A CLASS OF INVERSE CURVATURE FLOWS IN ℝⁿ⁺¹, II

Hu, Jin-Hua,Mao, Jing,Tu, Qiang,Wu, Di Korean Mathematical Society 2020 대한수학회지 Vol.57 No.5

We consider closed, star-shaped, admissible hypersurfaces in ℝⁿ⁺¹ expanding along the flow Ẋ = |X|^α-1 F^-β, α ≤ 1, β > 0, and prove that for the case α ≤ 1, β > 0, α + β ≤ 2, this evolution exists for all the time and the evolving hypersurfaces converge smoothly to a round sphere after rescaling. Besides, for the case α ≤ 1, α + β > 2, if furthermore the initial closed hypersurface is strictly convex, then the strict convexity is preserved during the evolution process and the flow blows up at finite time.

Expression and Significance of TSGF, CEA and AFP in Patients Before and after Radical Surgery for Colon Cancer

Hu, Yi,Wang, Jing-Liang,Tao, Hai-Tao,Wu, Bai-Shou,Sun, Jin,Cheng, Yao,Dong, Wei-Wei,Li, Rui-Xin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

Objective: To explore the expression and significance of tumor specific growth factor (TSGF), carcinoembryonic antigen (CEA) and alpha fetoprotein (AFP) in cancer tissue and serum of patients with colon cancer. Materials and Methods: Radical surgery for colon cancer was performed on 43 patients with laparoscopu under conditions of general anesthesia. The Elisa method was used to detect the levels of serum TSGF, CEA and AFP before and after radical operation, and cancer tissue underwent TSGF, CEA and AFP immunohistochemistry staining after laparoscopic surgery. The decreased conditions of serum TSGF, CEA and AFP in patients with colon cancer at different levels of differentiation and clinical stagings were analyzed, and the relationships of expression rates between histological types, colon cancer morphology, lymph node metastasis and TSGF, CEA as well as AFP in cancer tissue were assessed. Results: Compared with before radical surgery, the levels of serum TSGF, CEA and AFP decreased notably in patients after operations (p<0.01). The decreased degree of TSGF and CEA was the largest in patients with poorly differentiated cancer tissue (p<0.01), while that of AFP was noted in patients with moderately differentiated cancer tissue (p<0.01). The decreased degree of TSGF and AFP was the largest in patients at phase Dukes A (p<0.01), while that of CEA in patients at phase Dukes C (p<0.01). There were no significant differences among the positive expression rates of TSGF, CEA and AFP with different histological types and colon cancer morphologies (p>0.05). The positive expression rates of TSGF and CEA in patients with lymph node metastasis were significantly higher than those without lymph node metastasis (p<0.01). Conclusions: TSGF, CEA and AFP can be used to evaluate the effect of radical operation for colon cancer, and the changed levels of different markers are associated with tumor differentiation, clinical stating and presence or absence of lymph node metastasis.

Sequential fusion to defend against sensing data falsification attack for cognitive Internet of Things

Wu, Jun,Wang, Cong,Yu, Yue,Song, Tiecheng,Hu, Jing Electronics and Telecommunications Research Instit 2020 ETRI Journal Vol.42 No.6

Internet of Things (IoT) is considered the future network to support wireless communications. To realize an IoT network, sufficient spectrum should be allocated for the rapidly increasing IoT devices. Through cognitive radio, unlicensed IoT devices exploit cooperative spectrum sensing (CSS) to opportunistically access a licensed spectrum without causing harmful interference to licensed primary users (PUs), thereby effectively improving the spectrum utilization. However, an open access cognitive IoT allows abnormal IoT devices to undermine the CSS process. Herein, we first establish a hard-combining attack model according to the malicious behavior of falsifying sensing data. Subsequently, we propose a weighted sequential hypothesis test (WSHT) to increase the PU detection accuracy and decrease the sampling number, which comprises the data transmission status-trust evaluation mechanism, sensing data availability, and sequential hypothesis test. Finally, simulation results show that when various attacks are encountered, the requirements of the WSHT are less than those of the conventional WSHT for a better detection performance.

