Making the Posthuman: Unmaking the Humanity

( Kim¸ Jin Kyung ) 동국대학교 영어권문화연구소 2019 영어권문화연구 Vol.12 No.2

The purpose of this paper is to interrogate the possibility of the posthuman as a concept that can transcend the limits of the universal humanities. The concept of the posthuman in the context of philosophical and sociopolitical discourses is examined for its implication which is not confined to the meaning of the technological improvement of the human body, but extends to the concept that helps to overcome many prejudices and discriminations in the societies. At the advent of the machines with superintelligence, the need of redefining the human arises with spreading anxiety over the humanness. Rosi Braidotti and N. Katherine Hayles investigate the concept of the posthuman to give answers to various questions concerning the formation of the posthuman. Both Hayles and Braidotti explicate the concept of the posthuman based on the materiality which Spinoza and Descartes provide the foundational thoughts. The concept of the human entails being alive with the biological body and mental ability to perceive the environment. Such a notion was conceived and developed within the western philosophical canon, and still occupies a position in defining the human consciousness in contrast with the consciousness of the artificial intelligence. What I portray in this essay is not to reiterate the conventional notions around the posthuman, but to argue that the real interest of the posthuman studies lies in questioning how the concept of the human can be reconceived in making the posthuman.

청소년들의 최대 골량 향상을 위한 운동 가이드라인

민석기 ( Seok-ki Min ),오태웅 ( Taewoong Oh ),김상현 ( Sang Hyun Kim ),조진경 ( Jinkyung Cho ),정호연 ( Ho-yeon Chung ),박동호 ( Dong-ho Park ),김창선 ( Changsun Kim6 ) 한국운동생리학회(구 한국운동과학회) 2020 운동과학 Vol.29 No.1

PURPOSE: An increase in bone mineral density during adolescence increases resistance to fractures in older age. The Korean Society for Bone and Mineral Research and the Korean Society of Exercise Physiology developed exercise guidelines to increase the peak bone mass (PBM) in adolescents based on evidence through a systematic review of previous research. METHODS: Articles were selected using the systematic method, and the exercise guidelines were established by selecting key questions (KQs) and defining the effects of exercises based on evidence through a literature review for selecting the final exercise method. There were 9 KQs. An online search was conducted on articles published since 2000, and 93 articles were identified. RESULTS: An increase in PBM in adolescence was effective for preventing osteoporosis and fractures in older age. Exercise programs as part of vigorous physical activity (VPA) including resistance and impact exercise at least 5 to 6 months were effective for improving PBM in adolescents. It is recommended that resistance exercise is performed 10 to 12 rep·set^-1 1-2 set·region^-1 and 3 days·week^-1 using the large muscles. For impact exercises such as jumping, it is recommended that the exercise is performed at least 50 jumps·min^-1, 10 min·day^-1, and 2 days·week^-1. CONCLUSIONS: Exercise guidelines were successfully developed, and they recommend at least 5 to 6 months of VPA, which includes both resistance and impact exercises. With the development of exercise guidelines, the incidence of osteoporosis and fractures in the aging society can be reduced in the future, thus contributing to improved public health.

Dendritic planarity of Purkinje cells is independent of Reelin signaling

Kim, Jinkyung,Park, Tae-Ju,Kwon, Namseop,Lee, Dongmyeong,Kim, Seunghwan,Kohmura, Yoshiki,Ishikawa, Tetsuya,Kim, Kyong-Tai,Curran, Tom,Je, Jung Ho Springer Berlin Heidelberg 2015 BRAIN STRUCTURE AND FUNCTION Vol.220 No.4

<P>The dendritic planarity of Purkinje cells is critical for cerebellar circuit formation. In the absence of Crk and CrkL, the Reelin pathway does not function resulting in partial Purkinje cell migration and defective dendritogenesis. However, the relationships among Purkinje cell migration, dendritic development and Reelin signaling have not been clearly delineated. Here, we use synchrotron X-ray microscopy to obtain 3-D images of Golgi-stained Purkinje cell dendrites. Purkinje cells that failed to migrate completely exhibited conical dendrites with abnormal 3-D arborization and reduced dendritic complexity. Furthermore, their spines were fewer in number with a distorted morphology. In contrast, Purkinje cells that migrated successfully displayed planar dendritic and spine morphologies similar to normal cells, despite reduced dendritic complexity. These results indicate that, during cerebellar formation, Purkinje cells migrate into an environment that supports development of dendritic planarity and spine formation. While Reelin signaling is important for the migration process, it does not make a direct major contribution to dendrite formation.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00429-014-0780-2) contains supplementary material, which is available to authorized users.</P>

miAssociation between Mitofusin 2 Gene Polymorphisms and Late-Onset Alzheimer’s Disease in the Korean Population

