진해지역 도시관급수불화사업효과에 관한 조사연구

이충섭,성진효,김동기 ( Choong Sub Lee,Jin Hyo Seong,Dong Kie Kim ) 대한예방치과·구강보건학회 1996 大韓口腔保健學會誌 Vol.20 No.2

Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향

김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.

Actinobacillus actinomycetemcomitans의 Lipopolysaccharide에 대한 단클론항체의 제작 및 특성

성진효,이영종,김동기,장기완 대한구강보건학회 2003 大韓口腔保健學會誌 Vol.27 No.4

Actinobacillus actinomycetemcomitans(A.actinomyceremcomitans), a nonmotile, gram negative facultative anaerobic coccobacillus, is supposed to be an important etiological agent in localized juvenile periodontitis and associated with adult type periodontitis. Lipopolysaccharide(LPS) is one of the various virulent factors of A. actinomycetemcomitans and can directly or indirectly cause destruction of periodontal tissue. The purpose of this study was to produce and characterize the monoclonal antibody to LPS of A.actinomycetemcomitans. The results were as follows; 1. The LPS yield of A. actinomycetemcomitans was 0.7% based on dry cell weight. 2. The antibody titers of immuninzed serum with 5.2 × 10^(8) bacteria were 1:64,000 to whole cells and 1:8,000 to LPS. 3. From three times of cloning the antibody producing hybridomas using limitation dilution method, ten monoclones producing monoclonal antibody to LPS of A.actinomycetemcomitans were obtained. 4. Ten monoclonal antibodies to LPS of A. actinomycetemcomitans were not found to cross-react with LPS of Escherichia coli(E. coli). These results indicate that the monoclonal antibody to LPS of A. actinomycetemcomitans was specific for A. actinomycetemcomitans.

알쯔하이머형 치매환자 뇌파의 시공간적 패턴분석 : Karhunen-Loeve 방법을 통한 뇌파분석의 임상적용을 위한 예비연구

고효진,김형래,김대진,김수용,박성종 대한신경정신의학회 2000 신경정신의학 Vol.39 No.2

연구목적: 뇌파의 시공간적 패턴분석(spatio-temporal pattern analysis)방법을 이용하여 알쯔하이머형 치매의 진단 특히 초기 치매환자의 진단에 대한 예비연구를 하고자 하였다. 방법: 알쯔하이머형 치매환자 10명과 정상대조군 10명을 대상으로 하여 Karhunen-Loeve 분해법을 이용한 시공간적 패턴분석을 통하여 비교하였다. 결과: 첫째, 세가지 주요패턴 중 가장 많은 빈도를 보인 으뜸패턴에서 알쯔하이머형 치매환자는 좌우측 비대 칭성이 정상대조군에 비해 뚜렷해지는 형태를 보였다. 둘째, 으뜸패턴을 비교하여 뇌의 각 부분에 대한 차이를 보았을 때 알쯔하이머형 치매환자는 대조군에 비해 주로 좌측 두정부와 측두엽 부위에서 고유값의 유의한 차이가 있었다. 셋째, 으뜸패턴 전개계수의 Fourier amplitued spectrum 분석을 통하여 알쯔하이머형 치매환자 10명중 6명에서 상당히 큰 진폭의 상승부분을 관찰할 수 있었으며 정상대조군에서는 이러한 진폭의 이상소견이 관찰되지 않았다. 결론: 본 연구의 결과는 알쯔하이머형 치매으 병태생리적 위치가 좌측 측두-두정엽에 있음을 시사하였으며 앞으로 시공간적 패턴분석 방법이 알쯔하이머형 치매환자의 진단에 유용하게 사용될 수 있도록 추후연구가 필요할 것으로 생각하였다. Objectives: We introduce a novel analysis method of spatio-temporal pattern analysis of EEG. Using it, we presents a results discriminating severe Alzheimer's disease patients from normal subjects. Methods: To the groups of 10 Alzheimer's disease patients and 10 normal aged subjects, we applied the Karhunen-Loeve decomposition method and observed their principal patterns and time-varying dynamics. Results: First, there was a first primaty pattern of the eigenvector in Alzheimer's disease patients that showed opposite polarities at the left and the right hemispheric regions. Second, the Alzheimer's disease patients had significantly different average values of the eigenvector at the left parieto-temporal area than the normal controls did. Third, some Alzheimer's disease patients had one, coherent frequency component in the Fourier amplitude spectrum of the first pattern expansion coefficient. Conclusions: Our results suggest that the pathophysiologic site of Alzheimer's dementia may be left temporo-parietal area in brain and further studies need to evaluate whether the spatio-temoral pattern analysis could be used to diagnose Alzheimer's dementia patients.

