尹草窓의 生涯와 草窓訣에 關한 硏究

金準泰,尹暢烈 대한한의학원전학회 1992 대한한의학원전학회지 Vol.6 No.-

I have studied life of Yoon-Dong-Li(尹東里), who applied Un-Ki(運氣) theory to medicine during Suk-Jong(肅宗) to Jeong-Jo(正祖) in Yi-Dynasty and also studied his existing writings named 《Cho-Chang-kyeol》(草窓訣). The referenced original work prints were based on 1980's pring of Chung-Ku oriental medical society and National Central Library and The academy a korean studies possessed print. Studied with these books, I have concluded as follows. 1. Yoon-Dong-Li(尹東里) courtesy name is Ja-Mi(子美), pen name is Cho-Chang(草窓). He was born in 1705, Suk-Jong(肅宗) 31yrs, and died in 1784, Jeong-Jo(正祖) 3yrs in Yi-Dynasty. He had lineage of third-generationed-doctor and learned medicine from his uncle, Yoon-Woo-Kyo(尹雨敎). His father Yoon-Yi-Kyo(윤이교) gaved him second influence. 2. Confucianal physician in Ming Dynasty You-Bu(劉溥) respected Ju-Ryeom-Kyo(周濂溪), confucianist in Song-Dynasty and You-Bu(劉溥) does not removed grass in front of window (because in chinese, Cho-Chang(草窓) means grass in front of windows), and named himself Cho-Chang(草窓). Yoon-Dong-Li(尹東里) followed this suit so called himself Cho-Chang(草窓). 3. The main contents of 《Cho-Chang-Kyeol》(草窓訣), <Un-Ki-Yeon-Lon>(運氣衍論) was written in 1725, when Yoon-Dong-Li(尹東里) was 21yrs old and printed in 1736. The other part of 《Cho-Chang-Kyeol》(草窓訣), <Yong-Yak-Pyeon>(用藥篇) was written in 1746. These two parts were not written in the same time. The <Un-Ki-Yeon-Lon>(運氣衍論) was written 11years earlier than <Yong-Yak>(用藥). Two parts were combined another day and named 《Cho-Chang-Kyeol》(草窓訣). 4. Existing 《Cho-Chang-Kyeol》(草窓訣) is transcribed printing with the content of "Five elements motion and the six kind of natural factors theory"(五運六氣論). Each edition is generally similar in content, but also has different points each other so naw we hardly finds a complete set of works. 5. 《Cho-Chang-Kyeol》(草窓訣) is a first technical book which treats of Un-Ki(運氣) theory in korea. 6. The contents of <Un-Ki-Yeon-Lon>(運氣衍論) of 《Cho-Chang-Kyeol》(草窓訣) is mechanism of diease according to excess and insuffciency of five elements motion and six kinds of natural factors, and symptoms and priscriptions, includes variated priscriptions. 7. Two parts in <Un-Ki-Yeon-Lon>(運氣衍論) of 《Cho-Chang-Kyeol》(草窓訣), 'Sang-tong'(相通) and 'Kak-Tong'(各通), threats of mechanisim of the disease according to five elements, with the principle of inter-promoting and inter-acting, in the change of ten heavenly stems and five elements motion. 8. In the <Yong-Yak-Pyeon>(用藥篇) of 《Cho-Chang-Kyeol》(草窓訣) describes priscription for clinical application according to Un-Ki(運氣) and also records about misuse of medicine. 9. In the 《Cho-Chang-Kyeol》(草窓訣), most of priscription are common using one, which also found in 《Dong-Ui-Bo-Gam》(東醫寶鑑) and there are few of priscriptions by Yoon-Dong-Li(尹東里).

