曉瑩 『羅湖野錄』中所保存佚文及其評說-以「禪本草」、「炮炙論」為中心

Huang Jing Jia 중국학연구회 2018 중국학연구 Vol.- No.86

The Zen Notes-"Luo Hu Ye Lu"(羅湖野錄)written by Xiao Ying, this book contains the " Chan Ben Cao "(禪本草)made by Hui Ri Wen Ya and the " Pao Zhi Lun "(炮炙論)made by Zhan Tang Wen Zhun. These two articles are not included in other documents in the Song Dynasty. They are two essays recorded in the "Luo Hu Ye Lu". The former imitates the style of " Chan Ben Cao " and uses the "Zen" metaphor to explain the efficacy of meditation. The latter imitates the method of concocting medicine, and explains the practice method and the second method of using Zen as medicine. This research focuses on revising the content of anecdotes “Chan Ben Cao” and “Pao Zhi Lun” collected in Zen Note - Luo Hu Ye Lu, and conduct textual research on the versions spread. Then discusses Xiao Ying's comments at the end of the transcript, in order to understand the literature value and creative meaning of the two articles. This two-character style is humorous and must be read in a coherent way to understand the meditation meaning of the echo. Xiao Ying inherits from Zong Gao, and Zong Gao had studied from Zhan Tang Wen Zhun . Therefore, Xiao Ying's " Luo Hu Ye Lu " contains these two essays. On the one hand, it has its own source of learning, and on the other hand, it also preserves important Zen literature for the Song Dynasty. 宋代曉瑩所作禪林筆記『羅湖野錄』中,記錄許多禪門遺行逸事,具有補充史傳記錄的史料價值。其中載錄了慧日文雅所作「禪本草」和湛堂文準所作「炮炙論」全文,此二文不見載於宋代其他文獻,是『羅湖野錄』所輯錄的兩篇佚文。前者仿『本草』體例,以「禪」喻藥,說明禪修之功效;後者仿炮製之法,說明此一味禪藥之修練方法和次第。本文主要從『羅湖野錄』之後,考察「禪本草」、「炮炙論」的文本流傳和變化歷程,「禪本草」在明代『韋弦佩』、『佛祖綱目』中尚存全本,至袁中道效顰而作「禪門本草補」,其後『五朝小說』、『重校說郛』便誤將「禪門本草補」混淆為「禪本草」了。所幸清代『禪苑蒙求拾遺』中仍保存完整的「禪本草」全文。「炮炙論」的部分,今可見之版本從『羅湖野錄』,到明代的『佛祖綱目』、『韋弦佩』皆有收錄,三者內容一致並無任何變動。其次,曉瑩在抄錄二文之末加上個人的評說意見,此二文以本草的體例來表述禪修的功效和方法,以及炮製禪方的步驟,文字風格詼諧,必須連貫來讀,方能理解其中隱含呼應的禪思脈絡。曉瑩嗣法於宗杲,而宗杲曾從學於文準,因此,曉瑩『羅湖野錄』收錄這兩篇佚文,一方面有其學法淵源,一方面也為宋代禪門保存了重要的論禪文獻。

Clinical Study on Lobaplatin Combined with 5-Fu and Concurrent Radiotherapy in Treating Patients with Inoperable Esophageal Cancer

Jia, Xiao-Jing,Huang, Jing-Zi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15

Objective: To investigate short- and long-term treatment effects and side reactions of lobaplatin plus 5-Fu combined and concurrent radiotherapy in treating patients with inoperable middle-advanced stage esophageal cancer. Methods: Sixty patients with middle-advanced stage esophageal squamous cell cancer were retrospectively analyzed. All patients were administered lobaplatin (50 mg intravenously) for 2 h on day 1, and 5-Fu ($500mg/m^2$) injected intravenously from day 1 to 5 for 1 cycle, in an interval of 21 days for totally 4 cycles. At the same time, late-course accelerated hyperfractionated three-dimensional conformal radiotherapy was performed. Patients were firstly treated with conventional fractionated irradiation (1.8 Gy/d, 5 times/week, a total of 23 treatments, and DT41.4 Gy), and then treated with accelerated hyperfractionated irradiation (1.5 Gy, 2 times/d, a total of 27 Gy in 9 days, an entire course of 6-7 weeks, and DT 68.4Gy). Results: All patients completed treatment, including 10 complete response (CR), 41 partial response (PR), 7 stable disease (SD), and 2 progressive disease (PD). The total effective rate was 85.0% (51/60). Thirty-nine patients had an increased KPS score. One-, 2-, and 3-year survival rates were 85.3%, 57.5%, and 41.7%, respectively. The median survival time was 27 months. The adverse reactions included myelosuppression, which was mainly degree I and II. The occurrence rate of radiation esophagitis was 17.5%. No significant hepatic or renal toxicity was observed. Conclusion: Lobaplatin plus 5-Fu combined with concurrent radiotherapy is safe and effective in treating patients with middle-advanced stage esophageal cancer. However, this result warrants further evaluation by randomized clinical studies.

