Adult invasive pneumococcal disease in the Republic of Korea: Risk medical conditions and mortality stratified by age group

Kim, Jong Hun,Baik, Seung Hee,Chun, Byung Chul,Song, Joon Young,Bae, In-Gyu,Kim, Hyo Youl,Kim, Dong-Min,Choi, Young Hwa,Choi, Won Suk,Jo, Yu Mi,Kwon, Hyun Hee,Jeong, Hye Won,Kim, Yeon-Sook,Kim, Jeong Elsevier 2018 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES Vol.74 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>This study aimed to characterize the risk factors for mortality in adult patients with invasive pneumococcal disease (IPD) stratified by age groups, after implementation of the national immunization program of 23-valent polysaccharide vaccine (PPSV23) for those aged ≥65 years in the Republic of Korea (ROK).</P> <P><B>Methods</B></P> <P>Clinical data and pneumococcal isolates from adult patients with IPD (≥18 years of age) were collected prospectively from 20 hospitals through the nationwide surveillance program from March 2013 to October 2015.</P> <P><B>Results</B></P> <P>A total of 319 patients with IPD were enrolled. Median age was 69 years. Overall in-hospital mortality was 34.2%: 17.1% in those aged 18–49 years, 23.7% in those aged 50–64 years, 33.0% in those aged 65–74 years, and 51.0% in those aged ≥75 years (<I>p<</I> 0.001). In particular, early death within 7days of hospitalization accounted for 60.6% (66/109). While old age (≥65 years), higher Pitt bacteremia score (≥4), and bacteremic pneumonia were independently associated with IPD mortality in all age groups, an additional mortality risk factor of immunocompromised status was identified for patients aged 50–64 years. PPSV23 serotypes accounted for 64.4% (122/189) of the pneumococcal isolates serotyped.</P> <P><B>Conclusions</B></P> <P>This study suggests that vaccine-type IPD continues to place a substantial burden on older adults in the ROK, necessitating an effective vaccination strategy for those at higher risk.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization of the elderly with the 23-valent polysaccharide vaccine (PPSV23) was implemented in Korea in 2013. </LI> <LI> Overall in-hospital mortality was 34.2% for adult invasive pneumococcal disease (IPD) and 51.0% for patients ≥75 years of age. </LI> <LI> Mortality risks were older age, higher bacteremia score, and immunocompromised status. </LI> <LI> An effective vaccination strategy for those at higher risk of IPD is needed. </LI> </UL> </P>

생쥐 배아의 체외배양시 저농도 산소 환경이 배아 발달에 미치는 영향

유정현(Jong Hyun Woo),황경주(Kyung Joo Hwang),양현원(Hyun Won Yang),이치형(Chi Hyeong Lee),양정인(Jeong In Yang),권혁찬(Hyuck Chan Kwan),오기석(Kie Suk Oh) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12

N/A Objective: It is known that mouse embryos before implantation develop in a low oxygen environment of 3- 8% concentration and with antioxidant materials such as vitamins, antioxidant enzymes, ferrous binding proteins, and albumin in follicular and tubal fluids. However, the 20% oxygen culture condition with chemically defined media might be produce an abundance of ROS, and leads to developmental delay or developmental block in vitro. In this study, we attempt to elucidate the relationship between intracellular H2O2 production and embryo development in different oxygen culture conditions of mouse embryos. Methods: Prenuclear embryos from C57BL/CBA Fl hybrid and ICR mouse were cultured in incubators which provided 5% carbon dioxide, 20% oxygen and 5% carbon dioxide, 5% oxygen. Measurement of H2O2 level in a embryo was performed with DCHFDA(2,7 -dichlorodihydroflourescein diacetate)and analyzed with Quanti-cell 700, and the number of blastomeres was counted with DAPI( 4, 6'-diamidino-2-phenylindole). Results: Oxygen concentration of the culture medias was significantly higher in the 20% oxygen environment compared to that of 5% oxygen environment. Culture of mice embryos in high oxygen condition leads to high HO concentrations at 2 cell stage and developmental delay or 2-cell block regardless of the strain. But in a 5% oxygen environment, which is similar to in-vivo conditions HO production was suppressed continuously through out culture and development of embryos was definitely improved. Conclusion: These results suggest that there is a difference in the production of ROS or protective mechanism according to the mouse strains and stage of development, and it is thought that in-vitro culture in 5% oxygen environment provides stable in vivo equilibrium but in a 20% oxygen environment there is production of ROS which overcome the protective mechanism which leads to cellular damage and embryo developmental delay.

