Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study

Choi, You-Jung,Choi, Eue-Keun,Han, Kyung-Do,Jung, Jin-Hyung,Park, Jiesuck,Lee, Euijae,Choe, Wonseok,Lee, So-Ryoung,Cha, Myung-Jin,Lim, Woo-Hyun,Oh, Seil Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.273 No.-

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atrial fibrillation (AF) and stroke are common in hypertrophic cardiomyopathy (HCM). We aimed to determine the prevalence and incidence of AF and stroke in patients with HCM during a 10-year period.</P> <P><B>Methods</B></P> <P>Using the Korean National Health Insurance Services database, we identified patients diagnosed with HCM from the entire Korean population between 2005 and 2015. The annual prevalence and incidence of AF and stroke in HCM patients were estimated.</P> <P><B>Results</B></P> <P>The prevalence of AF in HCM patients has gradually increased to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. The incidence of AF ranged from 4.1 to 5.5%, a similar trend was observed for each year in HCM patients. The prevalence of stroke in HCM patients was approximately 10%, while that in HCM patients with AF was about 20%. During 8741 person-years, AF-related stroke occurred in 257 subjects among 2309 HCM patients with new-onset AF. The overall incidence rate of AF-associated stroke was 2.94 per 100 person-years. In subgroup analysis, the incidence rate of AF-associated stroke was 1.49 per 100 person-years in the under 45 year-old group and 1.48 per 100 person-years in the group with CHA<SUB>2</SUB>DS<SUB>2</SUB>­VASc score of 0 or 1 point in HCM patients.</P> <P><B>Conclusions</B></P> <P>The prevalence of AF in HCM patients gradually increased over 10 years. The annual risk of AF-associated stroke in HCM was over 1% even in younger patients and those with CHA<SUB>2</SUB>DS<SUB>2</SUB>­VASc score of 0 or 1 point, which provide evidence to support the prevention of stroke in HCM patients with AF.</P> <P><B>Highlights</B></P> <P> <UL> <LI> This is the first largest nationwide study on hypertrophic cardiomyopathy (HCM), a rare myocardial disease in Korea. </LI> <LI> The prevalence of AF in HCM patients gradually increases to 1.6-fold from 13.4% in 2005 to 20.9% in 2015. </LI> <LI> The annual incidence of AF in HMC patients was about 5%, and higher in female and the elderly. </LI> <LI> The prevalence of stroke in HCM patients with AF was about 20%, which were more than twice that in overall HCM patients. </LI> <LI> The risk of AF-related stroke in HCM patients was >1% per person-year even in younger patients or low CHA<SUB>2</SUB>DS<SUB>2</SUB>­VAS<SUB>C</SUB> score. </LI> </UL> </P>

Diisobutyldiisobutylaminoalane에 의한 유기작용기의 선택환원

차진순,이광우 嶺南大學校 基礎科學 硏究所 1998 基礎科學硏究 Vol.18 No.-

The reducing characteristics of diisobutyldiisobutylaminoalane (DIBAN Bu₂) as a chemoselective reducing agent in the reduction of carbony1 compounds, have been studied systematically. Aldehydes are smoothly reduced to the corresponding alcohols by diisobutyldiisobutylaminoalane in ether solution with excellent purity.

쇠고기육중의 방사선 유래 휘발성물질의 분석

차용준,박지영,김훈,박승영,조우진,송양순,유영재 창원대학교 생활과학연구소 2000 생활과학연구 Vol.4 No.-

This study was conducted to identify irradiation-derived volatile components, having positive-correlation with irradiation doses, which may play roles as maker materials for detecting post-irradiation in pork meat. The volatile components of irradiated(0, 1, 3, 5 and 10 kGy doses) pork(Belly) meat was analyzed by liquid liquid continuous extraction(LLCE)/GC/MSD methods. By the results of linear regression analysis between irradiation doses and volatile component amounts in fresh pork, 3 compounds including γ-octalactone(r=0.82), 1-octen-3-ol(r=0.90) and butanoic acid(r=0.81) had high correlations with irradiation doses.

