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Kim, Ji Yeong,Jeon, Woo Joo,Kim, Dong Hwee,Rhyu, Im Joo,Kim, Young Hwan,Youn, Inchan,Park, Jong Woong Medknow PublicationsMedia Pvt Ltd 2014 Neural regeneration research Vol.9 No.14
<P>Platelet-rich plasma containing various growth factors can promote nerve regeneration. An inside-out vein graft can substitute nerve autograft to repair short nerve defects. It is hypothesized that an inside-out vein graft filled with platelet-rich plasma shows better effects in the repair of short sciatic nerve defects. In this study, an inside-out vein autograft filled with platelet-rich plasma was used to bridge a 10 mm-long sciatic nerve defect in rats. The sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better improved than that of rats with a simple inside-out vein autograft. At 6 and 8 weeks, the sciatic nerve function of rats with an inside-out vein autograft filled with platelet-rich plasma was better than that of rats undergoing nerve autografting. Compared with the sciatic nerve repaired with a simple inside-out vein autograft, the number of myelinated axons was higher, axon diameter and myelin sheath were greater in the sciatic nerve repaired with an inside-out vein autograft filled with platelet-rich plasma and they were similar to those in the sciatic nerve repaired with nerve autograft. These findings suggest that an inside-out vein graft filled with platelet-rich plasma can substitute nerve autograft to repair short sciatic nerve defects.</P>
Branching Patterns and Anatomical Course of the Common Fibular Nerve
Goo Young Kim,Chae Hyeon Ryou,Ki Hoon Kim,Dasom Kim,Im Joo Rhyu,Dong Hwee Kim 대한재활의학회 2019 Annals of Rehabilitation Medicine Vol.43 No.6
Objective To present the branching patterns and anatomical course of the common fibular nerve (CFN) and its relationship with fibular head (FH). Methods A total of 21 limbs from 12 fresh cadavers were dissected. The FH width (FH_width), distance between the FH and CFN (FH_CFN), and thickness of the nerve were measured. The ratio of the FH_CFN to FH_width was calculated as follows: <1, cross type and ≥1, posterior type. Angle between the CFN and vertical line of the lower limb 5 cm proximal to the tip of the FH was measured. Branching patterns of the lateral cutaneous nerve of the calf (LCNC) were classified into four types according to its origin and direction as follows: type 1a, lateral margin of the CFN; type 1b, medial margin of the CFN; type 2, lateral sural cutaneous nerve (LSCN); and type 3, CFN and LSCN. Results In the cross type (15 cases, 71.4%), the ratio of FH_CFN/FH_width was 0.83 and the angle was 13.0°. In the posterior type (6 cases, 28.6%), the ratio was 1.04 and the angle was 11.0°. In the branching patterns of LCNC, type 2 was the most common (10 cases), followed by types 1a and 1b (both, 5 cases). Conclusion Location of the CFN around the FH might be related to the development of its neuropathy, especially in the cross type of CFN. The LCNC showed various branching patterns and direction, which could be associated with difficulties of electrophysiologic testing.
ADP에 의해서 활성화된 인혈관세포의 Prothrombin과 골타액단백 부착에 관여하는 Integrin avβ3, avβ5, a5β1의 특성
주승재,최휘,김성만,차태준,이재우 고신대학교 의학부 2003 高神大學校 醫學部 論文集 Vol.18 No.1
Background : One of the most important features of integrins is that they exist in active and inactive states. Adenosine diphosphate (ADP), which is usually secreted from activated platelets, may activate integrins on vascular on vascular cells. Each integrin has its own activation-dependent ligands that have much higher affinity to active form than inactive one. Integrins that might mediate adhesion of human vascular cells to prothrombin(PT) and bone sialoprotein (BSP) after ADP stimulation were investigated. Methods : PT and BSP were used as activation-dependent ligands in adhesion assay. Adhesions of human umbilical vein endothelial cells (HUVEC) and human aortic smooth muscle cells (HASMC) were measured after stimulating with 100 μM of ADP, using ligand-coated 24-well plate and Fluorescence Multi-Well Plate Reader. Results : ADP activated HUVEC and HASMC to increase adhesions to PT and BSP in a dose-dependent manner. Adhesions of ADP-stimulated HUVEC to PT and BSP were almost completely inhibited by c7E3, a blocking monoclonal Ab to integrin β₃(96% and 92% inhibition, respectively), but not by P5H9, a blocking monoclonal Ab to integrin α_vβ_5. Adhesion of ADP-stimulated HASMC to PT was completely blocked by P5H9 (92% inhibition), but was not affected by c7E3. Adhesion of ADP-stimulated HASMC to BSP was partially inhibited either by P5H9 (46% inhibition) or by JBS5, a blocking monoclonal Ab to integrin inhibition), but was not affected by c7E3. However, it was completely blocked by cRGD (93% inhibition). Conclusion : These results indicate that the adhesion of ADP-stimulated HUVEC to PT or BSP was mediated by integrin α_vβ₃ and several integrins appeared to be involved in the adhesion of ADP-stimulated HASMC. While the adhesion of HASMC to PT was mediated by integrin α_vβ_5, the adhesion to BSP was associated with integrins α_vβ_5 and α_5β₁.
정휘정(Hwee Jeong Cheong),노주영(Joo Young Roh),오칠환(Chil Hwan Oh),김수남(Soo Nam Kim) 대한피부과학회 1990 대한피부과학회지 Vol.28 No.3
A 21-year-old female is presented with semicircular lipoatrophy, which had developed since birth with annular depressed strophic lesion of the left thigh. Biopsy specimen from the depressed area of left thigh showed no abnormal pathologic findings. But X-ray and CT scan of the lower extremity revealed remarkably reduced fat layer of the left thigh, compared to the right side. (Kor J Dsrmatol 28(3): 358 361, 1990)
사람 적혈구 알데히드 탈수소효소의 정제와 특성에 관한 연구
김주희,주충노 ( Joo Hwee Kim,Chung No Joo ) 생화학분자생물학회 1992 BMB Reports Vol.25 No.5
Aldehyde dehydrogenase (ALDH) isozymes of human erythrocyte were separated and purified. ALDH having low K_m value (74.6 μM) and high K_m value (174 μM) for acetaldehydde were named low K_m, ALDH and high K_m ALDH respectively. For low K_m, ALDH, both NAD^+ and NADP+ could be used as coenzyme, but high K_m ALDH used only NAD^+. Their molecular weights were determined according to pore-gradient polyacrylamide gel electrophoresis and found that low K_m ALDH was 269,000 dalton and high K_m, ALDH 273,000 dalton. SDS-polyacrylamide gel electrophoresis showed that they were both homotetramer, composed of four identical subunits. The molecular weight of subunit of these two isozymes were 59,500 and 60,600 dalton respectively. Both, high K_m and low K_m ALDH showed esterase activity as well as dehydrogenase activity. They were very stable at 35℃ and optimum pH of both isozymes were 9.5. isoelectric point of low K_m ALDH was 5.5.