만성골반통의 동서의학적 고찰 : 부인과 질환으로 중심으로

김순열 ( Soon Yeol Kim ),윤종원 ( Jong Won Yoon ) 동국대학교 한의학연구소 1996 東國韓醫學硏究所論文集 Vol.5 No.-

The purpose of this study was to generalize the conception of chronic pelvic pain(CPP)through the literature of oriental medicine and occidental medicine. The results are obtained as follows. First, chronic pelvic pain(pain of more than 6 months' duration) may include pain of gynecologic, gastroenterologic, urologic neurologic, and musculoskejetal origin. In this study, the etiologic of chronic pelvic pain may remain obscure and the relationship between certain types of pathologic, such as endometriosis or adhesions, and the pain response may be inconsistent and often inexplicable. Second, the causes of CPP through the literature of oriental medicine were reviewed as pains due to a wind-pathogen, a cold, disorder of Qi, disorder of blood stasis, a improper diet, disorder of fluid, and deficiency type etc... And the charateristic pains were concerned with a aching pain, a heavy pain, a distending pain, a pain due to mass in the abdoman, a pain likes pulling etc... The degree an4 classification of charateristic pains in current of time were dependent on subjective factors. Third, in oriental medicine, it wasn`t to be suggested concretely recognition of etiological factor in pain, But they recognised that facters were influenced by pain. For example, diretic peripheral demages were concerned with a blood stasis, a phlegm, a damp phlegm, heart, and the pains that were occurrenced by sevn emotions were concerned with a stagnancy of Qi or a stagnancy of liver-Qi.

Political and Economic Situations of the Commonwealth of Independent States and Confronting Tasks of Koreans

Yoon,In-Jin/Jang,Won-Chang/Lee,Kwang-Kyu/Rhee,Jong-Hoon/Sim,Heon-Yong 고려대학교 아세아문제연구소 2001 亞細亞硏究 Vol.44 No.2

Cloning and mRNA Expression Analysis of the Gene Encoding Phenylalanine Ammonia-Lyase of the Ectomycorrhizal Fungus Tricholoma matsutake

( Hyeok Jun Yoon1 ),( Young Hyun You ),( Ye Eun Kim ),( Young Ja Kim ),( Won Sik Kong ),( Jong Guk Kim ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.8

The ectomycorrhizal fungus Tricholoma matsutake grows symbiotically with Pinus densiflora. Phenylalanine ammonia-lyase (E.C. 4.3.1.24) catalyzes the conversion of L-phenylalanine to trans-cinnamic acid. The role of fungal phenylalanine ammonia-lyase, however, has not been clear until now. In this study, the gene encoding phenylalanine ammonia-lyase (PAL), which was isolated from T. matsutake, was cloned and characterized. The PAL gene (tmpal) consists of 2,160 nucleotides, coding for a polypeptide containing 719 amino acid residues. The deduced amino acid sequence of tmpal from T. matsutake shows high identity (70%) with that from Laccaria bicolor. Comparative analysis of the PAL genes among T. matsutake and other species of the class Agaricomycetes showed that both active sites and binding sites were significantly conserved among these genes. The transcriptional analysis of the PAL gene revealed a differential gene expression pattern depending on the developmental stages (mycelium, primordium, stipe, pileus, and gills) of T. matsutake. These results suggest that the PAL gene in T. matsutake plays an important role in multiple physiological functions.