1-Pyrrolyldiisobutylalane에 의한 유기화합물의 선택환원

차진순,이광우 嶺南大學校基礎科學硏究所 2002 基礎科學硏究 Vol.22 No.-

The reducing characteristics of 1-pyrrolyldiisobutylalane (DIBAPyr) as a selective reducing agent in the reduction of organic compounds have been studied systematically. Aldehydes and ketones are rapidly reduced to the corresponding alcohols by DIBAPyr in ether solution with excellent purity. Epoxides and acid chlorides are converted to the corresponding alcohols. Finally, carboxylic acids and alkenes are essentially inert to DIBAPyr.

양수 다발성 수지 재접합수의 치험례 : 4 cases report

차진한,박명철,김우경,한근태,김수신,백세민 大韓成形外科學會 1990 Archives of Plastic Surgery Vol.17 No.2

Since the first successful replantation operation, several reports have been recorded replantated finger survival with high success rates. But ten and nine digits amputations are not common. It is even more unusual to have all digits suitable for replantation. 4 cases are presented where replantation of ten and nine digits were done at the department of PRS. Guro Hospital, Korea University from March 1987 to Jun 1988. In these cases, the patients were young and healthy, all of ten and nine digits were sharply amputed near the proximal phalanx, so a replantation team of 8 surgeons in alternating fashion replanted all ten and nine digits over 30 hours and each patient received 28 pints of whole blood during the procedure. Under general anesthesia, replantatin of both started simultaneously. All digits survived completely except partial necosis of right little finger in case 1. The ischemic time of each digit ranged from 4 hours and 45 minutes to 31 hours as shown in table 5. The long ischemic time did not criticaly affected the survival of amputated digit. Follow-up was from 12 months to 20 months postoperatively. The functional evaluation revealed as follows: 1. The grasping power ranged 13 lb to 65 lb(average;39.7lb) 2. The pinching power with index finger ranged 5 lb to 15 lb(average:10.2 lb) 3. The palm to pulp distance ranged 0 cm to 6 cm.(average;2.2cm) 4. The two point discrimination ranged 2.5mm to 22mm.(average;7.8mm) 5. The shape of digits were acceptable aesthetically. 6. All 4 patients were able to use both hands well in all activities of daily living.

Orthopantomography에 依한 過剩齒와 先天性 缺捐齒의 發生頻度에 關한 考察

車文豪,金泰鎭,禹元燮 大韓小兒齒科學會 1975 大韓小兒齒科學會誌 Vol.2 No.1

We observed the orthopantomography taken by 800 children who came to our pedodontic department, School of Dntistry, S.N.U. and also got the incidence of supernumerary and congenital missing teeth as follows. ① The children who had supernumerary or congenital missing teeth were 9.75% of all. ② In incidence of supernumerary teeth, male was 0.50% higher than female ③ Incidence of conginital missing teeth was 7.0% and male was 1.0% higher than female. ④ Incidence of congeintal missing teeth was mainly arised from mandible.

