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Xiong, Wei,Jiang, Yong-Xin,Ai, Yi-Qin,Liu, Shan,Wu, Xing-Rao,Cui, Jian-Guo,Qin, Ji-Yong,Liu, Yan,Xia, Yao-Xiong,Ju, Yun-He,He, Wen-Jie,Wang, Yong,Li, Yun-Fen,Hou, Yu,Wang, Li,Li, Wen-Hui Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Preoperative 5-fluorouracil (5-FU)-based chemoradiotherapy is a standard treatment for locally advanced colorectal cancer (CRC). However, CRC cells often develop chemoradiation resistance (CRR). Recent studies have shown that long non-coding RNA (lncRNA) plays critical roles in a myriad of biological processes and human diseases, as well as chemotherapy resistance. Since the roles of lncRNAs in 5-FU-based CRR in human CRC cells remain unknown, they were investigated in this study. Materials and Methods: A 5-FU-based concurrent CRR cell model was established using human CRC cell line HCT116. Microarray expression profiling of lncRNAs and mRNAs was undertaken in parental HCT116 and 5-FU-based CRR cell lines. Results: In total, 2,662 differentially expressed lncRNAs and 2,398 mRNAs were identified in 5-FU-based CRR HCT116 cells when compared with those in parental HCT116. Moreover, 6 lncRNAs and 6 mRNAs found to be differentially expressed were validated by quantitative real time PCR (qRT-PCR). Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis for the differentially expressed mRNAs indicated involvement of many, such as Jak-STAT, PI3K-Akt and NF-kappa B signaling pathways. To better understand the molecular basis of 5-FU-based CRR in CRC cells, correlated expression networks were constructed based on 8 intergenic lncRNAs and their nearby coding genes. Conclusions: Changes in lncRNA expression are involved in 5-FU-based CRR in CRC cells. These findings may provide novel insight for the prognosis and prediction of response to therapy in CRC patients.
Choi, Yong-Woo;Kim, Sun-Mi;Jin, Xiong-Jie;Kwak, Ji-Yeong;Jung, Ju-Yang;Mun, Jun-II;Lim, Hong-Seok 중앙대학교 의과대학 의과학연구소 2012 中央醫大誌 Vol.37 No.1/2
The use of drug eluting stent (DES) has been increased in recent years because of its ability to inhibit neointimal proliferation. However, it may affect the normal healing process of the vessel wall after vascular injury and may be associated with coronary artery aneurysm formation in rare cases. We report a case of angiographic spontaneous resolution of coronary aneurysm developed after implantation of sirolimus-eluting coronary stent at the left anterior descending artery, diagonal branch, and left circumflex artery. But, there was discrepancy between intravascular ultrasound (IVUS) and coronary angiographic findings. IVUS demonstrated no significant shrinkage of maximal external elastic membrane (EEM) compared to earlier examination but echogenic tissue was filled in the free space between the stent and EEM at the stented segments where the angiographic resolution of the aneurysm occurred. We found out that an angiographic resolution of coronary aneurysm does not always guarantee real shrinkage of vessel wall, and fill-up of aneurismal space with thrombus or tissue could be an important mechanism of spontaneous resolution of DES related coronary aneurysm. Optimal treatment could be decided based on longer-term follow-up of patients which provide more accurate characterization of the consequences of DES-related aneurysm.
Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease
Xiong Liu-Lin,Xue Lu-Lu,Du Ruo-Lan,Niu Rui-Ze,Chen Li,Chen Jie,Hu Qiao,Tan Ya-Xin,Shang Hui-Fang,Liu Jia,Yu Chang-Yin,Wang Ting-Hua 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In recent years, biomarkers have been integrated into the diagnostic process and have become increasingly indispensable for obtaining knowledge of the neurodegenerative processes in Alzheimer’s disease (AD). Peripheral blood mononuclear cells (PBMCs) in human blood have been reported to participate in a variety of neurodegenerative activities. Here, a single-cell RNA sequencing analysis of PBMCs from 4 AD patients (2 in the early stage, 2 in the late stage) and 2 normal controls was performed to explore the differential cell subpopulations in PBMCs of AD patients. A significant decrease in B cells was detected in the blood of AD patients. Furthermore, we further examined PBMCs from 43 AD patients and 41 normal subjects by fluorescence activated cell sorting (FACS), and combined with correlation analysis, we found that the reduction in B cells was closely correlated with the patients’ Clinical Dementia Rating (CDR) scores. To confirm the role of B cells in AD progression, functional experiments were performed in early-stage AD mice in which fibrous plaques were beginning to appear; the results demonstrated that B cell depletion in the early stage of AD markedly accelerated and aggravated cognitive dysfunction and augmented the Aβ burden in AD mice. Importantly, the experiments revealed 18 genes that were specifically upregulated and 7 genes that were specifically downregulated in B cells as the disease progressed, and several of these genes exhibited close correlation with AD. These findings identified possible B cell-based AD severity, which are anticipated to be conducive to the clinical identification of AD progression.
