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허명진(Myeong Jin Huh) 한국언어치료학회 2015 言語治療硏究 Vol.24 No.1
Purpose: Hearing children can talk by recognizing the speech of another speaker. Hearing impaired children can develop correct articulation through having a cochlear implant. Previous studies looked at various background factors to speech recognition ability for cochlear implanted (CI) people, including chronological age, age at cochlear implantation, hearing period with CI, and language age. The purpose of this study was to find the background factors affecting articulation production when CI people speak. Methods: Forty-nine CI people who have had speech processor cochlear implants for at least one year and who are without other problems such as mental disorders or autisum participated in the study. To collect the speech samples, U-Tap and receptive language ability tests were used. All data was subjected to one-way ANOVA and multiple regression analysis. Results: The results show that correct articulation on CI people was about 80% and was affected by the background factors of hearing periods and language age. That is, when hearing periods were longer, correct articulation increased. Language age showed the same results as hearing period. At chronological age, correct articulation scores of 4-7 year-old children were higher than children older than seven. When age at CI operation was lower, correct articulation scores were higher. However, the most influential background factor to articulation production was language age and hearing period with CI. Conclusions: People with cochlear implants improved their articulation production, but showed little improvement above the age of seven. These findings could be due to the limited acoustic range of cochlear implants and lack of auditory nerves in hearing impaired people. Among background factors of CI people, hearing age with CI and language age play important roles in articulation production.
음폐수 이용 혐기성 소화의 내부 pH 조절에 따른 바이오가스 전환율 비교 및 미생물 군집도 분석
윤여명(Yeo Myeong Yun),조시경(Si Kyung Cho),정다영(Da Young Jeong),이은진(Eun Jin Lee),허관용(Kwan Yong Huh),신동혁(Dong Hyuk Shin),이창규(Chang Kyu Lee),신항식(Hang Sik Shin) 大韓環境工學會 2013 대한환경공학회지 Vol.35 No.8
본 연구에서는 음폐수를 이용 낮은 유기물 부하율에서 소화조 내부 pH 조절 유무에 따른 소화조 운전의 바이오가스 발생량 및 미생물 군집도 변화에 대한 비교 분석했다. 그 결과, 내부 pH를 조절하지 않은 반응조는 pH, Free ammonia, Volatile fatty acid의 증가에 의한 반응조 안정성이 떨어짐에도 불구하고 내부 pH 조절 반응조와 비슷한 바이오가스 전환율을 보였다. 이는 미생물 군집도 분석 결과에 따르면 외부환경에 대한 내성이 강한 Methanosarcina sp.의 우점에 의해 반응조의 안정성을 유지할 수 있었던 것으로 나타났다. In this study, the performance and microbial community of anaerobic digestion fed by food waste leachate at low organic loading rate were investigated with and without internal pH control. Experimental results show that similar biogas yield was achieved in both reactors regardless of increase in pH, the concentrations of free ammonia and volatile fatty acids in case of without internal pH controlled one. The results of a methanogenic community analysis by Polymerase Chain Reaction and Denaturing Gradient Gel Electrophoresis revealed that the apparent preponderance of Methanosarcina sp. could be one of reasons for the maintenance of reactor stability.
Clinical significance of coagulation factors in operable colorectal cancer
Lee, Suee,Huh, Seok Jae,Oh, Sung Yong,Koh, Myeong Seok,Kim, Sung-Hyun,Lee, Ji Hyun,Han, Jin Young,Choi, Hong Jo,Kim, Su Jin,Kim, Hyo-Jin D.A. Spandidos 2017 Oncology letters Vol.13 No.6
<P>Abnormal hemostasis in cancer patients has prev iously been studied. The primary objective of the present study was to evaluate the association between preoperative hemostasis markers and clinicopathological parameters, and to identify a hemostasis marker affecting survival in patients following curative resection for colorectal cancer. A total of 170 patients who underwent curative surgery for colorectal carcinoma were evaluated. Preoperative coagulation tests included platelet, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, D-dimer and fibrinogen degradation product (FDP). The clinicopathological variables, including age, gender, tumor location (rectum/colon), tumor size (≥5 cm vs. <5 cm), depth of tumor invasion, lymph node metastasis, stage, lymphovascular invasion, margin involvement and histological differentiation were analyzed. The median age of analyzed patients was 63 years (range, 28–84). The male to female ratio was 62:38. Increased levels of plasma fibrinogen, PT and platelet count (PLT) were associated with larger tumor size (P<0.001, P=0.015 and P=0.002, respectively). Increased plasma fibrinogen levels were significantly associated with depth of tumor invasion and stage (P=0.014 and P=0.048, respectively). Increased plasma D-dimer and FDP levels were significantly associated with tumor node metastasis stage (P=0.031 and P=0.002, respectively). Prolonged PT level (≥11.7 sec), hyper-fibrinogenemia (≥327 mg/dl), high D-dimer level (≥1.3 µg/ml) and increased FDP level (≥2.7 µg/ml) were the prognostic factors associated with shorter survival. Preoperative plasma fibrinogen level was significantly associated with tumor size and depth of tumor invasion. Preoperative plasma prolonged PT level, hyperfibrinogenemia, high D-dimer level and increased FDP level may function as hemostasis markers that predict overall survival in operable patients with colorectal cancer.</P>
Sang-Rae Lee,Kang-Jin Jeong,Sang-Hyun Kim,Keun-Su Kim,Sung-Jin Kim,Young-Hyun Kim,Jae-Won Huh,Ekyune Kim,Myeong-Su Kim,Jun-Gyo Suh,Kyu-Tae Chang 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.4
A low endotoxic Outer membrane vesicles (OMVs) vaccine platform was established with an msbB genedeleted (ΔmsbB) Salmonella enteritidis mutant. The Salmonella ΔmsbB mutant displayed lipopolysaccharide phenotypic changes showing faster migration of the lipid A-core region in an SDS-PAGE analysis and the increased amount of penta-acyl lipid A due to the MsbB deficiency. In an endotoxicity assay, BALB/c mice injected intraperitoneally with the Salmonella ΔmsbB mutant survived for 10 days, whereas mice injected intraperitoneally with the wild type survived for 5 days. Also, all mice inoculated orally with the ΔmsbB mutant survived for 30 days but 70% of mice inoculated orally with wild type survived. Electron microscopically, the Salmonella ΔmsbB mutant produced a larger amount of OMVs than the wild type. In immunogenicity tests, all sera from mice groups immunized with the wild type, ΔmsbB mutant, and their OMVs, showed significantly higher IgG levels. This result was consistent with higher bactericidal activities against wild type S. enteritidis, compared to the negative control. However, there were no significant differences in serum IgG levels and the bactericidal activities of the immune sera between the four mice groups. The viable counts of S. enteritidis recovered from the spleen and liver of four preimmunized mice groups after 5 days of the bacterial challenge showed significant reductions of the live bacteria. Conclusively, the ΔmsbB mutant of S. enteritidis produced relatively low endotoxic OMVs, which was verified in this study for its potential to be a non-replicating Salmonella vaccine candidate.