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RISS 인기검색어
- 검색키워드
- 저자 : Jitendra Patel (검색결과 5 건)
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Age-related changes in hematological and biochemical profiles of Wistar rats
Suresh Patel,Satish Patel,Ashvin Kotadiya,Samir Patel,Bhavesh Shrimali,Nikita Joshi,Tushar Patel,Harshida Trivedi,Jitendra Patel,Amit Joharapurkar,Mukul Jain 한국실험동물학회 2024 Laboratory Animal Research Vol.40 No.1
Background: Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research. Hematological and biochemical laboratory data are essential for evaluating specific variations in the physiological and functional profile of a laboratory animal. Establishing hematological and biochemical reference values for Wistar (han) rats at various age intervals was the goal of this work. Male and female Wistar rats (n = 660) of ages 6–8 weeks, 10–14 weeks and > 6 months were used in the experiment. Blood and serum were collected from these rats under fasting conditions. Results: We observed that the majority of hematological and biochemical parameters were significantly influenced by sex and age. Hematological changes were significantly correlated to aging were increased red blood cells, hemoglobin, hematocrit, neutrophils, monocytes and eosinophils in both sexes, as well as decreased platelet, mean corpuscular volume, mean corpuscular hemoglobin and lymphocytes in both sexes. White blood cells of male rats were considerably higher than those of female rats in all age ranges. For biochemistry, increase in glucose, total protein and creatinine were seen in both sexes, along with increases in urea in females and alanine aminotransferase in males. Age was significantly associated with decreased alkaline phosphatase in both sexes. Conclusions: When using Wistar rats as a model, these reference values may be useful in evaluating the results.
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Niraj A. Shah,Laxit K. Bhatt,Rajesh J. Patel,Tushar M. Patel,Nayankumar V. Patel,Harshida G. Trivedi,Nilam R. Patel,Jitendra H. Patel,Satish D. Patel,Rajesh S. Sundar,Mukul R. Jain 한국실험동물학회 2022 Laboratory Animal Research Vol.38 No.4
Background: Nonhuman primates are used for research purposes such as studying diseases and drug discovery and development programs. Various clinical pathology parameters are used as biomarkers of disease conditions in biomedical research. Detailed reports of these parameters are not available for Indian-origin rhesus macaques. To meet the increasing need for information, we conducted this study on 121 adult Indian rhesus macaques (57 wild-sourced and 64 inhouse animals, aged 3–7 years). A total of 18 hematology and 18 biochemistry parameters were evaluated and reported in this study. Data from these parameters were statistically evaluated for significance amongst inhouse and wild-born animals and for differences amongst sexes. The reference range was calculated according to C28-A3 guidelines for reporting reference intervals of clinical laboratory parameters. Results: Source of the animals and sex appeared to have statistically significant effects on reference values and range. Wild-born animals reported higher WBC, platelets, neutrophils, RBC, hemoglobin, HCT, MCV, and total protein values in comparison to inhouse monkeys. Sex-based differences were observed for parameters such as RBCs, hemoglobin, HCT, creatinine, calcium, phosphorus, albumin, and total protein amongst others. Conclusions: Through this study, we have established a comprehensive data set of reference values and intervals for certain hematological and biochemical parameters which will help researchers in planning, conducting, and interpreting various aspects of biomedical research employing Indian-origin rhesus monkeys.
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Vaghela, Jitendra H.,Shah, Jigna H.,Patel, Jaladhi H.,Purohit, Bhargav M. The Korean Dental Society of Anesthsiology 2020 Journal of Dental Anesthesia and Pain Medicine Vol.20 No.1
Background: Surgical extraction of third molars is associated with postoperative pain and swelling at the extraction site. Pain is commonly managed using non-steroidal anti-inflammatory drugs (NSAIDs). Postoperative pain is usually moderate to severe in the first 12 h postoperatively and lasts for 3-5 days. However, with NSAIDs, these symptoms usually subside within 24 h. Diclofenac sodium and etodolac are NSAIDs, more selectively cyclooxygenase-2 inhibitors, with good analgesic efficacies. Methods: We compared the safety and analgesic efficacy of diclofenac sodium with etodolac peroral after surgical extraction of third molars in a double-blind, double-dummy, parallel-group study. The subjective pain improvement and pain relief after 2, 6, 24, 48, and 72 h using the visual analogue scale were measured as the study outcome. Results: Etodolac was equivalent to diclofenac sodium in pain alleviation at all postoperative time periods. No significant differences were found between diclofenac sodium and etodolac groups (P > 0.05). Both study medications were well tolerated and safe with mild adverse effects in only a few participants. Conclusion: Diclofenac sodium and etodolac are comparable in terms of analgesic efficacy and safety after surgical removal of third molars.
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3D Printing: It’s Microfluidic Functions and Environmental Impacts
Abhishek Sharma,Jitendra K. Pandey,Surajit Mondal,Amit Kumar Mondal,Soumadeep Baksi,Ravi Kumar Patel,추원식 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.4 No.3
Innovative micro products essential for the utilization of a wide variety of macro subjects have complicated three-dimensional (3D) microstructures in addition to a high aspect ratio. Till date, many micro manufacturing processes have been developed, but a specific class of such processes is applicable for fabrication of true 3D micro assembly. The aptitude to process a broad range of materials and the ability to fabricate functional and geometrically complicated, 3D microstructures provides the additive manufacturing (AM) processes which significant profits over traditional methods, such as lithography-based or micromachining approaches investigated widely in the past. In this paper, 3D micro-AM processes have been classified into three main groups, including scalable micro-AM systems, 3D direct writing, and hybrid processes, and the key processes have been reviewed comprehensively. Principle and recent progress of each 3D micro-AM process have been described, and the advantages and disadvantages of each process have low-cost along with its occupational health safety & environmental issues.
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Synthesis and characterization of Dy<sub>x</sub>CoFe<sub>2−x</sub>O<sub>4</sub> nanoparticles
Kumar, Hemaunt,Singh, Jitendra Pal,Srivastava, R.C.,Patel, K.R.,Chae, Keun Hwa Elsevier 2017 Superlattices and microstructures Vol.109 No.-
<P><B>Abstract</B></P> <P>In the present work, we report the synthesis of Dy doped CoFe<SUB>2</SUB>O<SUB>4</SUB> nanoparticles using chemical method. Doping of Dy ions upto 0.15 in the host lattice does not result into impurity phase as revealed from X-ray diffraction (XRD) and Raman spectroscopy measurments. Near edge X-ray absorption fine structure measurments show the modification of Fe(3<I>d</I>)-O(2<I>p</I>) states and onset of 3+ valence state of Dy ions. Rietveld Refinment of XRD patterns, Mössbauer spectroscopy and Fe <I>K</I>-edge extended X-ray absorption fine structure measurments show cation reditribution after doping with Dy ions. All the synthesized nanoparticles exhibit ferrimagnetic like behavior. Coercivity increases with Dy doping concentration. Variation of saturation magnetization with Dy concentration is explained on the basis of cation redistribution and size effect.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Synthesis of Dy<SUB>x</SUB>Co<SUB>1-x</SUB>Fe<SUB>2−x</SUB>O<SUB>4</SUB> upto Dy concentration of 0.15. </LI> <LI> Local electronic structure modifies slightly with Dy doping. </LI> <LI> Dy<SUP>3+</SUP> ions modify the magnetic behavior. </LI> </UL> </P>
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