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Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer’s disease
Ji-Jing Yan,Won-Gyun Ahn,Jun-Sub Jung,Hee-Sung Kim,Ashraful Hasan,Dong-Keun Song 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.4
BACKGROUND: Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS: We investigated the effects of ADA extract on two mouse models of Alzheimer’s disease (AD); intracerebroventricular injection of β-amyloid peptide (Aβ) and amyloid precursor protein/presenilin 1 (APP/PS1)-transgenic mice. RESULTS: Intra-gastric administration of ADA stem extract (0.25 g/kg, every 12 hrs started from one day prior to injection of Aβ1-42 until evaluation) effectively blocked Aβ1-42-induced impairment in passive avoidance performance, and Aβ1-42-induced increase in immunoreactivities of glial fibrillary acidic protein and interleukin (IL)-1α in the hippocampus. In addition, it alleviated the Aβ1-42-induced decrease in acetylcholine and increase in malondialdehyde levels in the cortex. In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-1β in the brain. CONCLUSIONS: The results of this study suggest that ADA stem extract may be useful for prevention and treatment of AD.
A Novel Clotrimazole-Loaded Suppository with Effective Anti-tumor Activity
( Jing Ji Xuan ),( Jong Tae Kim ),( Dong Hoon Oh ),( Hong Hee Han ),( Won Seok Lee ),( Jong Sook Lee ),( Jong Dal Rhee ),( Chul Soon Yong ),( Jong Soo Woo ),( Jung Ae Kim ),( Han Gon Choi ) 한국약제학회 2008 Journal of Pharmaceutical Investigation Vol.38 No.5
Life Science : A Novel Clotrimazole-Loaded Suppository with Effective Anti-tumor Activity
( Jing Ji Xuan ),( Jong Tae Kim ),( Dong Hoon Oh ),( Hong Hee Han ),( Won Seok Lee ),( Jong Sook Lee ),( Jong Dal Rhee ),( Chul Soon Yong ),( Jong Soo Woo ),( Jung Ae Kim ),( Han Gon Choi ) 영남대학교 약품개발연구소 2009 영남대학교 약품개발연구소 연구업적집 Vol.19 No.-
Jing Ji,Zhichao Xu,Liangqin Jiang,Chaoqing Yuan,Yunfeng Zhang,Lijian Zhou,Shilong Zhang 한국강구조학회 2018 International Journal of Steel Structures Vol.18 No.4
This paper was concerned with the nonlinear analysis on the overall stability of H-type honeycombed composite column with rectangular concrete-fi lled steel tube fl anges (STHCC). The nonlinear analysis was performed using ABAQUS, a commercially available fi nite element (FE) program. Nonlinear buckling analysis was carried out by inducing the fi rst buckling mode shape of the hinged column to the model as the initial imperfection with imperfection amplitude value of L /1000 and importing the simplifi ed constitutive model of steel and nonlinear constitutive model of concrete considering hoop eff ect. Close agreement was shown between the experimental results of 17 concrete-fi lled steel tube (CFST) specimens and 4 I-beams with top fl anges of rectangular concrete-fi lled steel tube (CFSFB) specimens conducted by former researchers and the predicted results, verifying the correctness of the method of FE analysis. Then, the FE models of 30 STHCC columns were established to investigate the infl uences of the concrete strength grade, the nominal slenderness ratio, the hoop coeffi cient and the fl ange width on the nonlinear stability capacity of SHTCC column. It was found that the hoop coeffi cient and the nominal slenderness ratio aff ected the nonlinear stability capacity more signifi cantly. Based on the results of parameter analysis, a formula was proposed to predict the nonlinear stability capacity of STHCC column which laid the foundation of the application of STHCC column in practical engineering.
Ji-Ying Shi,Deng-Yu Zhang,Fei Xue,Ya-Jing Li,Wen Qiao,Wen-Jing Yang,Yi-Ming Xu,Ting Yang 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.5
This paper presents a moth-flame optimization (MFO)-based maximum power point tracking (MPPT) method for photovoltaic (PV) systems. The MFO algorithm is a new optimization method that exhibits satisfactory performance in terms of exploration, exploitation, local optima avoidance, and convergence. Therefore, the MFO algorithm is quite suitable for solving multiple peaks of PV systems under partial shading conditions (PSCs). The proposed MFO-MPPT is compared with four MPPT algorithms, namely the perturb and observe (P&O)-MPPT, incremental conductance (INC)-MPPT, particle swarm optimization (PSO)-MPPT and whale optimization algorithm (WOA)-MPPT. Simulation and experiment results demonstrate that the proposed algorithm can extract the global maximum power point (MPP) with greater tracking speed and accuracy under various conditions.
