대는 학문, 예술, 사회, 문화 전반에 걸쳐 획일화된 구분이 사라지고 있다. '퓨전' 이라는 양식이 일반화된 것은 포스트모더니즘의 다원주의 논리에 기인한 것이다. 따라서 현대 메이크업에서는 테크닉보다는 정형화된 틀을 벗어나는 것에 더욱 주력하고 있다. 특히 바디페인팅의 영역은 미술이나 무용의 영역과 딱히 구분되지 않는다.

Guinea pig의 腹腔動脈과 前腸間膜動脈에 관하여

金鍾涉,朴重錫,曺台純 慶尙大學校 1980 論文集 Vol.19 No.1

In order to investigate the variation in the pattern of origin of the celiac and the cranial mesenteric arteries, forty-four specimens (guinea pig) anesthetized by ethyl ether were heparinized and exsanguinated. Neoprene latex solution was injected into common carotid artery of thirty-two specimens for gross dissection. Twelve specimens angiography were prepared by injecting fifty per cent of barium sulfate solution into exsanguinated animals and then radiographed on a soft X-ray apparatus (Shimadzu Waltes 60). 1. The celiac artery and the cranial mesenteric artery were observed to be arosed mostly from a common trunk of the abdominal aorta, the celiac-cranial mesenteric trunk(68.2%), but in three animals from thirty specimens an anastomotic branch was examined between the abdominal aorta and the celiac artery(6.8%). 2. The celiac artery and the cranial mesenteric artery were branched from separated origin of the abdominal aorta(31.8%), and an anastomotic branch was examined between the celiac artery and the celiac-cranial mesenteric trunk(6.8%) in three animals from thirty specimens. 3. the hepatic artery was arosed from three different origin such as celiac artery branched from celiac-cranial mesenteric trunk(45.4%), celiac-cranial mesenteric trunk(22.2%) and the celiac artery branched from the abdominal aorta(31.8%).

서울지역에서의 VOCs 오염원 기여도 추정에 관한 연구

봉춘근,윤중섭,황인조,김창녕,김동술 한국대기환경학회 2003 한국대기환경학회지 Vol.19 No.4

A field study was conducted during the summer time of 2002 to determine compositions of volatile organic compounds (VOCs) emitted from vehicles and to develop source emission profiles that is applied to CMB model to estimate the source contribution of certain area. Source emission profile is widely used for the estimation of source contribution by the chemical mass balance model and have to be developed applicable fur the large1 area of estimation. This study was aimed to develop source emission profile and estimation of source contribution of VOCs after application of the chemical mass balance (CMB) receptor model. After considering the emission inventory and other research results for the VOCs in Seoul, Korea, the sources like vehicle emission(tunnel), gas station (gasoline, diesel), solvent usage (painting operation, dry cleaning, graphic att), and gas fuels were selected for the major VOCs sources. Furthermore, ambient air samples were simultanceusly collected from 09:00 to 11:00 for four days at eight different official air quality monitoring sites as receptors in Seoul during summer of 2001. Source samples were collected by canisters, and then about seventy volatile organic compounds were analyzed by gas chromatography with flame ionization detector (GC/FID). Based on both the developed source profiles and the database of the receptors, CMB model was intensively applied to estimate mass contribution of VOCs sources. Examining the source profile from the vehicle, the portion of alkanes of VOCs was highest, and then the portion of aromatics such toluene, m/p-xylene were followed In case of gas fuel, they have their own components: the content of butane. propane. ethane was higher than any other component according tn the fuel usage. The average of the source apportionment on VOCs for 8 sites showed that the major sources were vehicle emission and gas fuels. me vehicle emission source was revealed as having the highest contribution with an average of 49.6% and followed by solvent with 21.3%, gas fuel with 16.1%, gasoline with 13.1%.

발생원별에 따른 PAHs 배출특성

박찬구,윤중섭,김민영,손종열,모세영 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.3

The results of individual PAH source profiles that can be applied to receptor model are as follows. The sum of 16 PAH concentrations was 391.41 ng/S㎥ in a tunnel. Phenanthrene was the most abundant compound among 16 PAH, and then pyrene, fIuoranthene, anthracene, and naphthalene can be seen in elevated contents. 11,056.61 ng/S㎥ of 16 PAH concentrations in BC oil boiler was two times higher than 6,582.57 ng/S㎥ of those in LNG boiler. Naphthalene was the most abundant compound in both facilities. Phenanthrene, anthracene. and acenaphthylene were the second dominant compound group in order from both facilities. BC oil boiler had relatively high concentration of pyrene compared to LNG boiler that had high concentration of fluorene and did not detect pyrene. The sum of 16 PAH concentrations emitted from MSW incinerators after APCD (air pollution control device) was three times higher than those from MSW incinerators bcfore APCD. However, the concentrations of more than 4-ring PAH compounds (e.g., benzo (a)anthracene) before APCD were higher than those after APCD. This fact implies that PAHs generated by combustion process are eliminated in APCD and they are continuously produced in stack or atmosphere by PAHs precursors.

