Azathioprine에 반응을 보인 류마티양 관절염에 의한 경막염(Pachymeningitis)1예

배광봉,이정호,이정찬,곽상혁,강정현,김철희,김현수,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Rheumatoid arthritis frequently involves the cervical spine and may lead to neurologic impairement. However, direct involvement of CNS structures by inflammatory cells has been reported infrequently. The prevalence of this complication of rheumatoid arthritis is unknown. Inflammatory CNS involvement in rheumatoid arthritis reportedly occurs in the setting of longstanding, active, erosive articular disease and is accompanied by extracranial and extraspinal nodules and vasculitis. This is diagnosed by radiologic finding of CNS nodules or meningeal thickening and by biopsy or autopsy. Treatment with corticosteroid, cytotoxic agent or surgical decompression is helpful. But the majority of patients die within several months of onset of neurologic symptom. Recently, we experienced a case of pachymeningitis caused by rheumatoid arthritis, which resolved repeatedly with azathioprine treatment.

항암화학요법을 받는 암 환자에 대한 Nucare^R의 영양지지효과

조덕연,김현수,곽상혁,강정현,김철희,배광봉,김종숙,박상준,윤환중,김삼용 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

Purpose : The purpose of this study was to evaluate the effect of nutritional support with enteral liquid supplement in cancer patients receving chemotherapy for possible benefit in nutritional, immunologic and golbal function of patients. Patients and Methods : From October 1995 to February 1997, 30 advanced cancer patients receving chemotherapy were divided two roups. The Nycare group, in addition to normal diet, Nucare^R enteral supplement was given for 1week right after chemotherapy for the duration of 2 chemotherapy cycles. Control group received only normal diet without parenteral fluid supplement for 2 chemotherapy cycles. Results : Median ages were 53 end 56 years for Nucare group and Contrl group respectively. Performance scores was less than 2 by ECOG scale. All patients were stage Ⅲ or Ⅳ. The physical parameters, such as weight, arm muscle circumference(AMC) and triceps skin fold(TSF) were decreased in both groups after 2 cycles of anticancer therapy. but it was less severe in Nucare group(p<0.05). Serum transferrin was maintained in mild deficit state in Nucare group, whereas it aggravated form mild to moderate deficit in Control group(p<0.05). Serum albumin level increased in Nucare group without statistical significance. but it decreased from normal to mild deficit in Control group. Serum total protein did not change significantly in Nucare group. but in Control group, serum total protein was decreased from 7.24±0.9 to 6.52±0.5(P<0.05). Total lymphocyte count did not change significantly in both groups. Conclusion : This study shows that the nutritional support with Nucare^R was effective in the prevention of nutritional deficit status in patients receving a nticancer chemotherapy.

新生兒 死亡에 對하여

曺仲鉉,鄭瑀甲 金原出版 1978 小兒科 Vol.19 No.8

신경성 식용부진증의 과거력에 따른 폭식 환자의 심리적 특성

이정현,조혜현,신미연,김준기 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.4

Objectives : This study compared cognitive-behavioral traits related to eating behaviors, obsessive-compulsive traits, and depression levels in bulimic subjects with and without a history of anorexia nervosa according to the perspective that there are common diagnostic transitions over time in subgroups of eating disorders (anorexia nervosa, bulimia nervosa, and eating disorder not otherwise specified). Methods : We compared EDI-2, MOCI, and BDI scores between the bulimic group with a history of anorexia (n=98), the bulimic group without a history of anorexia (n=99), and the non-clinic group (n= 100) by ANOVA. Results : The bulimic group with a history of anorexia showed significantly higher scores on four of the EDI-2 subscales (Ineffectiveness, Interoceptive Awareness, Impulse Regulation and Social Insecurity) than the other two groups. They also indicated significantly higher scores on both the MOCI subscale 'rumination' and BDI than both the other groups. Conclusion : These findings suggest that it is important to consider a prior history of anorexia nervosa in order to understand symptom sevehty in patients with bulimia. Psychological variables such as ineffectiveness, impulse regulation, social insecurity, rumination, and depression are crucial to consider while treating bulimics with a history of anorexia.

