Anti-Cancer, Anti-Diabetic and Other Pharmacologic and Biological Activities of Penta-Galloyl-Glucose

Zhang, Jinhui,Li,Kim, Sung-Hoon,Hagerman, Ann E.,Lü,, Junxuan Springer-Verlag 2009 Pharmaceutical research Vol.26 No.9

Tanshinones from Chinese Medicinal Herb Danshen (Salvia miltiorrhiza Bunge) Suppress Prostate Cancer Growth and Androgen Receptor Signaling

Zhang, Yong,Won, Suk-Hyun,Jiang, Cheng,Lee, Hyo-Jeong,Jeong, Soo-Jin,Lee, Eun-Ok,Zhang, Jinhui,Ye, Min,Kim, Sung-Hoon,Lü,, Junxuan Springer-Verlag 2012 Pharmaceutical research Vol.29 No.6

Identification and Functional Analysis of RelA/SpoT Homolog (RSH) Genes in Deinococcus radiodurans^s

( Jinhui Wang ),( Ye Tian ),( Zhengfu Zhou ),( Liwen Zhang ),( Wei Zhang ),( Min Lin ),( Ming Chen ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.12

To identify the global effects of (p)ppGpp in the gram-positive bacterium Deinococcus radiodurans, which exhibits remarkable resistance to radiation and other stresses, RelA/SpoT homolog (RSHs) mutants were constructed by direct deletion mutagenesis. The results showed that RelA has both synthesis and hydrolysis domains of (p)ppGpp, whereas RelQ only synthesizes (p)ppGpp in D. radiodurans. The growth assay for mutants and complementation analysis revealed that deletion of relA and relQ sensitized the cells to H₂O₂, heat shock, and amino acid limitation. Comparative proteomic analysis revealed that the bifunctional RelA is involved in DNA repair, molecular chaperone functions, transcription, the tricarboxylic acid cycle, and metabolism, suggesting that relA maintains the cellular (p)ppGpp levels and plays a crucial role in oxidative resistance in D. radiodurans. The D. radiodurans relA and relQ genes are responsible for (p)ppGpp synthesis/hydrolysis and (p)ppGpp hydrolysis, respectively. (p)ppGpp integrates a general stress response with a targeted re-programming of gene regulation to allow bacteria to respond appropriately towards heat shock, oxidative stress, and starvation. This is the first identification of RelA and RelQ involvement in response to oxidative, heat shock, and starvation stresses in D. radiodurans, which further elucidates the remarkable resistance of this bacterium to stresses.

A synthetic decursin analog with increased in vivo stability suppresses androgen receptor signaling in vitro and in vivo.

Zhang, Yong,Shaik, Ahmad Ali,Xing, Chengguo,Chai, Yubo,Li, Li,Zhang, Jinhui,Zhang, Wei,Kim, Sung-Hoon,L?, Junxuan,Jiang, Cheng M. Nijhoff ; Kluwer Academic Publishers 2012 Investigational new drugs Vol.30 No.5

<P>Targeting androgen receptor (AR) signaling with agents distinct from current antagonist drugs remains a rational approach to the prevention and treatment of prostate cancer (PCa). Our previous studies have shown that decursin and isomer decursinol angelate (DA), isolated from the Korean medicinal herb Angelica gigas Nakai, interrupt AR signaling and possess anti-PCa activities in vitro. In the LNCaP PCa cell model, these pyranoccoumarin compounds exhibit properties distinct from currently used antagonists (e.g., Casodex). However, both are rapidly de-esterified to decursinol, a partial AR agonist. We report here that a synthetic decursin analog, decursinol phenylthiocarbamate (DPTC), has greater in vivo stability than the parent compounds. DPTC-decursinol conversion was undetectable in mice. Furthermore, in LNCaP cells, DPTC decreased prostate specific antigen (PSA) expression, down-regulated AR abundance and mRNA and inhibited AR nuclear translocation. The effect of DPTC on AR and PSA mRNA and protein abundance was also observed in VCaP cells expressing wild type AR. DPTC inhibited growth of both PCa cell lines through G(1) cell cycle arrest and apoptosis, as did decursin and DA. Furthermore, i.p. administration of DPTC for 3 weeks suppressed the expression of AR target genes probasin and Nkx3.1 in mouse prostate glands. Overall, our data suggest that DPTC represents a prototype lead compound for development of in vivo stable and active novel decursin analogs for the prevention or therapy of PCa.</P>