구개부에 발생한 다형성선종의 치험례

이창진,김태열,김효언,김희광,전인성,윤규호 대한악안면성형재건외과학회 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.2

Pleomorphic adenoma is the most common of all salivary gland tumors, constituting over 50 per cent of all cases of tumors, and approximately 90 per cent of all benign salivary gland tumors. Since the term mixed tumor' was introduced by Broca for its dual origin of epithelial and mesenchymal elements, the term plemorphic adenoma suggested by Willis characterizes closely the unusual histologic pattern of the lesion. The parotid gland is the most common site but it may occur in any of the salivary glands. It is somewhat more frequent in women and in the fourth to sixth decades, but they are also relatively common in young adult and have been known to occur in children. Treatment of choice is surgical excision. Adequate surgery with safe margin reduce its recurrence rate. We represent a case of pleomorphic adenoma with literature review in 65-year old male occured in the palate. The lesion was successfully treated by surgical excision.

전기품질비용시스템의 구축에 관한 연구

서현진,고성효,이경찬 제주대학교 관광산업연구소 2001 産經論集 Vol.15 No.2

압출용 다이스의 Melt-고분자 열유동 기초연구

정효희,김재열,최진호,유신,윤성운,홍철,김종문 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

As importance part of extruder, hopper(Hopper) been raw material supply wealth, main frame that screw and barrel that transformation of supply raw material attains are because deformed raw material is fearful finally extrusion to done dies attain. Extruder is divided by greatly above 3 but hopper has assembled in dehumidification of raw material and supply of smooth raw material, and make in Melt state as raw material is stabilized because main frame consists of screw and barrel and Melt does anaphora as done material is stabilized. And dies that is last part between barrel with screw anaphora done Melt material as is stabilized without causing change that is much depending on anaphora of screw from dies way out as correct product produce make to. In this treatise, make anaphora can present ideal dies basis design using CFdesign that is heat & flow analysis programs so that can produce detailed product through pipe channel flow analysis of stable dies applying anaphora value of do polymer raw material in Screw.

혼합 치열기 어린이의 치은 섬유종증

한효정,최병재,김진,김성오,손홍규 大韓小兒齒科學會 2004 大韓小兒齒科學會誌 Vol.31 No.4

치은 섬유종증은 유리 치은과 부착 치은이 점진적으로 증식되는 비염증성 질환이다. 대부분 가족력이 있으며 영구치 맹출과 함께 발병하지만 유치 맹출 시기에, 드물게 출생 시부터 나타나기도 한다. 본 6세 여아의 경우 태어날 때부터 치은의 일부가 증식되어 있었고 가족력 및 치은 증식을 유발하는 약물을 복용한 병력은 없었다. 구강 내 검진 시 섬유성 치은 증식이 관찰되어 절제 생검을 시행하였고 그 결과 치은 섬유종증으로 진단하였다. 치은 섬유종증의 치료는 치은 절제술과 철저한 구강 위생의 관리이다. 그러나 치료 후 재발성 때문에 치료 시기에 대해서는 논란 중이다. 일반적으로 영구치가 모두 맹출 한 이후에 치료할 것을 추천하지만 조기 치료는 구강의 기능 및 환아의 심미적, 심리적인 문제점을 개선시켜 주는 장점이 있다. Gingival fibromatosis is a non-inflammatory oral disease, characterized by slowly progress enlargement of the free and attached gingiva. Gingival fibromatosis may have familial tendency. Gingival enlargement usually begins with the eruption of the permanent dentition but can also develop with the eruption of the primary dentition. In this case, a 6-year-old female had gingival enlargement at birth. There was no familial, medical and pharmacologic history of gingival overgrowth. Treatment is gingivectomy with a rigorous program of oral hygiene. Recurrence of gingival fibromatosis may well be inevitable. Therefore there is no general aggrement as to the timing of surgical intervention. Generally the best time is when all the permanent teeth have erupted. However early intervention can improve oral function and esthetic and psychologic effect.

Kirschner wire를 사용한 과두하 골절의 구강내 접근법

김성일,김승룡,백진아,고승오,신효근 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.3

The treatment of mandibular subcondylar fractures is a matter of controversy. The majority of mandibular subcondylar fracture are treated by closed reduction, but the displaced or dislocated mandibular subcondylar fractures may be treated by open reduction. The characteristics of open reduction are the anatomical reduction, the functional restoration, the rapid function, the maintenance of vertical ramus dimension, the better appearance and the less resultant TMJ problem etc. When an open reduction is considered, the wire, miniplate, lag screw and Kirschner wire are available with internal fixation. Of these, Kirschner wire is a simple method relatively and correct positioning of the wire achieves rigid fixation. But many open reduction methods for mandibular subcondylar fractures require extraoral approach. The extraoral approach has some problems, the facial scar and the risk of facial nerve injury. On the other hand, the intraoral approach eliminates the potency of the facial scar and the facial nerve injury, but is difficult to access the operation site. Since the intraoral approach was first described by Silverman (1925), the intraoral approach to the mandibular condyle has been developed with modifications. The purpose of this article is to describe the intraoral technique with the Kirschner wire on mandibular subcondylar fractures. Conclusion : The intraoral reduction with Kirschner wire on mandubular subcondylar fractures avoids the facial scar and facial nerve injury and is simple method to the extraoral approach. And it has minimal morbidity and better esthetics.

우리나라 건설업체의 원가기획 적용실태에 관한 연구

고성효,서현진,고성호 제주대학교 관광산업연구소 2001 産經論集 Vol.15 No.1