원문 : 저항성 운동이 노화 흰쥐 해마 및 소뇌의 신경가소성 인자 발현 및 미세구조와 신경학적 기능에 미치는 영향

김종오 ( Jong Oh Kim ),윤진환 ( Jin Hwan Yoon ) 한국운동생리학회(구 한국운동과학회) 2014 운동과학 Vol.23 No.3

김종오, 윤진환. 저항성 운동이 노화 흰쥐 해마 및 소뇌의 신경가소성 인자 발현 및 미세구조와 신경학적 기능에 미치는 영향. 운동과학, 제23권 제3호, 217-228, 2014. 본 연구는 노화로 인해 나타나는 기억력 감소와 균형감각의 저하를 저항성 운동이 지연시킬 수 있는지와 그 기전을 밝힘으로써, 노인운동처방학적 운동기전을 제시하고자 하는데 있다. 이러한 목적을 달성하기 위해 노화 흰쥐를 대상으로 tower climbing 운동을 12주간 실시한 후 신경기능학적 향상, 신경가소성 인자인 BDNF, TrkB의 발현 증가와 시냅스 관련 단백질인 synapsin I의 발현을 유도할 수 있는 지와 해마의 연접형성수준의 증가에 어떠한 영향을 미치는 지를 확인하고자 하였다. 본 연구에 이용된 실험동물은 Sprague-Dawley 계열의 노화 흰쥐 72주령 수컷과 대조군으로 10주령 수컷이 이용되었으며, 이들은 실험 전 일주일 동안 운동 환경에 대한 적응기간을 거친 후, 무작위 표본추출에 의하여 노화 쥐는 노화 대조군(aging control group, ACG; n=15)과 노화 운동군(aging and exercise-trained group, AEG; n=15)으로 분류되었고, 10주령의 정상 대조군(normal control group, NCG; n=15)이 비교군으로 이용되었다. 저항성 운동은 tower climbing protocol을 이용하여 1일 약 30분씩 3회(09시, 14시, 20시) 12주 동안 훈련시켰다. 공간학습과 기억력과 균형감각과 신경학적 기능평가는 Morris water maze와 balance beam 검사가 이용되었고, BDNF, TrkB와 synapsin I과 같은 단백질 분석은 Western blotting 방법이 이용되었다. 또한, 해마부위 연접형성수준의 변화는 투과전자현미경(TEM)적 관찰을 통해 확인하였다. 그 결과 본 연구에 수행된 저항성 운동인 tower climbing 운동의 12주간 훈련은 노화로 인해 해마, 소뇌 부위의 신경 및 연접가소성인자 감소로 인해 저하된 공간학습기억능력과 평형감각기능을 지연시키는데 효과적인 운동임을 확인할 수 있었던 연구이다. Kim, Jong-Oh, Yoon, Jin-Hwan. Effects of Resistance Exercise on Synaptic Plasticity Factor, Ultrastructural and Neurologic-Function in Hippocampus and Cerebellum of Aging Rats. Exercise Science, 23(3): 217-228, 2014. Aging results in cognitive and balance decline both in humans and animals. Neurogenesis in the hippocampus and cerebellum also declines with age. Traditionally, exercise has been used for the treatment of several neuro degenerative disorders. Thus, the purpose of this study was to investigate the effects of resistance exercise on spatial learning memory ability, the synapses and the synaptic-plasticity neurotrophic factor in hippocampus and cerebellum in aged-rats. The experimental animals were divided into three groups (n=15 in each group): the normal control group (NCG), the aging control group (ACG), the aging and exercise-trained group (AEG). Animals in the exercise group were performed to daily exercise on the tower climbing during 12 weeks. The spatial learning and memory capability was evaluated by Morris water maze in a separate set of rats. Also, the balance function was evaluated by Balance beam test. Western blotting analysis for the expression of BDNF, TrkB and synapsin I was performed. Electron microscopy were used to evaluate synaptic plasticity and quantitative electron microscopy was used to investigate morphological changes in the hippocampus. Measurements taken from analysis of the electron micrograph sets were used to calculate the spine synapses in hippocampus. Here in this study, it have shown that both synaptic plasticity neurotrophic factor expression and spine synapses were suppressed in aged-rat, whereas tower climbing exercise alleviated the aging-induced suppression of both synaptic-plasticity neurotrophic factor expression and spine synapses in the hippocampus of rats. The results of the present study indicate that tower climbing exercise may facilitate recovery from the CNS complications associated with aging by inducing enhanced the morphological development of synapses in the hippocampus via the augmentation of synaptic plasticity neurotrophic factor expression in the h ippocampus a nd t he cerebel l um.