Four Taeniasis saginata Cases Diagnosed at a University Hospital in Korea

Eun Jeong Won,신주현,이유정,김문주,강승지,Sook In Jung,Soo Hyun Kim,Jong Hee Shin,채종일,신성식 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.3

In recent years, the taeniasis has been rarely reported in the Republic of Korea (Korea). But in this study, we in- tend to report 4 taeniasis cases caused by Taenia saginata during a 5-month period (February to June 2018) at a unversity hospital in Gwangju, Korea. Worm samples (proglottids) discharged from all cases were identified by phenotypic and mo- lecular diagnostics. Mitochondrial cytochrome c oxidase subunit I sequences showed 99.4-99.9% identity with T. sagina- ta but, differed by 4% from T. asiatica and by 7% from T. multiceps, respectively. We found that tapeworms in 2 cases (Cases 2 and 3) yielded exactly the same sequences between them, which differed from those in Cases 1 and 4, sug- gesting intra-species variation in tapeworms. These taeniasis cases by T. saginata infection in this study, which occurred within a limited time period and region, suggest the possibility of a mini-outbreak. This study highlights the need for fur- ther epidemiological investigation of potentially overlooked cases of T. saginata infection in Korea.

유교이념과 덴동어미화전가

원종인 숙명여자대학교 2003 숙명語文論集 Vol.- No.5

Confucian ethics is dominant through the Chosun Dynasty and it is a fundamental principle of that period. In that society the rulling classes had prohibited strictly the remarriage of a woman by fidelity ideology which was an idea of Confucianism. But the social order was collapsed severly in late Chosun Dynasty. Dendong Omi whom we have analized in this article, didn't have a mind to follow the fidelity ideology. So she chose to start another marrige. She lost her husband four times and remarry three times. During flower pancake game she met a young widow who was in anguish whether she will marry or not. When Dendong Omi saw her situation, she told her own tough story. Finally the young widow escaped from the conflict about her marriage. The auther have presented repeatdly the lesson through Dendong Orni's pitiful life. The lesson is like this if one woman rernary , she must be hit by misfortune. So Dendong Omi Flower Pancake Song was written not for personal life but for establish ing Confucian ideology which had controlled the members in the society. The writer have inserted the life of Dendong Omi to the Dendong Omi flower Pancake Song that is abundant in lyricism. This work enlarged the formal patency and flexiblity of a boudoir poem. Traditional boudoir poim only spoke out moral lessons but the writer of Dendong Omi Flower Pancake Song put a story. the boudoir poem have been developed into high dimension form. It is the significance of Korean literature history.

유한요소법을 이용한 레일의 헤드에 존재하는 균열의 응력확대계수에 관한 연구

인경환,성기득,김종욱,조명래,양원호 成均館大學校 科學技術硏究所 1999 論文集 Vol.50 No.1

In recent years, the rolling stock is being increasingly developed. However, higher axle loads have increased the incidence of fatigue defects in railroad rails. Many of these fatigue-initiated defects develop in the head of the rail. The head defects are very important because they are generally not visible until they reach quite large size and they can lead to catastrophic rail fractures. In this paper, stress intensity factors(SIF) of a embedded crack in the head of the rail were analysed along the wheel positions relative to the crack plane and along the running condition using the finite element method.

In-vitro and in-vivo anti-inflammatory and antinociceptive effects of the methanol extract of the roots of Morinda officinalis

Kim, In-Tae,Park, Hee-Juhn,Nam, Jung-Hwan,Park, Young-Mi,Won, Jong-Heon,Choi, Jong-Won,Choe, Bong-Keun,Lee, Kyung-Tae EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

The anti-inflammatory effects of the methanol extract of the roots of Morinda officinalis (MEMO) (Rubiaceae) were evaluated in-vitro and in-vivo. The effects of MEMO on lipopolysaccharide (LPS)induced responses in the murine macrophage cell line RAW 264.7 were examined. MEMO potently inhibited the production of nitric oxide (NO), prostaglandin E₂and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages. Consistent with these results, the expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) at the protein level, and of iNOS, COX-2 and TNF-α at the mRNA level, was also inhibited by MEMO in a concentration-dependent manner. Furthermore, MEMO inhibited the nuclear factor kappa B (NF-κB) activation induced by LPS, and this was associated with the prevention of degradation of the inhibitor κB (IκB), and subsequently with attenuated p65 protein in the nucleus. The anti-inflammatory effect of MEMO was examined in rats using the carrageenan-induced oedema model. The antinociceptive effects of MEMO were assessed in mice using the acetic acid-induced abdominal constriction test and the hot-plate test. MEMO (100, 200㎎㎏^(-1) per day, p.o.) exhibited anti-inflammatory and antinociceptive effects in these animal models. Taken together, the data demonstrate that MEMO has anti-inflammatory and antinociceptive activity, inhibiting iNOS, COX-2 and TNF-α expression by down-regulating NF-κB binding activity.

한국무용전공 학생들의 체형에 관한 연구

원종세,강인숙 건국대학교 교육연구소 2001 論文集 Vol.25 No.-

We can know that a prize winner is smaller than a non-prize winner and has an outstanding difference in the breadth of neck, the length of hands than a non-prize winner. So a man who has long legs, long hands and a thin neck like a crane is excellent in body type when we compare a prize winner with a non -prize winner about body type in dance festival out of mojoring person in Korean dance Also, we can know that a prize winner weighs less than a non-prize winner by a small difference and has small chest circumference, small face, long length of arms and legs, and small breadth of face. But it was disclosed that a prize winner was thicker than a non-prize winner in the thickness of a thigh. We can know that a dance is a showing art and a long body type shows the expression of movement well visually by showing long about the length of moving line represented in the space of stage. But we can know that the thickness of a thigh in a prize winner is a result of Korean dance training. We also know that a man who is well built in the lower part of the body, especially muscle of a thigh is excellent than a man who has not in performing Korean dance.