Apoptosis and necroptosis‑inducing effects of arctigenin on nasal septum carcinoma RPMI‑2650 cells in 2D and 3D culture

Yoon‑Jin Lee,Kwan‑Sik Park,Byoung Joon Baek,Kyong‑Ae Lee,Sang‑Han Lee 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Backgrounds Arctigenin derived from the seeds of Arctium lappa Linnaeus is known as an anticancer drug candidate by targeting various pathways involved in anticancer therapy. Methods Using 2D monolayer and 3D spheroid culture systems in nasal septum carcinoma RPMI-2650 cells, the effects of arctigenin and dexamethasone on cell viability, ROS levels, ATP level, mitochondrial function, apoptosis and necroptosis were examined. Results The combination treatment of both compounds induced strong cytotoxicity, accompanied by increases of sub-G0/ G1 peak, annexin V-PE-positive cells, and ROS levels, loss of mitochondrial membrane potential, and decrease of cellular ATP content. These changes were observed as simultaneous induction of DNA damage, apoptosis, and necroptosis. A series of changes by arctigenin and dexamethasone were efficiently restored by decreasing ROS levels or supplementing ATP. Treatment of 3D spheroids with arctigenin and dexamethasone decreased cell viability in the spheroids, but it was slightly resistant than cells under 2D conditions. In addition, this phenomenon was accompanied by an increase in mediators for both apoptosis and necroptosis. Conclusion Results of this study suggest that the apoptosis and necroptosis-inducing effects of arctigenin are associated with ATP depletion due to oxidative mitochondrial dysfunction.

표면 거칠기가 난류 유동장에 미치는 효과에 대한 실험적 연구

윤준용 漢陽大學校 工學技術硏究所 1998 工學技術論文集 Vol.7 No.1

유동장의 속도나 난류 분포를 변화시키는 표면 거칠기 효과는 공학적으로 중요한 연구대상중의 하나이다. 현재까지 거칠기가 존재하는 표면위에서의 난류 유동장에 관한 연구자료는 많지 않으며, 그간의 연구자료는 거칠기 요소를 단순화시키거나 일정한 조건의 거칠기에 대해서만 다루었다. Patel, Yoon(1996)등이 거칠기 효과를 충분히 고려할수 있는 난류 모델을 개발하는등 수치 해석에서도 거칠기에 대한 응용이 이루어지고 있지만, 다양한 거칠기 효과를 연구한 자료는 미미하다. 이에 보다 다양한 거칠기 조건과 유동 조건에 기초한 유동장을 실험적으로 해석였다. 원하는 유동장을 생성시키고 다양한 거칠기 조건의 변화를 위해 직사각단면의 덕트에서 실험하였으며, 2차원 유동장의 난류 특성을 파악하기 위해 열선 유속계를 사용하였다. The effect of surface roughness that changes velocity profile or turbulent distribution of flow field is among the important engineering research area. Until now, there are few research works done on turbulent flows over rough surfaces. A little works dealt with simplified or constantly conditioned roughness elements. Even though study of roughness in the numerical analysis like that Patel and Yoon(1996) had developed about the turbulent model applicable to the roughness effect, only few studies of various roughness effect exist. So, the experimental analysis of the flows in more realistic and plausible conditions based on more various roughness types and flow conditions has done. To acquire the good flow conditions and to change the roughness conditions, duct with rectangular cross section was used as experimental apparatus, and hot-wire anemometer was used for the measurements of 2-dimensional turbulent characteristics.

알레르기 환자에서 MAST-CLA 검사의 의의

남해선,황규윤,,백병준,정윤영,오천환,조성란,박준수 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