Analysis on the Characteristics and Prognosis of Pulmonary Neuroendocrine Tumors

Wu, Bai-Shou,Hu, Yi,Sun, Jing,Wang, Jin-Liang,Wang, Peng,Dong, Wei-Wei,Tao, Hai-Tao,Gao, Wen-Juan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5

Objective: To retrospectively review the clinical characteristics and analyze the prognostic factors of Chinese patients with pulmonary neuroendocrine tumors. Materials and Methods: The clinical data of 176 patients with pulmonary neuroendocrine tumors in Chinese PLA General Hospital from Mar., 2000 to Oct., 2012 were retrospectively analyzed. The parameters were evaluated by univariate and multivariate analysis, including the gender, age, smoking history, family history, TNM staging, localization (central or peripheral), tumor size, nodal status, histological subtype and treatment (operation or non-operation). Results: There were 23 patients with typical carcinoids (TC) (13.1%), 41 with atypical carcinoids (AC) (23.3%), 10 with large cell neuroendocrine carcinoma (LCNEC) (5.7%) and 102 with small cell lung cancer (SCLC) (57.9%). The median follow-up time was 64.5 months for AC, 38 months for LCNEC and 27 months for SCLC. The typical carcinoid censored data was 18 (more than 50% of the patients), so the median follow-up time was not obtained, and actuarial 5-year survivals for TC, AC, LCNEC and SCLC were 75.1%, 51.7%, 26.7% and 38.8%, respectively. COX univariate analysis revealed that the age (P=0.001), histological subtype (P=0.005), nodal status (P=0.000), treatment (P=0.000) and TNM staging (P=0.000) were the prognostic factors of the patients with pulmonary neuroendocrine tumors, whereas its multivariate analysis showed that only the age(P=0.001), TNM staging (P=0.002) and treatment (P=0.000) were independent prognostic factors. Conclusions: Radical surgery remains the treatment of choice, and is the only curative option. The age, TNM staging and treatment are confirmed to be the independent prognostic factors in multivariable models for pulmonary neuroendocrine tumors.

A Modified PiggyBac Transposon System Mediated by Exogenous mRNA to Perform Gene Delivery in Bovine Mammary Epithelial Cells

Guangdong Hu,Jing Wang,Hui Huang,Fusheng Quan,Jian Kang,Yongyan Wu,Yuanpeng Gao,Feng Su,Minghao Shao,Yong Zhang 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.2

Transposons are widely used for geneticengineering in various model organisms. Recently, piggyBac(PB) has been developed as a transposable and efficientgene transfer tool in mammalian cells. In the present study,we developed three types of PB transposon systemscontaining a dual plasmid system (DPS), a single plasmidsystem (SPS), and a DNA-mRNA combined system (DRPS)and characterized their basic properties in HEK293 cells. The basic elements of the donor plasmid included aselectable-reporter gene expression cassette, two loxP sitesin the same orientation, a multiple cloning site, and twochicken β-globin insulator core elements. We further identifiedthe function of the selectable-reporter and examined PBintegration sites in the human genome. Moreover, wecompared the transposition efficacy and found that SPStransposed more efficiently, as compared to DPS; integrationinto the host genome was determined by measuring PBaseactivity. Results discovered the loss of PBase activity in theDRPS, indicating that this system is much more biologicallysafe, as compared to DPS and SPS. Finally, we employedthe DRPS to successfully perform a gene delivery intobovine mammary epithelial cells (BMECs). Taken together,the information from this study will improve the flexibilityof PB transposon systems and reduce the genotoxicity ofPBase in genetic engineering.

Enteric dysbiosis-linked gut barrier disruption triggers early renal injury induced by chronic high salt feeding in mice

Jingjuan Hu,Haihua Luo,Jieyan Wang,Wenli Tang,Junqi Lu,Shan Wu,Zhi Xiong,Guizhi Yang,Zhenguo Chen,Tian Lan,Hongwei Zhou,Jing Nie,Yong Jiang,Peng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Chronic high-salt diet-associated renal injury is a key risk factor for the development of hypertension. However, the mechanism by which salt triggers kidney damage is poorly understood. Our study investigated how high salt (HS) intake triggers early renal injury by considering the ‘gut-kidney axis’. We fed mice 2% NaCl in drinking water continuously for 8 weeks to induce early renal injury. We found that the ‘quantitative’ and ‘qualitative’ levels of the intestinal microflora were significantly altered after chronic HS feeding, which indicated the occurrence of enteric dysbiosis. In addition, intestinal immunological gene expression was impaired in mice with HS intake. Gut permeability elevation and enteric bacterial translocation into the kidney were detected after chronic HS feeding. Gut bacteria depletion by non-absorbable antibiotic administration restored HS loadinginduced gut leakiness, renal injury and systolic blood pressure elevation. The fecal microbiota from mice fed chronic HS could independently cause gut leakiness and renal injury. Our current work provides a novel insight into the mechanism of HS-induced renal injury by investigating the role of the intestine with enteric bacteria and gut permeability and clearly illustrates that chronic HS loading elicited renal injury and dysfunction that was dependent on the intestine.