유류비축기지 설계를 위한 대심도 경사공에서의 수압파쇄 초기응력 해석

최성웅,신희순,박찬,신중호,배정식,이형원,박종인,전한석,Choi, Sung-Oong,Shin, Hee-Soon,Park, Chan,Syun, Joong-Ho,Bae, Jeong-Sik,Lee, Hyeong-Won,Park, Jong-In,Jeon, Han-Seok 한국지반공학회 1999 한국지반공학회논문집 Vol.15 No.4

유류비축용 지하저장공동의 설계를 위하여 수압파쇄시험에 의한 현지암반내 초기응력 해석이 수행되었다. 부지 내 2개의 경사 시추공에 대해 수행된 금번 시험은 국내 기술진에 의한 지하비축기지 적용의 첫 사례이다. 또한, 경사공 해석기법을 처음으로 도입하여 수직공 해석기법에 의한 결과와 비교, 해석기법의 타당성을 검증함으로써 향후 수압파쇄시험의 적용범위 확대를 기대할 수 있었다. 특히 인근 지역이라도 지형적 또는 지질학적 특성에 따라 초기응력의 크기는 달라질 수 있음을 보여주었으며, 동일 시추공 내에서라도 구조선 등과 같은 뚜렷한 불연속면이 있을 경우초기응력의 방향이 심도에 따라 변화될 수 있음을 보여주었다. Hydraulic fracturing tests were performed in two inclined boreholes for the design of underground oil storages in Korea. Extensions of their application limits were expected through a precise comparison between the interpretation techniques for the vertical and the inclined boreholes. Especially, it was verified that the magnitude of in-situ stress can be varied even in the same rock mass with a variety of geographic/geotechnical characteristics. It was also demonstrated that its orientation can be changed even in the same borehole with the existence of explicit discontinuities.

In-line Monitoring of an Oxide Ion in LiCI Molten Salt Using a YSZ Based Oxide Ion Selective Electrode

Cho, Young-Hwan,Jeon, Jong-Seon,Yeon, Jei-Won,Choi, In-Kyu,Kim, Won-Ho Korean Nuclear Society 2004 Nuclear Engineering and Technology Vol.36 No.5

The electrode potential characteristics of a YSZ based membrane metal oxide electrode have been studied in molten LiCL at $700^{\circ}C$ by the potentiometric method. The electrode exhibited a good potential response to log[$O^2$] and data reproducibility. The calibration plot (potential vs. log[$O^2$] was found to be linear, obeying the Nernst equation. The electrode potential showed a good reversibility corresponding to increase/decrease of the oxide ion present in the molten LiCl. The physical and chemical durability appeared to be sound after several repeated uses, resulting in reproducible results. However, "the proposed electrode" failed when metallic Li was present in the melt.

Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases

Jha, Mithilesh Kumar,Kim, Jong-Heon,Song, Gyun Jee,Lee, Won-Ha,Lee, In-Kyu,Lee, Ho-Won,An, Seong Soo A.,Kim, SangYun,Suk, Kyoungho Elsevier 2018 Progress in neurobiology Vol.162 No.-

<P><B>Abstract</B></P> <P>Astrocytes, which are homeostatic cells of the central nervous system (CNS), display remarkable heterogeneity in their morphology and function. Besides their physical and metabolic support to neurons, astrocytes modulate the blood-brain barrier, regulate CNS synaptogenesis, guide axon pathfinding, maintain brain homeostasis, affect neuronal development and plasticity, and contribute to diverse neuropathologies via secreted proteins. The identification of astrocytic proteome and secretome profiles has provided new insights into the maintenance of neuronal health and survival, the pathogenesis of brain injury, and neurodegeneration. Recent advances in proteomics research have provided an excellent catalog of astrocyte-secreted proteins. This review categorizes astrocyte-secreted proteins and discusses evidence that astrocytes play a crucial role in neuronal activity and brain function. An in-depth understanding of astrocyte-secreted proteins and their pathways is pivotal for the development of novel strategies for restoring brain homeostasis, limiting brain injury/inflammation, counteracting neurodegeneration, and obtaining functional recovery.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Astrocytes are important regulators of brain functions, and crucial functions are executed via astrocyte-secreted proteins. </LI> <LI> Astrocyte-secreted proteins play key roles in physiological processes and execute both detrimental and beneficial actions in CNS disorders. </LI> <LI> Understanding the many functions of astrocyte-secreted proteins under specific spatiotemporal conditions may lead to major advancements in astrocyte biology. </LI> <LI> Functional dissection of astrocyte-secreted proteins can facilitate the development of novel diagnostic and therapeutic strategies for neurological disorders. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>