To evaluate usefulness of application of MAST-CLA to indetify allergens, authors conducted MAST-CLA allergen-specific IgE assay and collected allergy related symptoms in 118 allergic patients diagnosed at Soonchunhyang University Chunan Hospital during October 1998 through January 2000. The results were as followings; 1. The mean (SD) age was 23.1 (±12.17) years old and teenagers accounted for 33.1% of patients. 2. The frequent allergic symptoms were sneezing (59.3%), rhinorrhea (53.4%), nasal stiffness (44.1%), itching sensation (24.6%), cough or sputum (16.1%), and eye symptom (8.5%) in order. 3. Among these subjects, 62.7% of patients revealed at least more than one specific allergen and 70.3% showed elevated total IgE levels by MAST-CLA. The three most frequent specific allergens were Dermatophagoides farinae (47.5%), Dermatophagoides pteronyssinus (45.8%), and house dust (30.5%). 4. While age was not significantly related to positive of both specific allergens and total IgE (P>0.05), sneezing and nasal stiffness were significantly associated with positive of specific allergen and total IgE, respectively (both P<0.05). 5. Total IgE increased with the number of specific allergens, but both specific allergen and total IgE were not significantly related to increases of allergic symptoms (P>0.05). In conclusion, our data suggest that MAST-CLA allergen-specific IgE assay is useful measure for identification of causative allergens in allergic patients, however, it is recommended that more specific allergic antigens should be determined and replaced or added to Korean inhalent panel of MAST-CLA.

Large Scale 2차원 자연지형 위에서 대기유동에 관한 수치적 연구

윤준용,강승규 漢陽大學校 工學技術硏究所 1997 工學技術論文集 Vol.6 No.1

The objective of this paper is to develop a computational model for the prediction of the pollutant spread from a complex terrain. The model comprises a two-dimensional, steady state and incompressible flow. This paper is to suggest velocity profile which is very important in the prediction of air pollution. This computational result can apply to predict the spread of pollutants for Sanbon city.

프로젝트 초기 단계에서의 분쟁방지를 위한 분쟁요인 추출에 관한 연구 : 턴키공사 사례 중심으로 Focusing on Turn-Key Project

윤준선,권기범,서춘택,백준홍 韓國仲裁學會 2004 중재연구 Vol.14 No.1

Although we try to increase the order of turn key construction for the international competitiveness strengthening, the construction quality advancement and the productivity enhancement of the public sectors, the problems of the domestic turn key systems are causing the hardships of all the participants and many possible disputes. The home turn key constructions have been activated since 1997. A lot of trial and error had been experienced in these days, and the turn key systems have been changed little by little. But the bases are continuously kept because of their reflecting all the participants' opinions. In the inner turn key constructions the problems of uniform types are repeatedly occurred, and, especially, many problems happen up to the stage of early stage owing to the specialties of the turn key construction. So the dispute factors of the Korean turn key constructions were abstracted through the literature searches, the site document examinations, the case studies and the interviews with the experts. When the technicians meeting the interior turn key construction for the first time and working here now are well acquainted with only these factors, many disputes will be prevented.

FEM에 의한 Al07075/CFRP 적층재의 탄성계수 해석

윤한기,안광주,김연겸,박준수 東義大學校産業技術開發硏究所 1998 産業技術硏究誌 Vol.12 No.-

As for the properties on both the aluminum and the CFRP which are used to make A17075/CERP multi-layered hybrid composites, CRALL(carbon reinforced aluminum laminate). For CRALL specimen, FEM analysis is compared with experimental results. It is shown that the rule of mixture is well agreed with experiment result in A/C 0001 layered 1 ply. However, differences are conceivable in A/C 0003 and A/C and A/C 0005 because of the effect of fiber volume fraction. In the A/C 0001 specimen case, the elastic modulus of the unnotched and circular notched CRALL specimen by FEM analysis are agreed with the experimental results, but that of A/C 0003 and A/C 0005 specimens had high CFRP volume fraction doesn't agree with experimental results.