Comparison of virgin and reused 15-5 PH stainless steel powders for laser powder bed fusion process

Zhang, Jing,Hu, Bin,Zhang, Yi,Guo, Xingye,Wu, Linmin,Park, Hye-Yeong,Lee, Je-Hyun,Jung, Yeon-Gil Springer-Verlag 2018 Progress in additive manufacturing Vol.3 No.1

Bevacizumab Concomitant with Chemotherapy is Effective in Treating Chinese Patients with Advanced Non-Squamous Non-Small Cell Lung Cancer

Sun, Jing,Hu, Yi,Wu, Bai-Shou,Wang, Jin-Liang,Tao, Hai-Tao,Zhang, Su-Jie Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14

Objectives: To retrospectively review the safety and clinical efficacy of bevacizumab concomitant with chemotherapy in Chinese patients with advanced non-squamous non-small cell lung cancer (NSNSCLC). Methods: Clinical data for 79 patients with NSNSCLC who received bevacizumab concomitant with chemotherapy in Chinese PLA General Hospital from April 28th 2009 to May 5th 2013 were retrospectively reviewed to analyze the clinical efficacy including disease control rate (DCR), overall response rate (ORR), progression-free survival (PFS), overall survival (OS), the Eastern Cooperative Oncology Group (ECOG) score and the safety. Results: The Eastern Cooperative Oncology Group (ECOG) score was 0-2. By the final cutoff date (June 9, 2013), 54 (68.4%) patients had disease progression and 37 (46.8%) died. The ORR was 32.9% and the DCR was 83.5%. The ORR of the first-, second-, and third- or later-line treatments were 51.4%, 25.0% and 12.5%, while the DCR were 94.3%, 80.0% and 70.8%, respectively. The median OS (mOS) and PFS (mPFS) were 13.5 and 5.83 months, respectively. The mOS of patients with the first-, second-, and third- or later- line treatments were 16.2, 10.9 and 8.30 months, while the mPFS were 7.27, 5.90 and 5.17 months, respectively. Chemotherapy-related adverse events included myelosuppression, vomiting, hepatic dysfunction and renal dysfunction, while the common serious bevacizumab-related adverse events were thromboembolic problems, gastrointestinal perforation and reversible posterior leukoencephalopathy syndrome, which could be well managed. Conclusions: Bevacizumab concomitant with chemotherapy is effective and the related toxicity can be well tolerated in Chinese patients with NSNSCLC.

Photocatalytic oxidation of gas-phase Hg0 by carbon spheres supported visible-light-driven CuO–TiO2

Jiang Wu,Chaoen Li,Xiantuo Chen,Jing Zhang,Lili Zhao,Tianfang Huang,Tao Hu,Chong Zhang,Bu Ni,Xiao Zhou,Pankun Liang,Wenbo Zhang 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.46 No.-

A simplified approach for the fabrication of CuO/TiO2@C is demonstrated. In this study, low cost CuO/TiO2@C photocatalysts (CSs loading 0.25–2 wt.%) were prepared, characterized and evaluated for gasphaseHg0 oxidation. The obtained CuO/TiO2@C photocatalysts were used to remove gaseous elementalmercury under UV light and LED respectively, and the optimum doping of content of CSs was determined. The results showed that the CuO/TiO2@C photocatalysts were highly efficient in oxidizing Hg0, reachingabove 64% when the CSs doping reached 0.5 wt.%. We have proposed that the probable mechanism bywhich CuO/TiO2@C photocatalysts remove gaseous elemental mercury: with CSs doping, CSs can act assensitizer and transfer electrons to the semiconductors, triggering the formation of very reactive radicalsto improve photocatalytic efficiency.

Experimental investigation of masonry walls supported by steel plate-masonry composite beams

Deng-Hu Jing,Jian-Fei Chen,Giuseppina Amato,Ting Wu,Shuang-Yin Cao 국제구조공학회 2018 Steel and Composite Structures, An International J Vol.28 No.6

Masonry walls are sometimes removed in buildings to either make new passages or increase the usable space. This may change the loading paths in the structure, and require new beams to transfer the loads which are carried by the masonry walls that are to be removed. One possible method of creating such new beams is to attach steel plates onto part of the existing walls to form a steel plate-masonry composite (SPMC) beam, leading to a new structure with part of the masonry wall supported by a new SPMC beam. This paper presents an experimental investigation into the interaction between the SPMC beam and the masonry wall above. Five SPMC beams supporting a masonry wall were tested to study the influence of parameters including the height-to-span ratio of the masonry wall, height of the beam and thickness of the steel plates. The test results, including failure mode, load-carrying capacity, load-deflection curves and strain distribution, are presented and discussed. It is found that for developing better arching effect in the masonry wall the ratio of the in-plane flexural stiffness of the masonry wall to the flexural stiffness of the SPMC beam must be between 2.8 and 7.1.