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아시클로비어 고체분산체의 용해도에 대한 수용성 고분자의 종류 및 배합 비율에 따른 효과
안용산,이하영,홍금덕,정성범,조선행,이종문,이해방,강길선 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4
Acyclovir (ACV) is one of the most effective and selective agents against viruses of the herpes group. Because of low solubility, bioavailability of ACV has shown below 30% with oral dosage form. In our previous study, we reported that the fabrication of solid dispersion of ACV was possible and the solid dispersion of ACV and PVP was the most useful in all samples. In this study, we examined the effect of mixture ratio of polymers (PEG and PVP) to ACV. Solubility of ACV was dramatically increased up to 25 mg/ml in 80°C distilled water. So water was used as a solvent to eliminate problem of residual solvent. Spray drying method was used for the solid dispersion of ACV as solvent extraction. Different scanning calorimeter was used to check degradation of drug. Polymer carriers were PEG 6,000 and PVP. In summary, ACV-PVP (1:3) showed the best solubility in distilled water.
아시클로비어와 수용성 고분자를 이용한 고체분산체 제조 및 생체외 방출
안용산,이하영,홍금덕,정성범,조선행,이종문,이해방,강길선 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.3
Acyclovir(ACV) is an important antiviral drug used extensively against infections caused by herpes viruses, especially herpes simplex and varicella zoster. Because of high crystallinity and large particle size, solubility of intact ACV is very low in water(1.3 ㎎/㎖). The goal of this work is to enhance the solubility of ACV. To make solid dispersion, Polyethyleneglycol. Hydroxyprophylmethyleelluose and Polyvinylpyrrolidone were used as polymer carriers in this work. Polymer carriers and drug were dissolved in acetic acid. And then spray drying method and freeze drying method were used as solvent extraction. Morphology, crystallization and functional group were characterized using SEM. XRD and ET-IR. The result of in vitro test showed the sample using PVP as polymer carrier had higher dissolution rate(up to 466%) than intact ACV.
자가미세유화를 이용한 이부프로펜 액상제제의 제조와 특성
안용산,송지희,강복기,김문석,조선행,이종문,이해방,강길선 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1
Ibuprofen (IBU), is a non-steroidal anti-inflammatory drug, used to treat rheumatoid arthritis, removal of fever and mild to moderate pain. Because of small dosage and very low accumulation in the body, IBU has been used to heal children's fever. However, IBU was very low solubility in a low pH and water (in water 0.03∼2.5 ㎎/ml). A nanoemulsion containing IBU by means of self-micromulsion drug delivery system (SMEDDS) was prepared in order to enhance the solubility of IBU. The SMEDDS was composed of cosurfactant, oil and surfactant. The solubility of IBU in various components such as cosurfactant, oil and surfactant was examined. Carbitol^(??) (389.99±20.5 ㎎/ml) as a cosurfctant, Labrafil^(??) M1944CS (90.16±1.60 ㎎/ml) as an oil and Cremopher^(??) RH-40(239.01±2.8 ㎎/ml) as a surfactant were used in this study for preparing SMEDDS. Optimized formulation of SMEDDS was obtained by phase diagram which express the section of nanoemulsion formation. The SMEDDS containing IBU had higher dissolution rate than conventional IBU sirups. Thus the SMEDDS was a potential candidate of stable conventional and effective oral dosage form for IBU.
형상기억고분자 복합재료 안테나의 제조 및 전개 거동 분석
안용산,김진수,구남서,박미선,김연태,박종규,유웅렬 한국복합재료학회 2018 Composites research Vol.31 No.6
Shape memory polymer composites have been studied for deployable antennas in space because they have advantages of lightweight, large deformability, good processability, and low cost. In this research, shape memory polymer composites (SMPCs) were manufactured using carbon nanotubes (CNTs) as reinforcements and were used to fabricate SMPC antenna. The SMPCs were prepared by dispersing CNTs in the polymer matrix. Various dispersion methods were investigated to determine the most suitable one, focusing on the mechanical properties of SMPCs including their fracture behavior. The shape memory properties of SMPCs were measured and finally, the deployment behavior of the SMPC antenna was analyzed. 형상기억고분자 복합재료는 가볍고, 변형률이 크며, 좋은 가공성과 비용적인 측면에서의 장점으로 우주환경에서 사용되는 전개형 안테나 재료로의 활용이 검토되고 있다. 본 연구에서는 탄소나노튜브를 보강재로 하여물성이 향상된 형상기억고분자 복합재료를 제조하고, 이를 사용하여 전개형 안테나를 제작하였다. 탄소나노튜브를 형상기억고분자 기지재 안에 분산시키기 위해 다양한 방법이 사용되었고 물성적인 측면에서 우수한 분산 방법을 탐색하였다. 이렇게 제조된 형상기억고분자 복합재료의 형상기억거동을 평가하였고 형상기억고분자 복합재료 안테나의 전개 거동을 분석하였다.