수종의 cytokine이 배양중인 조골세포에 미치는 영향

李鐘烈,高鮮一,金正根 단국대학교 치의학연구소 1995 단국대치의학연구소논문집 Vol.7 No.1

수종의 cytokine이 배양중인 조골세포에 미치는 영향

李鍾烈,高鮮一,金正根 단국대학교 치의학연구소 1995 논문집 Vol.7 No.1

Evidence indicates that cytokines are involved in the initiation and progression of chronic inflammatory diseases. Recent evidence demonstrates major roles of growth factors and cytokines as mediators for bone growth and remodeling. Bone remodeling is a local phenomenon which occurs in discrete packets throughout the skeleton. The cellular events which comprise the remodeling sequence are controlled by cytokines which are generated in the microenvironment of the bone resorbing area. These cytokines are derived from marrow mononuclear cells or from bone cells themselves, or they are incorporated into the bone matrix and released in biologically active form as bone resorb. But evidence is accumulating that some of these cytokines play an important role not just in physiological bone remodeling, but also in common diseases of bone remodeling such as osteoporosis, osteopetrosis, Paget's diseases and malignant diseases which involve bone and chronic inflammatory diseases such as rheumatoid arthritis and periodontal diseases. Also, these cytokines are derived from bone cells themselves, these receptors are present in bone cells. Therefore, this experiment developed a culture of osteoblastic cells from embryonic chicken calvaria to examine the possible role of some cytokine in osteoblast function. This experiment was performed 1) to examine the effect of cytokines on the acid phosphatase activity of chicken osteoblast and 2) to examine the effect of cytokines on the alkaline phosphatase activity of chicken osteoblast and 3) to study the effect of cytokines on the bone nodule formation of chicken osteoblast in long-term cultures. The observed results were as follows. 1. Cytokines and cytokine combination stimulate the release of acid phosphatase into cultured medium in cultures of chicken osteoblast. 2. Cytokines and cytokine combination increase the activity of acid phosphatase of cell extract in cultures of chicken osteoblast. 3. Cytokines and cytokine combination decrease the activity of alkaline phosphatase of cell extract in cultures of chicken osteoblast. 4. Less bone nodules were formed by cytokines than in control group.

황사현상시 대기중 충부유분전(TSP)와 TSP중의 중금속 및 무기성 이온 조사 연구

손종렬,정호철,양광수,이용성 高麗大學校 倂設 保健大學 保健科學硏究所 1998 保健科學論集 Vol.24 No.1

The study was performed to investigate the influence of dust transportation from China contient to Korea by Yellow Sand phenomena and evaluate the aerosol during the period of Yellow Sand phenomena in Seoul, from Apr. to Oct. 1998. The TSP(Total Suspended Particulates) was collected by High Volume Air Sampler. The concentration of heavy metals in TSP were analysed by AAS and the inorganic ion of TSP were analysed by IC. The results were as follows: 1. The average concentration of TSP were 249.18㎍/㎥ at sampling point during the Yellow Sand phenomena were twice higher than that in Non-Yellow Sand which was 121.98㎍/㎥. 2. The average concentration of heavy metals in TSP during Yellow Sand phenomena and Non-Yellow Sand were Zn>Al>Fe>Pb>Mn>Cr>Ni>Cu>Cd. 3. In comparion with the ordinary time, the average concentration of anionic ions in TSP during Yellow Sand phenomena were Cl^(-)>S0₄^(2)>NO₃^(-)>F^(-)>P0₄>Br^(-), those of Non-Yellow Sand were Cl^(-)>NO₃^(-)>SO₄^(-2)>F^(-)>PO₄^>Br^(-), and that of cationic ions in TSP during Yellow Sand phenomena were Na^(+)>K^(+)>NH₄^(+).

실내환경중의 산소발생기 사용에 대한 인식도 평가

손종렬,조윤수,이규현,황상용 대한위생학회 2003 대한환경위생공학회지 Vol.18 No.4

Recently, Indoor air quality(IAQ) in workplace, residential environments and office has been concern of people, scientists and related the public. The oxygen in air was very important and essential element in every aspect of life. This study was performed on a questionnaire survey of 400 people about their awareness of indoor air quality, oxygen generators and measured of oxygen concentration in indoor environment. The results obtained were as follows; As respondents are having their 90% of daytime indoors a day, and 80% of them can feel indoor air pollutions degrees directly by particle matters. The control of most important problems of IAQ was the poor ventilation. We know that 22% of the respondents was recognized the oxgen generator. And for the installation of indoor pollution control equipment, 20% of all respondents installed oxygen generators because almost respondents was not satified the trust of ability purified indoor air pollutants. In the experimental results, it was found that the oxygen concentration of sampling sites were in the range of 20~23.5%. Therefore, it was recommended that the government related IAQ was suggested the guideline and control of oxygen generators. Finally, it appeared that the oxygen generators using indoor environment can be applied to new technology for cleaning of indoor air.