YoungJong Kim,JinKyung Park,WonSub Kang,SuKang Kim,Changsu Han,HaeRi Na,HaeJeong Park,JongWoo Kim,YoungYoul Kim,MoonHo Park,JongWoo Paik 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1

Objective-Mitochondrial dysfunction is a prominent and early feature of Alzheimer’s disease (AD). The morphologic changes observed in the AD brain could be caused by a failure of mitochondrial fusion mechanisms. The aim of this study was to investigate whether genetic polymorphisms of two genes involved in mitochondrial fusion mechanisms, optic atrophy 1 (OPA1) and mitofusin 2 (MFN2), were associated with AD in the Korean population by analyzing genotypes and allele frequencies. Methods-One coding single nucleotide polymorphism (SNP) in the MFN2, rs1042837, and two coding SNPs in the OPA1, rs7624750 and rs9851685, were compared between 165 patients with AD (83 men and 82 women, mean age 72.3±4.41) and 186 healthy control subjects (82 men and 104 women, mean age 76.5±5.98). Results-Among these three SNPs, rs1042837 showed statistically significant differences in allele frequency, and genotype frequency in the co-dominant 1 model and in the dominant model. Conclusion-These results suggest that the rs1042837 polymorphism in MFN2 may be involved in the pathogenesis of AD.

수소충전소 웹기반 가상교육 시뮬레이터 개발

김은용(Eunyong Kim),김진경(Jinkyung Kim),이영희,김은정(Eunjung Kim),김영규(Younggyu Kim),문일(Il Moon) 한국에너지학회 2008 한국에너지공학회 학술발표회 Vol.2008 No.-

본 연구에서는 수소 경제의 핵심 인프라 시설인 수소 충전소의 조업자 안전운전을 위한 교육 및 훈련 프로그램을 구축하였으며, 개발된 프로그램은 크게 수소안전교육 모듈, 수소 충전소 가상체험 모듈, 가상 사고 시나리오 모듈로 구성되어 있다. 수소안전교육 모듈에서는 수소 사고의 특징과 안전 물성 등의 자료를 수록함으로써 수소에 안전에 대한 이해를 돕도록 하였으며, 가상체험 모듈에서는 충전소의 구성과 용도를 3D Virtual Reality 기술을 도입해 간접 체험할 수 있도록 하였다. 또한 가상사고 모듈에서는 수소 충전소에서 일어날 수 있는 사고에 대한 동적 모사를 수행하여 사고의 전개 과정 및 결과를 체험해 볼 수 있도록 하였다. 이와 함께 사고가 일어났을 경우 신속하고 정확한 대응을 통해 피해를 최소화하기 위한 ERP(Emergency Response Plan)과 SOP(Standard Operating Procedure)를 개발하였다.

Single atomic spin sensing of magnetic interactions in a tunnel junction

Jinkyung Kim,Won-jun Jang,Thi Hong Bui,Deung-Jang Choi,Christoph Wolf,Fernando Delgado,Yi Chen,Denis Krylov,Soonhyeong Lee,Sangwon Yoon,Christopher P. Lutz,Andreas J. Heinrich,Yujeong Bae 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1

Single spins are widely regarded as a leading candidate for realizing next-generation quantum devices for sensing and quantum information processing. Detection and coherent control of single spins require to localize single spins and characterize its magnetic surroundings. Scanning tunneling microscopy in combination with electron spin resonance (ESR-STM) technique [1] enables a direct access to the quantum states of single magnetic atoms or molecules on surfaces. Using ESR-STM, we investigated spin resonance of hydrogenated Ti (TiH) atoms adsorbed on bridge binding site of MgO in a two-dimensional vector magnetic field. Here, the spin 1/2 TiH atom with no magnetic anisotropy was employed as a probe of magnetic environments at the tunnel junction. We found both ESR frequency and amplitude change as a function of the angle of vector magnetic fields. The resonance frequency varied by different vector magnetic fields indicates an anisotropy of the g-factor, resulting from the variation of angular momentum contributions due to the crystal fields. We developed a stereoscopic way to unravel the g-factor along the three principal axes. Moreover, ESR amplitude dependence on the direction of magnetic fields provides the further understanding of ESR mechanisms, which results from two factors, tunneling magnetoresistance (TMR) effect at the spin-polarized STM junction and the transverse magnetic field to drive ESR. Our results will enable to predict ESR active spin centers on different substrates as well as in other quantum-nanoscience platforms.