신선육및 육가공제품에 대한 소비자의 인식도 및 소비실태조사 제 2 보 . 육가공제품의 소비실태 및 구매성향

안병윤,김종원,이유방 ( Byung Yoon Ahn,Jong Won Kim,Yu Bang Lee ) 한국축산학회 1981 한국축산학회지 Vol.23 No.1

A total of 1006 households residing in Seoul, Taegu and Cheonan were surveyed to investigate the consumption pattern and purchasing tendency of processed meat products under the current marketing system. The results are as follows: 1. The average frequency of purchasing meat products was 3-4 times a month and the frequency was closely related to the monthly income of the consumers. A mere 6 percent of respondents with relatively high income purchased more than 10 times per month; whereas, sixty percent of respondents less than 3 times, indicating the consumption of processed meats is at very low level. 2. Sausage(fish-red meat mixture) was purchased most frequently(75%) by all consumption of ham was relatively high (∼20%) at the monthly income level of more than 400,000 won. 3. Meat products were chiefly consumed by children(71%) and teenagers(19%), and were used as side dish in lunch box(41%) or main meal(30%). 4. The average consumers purchased meat products primarily from supermarkets (53.1%), grocery stores(22.5%) and meat shops(16.5%). 5. The procurement of processed meat was determined either by the sole decision of housewife(56%) or by the recommendation of family members(27%). Good nutrition(40.7%) and convenience(29.1%) were the predominant reasons of baying processed meats. The low income people set the highest priority in good nutrition, whereas the high income people in convenience. 6. Forty one percent of respondents have the experience of having purchased foreign products, 15% of them having asserted the superiority of domestic products, while 43% expressed the reverse opinion.

The Longitudinal Trend of Cardiac Surgery in Korea from 2003 to 2013

Lee, Kyeong Soo,Kim, Chang Suk,Park, Jong Heon,Hwang, Tae Yoon,Kim, Sang Won,Sim, Sung Bo,Lee, Kun Sei The Korean Society for Thoracic and Cardiovascular 2016 The Korean Journal of Thoracic and Cardiovascular Vol.49 No.sup

Background: The purpose of this study was to investigate longitudinal changes of the utilization of operational and surgical medical care inside and outside a metropolitan area over 10 years, analyzing the residential areas of patients and the locations of medical facilities for major cardiovascular surgery. Methods: Data analysis was conducted by classifying the addresses of patients and the locations of medical care facilities of metropolitan cities and provinces, using data from the National Health Insurance Corporation from January 2003 to December 2013. Results: There is serious concentration of major heart surgery to medical facilities in Seoul; this problem has not improved over time. There were differences in percentages of surgical procedures performed in the metropolitan areas according to major diseases. In the case of Busan and Daegu provinces, at least 50% of the patients underwent surgery in medical facilities in the city, but there are other regions where the percentage is less than 50%. In the case of provinces, the percentage of surgical procedures performed in medical facilities in Seoul or nearby metropolitan cities is very high. Conclusion: Policies to strengthen the regional capabilities of heart surgery and to secure human resources are required to mitigate the concentration of patients in the capital area. Many regional multi-centers must be designated to minimize unnecessary competition among regional university hospitals and activate a win-win partnership model for medical services.

소아 알레르기비염의 경제적 부담 평가를 위한 다기관 조사

공도연 ( Do Youn Kong ),김경원 ( Kyung Won Kim ),김우경 ( Woo Kyung Kim ),민택기 ( Taek Ki Min ),박용민 ( Yong Mean Park ),안재억 ( Jae Ouk Ahn ),양현종 ( Hyeon Jong Yang ),염혜영 ( Hye Yung Yum ),윤혜선 ( Hae Sun Yoon ),전유훈 ( 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.2