단기간의 저용량 Cytosine arabinoside 치료에 반응하였던 Down 증후군에 병발한 급성골수성백혈병 1례

김현수,이정호,이정찬,강정현,곽상혁,김철희,배광봉,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The incidence of hematologic disorders in patients with Down's syndrome is significantly increased, about 14∼30 - fold higher than in general population and includes neonatal transient abnormal myelopoieis and acute leukemias. The age of onset of leukemia in Down's syndrome is peaking first in the newborn period and then under 4 years of age. Down's syndrome with acute leukemia above the age of 20 is very rare and it's treatment oucome is unclear. The treatment of Down's syndrome with leukemia has been controversial because of toxicity and associated congenital cardiac and other abnormalities. But if treated adequately, children with Down's syndrome show a favorable response to anti-leukemia therapy. A 24-year-old man with Down's syndrome was first seen for the evaluation of anemia and thrombocytopenia. The peripheral blood morphology and bone marrow study revealed acute myelogenous leukemia, cytogenetic study of bone marrow showed trisomy 21. Beacuse of his sicioeconomic condition and medical abnormalities including deafness, visual loss, he was treated with low dose subcutaneous cytosine arabinoside(Ara-C) for 11 days. Complete remission was obtained after 37 days. The complete remission lasted for 5 months. He subsequently relapsed, and died 6 months later.

FCL(5-FU, Carboplatin, Leucovorin) 항암 화학요법에서 Gm-CSF의 효과

최지영,김현수,김종숙,박상준,윤환중,조덕연,남상륜,김삼용 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Background: One of the major side effects of cancer chemotherapy is myelosuppression. Neutropenia and/or thrombocytopenia are dose-limiting factors in chemotherapy. Colony-stimulating factor induces proliferation and functional maturation of hematopoietic progenitor cells. GM-CSF is primarily active on progenitor cells of granulocytic and monocytic lineage. Methods: Fifteen patients with histologically proven malignancy diagnosed at Chungnam National University Hospital from January 1993 to August 1995 were included in this study. We could evaluate the clinical efficacy of GM-CSF in 13 patients undergoing FCL(5-FU, Carboplatin and Leucovorin) chemotherapy; the first cycles involved no GM-CSF while the second cycles involved GM-CSF on day 6 through 15 of chemotherapy. Results: 1) The subjects were fifteen patients in all, there were five patients with head and neck cancer, which was the most common types of maligancy. There were four patients with colon cancer, two patients with stomach cancer, and one patient with breast cancer, gallbladder cancer, cervix cancer and cholangiocarcinoma respectively, two patients, who did not complete two cycles of chemotherapy were excluded. 2) Age distribution was from 38 years to 78 years with a median age of 57. 3) In FCL chemotherapy cycles with GM-CSF, the duration of neutropenia(<500/μL) was 0.5±0.3 day, while FCL chemotherapy cycles without GM-CSF, it was 2.9±0.7 day(P=0.008). 3) There was no significant difference in platelet count between the two chemotherapy cycles(P=0.133). 4) Febrile duration without GM-CSF was 4.9±2.1 day, but with GM-CSF the duration was 1.3±0.7 day, which was significantly different(P=0.003). The duration of antibiotics use with GM-CSF was 1.7±1.2 day and without GM-CSF was 6.8±3.2 day, also significantly different(P=0.002). But hospital stay between the two cycles were not significantly different(P=0.064). Conclusion: GM-CSF was effective in preventing or restoring bone marrow depression after FCL chemotherapy.

중증 재생불량성 빈혈 환자에서 신우신염에 대한 광범위항생제치료 중에 속발한 Saccharomyces cerevisiae 진균감염 1예

김철희,이정호,이정찬,강정현,곽상혁,배광봉,김현수,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1

Most patients with aplastic anemia who do not respond to immunosuppressive treatment or are not candidates for bone marrow transplantation die of infection or bleeding. The neutropenia in acute leukemia, aplastic anemia, or occurring subsequently to chemotherapy and bone marrow transplantation increases susceptibility to infection. In general, the number of infectious episodes correlate with the degree and duration of neutropenia. Global immunosuppression produced by conditioning for bone marrow transplantation or graft-versus-host disease, is associated with unusual bacterial and fungal pathogens, or serious viral and protozoan infections. In addition, repeated treatment with broad-spectrum antibiotics is associated with the emergence of resistant organisms and fungal diseases because of the altered microbial microenvironment of the host. The incidence of invasive fungal infection caused by Saccharomycetes eerevisiae in immunosuppressed patients is very rare, compared with that of infection by candida or aspcrgillus species. Cases of Saccharomycetes cerevisiae fungemia occurring in the course of treatment with broad-spectrum antibiotics are reported in patients with extensive burn or with prosthetic valve endocarditis. We experienced a case of urinary tract infection by Saccharomycetes cerevisiae in a 27-year old female patient with severe aplastic anemia. We report the case with a review of relevant literatures.