Prognostic Values of Various Clinical Factors and Genetic Subtypes for Diffuse Large B-cell lymphoma Patients: A Retrospective Analysis of 227 Cases

Zhou, De,Xie, Wan-Zhuo,Hu, Ke-Yue,Huang, Wei-Jia,Wei, Guo-Qing,He, Jing-Song,Shi, Ji-Min,Luo, Yi,Li, Li,Zhu, Jing-Jing,Zhang, Jie,Lin, Mao-Fang,Ye, Xiu-Jin,Cai, Zhen,Huang, He Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Aim: To analyze the significance of different clinical factors for prognostic prediction in diffuse large B-cell lymphoma (DLBCL) patients. Methods: Two hundred and twenty-seven DLBCL patients were retrospectively reviewed. Patients were managed with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) regimen or rituximab plus the CHOP (RCHOP) regimen. Results: Lactate dehydrogenase (LDH), ${\beta}2$-microglobulin (${\beta}2$-M), B symptoms, Ann Arbor stage and genetic subtypes were statistically relevant in predicting the prognosis of the overall survival (OS). In the CHOP group, the OS in patients with germinal center B-cell-like (GCB)(76.2%) was significantly higher than that of the non-GCB group (51.9%, P=0.032). With RCHOP management, there was no statistical difference in OS between the GCB (88.4%) and non-GCB groups (81.9%, P=0.288). Conclusion: Elevated LDH and ${\beta}2$-M levels, positive B symptoms, Ann Arbor stage III/IV, and primary nodal lymphoma indicate an unfavorable prognosis of DLBCL patients. Patients with GCB-like DLBCL have a better prognosis than those with non-GCB when treated with the CHOP regimen. The RCHOP treatment with the addition of rituximab can improve the prognosis of patients with DLBCL.

Research on the Comprehensive Benefit Evaluation of Electric Vehicle Technology Promotion and Application Under the Strategic Background of “Carbon Peaking and Carbon Neutrality”

Jia Dexiang,Li Xinda,Guo Shaodong,Liu Fang,Fu Chengcheng,Huang Xingde,Dong Zhen,Liu Jing 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3

On the one hand, as a substitute for traditional fuel vehicles, electric vehicles (EV) is an important measure to achieve “carbon peak and carbon neutralization” in transportation. On the other hand, as an energy storage unit in the new power system, it can make up for the disadvantages brought by renewable energy power generation. Therefore, scientifc and efective evaluation of EV benefts is the premise to promote the development of EV. In view of the characteristics of EV involving many interest groups and huge market potential, this paper introduces the comprehensive evaluation theory in operations research: analytic hierarchy process (AHP) and entropy weight method, and combines the respective advantages of the two methods to avoid the distortion of evaluation results caused by a single evaluation method. First of all, under the background of building a new power system and realizing a powerful automobile country, the EV promotion beneft evaluation index system is constructed from fve frst-class indexes and 18 s-class indexes of consumers, distribution network, charging network, social beneft and environmental beneft. Then, aiming at the shortcomings of single evaluation method, the subjective and objective combination method of AHP entropy weight method is established to solve each weight index, so as to realize the scientifc quantifcation of the index. Finally, a certain area of a coastal city is selected for example analysis. The results show that the evaluation method established in this paper has a positive efect on EV promotion, and can provide suggestions for EV promotion.

