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안준성,김민아,김상진,김응규 인제대학교 2006 仁濟醫學 Vol.27 No.-
Bacterial meningitis is frequently fetal or lead to severe neurological impairment. Cerebral infarction is a well known sequele of meningitis, occurring in as many as 10-20% of patients. But fetal cerebral infarction in bacterial meningitis is rare. We report a 61 year old woman who was admitted due to fever, headache and mental change for 3 days. On admission 7 days follow up Brain-CT revealed large and massive infarctions on both hemispheres. When bacterial meningitis is caused by Streptococcus pneumonia, there is a high prevalence of cerebral infarctions. The underlying mechanisms of cerebral infarction in bacterial meningitis are vasculitis, thrombosis, arachnoiditis, and compression of the arterial supply at the foramen magnum by herniation of the cerebellar tonsil.
안준성,김민아,김상진,김응규 인제대학교 2006 仁濟醫學 Vol.27 No.-
Brachial amyotrophic diplegia, a relatively stable variant of motor neuron disease, is characterized by weakness that is isolated to upper limbs and spared lower extremities, respiratory and bulbar musculature. This disease should be differentiated from other disease such as multifocal motor neuropathy, amyotrophic lateral sclerosis, monomelic amyotrophy and progressive muscular atrophy. We report two cases of brachial amyotrophic diplegia.
Byeong Cheol Min,Bon Wook Koo,Ki Seob Gwak,Hwan Myeong Yeo,Joon Weon Choi,In Gyu Choi 한국목재공학회 2011 목재공학 Vol.39 No.2
In this study, dilute acid pretreatment of Liriodendron tulipifera was performed for enzymatic hydrolysis. As the pretreatment temperature was increased, enzymatic hydrolysis and enzyme adsorption yield also increased. The highest enzymatic hydrolysis yield was 57% (gig) and enzyme adsorption was 44% (gig). Enzymatic hydrolysis yield was determined with weight loss of pretreated biomass by enzyme, and enzyme adsorption was a percentage of enzyme weight attaching on pretreated biomass compared with input enzyme weight. When L. tulipifera was pretreated with 1% sulfuric acid at 160℃ for 5 min., hemi-cellulose was significantly removed in pretreatment, but the lignin contents were constant. Other changes in surface morphology were detected on biomass pretreated at 160℃ by a field emission scanning electron microscope (FESEM). A large number of spherical shapes known as lignin droplets were observed over the entire biomass surface after pretreatment. Hemicellulose removal and morphological changes improved enzyme accessibility to cellulose by increasing cellulose exposure to enzyme. It is thus evidence that enzyme adsorption is a significant factor to understand pretreatment effectiveness.
다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예
최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.
구희정,서정길,김은희,허민도,정준기,박장수,강신원,박남규 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-
생리활성을 지닌 신경펩타이드의 구조와 활성간의 관계를 규명하기 위하여 고상법으로 합성한 세종류의 neuropeptide γ(mammalian-,trout- 그리고 goldfish-neuropeptide γ)를 사용하여 연구하였다. Circular dichroism spectra에 의하면 mammalian-,trout- 와 goldfish-neuropeptide γ는 완충액 조건하에 모두 random한 구조를 나타내었다. 중성 및 산성 지질 존재 하에서, mammalian-과 trout- neuropeptide γ는 여전히 random한 구조를 취하였다. 그러나, goldfish-neuropeptide γ는 중성 및 산성지질하에서 부분적으로 α-helix구조를 나타내었다. 장관 수축활성에 있어서는 carp 장관, guinea-pig 회장 그리고 rat십이지장에 대하여 비교하였다. Carp에 대해서는 goldfish-neuropeptide γ= trout- neuropeptide γ>mammalian-neuropeptide γ순으로 활서이 나타났다. 그러나, guinea-pig 회장과 rat십이지장에 대해서 mammalian-neuropeptide γ는 어류 유래성 neuropeptide g들 보다 높은 수축활성을 나타내었다. 이러한 결과들은 neuropeptide γ들이 종-특이적인 활성을 나타낸다는 것을 제시한다. The relationship between structure and biological activity was studied on the three neuropeptides(mammalian-,trout- and goldfish-neuropeptide γ)that were syntheized by the solid-phase method. Circular dichroism spectra showed that mammalian-,trout- and goldfish-neuropeptide γadopted an undered structure in buffer solution. In the presence od neutral and acidic liposomes, mammalian-and trout- neuropeptide γ also took a random structure. However, goldfish-neuropeptide γ took an α-helical structure in acidic liposomes. The intestinal motility response was investigated with carp interstines, guinea-pig ileums and rat duodenums. In case of carp intestine, contractine activity was as follows:goldfish-neuropeptide γ= trout- neuropeptide γ> mammalian-neuropeptide γ. On the other hand, the contracile activity of mammalian-neuropeptide γ was more potent than trout- and goldfish-neuropeptide γ in the guinea-pig ileums and rat duodenums. these results suggest that neuropeptide γs showed the species-specific activity.