목적: 알레르기비염의 유병률은 전 세계적으로 급격히 증가하고 있으며, 그에 따른 경제적 부담도 증가하고 있다. 그러나, 소아 알레르기 질환이 미치는 경제적 부담에 관한 국내 연구는 제한적이어서 소아 알레르기비염이 환자와 그 가족에게 미치는 경제적 부담을 산출하고자 본 연구를 진행하였다. 방법: 2008년 7월 1일부터 9월 31일까지 서울시 6개 2-3차 의료기관을 방문한 18세 이하 소아 알레르기비염 환자 및 보호자를 대상으로 설문 조사를 진행하였다. 설문을 통해 직접 의료비 (병·의원 진료비, 및 약제비 한방 진료비 및 약제비, 보완/대체요법비), 직접비의료비 (교통비, 환경개선비), 그리고 간접비용 (월 평균 노동 손실)을 조사하였고 그 결과를 질환의 중증도 및 유병 기간에 따라 분석하여 그 차이를 비교하였다. 결과: 모집된 262명의 대상 중 174명(66.4%)이 남자였고, 평균 연령은 6.54세였다. 대상군의 연간 평균 직접 의료비는 177만 원이었고 직접비 의료비는 57만 원이었다. 비록 통계학적 유의성은 없었지만, 알레르기비염의 중증도가 증가할수록 직접 의료비가 증가하는 경향을 보였고, (P=0.053) 유병 기간 또한 직접 의료비의 증가와 유의한 양의 상관 관계를 보였다. (R=0.195, P=0.002) 대상 환자 보호자의 약 17%가 아이의 알레르기비염으로 인해 직장에 결근 또는 조퇴를 경험한 것으로 조사되어 사회적 간접비용을 미루어 생각할 수 있었다. 결론: 알레르기비염이 미치는 경제적 부담은 질환의 중증도가 심할수록, 그리고 유병 기간이 길수록 증가하며, 이는 특히 한방 진료 및 치료비와 보완/대체요법비의 증가에 기인한 것으로 조사되었다. 따라서 알레르기비염으로 인한 경제적 부담을 줄이기 위해서는 환자와 보호자를 대상으로 근거 중심의 치료를 할 수 있도록 지속적이고 체계적인 교육이 필요할 것으로 사료된다. Purpose: The prevalence of allergic rhinitis is rapidly increasing and results in relatively high socio-economic burden on their family and community. However, studies on the economic burden of pediatric allergic rhinitis in Korea are limited. Therefore, we conducted this study to investigate the impact of pediatric allergic rhinitis on economic burden. Methods: Two hundred sixty two children with allergic rhinitis were enrolled in 6 secondary or tertiary medical centers in Seoul from July to September, 2008. We collected data of the economic burden of allergic rhinitis (direct medical costs, direct nonmedical costs, and indirect costs) by face to face questionnaire survey. We compared the economic burden according to the severity and the duration of allergic rhinitis. Results: The mean age of subjects was 6.54 years, and male were 174 (66.4%). Direct medical costs (10,000 Korean Won/yr) were 177.75, and direct nonmedical costs were 57.92. Although, there was no statistical significance, direct medical costs showed increasing trends in severe allergic rhinitis. (P=0.053) In addition, direct medical costs were positively correlated with duration of allergic rhinitis.( R=0.195, P=0.002). About 17% of the parents who care the allergic rhinitis children experienced the work absence due to their child s illness. Conclusion: The economic burdens of allergic rhinitis were positively correlated with the severity and duration of illness. Particularly costs for alternative medicine including oriental medicine` were related with severity and duration allergic rhinitis. Therefore, special efforts for education with evidence based treatment strategy are necessary to decrease the economic burden of allergic rhinitis.

Comprehensive clinical characterization of patients with BRCA1: c.5017_5019del germline variant

Yoon Ju Bang*,Won Kyung Kwon*,Jong-Won Kim,Jeong Eon Lee,Boo Yeon Jung,Mina Kim,Jisun Kim,Jeongshin An,Seung Pil Jung,Hong-Kyu Kim,Zisun Kim,Hyun Jo Youn,Jai Min Ryu,Sung-Won Kim 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.103 No.6

