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Expression profiles of HERV-K Env protein in normal and cancerous tissues
Jo, Jin-Ok,Kang, Yun-Jeong,Ock, Mee Sun,Song, Kyoung Seob,Jeong, Moon-Jin,Jeong, Soon-Jeong,Choi, Yung Hyun,Ko, Eun-Ji,Leem, Sun-Hee,Kim, Suhkmann,Kim, Heui-Soo,Cha, Hee-Jae Springer-Verlag 2016 Genes & Genomics Vol.38 No.1
<P>Human endogenous retroviruses (HERVs) have been proposed as etiological cofactors in chronic diseases such as cancer, autoimmunity and neurological disease. HERV RNA expression is also increased in several autoimmune diseases and cancers. However, only a few studies have analyzed the expression levels of HERV-derived proteins in normal and diseased tissues. Here, we investigated the expression profiles of HERV-K Env protein, which is the most well-known pathogen, from normal and cancer tissue microarray. Normal and cancer tissue microarray slides containing 59 normal or 60 tumor surgical specimens, respectively were immunostained with mouse monoclonal antibody to HERV-K and staining intensity was scored. The expression of HERV-K Env protein is generally low in normal tissues but high in specific tissues including bronchus submucosal gland, salivary gland acini, pancreas acini, testis seminiferous tubule, uterine cervix epithelium, ovary stroma, skin epidermis, and heart. The expression of HERV-K Env protein in tumors was usually higher than normal tissues and specifically high in breast, liver, stomach, prostate, and ovarian cancer. This study provides protein expression profiles of HERV-K Env protein in human normal and cancer tissues and provides a good reference for further studies on the expression patterns and roles of HERV-K Env protein in normal organs and various cancers. Further studies with specific organs or cancers and a statistically significant numbers of samples are necessary.</P>
Recycling and LFA‐1‐dependent trafficking of ICAM‐1 to the immunological synapse
Jo, Jae‐,Hyeok,Kwon, Min‐,Sung,Choi, Hyang‐,Ok,Oh, Hyun‐,Mee,Kim, Hyang‐,Jin,Jun, Chang‐,Duk Wiley Subscription Services, Inc., A Wiley Company 2010 Journal of cellular biochemistry Vol.111 No.5
<P><B>Abstract</B></P><P>Little is known about how adhesion molecules on APCs accumulate at immunological synapses. We show here that ICAM‐1 on APCs is continuously internalized and rapidly recycled back to the interface after antigen‐priming T‐cell contact. The internalization rate is high in APCs, including Raji B cells and dendritic cells, but low in endothelial cells. Internalization is significantly reduced by inhibitors of Na<SUP>+</SUP>/H<SUP>+</SUP> exchangers (NHEs), suggesting that members of the NHE‐family regulate this process. Once internalized, ICAM‐1 is co‐localized with MHC class II in the polarized recycling compartment. Surprisingly, not only ICAM‐1, but also MHC class II, is targeted to the immunological synapse through LFA‐1‐dependent adhesion. Cytosolic ICAM‐1 is highly mobile and forms a tubular structure. Inhibitors of microtubule or actin polymerization can reduce ICAM‐1 mobility, and thereby block accumulation at immunological synapses. Membrane ICAM‐1 also moves to the T‐cell contact zone, presumably through an active, cytoskeleton‐dependent mechanism. Collectively, these results demonstrate that ICAM‐1 can be transported to the immunological synapse through the recycling compartment. Furthermore, the high‐affinity state of LFA‐1 on T cells is critical to induce targeted movements of both ICAM‐1 and MHC class II to the immunological synapse on APCs. J. Cell. Biochem. 111: 1125–1137, 2010. © 2010 Wiley‐Liss, Inc.</P>
Jo, Yong Suk,Kwon , Sung Ok,Kim , Jeeyoung,Kim, Woo Jin AME Publishing Company 2018 Journal of thoracic disease Vol.10 No.8
<P>Conclusions: NGAL levels were significantly higher in ACO compared to non-ACO COPD in female subjects. After adjusting for gender as a confounding factor, the ability to distinguish ACO was better at higher levels of NGAL.</P>
Jin, Byung-Ok,Lee, Min-Ho,Jo, Jin-Seok,Jung, Ho-Jun,Kim, Chi-Ho,Kim, Hyeon-Tae Korean Society for Agricultural Machinery 2017 바이오시스템공학 Vol.42 No.2
Purpose: In this study, we attempted to analyze, by using a high-speed camera, the cutting shape as a function of cutting speed and feed rate. We compared the differences in cutting shape between domestic and foreign combines. Methods: Experiments were performed using plastic straws, and the results of two combine cutting blades, one from the Daedong Industry and one from Kuboda, were compared. The quality and performances of cutting were measured at three cutting positions: center and 68 cm to the left and right of the center. The feed rates were 0.6 m/s, 1.1 m/s, 1.6 m/s, and the cutting speeds were 600 RPM, 990 RPM, 1,380 RPM. For each speed, the cutting shape was measured three times, and the entire procedure was also repeated three times. Results: In the experiments, the domestic cutting blade achieved better results than the Japanese cutting blade. These results were obtained by studying the combination of feed rate and cutting speed, with the domestic combine attaining approximately 80% performance of the Japanese combine. We believe that additional data analysis is required, obtained from field experiments. Conclusions: The domestic cutting knives achieved better results than the Japanese cutting knives. These results are estimated from experiments conducted with different feed rates and cutting speeds; an in-depth analysis will require experiments in the real field with actual combines and a combination of multiple variables. Repeating the investigation on the length differences, broken and cut angle with various combinations of feed rate and cutting speed, will surely help to find the optimal cutting speed.
Jo, Hongil,Oh, Seung-Jin,Ok, Kang Min Royal Society of Chemistry 2017 Dalton Transactions Vol. No.
<▼1><P>A series of noncentrosymmetric (NCS) solid solutions and their structure–nonlinear optical property relationship are introduced for designing novel NCS materials more systematically.</P></▼1><▼2><P>A systematic approach toward the discovering of novel functional noncentrosymmetric (NCS) materials revealing technologically useful applications is an ongoing challenge. This Frontiers article investigates a series of NCS solid solutions with respect to their crystal structure and second-harmonic generation (SHG) response. The solid solutions include NCS polar aluminoborates, Al5−xGaxBO9 (0.0 ≤ <I>x</I> ≤ 0.5), rare earth element-doped bismuth tellurites, Bi2−xRExTeO5 (RE = Y, Ce, and Eu; 0.0 ≤ <I>x</I> ≤ 0.2), layered perovskites, Bi4−xLaxTi3O12 (0.0 ≤ <I>x</I> ≤ 0.75: Aurivillius phases) and CsBi1−xEuxNb2O7 (0.0 ≤ <I>x</I> ≤ 0.2: Dion–Jacobson phases), calcium bismuth oxides, Ca4Bi6−xLnxO13 (Ln = La and Eu; <I>x</I> = 0, 0.06 and 0.12), and sodium lanthanide iodates, NaLa1−xLnx(IO3)4 (Ln = Sm and Eu; 0 ≤ <I>x</I> ≤ 1). The origin of SHG for all the NCS solid solutions is discussed and the detailed structure–nonlinear optical (NLO) property relationships are elucidated. In addition, photoluminescence (PL) properties and subsequent energy transfer mechanisms for NCS solid solutions are provided.</P></▼2>