제5차 대한간학회 춘계학술대회 초록집 : 포스터 토의 순서 ; 뇌전이를 일으킨 원발성 간세포암의 임상양상

조세현 ( Jo Se Hyeon ),이계원 ( Lee Gye Won ),최민석 ( Choe Min Seog ),김현재 ( Kim Hyeon Jae ),주현중 ( Ju Hyeon Jung ),한남익 ( Han Nam Ig ),차상복 ( Cha Sang Bog ),이영석 ( Lee Yeong Seog ) 대한간학회 1999 Clinical and Molecular Hepatology(대한간학회지) Vol.5 No.1(S)

경주지역 석조문화재 풍화에 미치는 대기오염물질의 영향

정종현(Jung, Jong-Hyeon),정민호(Jung, Min-Ho),최원준(Choi, Won-Joon),서정호(Seo, Jung-Ho),황인조(Hwang, In-Jo),손병현(Shon Byung-Hyun) 한국산학기술학회 2010 한국산학기술학회논문지 Vol.11 No.2

경주시의 1∼3종에 해당하는 고정배출원에서 배출되는 오염물질 배출량은 PM-10 0.70 ton/yr, SO₂ 13.95 ton/yr, NOx 37.12 ton/yr로 조사되었고, 면오염원의 경우 PM-10 1.02 ton/yr, SO₂ 13.44 ton/yr, NOx 21.10 ton/yr로 나타났다. 또한 이동오염원의 오염물질 배출량은 PM-10 963.91 ton/yr, SO₂ 1415.02 ton/yr, NOx 5612.70 ton/yr로 조사되었다. 경주, 포항 및 주변지역의 대기 중 PM-10, SO₂ 및 NO₂의 농도분포를 확인한 결과, 고농도 지역은 주로 포항철강공단 및 이동오염원 주변이었다. 경주지역의 SO₂ 농도는 2006년 0.002 ppm에서 2015년 0.005 ppm으로, NO₂는 2006년 0.004 ppm에서 2015년 0.010 ppm으로 증가할 것으로 예측되었다. 이에 대기오염물질을 저감하기 위한 실천방안과 석조문화재를 환경오염물질 및 기타 화학적, 물리적, 생물학적 요인으로 부터 보호하기 위한 실천관리 프로그램이 적극적으로 도입되어야 할 시점으로 사료된다. The amount of pollutants from stationary sources of businesses classified into 1-3 type in Gyeongju was found to be 0.70 ton/yr for PM-10, 13.95 ton/yr for SO₂, and 37.12 ton/yr for NOx ; with respect to area sources, 1.02 ton/yr for PM-10, 13.44 ton/yr for SO₂, and 21.10 ton/yr for NOx ; and with respect to mobile sources 963.91 ton/yr for PM-10, 1415.02 ton/yr for SO₂, and 5612.70 ton/yr for NOx. This study surveyed the concentration distribution of PM-10, SO₂, and NO₂ in the air in around Gyeongju and Pohang, and found that high concentration was mainly distributed around Pohang Steel Industrial Complex and the around of mobile sources. In Gyeongju area, SO₂ was predicted to increase from 0.002 ppm in 2006 to 0.005 ppm in 2015, and that of NO₂ was predicted to increase from 0.004 ppm to 0.010 ppm during the same period. At this point, practicing guidelines to reduce air pollutants and management plan for environmental pollutants should be devised, and also practicing and management programs to protect the stone cultural properties from environmental pollutants and other chemical, physical, and biological factors should be actively introduced.

Xception 과 영상처리를 이용한 분말 공정에서의 과립 분류 방법

이현정(Hyeon Jung LEE),조혜연(Hye Yeon JO),양혜린(Hye Rin YANG),정의현(Eui Hyun JUNG) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.11

세라믹 분말 공정 과정에서 과립의 품질은 세라믹 제품의 품질에 큰 영향을 미친다. 전체 과립에서 비정상 과립의 비율이 높을수록 제품의 품질이 떨어질 확률도 높아진다. 따라서 제품의 품질을 높이기 위해서는 제품 공정 전에 전체 과립의 개수에서 비정상 과립의 비율을 파악하는 것이 중요하다. 본 논문에서는 현미경으로 촬영한 과립 이미지에서 영상처리를 통해 개별 과립을 검출하고, 딥러닝 모델인 Xception 을 사용하여 과립의 품질을 분류하는 알고리즘을 제안한다.