Purpose: We provide evidence for the reclassification of the BRCA1:c.5017_5019del variant by presenting the clinicopathological characteristics, clinical outcomes, and family history of breast or ovarian cancer in 17 patients with this variant. Methods: This study included breast or ovarian cancer patients tested for BRCA1/2 genes between January 2008 and June 2020 at 10 medical centers in Korea. We retrospectively reviewed 17 probands from 15 families who had the BRCA1:c.5017_5019del variant according to the electronic medical records. Results: We present 10 breast cancer patients and 7 ovarian cancer patients from 15 families identified as having BRCA1:c.5017_5019del and a total of 19 cases of breast cancer and 14 cases of ovarian cancer in these families. The ratio of breast-to-ovarian cancer was 1.3:1. Breast cancer patients with this variant showed a rich family history of breast or ovarian cancer, 8 patients (80.0%). The mean age at diagnosis was 45.4 years and 6 patients (60.0%) were categorized into hormone-receptor–negative breast cancer. Also, the ovarian cancer patients with this variant showed strong family histories of breast and/or ovarian cancer in 4 patients (57.1%). Conclusion: We presented clinical evidence for the reclassification of BRCA1:c.5017_5019del as a likely pathogenic variant (LPV). Reclassification as LPV could result in the prophylactic treatment and medical surveillance of probands, family testing recommendations, and appropriate genetic counseling of their families.

Antioxidant Components and Antioxidant Activity of Salvia miltiorrhiza‘DASAN’according to the Cultivation Period

Yoon Jeong Lee,Kyung Ho Ma,Jeong Hoon Lee,Jin Tae Jung,Myeong Won Oh,Young Ho Yoon,Jong Won Han 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

Salvia miltiorrhiza Bunge is a well known and important traditional medicinal herb because of its use in treating cardiovascular and cerebrovascular diseases. In this study, the antioxidant components and activity of ‘DASAN’, the first domestic cultivar of Salvia miltiorrhiza, were compared according to the cultivation period. The polyphenol content of ‘DASAN’ by cultivation period (1, 2 and 3 year) was 574.87, 343.41, and 331 mg/100 g, respectively. In addition, ABTS (255.73 mgAEAC/100 g), DPPH (245.83 mgAEAC/100 g) radical scavenging activity, and reducing activity(33.85 mgAEAC/100 g) of 1-year-olds were higher than those of 2 and 3-year-old. As the cultivation period increased, the antioxidant power showed a tendency to decrease, showing results similar to the results of analysis on the content of antioxidants. These results are considered to be useful data for setting optimal conditions for the cultivation period of ‘DASAN’ to help farmers. In addition, the results suggested that ‘DASAN’ could be considered as a new potential source of natural phenolic antioxidants for food, pharmaceutical, cosmetics or nutraceutical industries.

Leptin-induced adhesion and invasion in colorectal cancer cell lines

YOON, KYUNG-WON,PARK, SEON-YOUNG,KIM, JI-YOUNG,LEE, SU-MI,PARK, CHANG-HWAN,CHO, SUNG-BUM,LEE, WAN-SIK,JOO, YOUNG-EUN,LEE, JAE-HYUK,KIM, HYUN-SOO,CHOI, SUNG-KYU,REW, JONG-SUN Spandidos Publications 2014 ONCOLOGY REPORTS Vol.31 No.6

Introducing pulsed low-intensity ultrasound to culturing human umbilical cord-derived mesenchymal stem cells.

Yoon, Jong Hyun,Roh, Eun Youn,Shin, Sue,Jung, Nam Hee,Song, Eun Young,Lee, Dong Soon,Han, Kyou Sup,Kim, Joung Sung,Kim, Byoung Jae,Jeon, Hye Won,Yoon, Kang Sup Kluwer Academic Publishers 2009 Biotechnology letters Vol.31 No.3

<P>The human umbilical cord (hUC) is a source of adult tissue-derived mesenchymal stem cells (MSCs). A pulsed low-intensity ultrasound (PLIUS) method is described for increasing the yield of MSCs from whole hUC without enzymatic digestion or growth factor supplementation. Analysis of the immunophenotype of cells and a differentiation study were performed to show the compatibility of MSCs. The mean number of cells recovered from primocultures of hUC was 6 x 10(5) cells/cm. PLIUS resulted in a 3.3-fold increase in MSC yield at passage 0. PLIUS exposure increases the yield of hUC-MSCs by promoting release and enhancing proliferation.</P>