골격성 3급 부정교합 환자의 하악 소구치 발치를 통한 임상적 고찰

이진우,차경석 단국대학교 치의학연구소 1994 논문집 Vol.6 No.1

True Class Ⅲ malocclusions are difficult to treat because they reflect basal bone discrepancies and there are many limitations to conventional treatment mechanisms. The amount and the timing of growth of the mandible and maxilla cannot be assessed accurately, we cannot consider a Class Ⅲ malocclusion fully resolved until facial growth has ended. Since many of the conventional treatment procedures have limitations, we should consider the use of orthopedic appliance because appropriate force systems can be placed on the basal bone. Most Class Ⅲ malocclusions can be treated with orthodontic treatment only, but some require orthodontic treatment and surgery. Two valuable measurements to determine which procedure to use are the ANB angle and the Frankfort-mandibular angle (FMA). For many Class Ⅲ malocclusion, surgical treatment is the best alternative. Depending on the amount of skeletal discrepancy, surgical correction may consist of mandibular shortening, maxillary lengthening, or a combination of mandibular and maxillary procedures, however, there are still associated surgical risks and complications that must be considered, as well as the increased expense. Mandibualr premolar extraction treatment approach is a viable alterative in carefully selected skeletal class Ⅲ cases. This is certainly not a new approach to treatment of a Class Ⅲ case as this type of treatment was commonly used before the advent of orthognathic surgery. Some important factors to consider when estabilishing a Class Ⅲ molar relationship. The one must accept the potential sacrifice of the upper second and third molars unless the lower third molars erupt into occlusion. Maxillary first molar occludes with the mandibular second molar to the maxillary second molar occlude with mandibular third molars may erupt into occlusion at a later time. Detailing of the occlusion, especially in the upper second premolar-lower first molar area is very important, Given the risk of general anesthesia, trauma to the jaws, and possible risk to joint function that is often present in surgical treatment, I believe this treatment approach is a viable alternative in carefully Selected skeletal Class Ⅲ cases.

정상 교합을 나타내는 한국인 성인의 EMG특성에 관한 연구

이진우,차경석 단국대학교 치의학연구소 1994 단국대치의학연구소논문집 Vol.6 No.1

Angle Ⅱ級 不正交合者의 顎顔面骨格 特性에 關한 硏究

李鎭宇,車敬石 단국대학교 치의학연구소 1990 논문집 Vol.2 No.-

This investigation was designed to categorize Angle's class Ⅱ malocclusion groups through analyzing horizontal and vertical components of craniofacial skeleton in Angle's class Ⅱ malocclusion. The material selected for this study consisted in standard lateral cephalogram of two hundred and twenteen children, eighty eight boys and one hundred twenty four girls, aged 6 through 18 years, having Angle's class Ⅱ malocclusion. On the basis of findings of this study, the following results were obtained. 1. In horizontal skeletal classifications, 16 groups were classified according to FMN-A-B, SE-FMN-A, Ba-SEM-Me, Ba-Se/Ra P. The sequences that have relatively high frequency are as follows: a) Horizontal Group 16 b) Horizontal Group 12 c) Horizontal Group 13 d) Horizontal Group 9 & 15 2. In vertical skeletal classification, 8 groups were classified according to the PMV/PP, PMV/Occ. P. PMV/Mn. P. The sequences that relatively high frequency are as follows; a) Vertical Group A b) Vertical Group D c) Vertical Group C d) Vertical Group H 3. In vertical and horizontal skeletal classifications, the sequence that relatively high frequency are as follows; a) Group 13-A b) Group 16-A & 9-A c) Group 12-A & 15-A d) Group 16-C

청소년자녀와 어머니를 위한 세대간 이해증진 프로그램 개발 및 실시

김명자,이정우,계선자,박미선,송말희,김경아,박수선,유을용,정진희 대한가정학회 2003 Human Ecology Research(HER) Vol.41 No.1

The relationship between adolescent children and parents has a profound effect on not only the adolescents development into healthy adults but also the psychological welfare of the parent. A program focused to improve adolescents relationship with parents has not been developed until now. To achieve the educational goals enhancing mutual understanding, it is more effective to educate both the parents and adolescent childern. Thus, this study developed and carried out a program in which adolescent children and mothers, being fully in charge of raising children, participated. The study analyzed the program effects after implementing on 6 pairs of adolescent children and mothers. The results are as follows: 1) adolescent children and mothers placed high values on the fact that they can understand each other well, 2) both parties accepted each other by recognizing the inevitability of the generation gap, and 3) the program gave them a chance to admit that they should try to communicate openly. Most of all, adolescent children could find self-confidence while mothers could collect valuable data essential to raise children and build a new mother's role model adapting to social changes.