15番 空間群의 6가지 다른 表現

吳美蘭,金勁翰,李珍昊,徐日煥 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2

The space group number 15 can be expressed in six different ways as C2/c, A2/a, A2/n, C2/n, I2/a, and I2/c according to the setting of unit cell axes. The International Union of Crystallography has chosen C2/c for a standard space group of the space group number 15. In this paper, it has been shown that the six space groups are mutually transformed.

와동형태의 설계에 따라 치아에 발생되는 응력의 변화에 관한 연구 : 인레이의 경우

오세윤,김웅철,김지환,유진호 高麗大學校 倂設 保健大學 保健科學硏究所 1995 保建科學硏究論集 Vol.4 No.1

Because of the anatomical form of posterior teeth, the amount of tooth reduction near the marginal ridge area in the typical, widely used intracoronal cavity will be inevitably maximal, while occlusal forces on the restoration in this area will be relatively minimal In an attempt to dicrease the amount of tooth reduction at the marginal ridge area, a modified cavity for inlay with a uniform depth of 15mm, just as in amalgam filling was designed in this study. To analize the stress development in the teeth in that cavity design, 2㎏/㎟ distributive forces were applied on the inlay restoratives and obtained results were compared with that in the typical cavity design which had a flat pulpal wall with a depth of 1.5m at the central fossa area. Analysis was done with two dimensional finite technique. The obtained results were as follows : 1. The patterns of stress distribution and displacement showed no apparent differences. 2. The stress values and the amount of displacement developed, both in inlay cast gold and in the teeth, in the cavity with a uniform depth were less than that in the cavity with a flat pulpal wall. 3. Greatest maximum principle values were concentrated around the interface between the base of inlay body and the teeth.

고속회전 하는 정밀부품을 위한 연질/경질 코팅의 트라이볼로지적 특성에 관한 연구

오진규,정구현,김대은,유제환,김형재 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

Recently, rotating elements which use mechanical and electrical systems have been utilized for high speed and accuracy to increase the performance. The most important thing to get a more reliable system is to understand the friction, wear and characteristics which has an effect on various coated surfaces. In this study, the tribological characteristics of various soft/hard materials were investigated by using a custom-built pin-on-reciprocator tester. From the experimental results, it was found that the friction coefficients of the soft material coated surfaces were lower under various normal loads due to thier self-lubricating ability and material transfer to the counter surface.

친환경농업 농가 컨설팅에 대한 반응 조사

오환중,차광홍,정우진,김길용,박노동 全南大學校 農業科學技術硏究所 2011 農業科學技術硏究 Vol.46 No.-

The interactions between Environment-Friendly Agriculture Research Center (EFARC) and farmers in Jeonnam Province area who have practiced environment-friendly agriculture (EFA) under guidances of EFARC were investigated through enquete. The enquete was conducted during July - September, 2010. One hundred and eighty nine farmers responded all inquiries among 200 farmers. The main results are summarized as follows: 1. Rice was the predominant crop grown by farmers (49%), and the next major was hot pepper (12%). Most farmers (95.3%) have practiced environment-friendly agriculture at the levels of no-pesticide (55.6%), lower pesticide (32.8%), and organic (6.9%). 2. Major motivations of practicing EFA are for the production of safe foodstuffs (52.6%) and for an increase of income (40.1%). 3. Around 3 quarters of the environment-friendly agriculture products are shipped through Nonghyup, the cooperative marketing. The price margin between ordinary agriculture products and EFA products was of 5~10% for 63.5% farmers, of 10~20% for 14.3% ones, and of 20~30% for 14.8% ones. 4. Bottlenecks for practicing EFA are in the order of the unstability of shipping price (34.9%), cultivation techniques (20.1%), excess labor input (19.6%), and control of disease and insect pest (18%). 5. It turned out that more than 90% farmers who have practiced EFA under guidance of EFARC recognized the consulting activities of EFARC as to be helpful for them. 6. Establishment of national organizations which are specialized in consultation for EFApracticing farmers has been suggested.

