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- 저자 : Samir Patel (검색결과 2 건)
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Age-related changes in hematological and biochemical profiles of Wistar rats
Suresh Patel,Satish Patel,Ashvin Kotadiya,Samir Patel,Bhavesh Shrimali,Nikita Joshi,Tushar Patel,Harshida Trivedi,Jitendra Patel,Amit Joharapurkar,Mukul Jain 한국실험동물학회 2024 Laboratory Animal Research Vol.40 No.1
Background: Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research. Hematological and biochemical laboratory data are essential for evaluating specific variations in the physiological and functional profile of a laboratory animal. Establishing hematological and biochemical reference values for Wistar (han) rats at various age intervals was the goal of this work. Male and female Wistar rats (n = 660) of ages 6–8 weeks, 10–14 weeks and > 6 months were used in the experiment. Blood and serum were collected from these rats under fasting conditions. Results: We observed that the majority of hematological and biochemical parameters were significantly influenced by sex and age. Hematological changes were significantly correlated to aging were increased red blood cells, hemoglobin, hematocrit, neutrophils, monocytes and eosinophils in both sexes, as well as decreased platelet, mean corpuscular volume, mean corpuscular hemoglobin and lymphocytes in both sexes. White blood cells of male rats were considerably higher than those of female rats in all age ranges. For biochemistry, increase in glucose, total protein and creatinine were seen in both sexes, along with increases in urea in females and alanine aminotransferase in males. Age was significantly associated with decreased alkaline phosphatase in both sexes. Conclusions: When using Wistar rats as a model, these reference values may be useful in evaluating the results.
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High-speed compact silicon photonic Michelson interferometric modulator.
Patel, David,Veerasubramanian, Venkat,Ghosh, Samir,Samani, Alireza,Zhong, Qiuhang,Plant, David V Optical Society of America 2014 Optics express Vol.22 No.22
<P>We present the detailed analysis and characterization of a silicon Michelson modulator with short 500 μm phase shifters and a low VπLπ of 0.72 V-cm under reverse bias. We investigate optical modulation of reverse biased p-n and forward biased p-i-n junctions. We demonstrate for the first time that error-free operation up to 40 Gbps is possible with lumped silicon interferometric modulators. For reverse bias operation, we show that even greater bandwidth can be obtained with lower impedance drivers. Forward bias operation with pre-emphasized signals is shown to have clean eye diagrams up to 40 Gbps, however, error counting reveals a strong dependence on test patterns and that error-free operation is achievable for short pattern lengths.</P>
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