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이온쌍-고성능 액체크로마토그래피에 의한 감기약 시럽에서 타르색소 첨가물의 동시분석
김경옥(Jing Yu Jin),황호(Hu Huang),이범규(Beom-Gyu Lee),이원재(Wonjae Lee) 한국생물공학회 2010 KSBB Journal Vol.25 No.5
A simple and efficient analytical method for the simultaneous determination of seven tar color additives was developed using ion pair high performance liquid chromatography. The conditions for HPLC analysis were as follows: column, μ-Bondapak C18 (10 μm, 300 × 3.9 mm i.d.); gradient mobile phase, 0.025 mol/L ammonium acetate (containing 0.01 mol/L tetrabutylammonium bromide)-acetonitrile-methanol (65:25:10) as a mobile for fraction A and 0.025 mol/L ammonium acetate (containing 0.01 mol/L tetrabutylammonium bromide)-acetonitrilemethanol (40:50:10) as a mobile for fraction B; flow rate, 1.0 mL/ min; detection wavelength, 254/520/620 nm. We could attain to the detection limits as 0.01~0.05 μg/mL (254 nm) and 0.005~0.01 μg/mL (520 nm) for six red tar color additives, and 0.05 μg/mL (254 nm) and 0.002 μg/mL (620 nm) for Fast green FCF. This analytical method was applicable to determine the tar color additives contained in several commercial cold syrups.
Jingcui Yu,Songbin Fu,Peng Liu,Xiaobo Cui,Yu Sui,Guohua Ji,Rongwei Guan,Donglin Sun,Wei Ji,Fangli Liu,An Liu,Yuzhen Zhao,Yang Yu,Yan Jin,Jing Bai,Jingshu Geng,Yingwei Xue,Jiping Qi,Ki-Young Lee 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.1
Previously, we identified 3 overlapping regions showing loss of heterozygosity (LOH, R_1-R_3 from 11 to 30 cM) on chromosome 17 in 45 primary gastric cancers (GCs). The data indicated the presence of tumor suppressor genes (TSGs) on chromosome 17 involved in GC. Among the putative TSGs in these regions, HIC1 (in SR_1) and TOB1 (in SR_3) remain to be examined in GC. By immunohistochemistry (IHC), methylation-specific PCR (MSP) and western blot, we evaluated the expression and regulation status for HIC1 and TOB1 protein in GC. We narrowed down the deletion intervals on chromosome 17 and defined five smaller LOH subregions, SR_1-SR_5 (0.54 to 3.42 cM), in GC. We found that HIC1 had downregulated expression in 86% (91/106) and was methylated in 87% (26/30) of primary GCs. Of the primary GCs showing downregulation of HIC1 protein, 75% (18/24) had methylated HIC1 gene. TOB1 was either absent or expressed at reduced levels in 75% (73/97) of the GC samples. In addition, a general reduction was found in total and the ratio of unphosphorylated to phosphorylated TOB1 protein levels in the differentiated GC cell lines. Further analysis revealed significant simultaneous downregulation of both HIC1 and TOB1 protein in GC tissue microarray samples (67%, 52/78) and in primary GCs (65%, 11/17). These results indicate that silencing of HIC1 and TOB1 expression is a common occurrence in GC and may contribute to the development and progression of the disease.
Jin, Jing-Yu,Lee, Kyung-Ah,Kang, Jong-Seong,Kang, Young-Koo,Baek, Chae-Sun,Lee, Won-Jae 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
The liquid chromatographic enantiomer separation of H-fluorenylmethoxycarbonyl (FMOC) protected ${\alpha}$-amino acids was performed on nine polysaccharide-derived chiral stationary phases (CSPs). The cellulose derived coated CSPs, Chiralcel OD-H (separation factor = 1.09-2.70) and Chiralcel OD (separation factor = 1.08-2.55), had the best performance of all the CSPs for resolution of H-FMOC ${\alpha}$-amino acids and therefore, all analyte enantiomers were base-line separated on Chiralcel OD-H and/or Chiralcel OD. Enantioseparation on cellulosetris(3,5-dimethylpherylcarbamate) derived CSPs (Chiralcel OD-H, Chiralcel OD and Chiralpak IB) is generally greater than that on amylose tris(3,5-dimethylphenylcarbamate) derived CSPs (Chiralpak AD-RH, Chiralpak AD and Chiralpak IA). Additionally, coated type CSPs (Chiralcel OD-H or Chiralcel OD, and Chiralpak AD) generally provided better enantioseparation for these analytes than the covalently bonded type CSPs (Chiralpak IB and Chiralpak IA) with thesame chiral selector of cellulose tris(3,5-dimethylphenylcarbamate) and amylose tris(3,5-dime-thylphenylcarbamate), respectively. However, Chiralpak IB and Chiralpak IA had an advantage over the coated type CSPs in that a broader range of solvents could be used due to itscovalently bonded nature.