병원과 지역사회에서 메티실린 내성 황색 포도상구균(methicillin-resistant Staphylococcus aureus) 감염의 임상 분자역학 연구

박정원,이종섭,송준영,김철현,엄중식,정희진,김우주,박승철 대한화학요법학회 2002 대한화학요법학회지 Vol.20 No.2

목적 : 국내에서 1990년대 이후 중요한 병원균으로 대두되고 있는 methicillin-resistant S. ureus(MRSA)는 주로 입원환자에서만 분리되는 것으로 알려져 있으나, 최근들어 지역사회에서도 퍼져있는 것으로 알려지기 시작하였다. 이에 병원획득 및 지역사회획득 MRSA의 임상역학 및 분자역학적 연구를 통하여 획득요인, 병원과 지역사회 획득 균주간의 교류 양상등을 규명하고자 하였다. 방법 : 1998년 1월부터 12월까지 고려대 부속 구로병원에서 임상검체로부터 분리된 S. aureus 균주중에서 MRSA 균주의 빈도를 구하였고, 이중 1998년 10월 1개월 동안 분리되었던 42균주에 대하여 지역사회획득 균주와 병원획득 균주로 나누고, 임상역학적 조사를 하였다. 지역사회 획득 18주와 병원획득 22주에 대하여 PCR 방법으로 mecA 유전자를 확인하였고, PFGE를 시행하여 균주의 클론형(clonal type)을 결정하고 이 결과에 준하여 덴드로그램 분석을 시행하여 분자적 친밀도를 결정하였다. 결과 : 1998년 1년간 분리된 총 1,587주의 S. aeureus 균주중 73.8%(1,163주)가 MRSA 였다. 1998년 10월 1개월 동안 임상자료의 고찰이 가능하였던 MRSA 감염환자 42명 중 20명이 지역사회획득 환자였고, 병원획득 환자가 지역사회획득 환자보다 항생제사용 과거력(17 vs 5, p=0.001), 기저질환의 존재(18 vs 8, p=0.002) 등이 통계적으로 의미있게 높았다. 지역사회획득환자가 이루(7/20[35.0%] vs 2/22[9.1%] ; p=0.041)와 밀접한 관계가 있음도 확인하였다. 분자생물학적연구가 진행된 40주의 MRSA 균주는 모두 mecA 유전자 양성이었고, 18주의 지역사회획득 균주에서 총 8가지의 PFGE 클론형이 존재하였으며 A형이 가장 많았다(7/18, 38.8%). 22주의 병원획득균주에서는 6가지의 클론형이 존재하고 A형이 가장 많았으며(15/22, 68%), 15주의 지역사회획득 균주(83.3%)가 21주의 병원획득균주와 공통적인 클론형을 공유하고 있었다. 결론 : 지역사회 획득 MRSA는 주로 이루나 창상부위에서 많이 분리되는 반면 병원획득 MRSA는 객담에서 많이 분리되고 또한 당뇨병을 가진 환자에서 감염을 잘 일으키는 것으로 밝혀졌다. PFGE 분석 결과 원내감염은 단일균주에 의한 유행양상을 보였고, 지역사회에서도 같은 형의 균주에 의한 감염빈도가 가장 높음을 보여 MRSA 균주가 지역사회로 유입되어 지역사회내 MRSA 감염의 발생에 기여했을 것으로 사료된다. Background : Until recently, methicillin-resistant Staphylococcus aureus (MRSA) infection has been acquired primarily in hospital settings. During the late 1990s, the incidence of community-acquired MRSA infections has been increased in this university hospital. This retrospective study evaluated the clinical features and risk factors for community-acquired MRSA infection compared with hospital-acquired MRSA infection; and molecular relatedness of MRSA strains determined by pulsed-field gel electrophoresis(PFGE). Method: MRSA isolates collected from patients during October of 1998 were classified as community-acquired("community') or hospital-acquired("hospital") cases. MRSA infections were defined as hospital-acquired if organisms were isolated > 48 hours after admission to the hospital or isolated from patients with a history of admission to a hospital within the last 3 months. A comparative analysis of risk factors for community MRSA compared with hospital MRSA was performed. mecA gene PCR and PFGE of MRSA isolated was used as a tool of strain identification and molecular typing. Result : During one month, there were 42 patients with MRSA infection or colonization. Of 42 patients with MRSA isolates, 22(52%) were hospital cases and 20(48%) were community cases. Previous exposure to antibiotics(17 vs 5, p = 0.001) and presence of underlying diseases (18 vs 8, p = 0.002) were more common in hospital cases than in community cases. MRSA were more frequently isolated in otorrhea specimens from patients with otitis media in community cases compared with hospital cases. Of the 40 MRSA isolates subjected for PFGE typing, 18 were community isolates and 22 were hospital isolates. There were 8 distinct PFGE types among the 18 community isolates and type A was the most common clonal type (7/18, 38.8%). 22 hospital isolates were of 6 distinct PFGE types, and type A was dominant clonal type (15/22, 68%). PGFE subtyping indicated that 15(83.3%) of 18 community MRSA strains were clonally related with that of 21 hospital MRSA strains. Conclusion : Our results suggest that hospital MRSA strains may have disseminated in the community setting. PFGE subtyping support the finding that MRSA is circulating beyond nosocomial settings in the regional community.