항공용 복합재 단일겹침 접착 체결부의 제작공정에 따른 강도 연구
송민규(Min-Gyu Song),권진회(Jin-Hwe Kweon),최진호(Jin-Ho Choi),김효진(Hyo-Jin Kim),송민환(Min-Hwan Song),신상준(Sang-Joon Shin) 한국항공우주학회 2009 韓國航空宇宙學會誌 Vol.37 No.8
본 논문에서는 항공기 구조용 탄소 복합재 단일겹침 접착 체결부에서, 파손하중에 영향을 미치는 주요인자들의 효과를 실험으로 연구하였다. 실험을 위해 제작공정 4가지, 겹침 길이 5가지, 모재 두께 4가지에 대한 시편 총 335개를 제작하였다. 예상대로 겹침길이가 감소할수록, 모재두께가 증가할수록 파손강도가 높아지는 것을 확인하였다. 그러나 제작공정의 측면에서는, 접착제가 없는 일체성형 시편과 이차접착 시편의 강도가 동시접착이나 접착제를 사용한 일체성형 시편에서보다 높은 파손강도를 보이는 흥미로운 사실을 발견하였다. 특히 이차접착 시편의 강도가 일체성형 시편의 강도와 유사하거나 더 높은 현상을 발견하였는데, 이는 접착제의 강도가 모재의 층간강도보다 높거나 최소한 비슷한 수준임을 의미하는 것으로 볼 수 있다. Failure strengths of composite single-lap adhesive joints were investigated with various parameters such as manufacturing method, overlap length and adherend thickness. A total of 335 single-lap joint specimens were tested under tension. Specimens were fabricated with 4 different manufacturing processes; cocuring without and with adhesive, secondary bonding and co-bonding. Each manufacturing process has 5 different overlap lengths and 4 different thicknesses, respectively. As expected, failure strength is higher in thicker adherend joints and lower in larger overlap length specimens. Interesting result is that the secondary bonded joints show the higher strength than the cobonded and cocured joints with adhesive, and give close or even higher strength compared with non-adhesive cocured case.
다구찌기법을 이용한 선박용 커넥팅로드 예비성형체의 최적 설계
박준홍(Joon-Hong Park),강정호(Jung-Ho Kang),하민수(Min-Soo Ha),김승규(Seung-Gyu Kim),최성규(Seong-Gyu Choi),백동규(Dong-Gyu Baek),박영철(Young-Chul Park) 한국기계가공학회 2007 한국기계가공학회지 Vol.6 No.4
In this paper, propose an optimal design to improve the mechanical efficiency of gate valve made by forging method. In order to design the experiments using table of orthogonal array and optimization design is conducted as application of real response model to Taguchi method based approximation model using computer simulation. Also, from verification of the response model with optimized results was confirmed that usefulness and reliance of application Taguchi method to structural optimum design using finite element analysis and equation.