Depression and Structural Factors Are Associated With Symptoms in Patients of Irritable Bowel Syndrome With Diarrhea

( Jia Lu ),( Lili Shi ),( Dan Huang ),( Wenjuan Fan ),( Xiaoqing Li ),( Liming Zhu ),( Jing Wei ),( Xiucai Fang ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.4

Background/Aims A strong correlation between depression and irritable bowel syndrome with diarrhea (IBS-D) has been identified. The aim of this study is to identify the correlations among depression, structural factors, gastrointestinal (GI) and extra-GI symptoms, and efficacy of neuromodulators in patients with IBS-D. Methods Patients meeting the Rome III Diagnostic Criteria for IBS-D were enrolled. The intestinal symptoms and psychological states were evaluated using IBS-specific symptom questionnaires and Hamilton Depression Rating Scale. Results In total, 410 patients with IBS-D were enrolled, 28.8% (118/410) had comorbid depression. Patients with depression did not readily experience improvement in abdominal pain/discomfort after defecation, and had a higher prevalence of passing mucus, overlapping functional dyspepsia, and extra-GI symptoms. The structural factor “mental disorders” significantly correlated with main bowel symptom score and degree of pre-defecation abdominal pain/discomfort. No structural factor significantly correlated with bowel movements or stool form. Patients who had passing mucus, overlapping functional dyspepsia and extra-GI painful symptoms have higher score of “anxiety/somatization.” Patients with sexual dysfunction have higher score of “retardation symptoms.” In total, 28.3% of patients with IBS-D were prescribed neuromodulators. Baseline scores of “anxiety/somatization” and “retardation symptoms” positively correlated with improvement of diarrhea after paroxetine, and “sleep disturbances” positively correlated with improvement of abdominal pain/discomfort and diarrhea after mirtazapine. Conclusions Comorbid depression and higher scores of structural factors might aggravate GI and extra-GI symptoms other than bowel movements and stool form. Structural factors of Hamilton Depression Rating Scale correlated with efficacy of paroxetine and mirtazapine in patients with IBS-D. (J Neurogastroenterol Motil 2020;26:505-513)

A Method of Extract News Events Based on Three Level Models

Jing Lu,Mao Ye,Zhi Tang,Xiao-Jun Huang,Jia-Le Ma 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.5

In this paper, the method ofextract event from newspaper is proposed. First, the candidate sentences are select by using trigger word. Then, statistic models in three levels are consisted of extract model, which is sentences level, news level and topic level is used to extract event from candidate sentences and the probability of extracted events is calculated by three levels model. Finally, the method proposed in this paper is used to extract 4 type events. The experiment result shows this method have ideal effect on event extraction.

Toxoplasma gondii induces autophagy and apoptosis in human umbilical cord mesenchymal stem cells via downregulation of Mcl−1

Chu, Jia-Qi,Jing, Kai-Peng,Gao, Xiang,Li, Peng,Huang, Rui,Niu, Yan-Ru,Yan, Shou-Quan,Kong, Jun-Chao,Yu, Cai-Yuan,Shi, Ge,Fan, Yi-Ming,Lee, Young-Ha,Zhou, Yu,Quan, Juan-Hua Landes Bioscience 2017 Cell Cycle Vol.16 No.5

<P>Autophagy and apoptosis are critical for controlling Toxoplasma gondii (T. gondii) infection. T. gondii infection during pregnancy can damage the fetus and cause birth defects; however, the molecular mechanisms of this process are poorly understood. This study aims to determine the activities of autophagy and apoptosis as well as their regulatory mechanisms during T. gondii infection by using human umbilical cord mesenchymal stem cells (hUC-MSCs) as a model of congenital diseases. LC3B, a hallmark protein of autophagy was incrementally upregulated with the infection duration, whereas p62 was downregulated in T. gondii-infected hUC-MSCs. Concurrent to this result, the invasion of T. gondii into hUC-MSCs increased in a time-dependent manner. The expression levels of Bcl-2 family proteins including Bcl-2, Bcl-xL, Bim, Bax, Bid and Bak were not altered; however, Mcl-1 levels in hUC-MSCs were dramatically decreased upon T. gondii infection. In addition, at 24h post-infection, cleaved PARP and cleaved caspase-3 protein levels were elevated in hUC-MSCs. Importantly, Mcl-1 overexpression reduced the levels of autophagy- and apoptosis-related proteins in T. gondii-infected hUC-MSCs. Mcl-1 proteins were primarily expressed in the fraction containing mitochondria and strongly interacted with Beclin-1 under normal conditions; however, these interactions were remarkably attenuated by T. gondii infection. These results suggest that mitochondrial Mcl-1 is an essential signaling mediator regulating the activation of autophagy and apoptosis during T. gondii infection.</P>

β-Phase-Preferential Blow-spun Fabrics for Wearable Triboelectric Nanogenerators and Textile Interactive Interface

호동해,Jing Han,Jinrong Huang,Yoon Young Choi,Siuk Cheon,Jia Sun,Yanqiang Lei,Gyeong Seok Park,Zhong Lin Wang,Qijun Sun,조정호 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.1