A field determination method of D-T neutron source yields based on oxygen prompt gamma rays

Xiongjie Zhang,Bin Tang,Geng Nian,Haitao Wang,Lijiao Zhang,Yan Zhang,Rui Chen,Zhifeng Liu,Jinhui Qu Korean Nuclear Society 2023 Nuclear Engineering and Technology Vol.55 No.7

A field determination method for small D-T neutron source yield based on the oxygen prompt gamma rays was established. A neutron-gamma transport equation of the determination device was developed. Two yield field determination devices with a thickness of 20 mm and 50 mm were made. The count rates of the oxygen prompt gamma rays were calculated using three energy spectra processing approaches, which were the characteristic peak of 6.13 MeV, the overlapping peak of 6.92 MeV and 7.12 MeV, and the total energy area. The R-square of the calibration curve is better than 94% and the maximum error of the yield test is 5.21%, demonstrating that it is feasible to measure the yield of D-T neutron source by oxygen prompt gamma rays. Additionally, the results meet the requirements for field determination of the conventional D-T neutron source yield.

북경 여성 소비자의 화장품 정보탐색에 관한 연구

장금혜(Zhang, Jinhui),구혜경(Koo, Hye-Gyoung) 한국소비문화학회 2017 소비문화연구 Vol.20 No.3

우리나라를 비롯하여 주요 화장품 브랜드들이 중국 시장에 진출하고 있으나, 중국 소비자 고유의 특성과 중국 소비문화를 제대로 이해하지 못하여 실패한 경우가 다수이다. 본 연구는 중국 화장품 소비자들의 이해의 근간이 되는 정보탐색 행동을 구체적으로 확인하고자 하였다. 어떠한 정보원천에서 어떠한 정보 내용을 주로 탐색하는 지, 그리고 화장품 구매를 위한 정보탐색에 어느 정도 노력을 기울이는지를 규명하였다. 그리고 정보탐색노력 수준에 따라 정보탐색유형을 구분하는 시도를 하였다. 선행연구에서는 지각된 위험 및 관여도, 생애주기의 맥락이나 연령대 등이 화장품 정보탐색에의 영향요인으로 밝히고 있어 이것이 중국 화장품 소비자에게도 유사한 경향을 보이는지를 확인하고자 하였다. 연구목적의 달성을 위하여 북경에 거주하는 25세 이상 40대 초반 여성 소비자 400명을 대상으로 1대1 면접 설문조사를 수행하여 그 결과를 분석에 활용하였다. 그 결과 중국 소비자들은 화장품 구매를 위하여 본인의 경험 이나 가족, 친구 등 지인을 주요 정보원천으로 활용하고 있었고, 제품의 적합도를 확인하기 위한 관련 정보 탐색을 가장 활발히 하고 있는 것으로 나타났다. 그리고 주관적으로 스스로 평가하기를 정보탐색에 큰 노력을 기울이지 않는 것으로 나타났다. 정보탐색노력을 근거로 군집분석을 실시하고 소비자집단을 소극적 탐색형, 합리적 탐색형, 적극적 탐색형으로 구분하였다. 화장품 관여도나 지각된 위험, 연령대 및 생애주기별 특성 등에 따라 집단간 유의한 특성을 보이고 있으나 정보탐색 유형의 구분에 영향을 미치는 요인을 보다 명확히 규명하기 위하여 다항로짓분석을 실시하였다. 그 결과 소극적 탐색형에 비해 다른 두 집단의 경우 제품 사용 관련 내용과 제품 이미지 관련 내용을 더 많이 탐색하고, 본인 ․지인 정보원천 외의 원천을 더 이용하고 있는 것으로 나타났다. 중국 화장품 시장에 진출하여 성공하기 위해서는 중국 소비자 중심적인 정보제공채널의 확보와 신뢰의 구축이 요구된다. 그리고 중요한 화장품 정보가 무엇인지, 화장품 사용을 위해 탐색해야 하는 내용에 대한 교육적 접근, 정보원천 및 상품 등에 대한 인증을 고려하는 것이 필요하다. 그리고 현재는 판매접점에서의 정보원천 이용도가 낮아 판매채널과 정보제공채널을 결합하고 신뢰를 얻을 수 있는 방안의 모색이 요구된다. 