악안면 골격 형태에 따른 교합평면각의 변화에 관한 두부 방사선학적 연구

오세윤,김웅철,김지환,이준석,김진완,유진호,김태석 高麗大學校 倂設 保健大學 保健科學硏究所 1999 保健科學論集 Vol.25 No.1

A correlation analysis was made to understand the interaction between the growth patterns of some craniofacial skeletal components and occlusal plane inclination. 5 angular measurements(S.a. Ar.a, Go.a, UGo.a, LGo.a), 6 linear measurements(ACBL, PCBL, RH. MBL. AFH. PFH) and OP/SN. obtained from 83 cephalometric tracing records, were selected and the relationship between the occlusal plane angle and those measurements were analyzed statistically. Ramus Height(r=-0.55), Posterior Facial Height(r=-0.41), were found to be negatively related with Occlusal Plane angle, while Lower Gonial angle(r= 0.35), Saddle angle(r= 0.24) were found to be positively related with Occlusal Plane angle(p(0.05). The results obtained from the above analysis were further assessed with stepwise regression analysis, using Occlusal Plane angle as a dependant variable, and RH, LGo.a and S.a as explanatory variables. Stepwise regression analysis revealed that all the explanatory variables were found to be significant.(p<0.05) [OP/SN] = -8.74-0.33(RH)+0.23(S.a)+0.20(LGo.a). (R²=0.44). This stepwise regression analysis explains, to some extent, the relationship between the growth patterns of some craniofacial skeletal components and the occlusal plane inclination. 1. The inclination of Occlusal Plane angle is noticeably related with the growth patterns of some craniofacial skeletal components, i.e. RH, PFH, Saddle angle and Lower Gonial angle 2. In high Occlusal Plane angle, the Ram us Height tends to be shorter, and the Saddle angle and Lower Gonial angle tend to be obtuse.

압력용기의 설계기준 및 손상 평가

오환섭,정효진,박상필,손두익 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

The damage of the pressure courage by degradation can become the reason of unexpected break down or failure accident and it is very important because safety accident, the production loss, environmental pollution, social problems are occur. Consequently The result to investigat of failure accident for domestic pressure vessel, the factor of degradation is SCC, Sorrosion, Cavity, Crack

절골술을 이용한 안면교정

오석희,한기환,강진성 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.5

The most important factor in the beauty of the face is the harmony of the facial skeleton and soft tissue. The postoperative result is not always satisfying after only classic soft tissue surgery. The reason for dissatisfaction is disharmony of the facial skeleton. Recently, the development of maxillofacial surgical techniques enable disharmony of the facial skeleton to be successfully corrected. The authors have had experience with 33 cases of congenital and acquired facial deformities, from March of 1986 to February of 1989, and have followed them from 6 months to 2 years. We used an intraoral approach in most cases and got good results. There were four wound disruptions which were treated conservatively and resolved without sequelae.