Wearable textile electronics have been extensively developed with versatile functionality and self-powered autonomy. The nonwoven fabric fabricated by solution blow spinning (SBS) was successfully applied as the triboelectric layer in TENGs. The uniaxial elongation of the polymer chains along the fiber axis during the SBS process promoted the formation of polar β-phase crystals in the solution-blow-spun nanofibers, which led to a negative shift in the surface potential and enhancement of the TENG performances. The constructed fabric TENG delivered excellent output performances such as a high open-circuit voltage of 260 V, short-circuit current of 27μA, and high output power of 7mW. The proposed β-phase-preferential blow-spun fabric TENGs are highly promising for application to next-generation intelligent textronics and self-powered human robot interaction interfaces.

ox-LDL regulates proliferation and apoptosis in VSMCs by controlling the miR-183-5p/FOXO1

Fan Mingqiang,Huang Yinglong,Li Kunsheng,Yang Xiangxiang,Bai Jing,Si Qiaoke,Peng Zhengfei,Jia Chunwen,Zhang Qiangnu,Tao Ding 한국유전학회 2022 Genes & Genomics Vol.44 No.6

Background: microRNA-mRNA axes that are involved in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cells (VSMCs) proliferation/apoptosis imbalance need to be further investigated. Objective: To investigate the functional role of miR-183-5p/FOXO1 in VSMCs and its interaction with ox-LDL. Methods: RNA sequencing was used to detect transcriptome changes of VSMCs treated with ox-LDL. miR-183-5p and FOXO1 expression levels in VSMCs after ox-LDL treatment were assessed using qRT-PCR and western blotting. The regulatory effect of miR-183-5p on FOXO1 has been tried to prove using a dual-luciferase reporter assay. The functions of miR-183-5p, and FOXO1 were analyzed by CCK-8 assay and flow cytometry assay. The tissue samples or serum samples of high fat-feeding mice and carotid atherosclerosis patients were collected, and the levels of miR-183-5p/FOXO1 were analyzed. Results: RNA sequencing data showed 81 miRNAs including miR-183-5p was significantly changed after ox-LDL treatment in VSMCs. FOXO1, a miR-183-5p's potential target, was also down-regulated in ox-LDL treated cells. qRT-PCR and western blot found that expression of FOXO1 mRNA and protein significantly reduced in VSMCs treated with ox-LDL, accompanied by overexpression of miR-183-5p. miR-183-5p inhibited FOXO1 mRNA by binding to its 3' UTR. Interference miR-183-5p/FOXO1 could change proliferation/apoptosis imbalance in VSMCs under ox-LDL stimulation. Higher levels of miR-183-5p but reduced FOXO1 can be found in the thoracic aorta tissues of high fat-feeding mice. In serum samples from individuals with carotid atherosclerosis, Higher levels of miR-183-5p were observed. the miR-183-5p level was positively related to the level of serum ox-LDL in patients. Conclusions: Aberrant expression of miR-183-5p/FOXO1 pathway mediated ox-LDL-induced proliferation/apoptosis imbalance in VSMCs. The miR-183-5p/FOXO1 axis can potentially be utilized as the target in the treatment of patients with atherosclerosis.

Effect of Defatting and Enzyme Type on Antioxidative Activity of Shrimp Processing Byproducts Hydrolysate

Guang-Rong Huang,Jing Zhao,Jia-Xin Jiang 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.3

Shrimp processing byproducts (SPB) was digested by 6 proteases (trypsin, pepsin, neutrase, Protamex,Flavourzyme, and Alcalase) to produce antioxidative peptides. Both degree of hydrolysis (DH) and DPPH radical scavenging activity (DSA) of the Alcalase hydrolysate were the highest of all. The effect of defatting on DH and DSA of the Alcalase hydrolysate was significant. The DH decreased while the DSA increased after defatting of the byproducts. The antioxidative activity of Alcalase hydrolysate was also investigated using several in vitro assays,including DPPH, ABTS radical scavenging assays (ASA),reducing power assay, and chelating activity. The antioxidative activity of the hydrolysate was obviously concentration dependent. The SPB Alcalase hydrolysate exhibited notable DSA and ASA with the IC_50 values of 500 and 7.4 μg/mL, respectively. And the hydrolysate showed 38.9% chelating activity at 120 μg/mL level. The SPB Alcalase hydrolysate was a potential source of natural antioxidants.