In Vivo Imaging of Sentinel Nodes Using Fluorescent Silica Nanoparticles in Living Mice
Jeon, Yong Hyun,Kim, Young-Hwa,Choi, Kihwan,Piao, Jing Yu,Quan, Bo,Lee, Yun-Sang,Jeong, Jae Min,Chung, June-Key,Lee, Dong Soo,Lee, Myung Chul,Lee, Jaetae,Chung, Doo Soo,Kang, Keon Wook Springer-Verlag 2010 Molecular imaging and biology Vol.12 No.2
Possible Applications for Fascial Anatomy and Fasciaology in Traditional Chinese Medicine
Yu Bai,소광섭,Byung-Cheon Lee,Yong Huang,Chun-lei Wang,Jun Wang,Jin-peng Wu,Jing-xing Dai,Janos Palhalmi,Ou Sha,David Tai Wai Yew,Lin Yuan 사단법인약침학회 2010 Journal of Acupuncture & Meridian Studies Vol.3 No.2
Research using medical imaging instruments such as computed tomography and magnetic resonance imaging has led to the proposal that the fascial network distributed over the human body is the anatomical basis for the acupoints and meridians of traditional Chinese medicine. Therefore, we put forward a new theory of anatomy called fascial anatomy. In fascial anatomy, a human body is divided into two major systems. One is the supporting-storing system of unspecialized connective tissues. The other is a functional system. An undifferentiated non-specific connective tissue network, with the participation of the nervous and the immune systems, constitutes the supporting-storing system of the human body. The various differentiated functional cells in the body that are supported and surrounded by the supporting-storing system constitute the functional system. The discipline that studies the supporting-storing system and the mutual relationship between this system and the functional system in a living human body is called fasciaology. The establishment of fascial anatomy and fasciaology opens a new research field in anatomy; consequently, fasciaology will play a significant role in biological medicine and traditional Chinese medical research, as well as future clinical practice.
Jing Yu Jin,Kyung-Ah Lee,Jong Seong Kang,Young Koo Kang,백채선,이원재 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.5
The liquid chromatographic enantiomer separation of N-fluorenylmethoxycarbonyl (FMOC) protected α-amino acids was performed on nine polysaccharide-derived chiral stationary phases (CSPs). The cellulose derived coated CSPs, Chiralcel OD-H (separation factor = 1.09- 2.70) and Chiralcel OD (separation factor = 1.08-2.55), had the best performance of all the CSPs for resolution of N-FMOC α-amino acids and therefore, all analyte enantiomers were base-line separated on Chiralcel OD-H and/or Chiralcel OD. Enantioseparation on cellulose tris(3,5-dimethylphenylcarbamate) derived CSPs (Chiralcel OD-H, Chiralcel OD and Chiralpak IB) is generally greater than that on amylose tris(3,5-dimethylphenylcarbamate) derived CSPs (Chiralpak AD-RH, Chiralpak AD and Chiralpak IA). Additionally, coated type CSPs (Chiralcel OD-H or Chiralcel OD, and Chiralpak AD) generally provided better enantioseparation for these analytes than the covalently bonded type CSPs (Chiralpak IB and Chiralpak IA) with the same chiral selector of cellulose tris(3,5-dimethylphenylcarbamate) and amylose tris(3,5-dimethylphenylcarbamate), respectively. However, Chiralpak IB and Chiralpak IA had an advantage over the coated type CSPs in that a broader range of solvents could be used due to its covalently bonded nature.
Three-Level Bi-Directional Half-Bridge CLLC Resonant Converter for DC Micro-Grid
Hsuan-Yu Yueh,Jing-Yuan Lin,Haung-Jen Chiu,Chen-Yen Chu,Yu-Chen Chang,Sih-Yi Lee 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
A Three-Level Bi-Directional Half-Bridge CLLC Resonant DC-DC converter for DC micro-grid application is studied on this paper, which uses dual resonant tanks to achieve wide range voltage regulation and meanwhile employs bi-directional capability. All power switches on this converter can achieve ZVS function at the whole load and the voltage stress on all power switches at both sides can be clamped at half of input voltage and output voltage since the three-level circuit architecture using the proposed synchronous rectifier (SR) control, therefore, the voltage stresses of the transformer, resonant tanks, power switches and other components are only half compared with conventional half-bridge CLLC resonant converter, the downsizing rated of components selection can be more flexible. Finally, the laboratory prototype is built to verify the performance of voltage balancing on input/output capacitor, voltage stress on switches and efficiency, the measured efficiency can be up to 95.6% over different load conditions.