공주 공산성 원형연못의 지반에 대한 탄성파 굴절법 탐사

오진용,변성환,서만철 공주대학교 문화재보존과학연구소 2004 문화재과학기술 Vol.3 No.1

탄성파 탐사는 인공지진파를 이용하여 지표면 하부의 물성을 알아내는 지구물리탐사로서 20세기 초부터 석유탐사와 공학적 지반조사에 가장 널리 사용되었다. 굴절법 탄성파 탐사는 지층의 탄성파 속도를 알아내는 방법으로서 최근에는 석조문화재 등의 지반특성 조사에서 사용된 예가 있다. 이번 연구에서는 공주 공산성의 쌍수정 광장에 위치하는 공산성 원형연못 주변의 지반에 대하여 굴절법 탐사를 실시하였다. 쌍수정 광장은 기본의 발굴조사를 통하여 백제 추정왕궁지가 위치한 곳으로 알려졌으며, 광장 남쪽에 원형연못(상면직경 7.3m, 바닥직경 4.78m, 높이 3m)도 발굴되었다. 원형연못 주변에 5개 탄성파 측선을 설치하였고, 해머 타격점과 수신기 배열을 3가지 다른 방식을 적용하여 24m, 31m, 48m 측선길이의 굴절법 자료를 얻었다. 대체로 공산성 원형연못 주변의 지반은 3개 층으로 구성되어 있다. 각 층의 겉보기 속도는 약 261~391 m/s, 약 591~992m/s, 약 1950~3230 m/s이며, 첫 번째와 두 번째 측의 두께는 각각 약 2~2.4m 와 4.6~8.6m이다. 일반적으로 최하부 층의 속도는 기반암, 상부층들이 속도는 풍화토에 대응한다. 그러나 두 번째 층이 주시곡선 형태와 속도 범위는 국내 석탑 문화재 하부의 것과 유사한 것으로 보아 공산성 연못 주변은 인공적인 기초지반의 가능성을 제기하며, 그렇다면 공산성 원형연못은 파내려 간 것보다는 쌓아 올렸을 것이다. Seismic survey using artificial earthquake waves is one of the most popular geophysical method for petroleum exploration and engineering prospecting from the early 20th century. Recently seismic refraction method which can reveal the sub-surface velocity structure is introduced for the site characterization of the domestic stone pagodas. The purpose of this study is to understand seismic velocity structures of the underground near the Kongsansung Cirular Pond at the southern part of the Ssangsujung Park in Gongju. As the result of early excavations, the Ssangsujung Park has been known as the assumed site of the Palace of the Paekje Dynasty and Circular Pond (top diameter 7.3 m, bottom diameter 4.78m, and height 3m) was also discovered. Along 3 seismic lines near the Circular Pond, three kinds of source-receiver array are applied to obtain the refraction data with the corresponding maximum offset of 24m, 31m, and 48m. Shallow subsurface near the Circular Pond largely consists of three layers with the velocities of about 261~392 m/s, about 591~992 m/s, about 1950~3230 m/s, respectively. Upper two layers have the thickness of about 2~2.4 m and about 2.6~8.6 m each. In general, the bottom layer can be interpreted to the basement, and the upper layers with the lower velocities can be correlated to the weathered soil. Compared with the pattern of the traveltime-distance graph and the range of the velocities of the site near domestic stone pagodas, however, the middle layer can be interpreted as the artificial foundation. Consequently, the Kongsansung Circular Pond is possibly built upwardly rather than digging.

운동형태의 차이가 Alloxan유발 당뇨쥐의 혈당 및 인슐린 농도에 미치는 영향

윤진환,정일규,김종오,이희혁,지용석,오봉석,채정룡 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.1

The Purpose of this study was to investigate the effect of exercise intensity on blood glucose and insulin levels in diabetic rats with alloxan. Twenty sprague-dawley male rats were assigned to power training groups(n=10) and endurance training groups(n=10). Diabetes was induced by single injection of alloxan(50 mg/kg B.W) Blood glucose and insulin were determined every week for 4-weeks. The conclusion of this study follows as below: 1) There was significantly different on blood glucose levels in two groups. 2) There was significantly different on insulin levels in two groups These results suggest that proper exercise intensity in diabetic rats can significantly decrease blood glucose and insulin level and make good glycemic control. In conclusion, it has been found that regular prolonged endurance training with diabetic rats, improves insulin and blood glucose.