The Novel Infrared Target Localization Algorithm for Free Floating Space Robot
Xiong Luo,Xiaolu Jie,Huaping Liu,Fuchun Sun 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10
With regards to the complicated characteristic of outer space, the infrared target recognition system has been investigated for free floating space robot. A novel algorithm is proposed based on visual location method for free floating space robot. Firstly, we set an omnidirectional camera with fixed lens on the ceiling. Here, the free floating robot is moving on the platform. Especially, in order to reduce image noise, we fix an infrared filter in the lens. Then, we place a number of infrared-emitting diodes on the free floating space robot and the targets. Finally, we can get the accurate positions and angle information of the robot and the target according to the location of the infrared light. The experimental results prove that this approach presented in this paper is an effective method for target detection and static target capture for free floating space robot.
Jie Xu,Aizhen Xiong,Xunjiang Wang,Xing Yan,Yilin Chen,Xuanling Ye,Zhengtao Wang,Lili Ding,Li Yang 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.8
Pyrrolizidine alkaloids (PAs) are potent hepatotoxins that can cause liver damage. Hyperoside (Hyp), a natural flavonoid, can be extracted from medicinal plants. Hyp displays hepatoprotective activity in various liver diseases. However, the potential effect and mechanism of action of Hyp in ameliorating PA-induced liver injury remain obscure. This study aimed to explore the protective effect of Hyp against PA-induced hepatotoxicity and its underlying mechanism. We established an in vitro model of PAs in mouse primary hepatocytes and developed a mouse model of acute PA toxicity to investigate the protective effect of Hyp. We found that Hyp notably attenuated PA-induced hepatotoxicity. RNA-sequencing showed that the beneficial effect of Hyp against PA-induced hepatotoxicity was associated with the transcription factor EB (TFEB)-peroxisome proliferator-activated receptor-γ coactivator-1-α (PGC1α) pathway. Our results confirmed that both the autophagy-lysosomal pathway and mitochondrial biogenesis were induced by Hyp through TFEB nuclear translocation in PA-induced liver injury. Furthermore, we demonstrated that activation of the mechanistic target of rapamycin complex 1 (mTORC1) by MHY 1485 decreased TFEB nuclear translocation and abrogated the protective effect of Hyp against PA-induced liver injury in mice. In contrast, inhibition of mTORC1 activity increased the level of TFEB and reduced hepatotoxicity induced by PAs in mouse livers. Likewise, Hyp-induced TFEB activation was validated in vitro. In conclusion, Hyp can activate the TFEB-mediated autophagy-lysosomal pathway and mitochondrial biogenesis through inhibition of mTORC1 activity, alleviating the liver injury induced by PAs, thus suggesting the potential value of Hyp in the treatment of PA-induced hepatotoxicity.
Xiong Wenyu,Ye Jie,Gong Qichangyi,Feng Han,Shen Anwen,Xu Jinbang 한국자동차공학회 2020 International journal of automotive technology Vol.21 No.6
This study presents an adaptive dual closed-loop speed control strategy for the natural gas engine used in a range extender to improve the robustness against parameter uncertainties, unmodeled dynamics and unknown disturbance. Compared to existing methods, this strategy takes into account the influence of the throttle valve dynamics on the intake airflow in the design of the inner-loop intake pressure controller, which is strongly nonlinear, and considers the inaccuracy of the output torque as well as unknown disturbance in the outer-loop speed controller design, which is more practical. Furthermore, the controller is incorporated with an adaptive strategy to overcome the uncertainty of parameters using the information of the engine speed and the intake pressure. Theoretical analysis indicates that this strategy can meet the demands of the wide range speed regulation of the range extender engine without knowing the specific values of the engine parameters. Moreover, the capability of the proposed controller to preserve the performance in the presence of disturbance in various working conditions is evaluated by co-simulation on the platform of Matlab/Simulink with GTpower and experiments on a range extender.
Jie Deng,Yi Zhou,Shanshan Li,Lei Xiong,Jianli Wang,Shandong Yuan,Yaoqiang Chen 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.64 No.-
Three CeO2–ZrO2–Y2O3–La2O3 (CZ) nanomaterials with controllable crystallite size were prepared by a simple co-precipitation method combined with hydrothermal treatment at different temperatures. The material CZ-180 possesses a high surface area of 43.6 m2 g−1 and a low reduction temperature of 344 °C simultaneously even after aging at 1000 °C for 4 h. Moreover, with improving hydrothermal temperature, the incorporation of rear earth metals was accelerated and surface properties were modified. And higher Pd dispersion and larger proportion of active Pd2+ species were achieved on the modified surface of CZ-180. Consequently, the supported catalyst Pd/CZ-180 shows a superior three-way catalytic performance.