Colour Linear Array Image Enhancement Method with Constant Colour
Jing Ji,Suping Fang,Zhiqiang Chen 한국광학회 2022 Current Optics and Photonics Vol.6 No.3
Digital images of cultural relics captured using line scan cameras present limitations due to uneven intensity and low contrast. To address this issue, this report proposes a colour linear array image enhancement method that can maintain a constant colour. First, the colour linear array image is converted from the red–green–blue (RGB) colour space into the hue–saturation–intensity colour space, and the three components of hue, saturation, and intensity are separated. Subsequently, the hue and saturation components are held constant while the intensity component is processed using the established intensity compensation model to eliminate the uneven intensity of the image. On this basis, the contrast of the intensity component is enhanced using an improved local contrast enhancement method. Finally, the processed image is converted into the RGB colour space. The experimental results indicate that the proposed method can significantly improve the visual effect of colour linear array images. Moreover, the objective quality evaluation parameters are improved compared to those determined using existing methods.
Scheme for Implementing the Optimal Quantum Cloning via Long-range Off-resonant Raman Coupling
Jing-Ji Wen,연규황,Hong-Fu Wang,Shou Zhang 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.63 No.9
We propose a physical scheme to implement the optimal 1 ! 2 quantum cloning via long-rangeoff-resonant Raman coupling for distant atoms trapped in separate cavities connected by opticalfibers. We show that, if the single-qubit rotation angles are choosen appropriately, the optimalsymmetric (asymmetric) universal quantum cloning and optimal symmetric (asymmetric) phasecovariantcloning can be effectively realized. The scheme is insensitive to cavity decay, fiber loss, andatomic spontaneous emission because the effective long-distance interaction induced by long-rangeoff-resonant Raman coupling is mediated by the vacuum fields of the fiber and cavity and becausethe total system evolves in the decoherence-free subspace in which neither of the subsystems isexcited.
Jing Ji,Bing Li,Wenfu Zhang,Yingchun Liu,Chaoqing Yuan,Fei Xing 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.1
In order to study the cross-type rigid steel frame node hysteretic behavior of components, the axial compression ratio, H type steel column web thickness, girder section and stiffener as design parameters, 8 steel frame cross-type rigid joints and a T-type rigid joint are designed. Based on simplified mechanical model and constitutive relations of material, using ABAQUS software the corresponding finite element model is established and the hysteretic performance analysis is carried out. Through comparison between given T-type node test results and analysis results, both are in good agreement, thus the rationality of the finite element model established in this paper is verified. Simulation analysis of cross-type node is developed in further, load -displacement hysteretic curve of nodes, skeleton curve, envelope figure and the stress nephogram are extracted and comparative analysis is conducted, influence regularity of four parameters on the seismic behavior of the joints is obtained. The corresponding design suggestion for the axial compression ratio and column web and flange thickness ratio is proposed, design limit value of axial compression ratio of column should be taken as 0.5 and limit value of column web and flange thickness ratio is taken as 0.75,and these can provide reference for actual engineering design.
Therapeutic effects of lysophosphatidylcholine in experimental sepsis
Yan, Ji-Jing,Jung, Jun-Sub,Lee, Jung-Eun,Lee, Jongho,Huh, Sung-Oh,Kim, Hee-Sung,Jung, Kyeong Cheon,Cho, Jae-Young,Nam, Ju-Suk,Suh, Hong-Won,Kim, Yung-Hi,Song, Dong-Keun Nature Publishing Group 2004 Nature medicine Vol.10 No.2
Sepsis represents a major cause of death in intensive care units. Here we show that administration of lysophosphatidylcholine (LPC), an endogenous lysophospholipid, protected mice against lethality after cecal ligation and puncture (CLP) or intraperitoneal injection of Escherichia coli. In vivo treatment with LPC markedly enhanced clearance of intraperitoneal bacteria and blocked CLP-induced deactivation of neutrophils. In vitro, LPC increased bactericidal activity of neutrophils, but not macrophages, by enhancing H<SUB>2</SUB>O<SUB>2</SUB> production in neutrophils that ingested E. coli. Incubation with an antibody to the LPC receptor, G2A, inhibited LPC-induced protection from CLP lethality and inhibited the effects of LPC in neutrophils. G2A-specific antibody also blocked the inhibitory effects of LPC on certain actions of lipopolysaccharides (LPS), including lethality and the release of tumor necrosis factor-α (TNF-α) from neutrophils. These results suggest that LPC can effectively prevent and treat sepsis and microbial infections.