그리고 중국 화장품 소비자의 경우 우리나라 소비자와 달리 연령이나 생애주기의 영향을 받지 않는 것으로 나타나, 중국 여성의 화장 맥락과 화장 문화를 이해하고자 하는 후속연구가 필요하다고 보았다. Although major cosmetics brands are entering the Chinese market, but there are many cases where they fail to understand the characteristics of Chinese consumers and Chinese consumption culture. The purpose of this study is to identify the characteristics of Chinese cosmetics consumers, especially information seeking behavior. How to search mainly for information contents from some sources of information, and how much effort to search for information for purchasing cosmetics. And this study tried to distinguish the information search type according to the information search effort level. In previous studies, the perceived risk and involvement, the context of the life cycle, and the age range were found to be influential factors in the search for cosmetics information behavior. In order to achieve the purpose of the study, this study conducted a one - to - one interview to check the questionnaire for 400 female consumers who live in Beijing, China in the summer of 2016. As a result, Chinese consumers were using their personal experiences as well as family members and friends to purchase cosmetics as a main source of information, and it was found that they were most actively searching for relevant information to confirm the fitness of products. And did not make much efforts to search for information by subjective self-evaluation. Based on the information seeking effort, cluster analysis was conducted. Consumer groups were classified as passive search, rational search, and active search. The results of this study are as follows. First, there were significant differences between the groups according to cosmetics involvement, perceived risk, age and life cycle characteristics. However, in order to clarify the factors affecting the classification of information search types, multiple logit regression was conducted. As a result, it was found that the two other groups were more likely to use product - related content and product image - related content than the passive search type and to use sources other than the source of the information of the acquaintance. In the case of active exploration, It is confirmed that there is an influence. In order to enter the Chinese cosmetics market and succeed, it is necessary to secure China-oriented information channels and build trust. It is also necessary to consider certification of important cosmetic information, educational approaches to the content to be explored for cosmetic use, sources of information and products. Currently, the use of information sources at sales contacts is so low that it is necessary to search for a way to combine sales channels and information providing channels and gain trust. And Chinese cosmetics consumers do not seem to be influenced by age or life cycle unlike Korean consumers. Therefore, it is necessary to follow - up research to understand cosmetics context and make - up culture of Chinese women