염색시장분석에 관한 이론적 고찰

조정혜,이중섭,김문주 한국미용학회 2002 한국미용학회지 Vol.8 No.2

After the 1980's beauty market developed on the basis of perm and coloring and the 1990`s when various ways of coloring appeared as a main menu in beauty culture, hair dyeing is becoming a big trend of young people. As hair care companies present more various colors, competitions to secure customers get more fierce. Accordingly damages of hair are getting worse, and interests are moving into hair care. Accordingly, this paper analyzes hairdye market and suggests the possibility of developing a hair dye. First, it is to help hair care companies improve quality of hair dyes, second to make a systematic education for a hair dye. third, to raise specialized colorists and general customers acquisition of basic sense of a hair dye. As written as above, successful hair color marking lies inunder-standing the characteristics of hair and to suggest color trends as well as creating high coloring technique.

初生雛의 體重 및 臟器重量에 關한 硏究

河正基,金鍾涉,朴重錫 慶尙大學校 1980 論文集 Vol.19 No.1

本 試驗은 實用鷄인 Hisex와 Hybro의 種卵을 孵化시켜 發生直後의 初生雛에 대하여 體重, 腦, 眼球, 肺, 心腸, 腎臟, 胃, 卵黃?, 盲腸, 小腸, 結腸과 直腸의 重量을 測定하고, 各 項目의 平均과 標準誤差를 求하는 同時에 各項目間의 相關關係 및 回歸直線方程式을 調査하였든 바 그 結果는 다음과 같다. 1) Hisex의 調査項目中 體重은 35.312±0.324g, 腦의 重量은 0.873±0.009g, 眼球의 重量은 0.866±0.019g, 肺의 重量은 0.348±0.013g, 肝의 重量은 1.108g±0.015g, 心腸의 重量은 0.415g±0.010g, 腎臟의 重量은 0.292g±0.007g, 胃의 重量은 2.502g±0.045g, 卵黃?의 重量은 3.562g±0.186g, 盲腸의 重量은 0.294g±0.018g, 小腸의 重量은 1.200g±0.026g, 結腸과 直腸의 重量은 0.169g±0.009g이였다. 2)Hybro의 調査項目中 體重은 36.569±0.295g, 腦의 重量은 0.912±0.009g, 眼球의 重量은 0.920±0.019g, 肺의 重量은 0.386±0.011g, 肝의 重量은 1.140±0.051g, 心腸의 重量은 0.401±0.013g, 腎臟의 重量은 0.280±0.010g, 胃의 重量은 2.723±0.045g, 卵黃?의 重量은 3.464±0.158g, 盲腸의 重量은 0.446g±0.028g, 小腸의 重量은 1.414±0.040g, 結腸과 直腸의 重量은 0.203g±0.016g이였다. 3) Hisex와 HYbro의 各 測定成績間에서 相關關係를 調査한 結果 正과 負의 相關이 있었다. This study was carried out to measure the weight and correlation between body weight and each visceral organs in commercial day old chicks(Hisex and Hybro). Names of the visceral organs measured are brain, eyeball, llung, liver heart, kidney, stomach, yolk sac, cecum, small intestine and colon and rectum. The results obtained are summarized as follows: 1. Average weight of body, brain, eye-ball, lung, liver, heart, kidney, stomach, yolk sac, cecum, small intestine and colon and rectum of the Hybre chicks(Meat type)and standard error to the items measured were 36.569±0.324g, 0.873±0.009g, 0.860±0.019g, 0.348±0.013g, 1.108±0.015g, 0.415±0.010g, 0.292±0.07g, 2.502±0.045g, 3.562±0.186g,0.294±0.018g, 1.200±0.026g and 0.167±0.009g, respectively. 2. Average weight of body, brain, eye-ball, lung, liver, heart, kidney, stomach, yolk sac, cecum, small intestine and colon and rectum of the Hybre chicks(Meat type) and standard error to the items measured were 36.569±0.295g, 0.912±0.109g, 0.920±0.019g, 0.386±0.011g, 1.140±0.051g, 0.401±0.013g, 0.280±0.010g, 2.723±0.045g, 3.464±0.158g, 0.446±0.028g, 1.414±0.040g and 0.203±0.016g, respectively. 3. Positive correlation and inverse correlation between items investigated in Hybro and Hisex were found.

난치성 간질 치료에서 뇌량 절제술의 결과

김동석,최중언,정상섭,이병인 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.5