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- 저자 : Jiaxing Huang (검색결과 23 건)
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Dong Junguo,Huang Junfeng,Liu Jiaxing,Tang Yufang,Sivapalan Dhinesan,Lai Kefang,Zhong Nanshan,Luo Wei,Chen Ruchong 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.5
Gastroesophageal reflux disease (GERD) is a common cause of chronic cough (CC). However, the diagnosis of GERD associated with CC based on 24-hour esophageal pH-monitoring or favorable response to empirical anti-reflux trials is invasive and time-consuming. Lipid-laden macrophages (LLMs) are supposed to be a biomarker for micro-aspiration of gastric content in the respiratory tract. This study was conducted to collect LLMs by the sputum induction technique and observe the relationship among the amount of LLMs, cough severity, parameters of 24-hour esophageal pH-monitoring and therapeutic response. The 24-hour esophageal pH-monitoring and sputum induction were performed on 57 patients with suspected GERD associated with CC. Thirty-four patients were followed up after empirical anti-reflux trials of 8 weeks to record the therapeutic response. Lipid-laden macrophage index (LLMI), a semiquantitative counting of LLMs, showed no significant correlation with the values of 24-hour esophageal pH monitoring at the proximal or remote electrode. No difference in LLMI or DeMeester score, as well as cough symptom association probability, were found between the responders and the non-responders. Reflux symptoms were more common in the responders (50%) compared to the non-responders (6%) (P < 0.05). Our study suggests that LLMI shows limited utility in clinically diagnosing GERD associated with CC as an underlying etiology or in predicting response to anti-reflux therapy. Anti-reflux therapy is more effective for CC patients with reflux symptoms than for those without.
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Vulnerability of East Asian bumblebee species to future climate and land cover changes
Naeem, Muhammad,Liu, Meijuan,Huang, Jiaxing,Ding, Guiling,Potapov, Grigory,Jung, Chuleui,An, Jiandong Elsevier 2019 Agriculture, ecosystems & environment Vol.277 No.-
<P><B>Abstract</B></P> <P>Pollinators play a key role in agricultural and natural ecosystems, but their biodiversity is highly vulnerable to the impact of environmental changes. Here, we evaluated the distributional responses of 29 bumblebee species endemic to East Asia to future (2050s and 2070s) climate and land cover changes, and 17–27 (59–93 %) of the species exhibited range contraction. A decrease in species richness from 25 to 19 species in the highest region of central China was also detected due to range shifts of 17 km to 574 km. Furthermore, one (3.44%), three to five (10–17 %), and two to eight (7–28 %) of the 29 bumblebee species were predicted to become critically endangered, endangered and vulnerable in the future, respectively. Our study highlights the strong impact of environmental changes on species distributions, and we suggest strategies for the conservation of vulnerable species that include protecting the regions of high species richness and the most dominant land covers within the current range to mitigate the threat of environmental changes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Pollinators are under threat from climate and climate-induced land cover changes. </LI> <LI> Distributional responses were predicted for 29 bumblebee species in East Asia. </LI> <LI> Of the studied species, 59–93 % experienced range loss in the future. </LI> <LI> Species richness declined within central mainland China and northeastern Asia. </LI> <LI> Conserving regions with high species richness and dominant land covers is needed. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Characterization of HSP70 expression in drones of Apis cerana (Hymenoptera: Apidae)
Wang Deqian,Dong Jie,Huang Minjie,Ding Guiling,Huang Jiaxing 한국응용곤충학회 2022 Journal of Asia-Pacific Entomology Vol.25 No.1
Heat shock proteins (HSPs) constitute a superfamily of molecular chaperones that are rapidly biosynthesized in response to various biotic and abiotic factors. In this study, we first cloned the full-length HSP70 gene of the Eastern honeybee Apis cerana. Then, using real-time quantitative PCR, we explored HSP70 expression profiles in drones at different developmental stages, ages, and reproductive statuses (with and without semen). The fulllength HSP70 cDNA is 2421 bp, including a 1953-bp open reading frame (ORF) that encodes a polypeptide of 650 amino acids. The HSP70 gene consists of one intron and two exons. The phylogenetic analysis revealed that the HSP70 genes of A. cerana and Apis mellifera are the most closely related. We observed HSP70 expression at all selected developmental stages and detected the highest expression in pupae with an unpigmented body cuticle and brown eyes (Pb) and much lower expression in larvae hatched within 72 h. In adult drones of different ages, the highest expression level of HSP70 was observed in 16-day-old drones; significantly lower accumulation of HSP70 mRNA was detected in 4-day-old drones. There was no significant difference in HSP70 expression be tween drones with and without semen captured at the entrance, while the HSP70 gene expression level strikingly differed between drones captured at the entrance and the drones collected within the hive. Our study suggests that HSP70 might play a critical role in drone development and during reproductive mating events.