중국 여성 화장품 소비자 유형 연구

장금혜 ( Zhang Jinhui ),구혜경 ( Koo Hye Gyoung ) 한국소비자학회 2018 소비자학연구 Vol.29 No.2

중국 화장품 시장은 미국에 이어 세계 2위 규모이며, 향후 중국 화장품 시장의 빠른 성장이 예상된다. 현재 중국은 여성 기초 화장품을 중심으로 시장이 형성되어 있으며 해외 화장품 브랜드들의 진출뿐만 아니라 중국 로컬 브랜드의 약진 등 경쟁이 치열하다. 본 연구는 중국 화장품 소비자의 이해를 위하여 중국 북경에 거주하는 20대 후반부터 40대 초반의 여성 소비자를 대상으로 화장품 구매를 결정하는 요인과 라이프스타일을 고려하여 중국 여성 화장품 소비자의 유형화를 시도하였다. 그 결과, 중국 여성 화장품 소비자는 유행합리 복합형, 하이엔드형, 실용합리형, 무관심형의 4가지 유형으로 구분되었다. 유행합리형은 전체의 39.3%로 가장 높은 비율을 차지하였으며 색조화장품에 대한 관심도가 높고, 전통적인 오프라인 매장 외에 개인 SNS를 통한 화장품 구매도 이루어지는 집단이다. 하이엔드형은 화장품에 있어서 최고를 추구하고 많은 비용을 투자하며, 관여도 또한 가장 높은 집단으로 전체의 16.5%를 차지하고 있었다. 이들은 유행이나 패션에 민감하고 과시적이고 충동적인 성향도 갖추고 있다. 실용합리형의 경우 전체의 24.3%를 차지하고 있으며, 가격대비 가치를 중시하는 유형이며 전통적으로 검증된 화장품 전문점과 백화점, 대형마트 등 오프라인 매장을 주로 이용하는 것으로 나타났다. 마지막으로 무관심형은 전체의 20%를 차지며 화장품에 대한 관여도가 낮고 합리적인 성향을 보인다. 그러나 이들이 경제적으로 어려운 것은 아니며 전문적 종사자 비율이 높은 것으로 나타났다. 본 연구 결과를 토대로 중국 여성 소비자 유형별 화장품 구매 및 사용 특성. 사용 브랜드 및 고려 사항들을 확인하였으며 유형별 특성에 근거한 상품 개발 및 시장 진출 전략의 수립이 요구되며, 화장품 유통 사업 진출 시 중국 소비자의 신뢰를 확보할 수 있는 방안을 중요하게 고려해야 한다. 이를 위해 향후 중국에 거주하고 있는 소비자를 대상으로 실증 조사와 연구가 강화되어야 하며, 본 연구는 중국 화장품 소비자를 이해하고 중국 화장품 시장에 진출하는데 유용한 기초 자료를 제공하였다는데 의의가 있다. The Chinese cosmetics market is ranked second in the world after the United States, and there is a strong interest in the cosmetics market in China around the world. Women in their late 20s and early 40s who lead the Chinese cosmetics market are called generations after the 80th or 90th generations, and their values and lifestyles are different from those of the older generations. Especially, in China, the development and diffusion of information and communication technologies will make their purchase and usage of cosmetics very different. The purpose of this study is to classify Chinese consumers based on cosmetics purchasing factors and beauty - related lifestyle, and to compare the actual condition of purchase and use of cosmetics by each type. Chinese women cosmetics consumers are classified into four types: fashionable rational, hybrid, high - end, practical rational, and indifferent. The fashionable rational type accounted for the highest percentage of 39.3% of the total, and the interest in the color cosmetics is higher than the basic ones, and the cosmetics purchase through the personal SNS is also performed in addition to the traditional offline shops. The high-end type of cosmetics was found to be the best in terms of attracting the best, investing a lot of money, and occupying the highest level of involvement, accounting for 16.5% of the total. They are fashionable and fashion-conscious, and are inclined and impulsive. In the case of practical rational type, 24.3% of the total is used, and it is found that the ratio of using high-end local brand in China is higher than that of price-value oriented type. And, it has been shown that they mainly use offline shops such as traditionally proved cosmetics stores, department stores, and large-scale marts. Finally, the indifference type occupies 20% of the total, has a reasonable tendency, and is the group with the least involvement in cosmetics. However, they are not economically difficult, and the proportion of professionals is high. This study suggests that it is necessary to enter the Chinese market considering the preferred brands and items of Chinese consumers and that a strategic approach is needed to gain the trust of Chinese consumers. In the past, satisfaction with local brands has risen steadily compared to the past, which has lowered the preference and trust of Chinese local brands. Therefore, it is important for overseas companies to put more trust in quality. In terms of distribution, offline stores are still strong, but shopping and mobile shopping using SNS are active mainly in high-end type consumers, so it is necessary to prepare for distribution of cosmetics using mobile phone in future. It is very important for Chinese consumers to understand the behavior and characteristics of Chinese consumers at the moment of rapid growth of Chinese market because they have a different cultural background from consumers in other countries in Asia. The results of this study are as follows.