초음파 조사에 의한 슬러지 탈수특성 개량에 관한 연구

손종렬,이용성,유인성 高麗大學校 倂設 保健大學 保健科學硏究所 2001 保健科學論集 Vol.27 No.2

In this study, the series of ultrasonic irradiation for the improvement of sludge dewaterability in sewage treatment plant has been selected as a model reaction in the batch reactor system in order to obtain the basic data investigate the influence of various experimental parameters such as irradiation time, frequency and instensity of ultrasound. These experiments were performed on the ultrasonic frequency of 28 KHz, 40KHz and ultrasonic intensity of 50 W/㎠ 100W/㎠ And then the tests measured the Specific Resistance to Filtration(SRF), the dissolved solids concentration and Sludge Volume(SV30) in conditions of ultrasound. In experimental results, the dissolved solids concentration of filtrate was increase in proportional to the ultrasonic irradiation time. To the contrary, the SV30 and SRF were reduced in proportional to increase of irradiation time in each experimental conditions. This results meants that the efficiency of sludge dewaterability is due to the ultrasonic effect that changes the structures of sludge. Finally, it appeared that the technology using ultrasonic irradiation can be applied to the pre-treatment of sludges which are difficult to be dehydrated by the conventional methods.

Effect of Atrial Natriuretic Peptide on the Proliferation and Activity of Osteoblastic Cells

Jong-Ryeul Lee,Seon-Yle Ko,Jung-Keun Kim,Se-Won Kim 대한생리학회-대한약리학회 2000 The Korean Journal of Physiology & Pharmacology Vol.4 No.4

<P> Natriuretic peptides comprise a family of three structurally related peptides; atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP). The present study was performed to investigate the effect of ANP on the proliferation and activity of ROS17/2.8 and HOS cells which are well-characterized osteoblastic cell lines. ANP dose-dependently decreased the number of ROS17/2.8 and HOS cells after 48-hour treatment. ANP generally increased the alkaline phosphatase activity of ROS17/2.8 and HOS cells after 48 hr treatment, regardless of the fact that basal activity of alkaline phosphatase was much lower in HOS cells compared to that of ROS17/1.8 cells. ANP increased the NBT reduction by ROS17/2.8 and HOS cells. ANP showed the variable but no significant effect on the nitric oxide production by ROS17/2.8 and HOS cells. ROS17/2.8 and HOS cells produced and secreted gelatinase into culture medium, and this enzyme was thought to be the gelatinase A type with the molecular weight determination. The gelatinase activity produced by ROS17/2.8 cells was increased by the treatment of ANP. However, the enzyme activity was not affected by ANP treatment in the HOS cell culture. In summary, ANP decreased the proliferation and increased the alkaline phosphatase activity and NBT reduction of osteoblasts. These results indicate that ANP is one of the important regulators of bone metabolism.

국내 일부 학교 교실의 실내공기질 평가

손종렬(Jong-Ryeul Sohn),윤승욱(Seung-Wook Yoon),김윤신(Yoon-Shin Kim),노영만(Young-Man Roh),이철민(Cheol-Min Lee),손부순(Bu-Soon Son),양원호(Won-Ho Yang),이윤규(Yun-Gyu Lee),최한영(Han-Young Choi),이진성(Jin-Sung Lee) 한국실내환경학회 2006 한국실내환경학회지 Vol.3 No.1

Recently, indoor air quality (IAQ) in workplace, residence, and schools has been one of the major concerns of people, scientists and the related public. This study was performed to investigate the characteristics of indoor air quality(IAQ) in kindergartens, elementary school, middle schools, and high schools from June 2004 to May 2005 in Korea. We measured indoor air pollutants such as PM₁?, CO₂, formaldehyde, total bacteria colony(TBC), CO, radon, total volatile organic compounds(TVOCs), asbestos, and O₃ from school classrooms. The subjects were classified by building year based on the time span of 1, 1-3, 3-5, and 5-10 years. The levels of pollutants and physical factor in schools were compared with standards and guidelines of indoor air quality on the Ministry of Environment, the Ministry of Health and Welfare, and the Ministry of Education, and Human Resources Development of Korea. The major results obtained from this study can be summarized as follows. Asbestos and O₃ were not detected in all surveyed classrooms. However, we were able to detect CO, TBC, TVOCs, and formaldehyde in kindergartens, TBC in elementary schools, TBC, TVOCs and formaldehyde in middle schools, and formaldehyde in high schools. This study was conducted to provide a basis for the management IAQ in school. Therefore, we suggest that a national plan for the management of IAQ in school should be established through a long-term, continuous investigation for the proper assessment of IAQ in school and for the health risk assessment for student.

