Dimethylsulfoxide 용매속에서 Tropaeolin의 Polarography적 환원에 관한 연구

조재흥,윤석진,김두화 조선대학교 기초과학연구소 1986 自然科學硏究 Vol.9 No.1

反陽性子性 溶媒인 dimethylsulfoxide (DMSO)中에서 Tropaeolin에 대하여 직류폴 라로그래피적 거동을조사하였다. 0.05M NaCIO_4의 DMSO溶媒中에서 Tropaeolin은 /電子/段階의 還元過程을 거쳐 hydrazo化合物로 還元된다. 各段階의 還元電流는 擴散支配的 이었으며 一部 反應電流도 包含되었다. *공식은 원문참조 The direct current polarographic behavior of Tropaeolin in dimethyIsulfoxide as an aprotic solvent have been investigated. The reduction of Tropaeolin in 0.06M sodium perchlorate solution proceeds along two one-electron steps to give the corresp ending compound containing hydrazo group, each reduction wave was considerably diffusion controlled and irreversible. *formula see the original

항암제 처리한 백혈병 세포주에서의 Apoptosis 발현

김삼용,윤소현,김현수,김종숙,윤환중,김진경,조덕연 충남대학교 암연구소 1998 癌共同硏究所 硏究誌 Vol.2 No.1

The bcl-2 proto-oncogene encodes a 26 kD protein that promotes cell survival by blocking apoptosis. The bax protein is a member of the bcl-2 familly, now known to form heterodimers with the bcl-2 protein. The ratio of bax to bcl-2 is be critical in determining the fate of the cell in response to stimuli that can induce apoptosis. Extract of Pulsatilla Koreana (SB-31) showed promising antitumor activity in vitro with Topo I inhibitory action. In the present study, the relationship between apoptosis and the apoptosis related proteins, bcl-2 and bax were investigated in human leukemic cell lines HL-60, U-937 and CEM-CM3. All anticancer drugs(adriamycin, etoposide, camptothecin, SB-31) induced extensive apoptosis in HL-60, U-937 cells and CEM-CM3 cells. The expression of bcl-2 and bax protein were determined in cell lines by western blotting before and after incubation with anticancer drugs at different time points. 1) In HL-60 or U-937 cell lines, down regulation of bcl-2 and up-regulation of bax were found after incubation with ADR, VP-16 or camptothecin. 2) In HL-60 or U-937 cell lines, no significant change in bcl-2 or bax protein expression resulted after incubation with SB-31. 3) In CEM-CM3 cells, virtually no change was noted in bcl-2/bax expression after incubation with ADR, VP-16, camptothecin or SB-31. It is suggested that different leukemic cell lines use different pathways of apoptosis activation and a given cell may utilize different pathways of apoptosis activation in response to different cytotoxic agents.

적조생물구제농도의 Sodium Hypochlorite (NaOCl)의 노출에 따른 조피볼락 및 바지락의 조직학적 영향

한조희,김영석,허민도,정해진,박관하 한국환경독성학회 2001 환경독성보건학회지 Vol.16 No.2

In a previous study by Kim et al. (2000), sodium hypochlorite (NaOCI) has been demonstrated to be effective against algae that cause red tides. To secure the environmental safety of the chemical in practical use, effect of NaOC1, at concentrations. required for algicidal activity, on the histology of rockfish and little neck clam was examined. When the animals were exposed to NaOCI at concentrations of 0.5 or 2 ppm for I hr, there was no exposure-associated histological change in either animal. As the experimental exposure condition was set in consideration of the use, our results provide safety information necessary for practical application to marine fields.

선박의장 배치 설계의 검도를 위한 컴퓨터 지원 시스템의 개발 사례

노재정,조형석,전진영,성낙운 경성대학교 공학기술연구소 1999 공학기술연구지 Vol.6 No.-

The purpose of this study is to develop a computer support system for the inspection of the outfitting arrangement of a ship design, which will increase the accuracy and the effectiveness of the inspection process. This system is integrated with a ORACLE database for transferring and storing 3D CAD data into the inspection system, and a dVISE virtual reality system for displaying the attributes of entities and the inspection results.

스팸메일 포착을 위한 데이터마이닝 기법 비교

김동건,조진남,장도석 同德女子大學校 情報科學硏究所 2004 정보과학연구 Vol.8 No.-

스팸메일로 인한 사회적 손실이 급증하고 있는 가운데 스팸메일을 포착하는 각종 방법들이 개발되고 있다. 본 연구에서는 스팸메일엔진에 사용 가능한 데이터마이닝기법을 단일기법과 혼합기법으로 나누어 Spambase데이터에 적용하였다. 적용 결과, 가장 많이 쓰이고 있는 Naive Bayes기법의 성능이 가장 저조하였던 반면, SVM과 복합기법의 성능이 탁월한 것으로 나타났다. This study compares recently developed data mining algorithms for detecting spam mails. We have considered single classifiers, such as Naive Bayes classifier, LDA, QDA, logistic discriminant, and support vector machines and ensemble methods such as Bagging and Random Forest. While SVM and ensemble methods show excellent performance, Naive Bayes classifier which has been popular in detecting spam mails shows low performance.