A novel and environmentally friendly SO4 2- /CeO2 catalyst for the selective catalytic reduction of NO with NH3

Qiulin Zhang,Jinhui Zhang,Zhongxian Song,Ping Ning,,Hao Li,Xin Liu 한국공업화학회 2016 Journal of Industrial and Engineering Chemistry Vol.34 No.-

The SO42 /CeO2 catalyst showed excellent catalytic activity and remarkable resistance to H2O and SO2for the selective catalytic reduction of NO with NH3. The SO42 /CeO2 catalyst with 2.5 wt.% SO42 contentexhibited more than 90% of NO conversion at 229–485 8C. The characterization results revealed that theSO42 species were highly dispersed on the surface of CeO2 in the SO42 /CeO2 catalyst. Moreover, theaddition of SO42 into CeO2 obviously increased the surface Lewis and Brønsted acid sites, and it wasfound that only stable (1 1 1) lattice planes of CeO2 can be observed on the SO42 /CeO2 catalyst.

Mechanical Heterogeneity of Heat-Resistant EV31A Magnesium Alloy with Large Size Processed by Direct-Chill Casting

Deping Zhang,Boqiong Li,Chaojie Che,Baosheng Liu,Peng Cheng,Yali Zhao,Jinhui Zhang,Liren Cheng 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.10

High quality of large-sized EV31A benchmark alloy was fabricated by direct-chill casting, without significant composition segregation along its radial direction. As-cast samples show noticeable mechanical heterogeneity, such as strength decreasing but ductility increasing from the surface to the center positions of the ingot. After heat treatment, however, mechanical properties of the alloy are nearly the same in each position, indicating mechanical homogeneity, which is mainly attributed to the strengthening mechanism transition from grain-boundary hardening in as-cast samples to precipitation hardening in peak-aged samples. In addition, we found that solute hardening is the athermal strengthening which contributes more to high-temperature strength than precipitation hardening, as evidenced by lower strength loss from 25 to 250 °C in T4-treated sample than in peak-aged sample. Solute hardening effect is thermally stable and extends to high temperatures, which favors the retention of linear strain hardening by retarding dynamic recovery. This work thus provides new insight into designing heat-resistant Mg alloys and understanding mechanical heterogeneity of large-scale Mg alloy ingots.

Growth and replication of ordered ZnO nanowire arrays on general flexible substrates

Zhang, Su,Shen, Yue,Fang, Hao,Xu, Sheng,Song, Jinhui,Wang, Zhong Lin Royal Society of Chemistry 2010 Journal of materials chemistry Vol.20 No.47

<P>Vertically aligned and site controllable ZnO nanowire arrays have been synthesized and replicated <I>via</I> hydrothermal method on general flexible substrates. The replication was demonstrated for three generations. The morphology and density of the nanowire arrays could be optimized in the original generation by adjusting the chemical reaction parameters. The pattern of the original generation was inherited by the succeeding generations by a new transferring method. The growth mechanism of the replicated nanowire arrays was investigated with the help of inductively coupled plasma (ICP) etching and AFM tip scanning. The robustness of the ZnO nanowire arrays was obviously improved compared with the seedless ZnO nanowires grown on Au (111) surface, according to the excellent morphology preservation after ultrasonic wave treatment.</P> <P>Graphic Abstract</P><P>Vertically aligned and site controllable ZnO nanowire arrays have been synthesized and replicated <I>via</I> hydrothermal method on general flexible substrates. The replication was demonstrated for three generations. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0jm02915g'> </P>