Early Growth Response 1-Dependent Downregulation of Matrix Metalloproteinase 9 and Mouse Double Minute 2 Attenuates Head and Neck Squamous Cell Carcinoma Metastasis

Kim, Jinkyung,Kang, Sung-Min,Oh, Su Young,Kang, Soo Hyun,Lee, Inhan,Hwang, Jae Chan,Lee, Heon-Jin,Choi, So-Young,Hong, Su-Hyung S. Karger AG 2018 CELLULAR PHYSIOLOGY AND BIOCHEMISTRY Vol.50 No.5

<P><B><I>Background/Aims:</I></B> The functional relevance of early growth response-1 (EGR1) on cancer invasion remains controversial. The effect of EGR1 on the expression of MMP9, which is important for HNSCC invasion, is still disputed. There is no previous data showing the effect of EGR1 on mouse double minute 2 (MDM2), an enhancer of matrix metalloproteinase 9 (MMP9) expression. Our aim is to clarify the negative correlation between EGR1 expression and head and neck squamous cell carcinoma (HNSCC) metastasis. <B><I>Methods:</I></B> EGR1 mRNA and protein expressions were compared in normal and HNSCC tissues using The Cancer Genome Atlas (TCGA) dataset analysis or immunohistochemistry (IHC), respectively. <I>In vitro</I> cell invasion was evaluated Matrigel invasion assay. EGR1-dependent inhibition of MDM2 transcription was assessed by promoter–luciferase assay and chromatin immunoprecipitation (ChIP). <B><I>Results:</I></B> TCGA data showed that EGR1 mRNA levels are significantly higher in normal oral tissues as compared with HNSCC tumor tissues (adjusted P = 1.64x10<SUP>-16</SUP>). In addition, nonmetastatic HNSCC tissues showed significantly higher EGR1 mRNA levels as compared with metastatic tissues (adjusted P = 0.023). IHC analysis showed that primary tumor tissues expressed significantly higher levels of nuclear EGR1 compared with paired metastatic lymph node tissues (P < 0.05). EGR1 overexpression downregulated MMP9 and MDM2 protein expression. Consistent with these observations, TCGA data analysis found significantly fewer metastatic patients among a subgroup of population presenting higher EGR1 expressions with lower MMP9 and/or MDM2. <B><I>Conclusion:</I></B> Our data suggests that EGR1 prevents HNSCC metastasis through downregulation of MMP9 and MDM2. EGR1 might be a potential candidate to attenuate HNSCC metastasis.</P>

Application of TRIZ creativity intensification approach to chemical process safety

Kim, Junghwan,Kim, Jinkyung,Lee, Younghee,Lim, Wonsub,Moon, Il Elsevier 2009 Journal of loss prevention in the process industri Vol.22 No.6

<P><B>Abstract</B></P><P>This study develops a modified method of TRIZ to improve safety in chemical process design. This method is modified by the theory of TRIZ, which is inventive problem solving theory, for retrofit design of chemical process considering safety.</P><P>The original TRIZ is difficult to access to chemical process safety due to inapplicability and ambiguity of terminology in classification of these parameters. It is necessary to be modified TRIZ for chemical process safety. This study reorganized thirty-nine parameters of the TRIZ into six categories such as mechanic, operator, process upset, design, natural hazard and material. The modified TRIZ is tested to jacketed reactor and polyethylene reactor.</P>

Color harmony

JinKyung KIM 한국색채학회 2018 International Invitation Exhibition of Color Works Vol.- No.-

A CMOS Baseband Complex Bandpass Filter with a New Automatic Tuning Method for PHS Applications

JinKyung Kim,JiHoon Jung,YoungGun Pu,SukHwan Jang,Kang-Yoon Lee 대한전자공학회 2006 ITC-CSCC :International Technical Conference on Ci Vol.2006 No.2