음향방출을 이용한 콘크리트 부재의 미시적 파괴특성의 온라인 모니터링

윤동진,이진경,이준현 韓國非破壞檢査學會 1999 한국비파괴검사학회지 Vol.19 No.1

콘크리트는 다상(multi-phase)의 재료로서 구성되어지는 복합재료의 일종으로써 준취성(quasi-brittle)적인 재료적 특성을 가지고 있기 때문에 실제 복잡한 미시적 파괴특성을 나타낸다. 따라서 콘크리트 구조물의 안전성 확보를 위해서는 먼저 하중의 증가에 따른 콘크리트 내부의 변형특성 및 미시적 파손기구를 파악하여야 하며, 특히 실제 구조물에 있어서는 이들 특성들을 비파괴적으로 상시(on-line) 모니터링 하여야 할 필요가 있다. 따라서 본 연구에서는 3점 굽힘 하중을 받는 콘크리트 부재의 미시적 파손기구 및 각 파손기구에 대한 AE 특성을 명확히 함으로써 콘크리트 부재의 미시적 손상 및 파괴 특성을 비파괴적으로 평가하고 AE 발생원 위치 추정 기법을 이용하여 균열 발생 및 진전거동을 평가하였다. Since concrete is an inhomogeneous material consisting of larger aggregates and sand embedded in a cement paste matrix, it relatively shows a complex failure mechanism. In order to assure the reliability of concrete structure, microscopic fracture behavior and internal damage progress of concrete under the loading should be fully understood. In this study, an acoustic emission(AE) technique has been used to clarify microscopic failure mechanism and their corresponding AE signal characteristics of concrete under three-point bending test. In addition 2-dimensional AE source location has been performed to monitor the progress of an internal damage and the successive crack growth behavior during the loading. The relationship between AE signal characteristics and microscopic fracture mechanism is discussed.

住民運動參與의 決定要因에 관한 硏究

尹晙相,申尹澈 公州大學校 産業開發硏究所 1993 産業開發硏究 Vol.1 No.-

The objectives of the study were 1) to determine related variables of people's participation in collective action against three public community development administration projects, 2) to draw implications for development of democratic community development administration. To collect data, three areas in South Chung-Chong Province where such collective action took place were selected and a total of 261 residents were sampled as final subjects of survey. The degree of people's participation as dependent variable was measured mainly by Likert style ranging from 6-30 points on average. The independent variables were divided into two : individual attributes(sex, age, schooling, job, income, perceived level of living, period of living) and attitude valuables(community satisfaction, community cohesiveness, community leadership, political efficacy, political reliability, interest in community development project, benefit in community development project, wills of participation in community development project) Interview and/or questionnaire method was the main method of data collection. The statistics to determine related variables used in this study were analysis of variance and multiple regression analysis with a .01 significance level. The major findings of this study were as follows; 1. Five personal characteristics out of 5 associated with the degree of people's participation in collective action by analysis of variance were selected: sex, age, schooling, income, perceived level of living. 2. As a result of multiple regression analysis, seven variables of affecting people's participation in collective action, were determined: (1) interest in community development project, (2) income, (3) sex (4) age (5) community leadership, (6) benefit in community development project (7) political efficacy. Out of those seven variables the interest in community development project had the highest influence on the people's participation in collective action(10.9%). 3. Therefore, four implication were drawn for more efficient democratic community development administration: (1) planning of community development projects from below, (2) widening people's participation in community development administration, (3) openness information system from community development administration, (4) acclimatization of social movement through adult/continuing education.

네트워크 장비 시험센터 시스템의 설계

윤근수,이준원 安東大學校 工業技術硏究所 1999 공업기술연구논문집 Vol.6 No.1

국내 네트워크 장비 개발이 활발해짐에 따라 이들 장비들에 대한 검증이 중요하게 되어 네트워크 장비 시험센터가 설립되었다. 이 센터가 효율적으로 운용되기 위해서는 이용자들의 요구사항을 파악하여 반영하고 시험결과나 관련정보들을 효율적으로 수집하고 알려주는 시스템이 매우 중요하다. 따라서 본 논문은 웹 기반에 액티브 서버 페이지를 이용하여 언제 어디서나 누구든지 네트워크 장비 시험센터에 접속해서 설문조사를 통해 사용자의 요구 사항을 파악하여 반영하고, 네트웍 장비의 시험정보와 시험일정, 시험결과 및 관련정보를 데이터 베이스화하여 효율적으로 보여주고 관리 할 수 있는 시스템을 설계 및 구현하였다. The Network Equipment Test Center(NETC) was established and began to operate. To use the NETC effectively, the management system is required. The Network Equipment Test Center System is a system which retrieves and manages the informations related to the NETC. We design and implement the web based system.