科學敎育을 개선을 위한 硏究 : 美國의 North Carolina州를 中心으로 With Reference to the North Carolina Provrince in U.S.A

崔七南,曺在興,尹晳珍 조선대학교 교육연구소 1987 교과교육연구 Vol.10 No.-

五加皮의 效能에 대한 硏究

최민호,이계복,조규원,박진영,김경수,송정석,한종현 한국전통의학연구소 2003 한국전통의학지 Vol.13 No.1

The purpose of this study is to measure the changes of regional cerebral blood flow (rCBF) and blood pressure (BP) of Cortex Acanthopanacis in rats, and to determine the effect of Cortex Acanthopanacis on phenylephrine (PE) induced contraction of isolated rat thoracic aorts. The measurement was continually monitored by laser-doppler flowmeter (Transonic Instrument, USA) and pressure transducer (Grass, USA) in anesthetized adult Sprague-Dawley rats through the data acquisition system composed of MacLab and Macintosh computer. Contractile force was measured with force displacement transducer under 1.5 g loading tension. The result of this experiment was as following; 1. Cortex Acanthopanacis did not effect the changes of rCBF and blood pressure significantly. 2. Contractions evoked by phenylephrine were decreased significantly by Cortex Acanthopanacis 3. L-NNA, ODQ, atropine and indomethacin significantly altered the relaxation of Cortex Acanthopanacis. 4. Propranolol did not change the relaxation of Cortex Acanthopanacis. These results indicate that Cortex Acanthopanacis did not change the rCBF and BP, but Cortex Acanthopanacis can relax PE induced contraction of isolated rat thoracic aorta and that this increasing contraction related to endothelium and various mechanism.

우수 사과酒酵母의 分離와 利用에 關한 硏究

朴允仲,金燦祚,李錫健,吳萬鎭,孫天培 충남대학교 농업과학연구소 1978 農業技術硏究報告 Vol.5 No.1

Extensive selection works on wild yeasts of fruits were carried cut to obtain strains which are applicable to apple wine making. Among the total number of 1,358 yeast strains which were isolated from various fruit samples collected from the vicinity of Daejeon and other regions of Korea, the strains SH-49, SH-129 and SH-338 were found to be useful. Then experiments on their morphological and physiological characteristics, and on the aspects of practical use in apple wine making were proceeded. The results obtained were as follows: 1. The strains SH-49 and SH-129, particularly SH-49, were appeared to have good fermentation ability, tolerance to sulfur dioxide and to produce fine quality of apple wine. 2. Apple wines made by using the strain, SH-49 and SH-129 contained less amount of total acids than those by other strains. 3. Apple wines of SH-49 and SH-129 were clarified rapidly during the primary fermentation period, and their absorbancy at 430 nm after 45 days of storage were approximately half of others. 4. Apple wine of SH-338 contained higher amount of residual sugar and its quality was superior to others. It is considered that this strain could be used in the production of apple wine of a characteristic quality. 5. The strains SH-49 and SH-338 were identified as a Saccharomyces cerevisiae according to Taxanomic Study of Yeasts by Lodder, however, classification of SH-129 was suspended for further study.

항암제 처리한 백혈병 세포주에서의 Apoptosis 발현

김삼용,윤소현,김현수,김종숙,윤환중,김진경,조덕연 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

The bcl-2 proto-oncogene encodes a 26 kD protein that promotes cell survival by blocking apoptosis. The bax protein is a member of the bcl-2 familly, now known to form heterodimers with the bcl-2 protein. The ratio of bax to bcl-2 is be critical in determining the fate of the cell in response to stimuli that can induce apoptosis. Extract of Pulsatilla Koreana (SB-31) showed promising antitumor activity in vitro with Topo I inhibitory action. In the present study, the relationship between apoptosis and the apoptosis related proteins, bcl-2 and bax were investigated in human leukemic cell lines HL-60, U-937 and CEM-CM3. All anticancer drugs(adriamycin, etoposide, camptothecin, SB-31) induced extensive apoptosis in HL-60, U-937 cells and CEM-CM3 cells. The expression of bcl-2 and bax protein were determined in cell lines by western blotting before and after incubation with anticancer drugs at different time points. 1) In HL-60 or U-937 cell lines, down regulation of bcl-2 and up-regulation of bax were found after incubation with ADR, VP-16 or camptothecin. 2) In HL-60 or U-937 cell lines, no significant change in bcl-2 or bax protein expression resulted after incubation with SB-31. 3) In CEM-CM3 cells, virtually no change was noted in bcl-2/bax expression after incubation with ADR, VP-16, camptothecin or SB-31. It is suggested that different leukemic cell lines use different pathways of apoptosis activation and a given cell may utilize different pathways of apoptosis activation in response to different cytotoxic agents.

Synthesis of Ferrocenyl and Diphenyl Substituted Bispyridino-18-Crown-6 Ether for Chiral Recognition

Jo, Sun-Jin,Jin, Young-Eup,Kim, Jae-Hong,Suh, Hong-Suk Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.11

The article reports the synthesis of a novel bispyridino-18-crown-6 ether, 7-{[(5S,15S)-5,15-diphenyl- 3,6,14,17-tetraoxa-23,24-diazatricyclo[17.3.1.18,12]tetracosa-1(23),8(24),9,11,19,21-hexaen-10-yl]oxy}heptylferrocenamide 6, bearing the C2-symmetric diphenyl substituents as chiral barriers and the ferrocenyl groups serving as an electrochemical sensor, and its electrochemical study with D- and L-AlaOMe·HCl as the guest by cyclovoltametry.