전국 일부 학교 건축물 내의 실내 공기 및 인식도 조사

손종렬(Jong-Ryeul Sohn),윤승욱(Seung-Uk Yoon),김종혁(Jong-Hyuk Kim),이용식(Yong-Sik Lee),최한영(Han-Young Choi),김영성(Young-Sung Kim),손부순(Bu-Soon Son),양원호(Won-Ho Yang),김민회(Min-Hoi Kim) 대한환경위생공학회 2005 대한환경위생공학회지 Vol.20 No.3

Recently, indoor air quality (IAQ) in workplace, residential environments and schools has been concerned of people, scientists and related the public, and has recognized the healthy effectsrelated to IAQ, specially in schools in Korea. Therefore, objectives of this study in this study were to measure and compare the perception of IAQ of selected air pollutants in Seoul from April to September 2004. Measurement place measured 2 schools of Seoul and local 9 schools (by Kyonggi Province, Chungchong-bukdo Chungchong-namdo, Chollado-bukdo, Cholla-namdo, Kyongsang-bukdo, Kyongsang-namdo, Kwangju, schoolin Pusan each 1 place). Temperature, humidity, illumination, carbon monoxide, carbon dioxide, TBC (total bacteria count), noise, PM10, TVOC(total volatile organic compounds), HCHO (formaldehyde) were measured simultaneously. Also, we performed a questionnaire survey of 250 students and 50 teachers about their awareness for the importance of IAQ in their schools. Among this article, we handled noise, carbon monoxide, carbon dioxide, TBC, TVOC, HCHO, PM 10 in our conclusion. Major results were as follows ; Carbon monoxide (CO) was lower than indoor air standard of Korea. Carbon dioxide (CO₂) appeared that 4 schools among our sample target school exceeded in normal standard. 4 schools were almost similar with normal standard. TBC appeared that 7 schools among 11 schools were higher than standard. Noise measured school's mean value passed exceeded standard. And school which passed over standard appeared to 7 schools among 11 schools. HCHO was exceeded 4 schools by standard that excess and certainly interrelation between school's establishment year and facilities of construction was detected. PM10 was exposed all schools by fitness in standard. TVOC appeared that 9 schools among 11 measurement school was exceeded health effect standard of Japan.

대학 도서관 건물의 실내공기오염 실태조사 및 개선 방안에 관한 연구

이종렬(Jong-Ryeul Lee),정광섭(Kwang-Seop Chung),김영일(Young-Il Kim) 대한설비공학회 2010 대한설비공학회 학술발표대회논문집 Vol.2010 No.11

There are increasing number of cases that report headaches and fatigues caused by the indoor air quality, which nowadays is deteriorating due to the well-sealed doors and windows with improved airtightness and energy-efficiency resulting in less natural ventilation. Through this study, the indoor air quality of a university library in Seoul has been measured floor by floor in accordance with the official test method. The measured results are geometrized for analysis. To improve the indoor air quality, ventilation system is proposed and its effect on the indoor air quality is analyzed.

서울시 일부 학교의 실내 공기질 조사 및 인식도 평가

손종렬(Jong-Ryeul Sohn),변상훈(Sang-Hoon Byeon),김영환(Young-Whan Kim),김종혁(Jong-Hyeok Kim),조윤수(Yun-Su Cho),이재영(Jae-young Lee),박윤주(Youn-Ju Park) 대한환경위생공학회 2003 대한환경위생공학회지 Vol.18 No.3

Recently, Indoor air quality(IAQ) in workplace, residential environments and schools has been concern of people, scientists and related the public. And so in Seoul has recognized the healthy effect related to IAQ in schools. Therefore, the objective of this study reported in this article were to measure and compare the perception of IAQ of selected air pollutants at three different schools in Seoul. We performed a questionnaire survey of 400 students about their awareness for the importance of IAQ in our school. And we measured the IAQ of 3 schools considering as site region, construction year and studying level. The indoor air pollutants and parameters such as temperature, relative humidity, respirable particulate matter(PM10). formaldehyde(HCHO), total bacteria counts(TBC), carbon dioxide(C0₂), and noise were monitored in indoors. In results, all most response of occupant has recognized the awareness of IAQ at schools. The PM10. TBC and Noise level of all schools were higher than the standard of the public 150㎍/m³ and 500 CFU/rn³, the level formaldehyde(HCHO) was below 0.1 ppm of the healthy guideline of Korea And the concentration of CO₂ were investigated below 1,000 ppm of the standard implying ventilation in 2 schools except for 1 school(c school). Finally. the control of most important pollutants of IAQ in school were PM 10. TBC and Noise. Therefore, it can be concluded that the indoor air quality of selected 3 schools studied was perceived as acceptable. it is recommended that the government related IAQ was suggested the guideline and control of lAQ problems in schools. and all member relating school need to be effort to reduce the exposure of sources to undesirable indoor pollutants such as Particlate and Noise.