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Effect of Sheet Morphology on the Scalability of Graphene-Based Ultracapacitors
Luo, Jiayan,Jang, Hee Dong,Huang, Jiaxing American Chemical Society 2013 ACS NANO Vol.7 No.2
<P>Graphene is considered a promising ultracapacitor material toward high power and energy density because of its high conductivity and high surface area without pore tortuosity. However, the two-dimensional (2D) sheets tend to aggregate during the electrode fabrication process and align perpendicular to the flow direction of electrons and ions, which can reduce the available surface area and limit the electron and ion transport. This makes it hard to achieve scalable device performance as the loading level of the active material increases. Here, we report a strategy to solve these problems by transforming the 2D graphene sheet into a crumpled paper ball structure. Compared to flat or wrinkled sheets, the crumpled graphene balls can deliver much higher specific capacitance and better rate performance. More importantly, devices made with crumpled graphene balls are significantly less dependent on the electrode mass loading. Performance of graphene-based ultracapacitors can be further enhanced by using flat graphene sheets as the binder for the crumpled graphene balls, thus eliminating the need for less active binder materials.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2013/ancac3.2013.7.issue-2/nn3052378/production/images/medium/nn-2012-052378_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn3052378'>ACS Electronic Supporting Info</A></P>
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Jie Dong,Rui Guo,Minjie Huang,Deqian Wang,Jiaxing Huang 한국응용곤충학회 2020 Journal of Asia-Pacific Entomology Vol.23 No.1
Chinese sacbrood virus (CSBV) is a disastrous virus that fatally threatens honeybees (Apis cerana) in China. Here, we identified the complete genome of CSBV using the rapid amplification of cDNA ends (RACE) method and compared the obtained sequences with those of other SBVs through multiple sequence alignment. The results showed that the full-length of CSBV genome from Zhejiang Province (CSBV-ZJ) is 8824 bp and contains a single, large open reading frame (ORF) that encodes 2842 amino acids flanked by 190 nucleotides (nts) of the 5′-untranslated region (UTR) and 108 nts of the 3′-UTR. The multiple genome comparison showed that SBVs have five conserved domains and that CSBV-ZJ belong to SBV type II. The phylogenetic analysis demonstrated that the CSBV-ZJ strain was similar to the CSBV from Fuzhou (CSBV-FZ) strain. Colonies collected from most of the sampling sites in the area surrounding Qiandao Lake were carriers of CSBV. The haplotypes of the VP1 gene formed a network with radiated and reticular structures. In conclusion, this characterization of the CSBV-ZJ genome will help us understand the SBV prevalence mechanism and aid the protection of honeybees.
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Hybrid Recommendation Algorithm for User Satisfaction-oriented Privacy Model
Yinggang Sun,Hongguo Zhang,Luogang Zhang,Chao Ma,Hai Huang,Dongyang Zhan,Jiaxing Qu 한국인터넷정보학회 2022 KSII Transactions on Internet and Information Syst Vol.16 No.10
Anonymization technology is an important technology for privacy protection in the process of data release. Usually, before publishing data, the data publisher needs to use anonymization technology to anonymize the original data, and then publish the anonymized data. However, for data publishers who do not have or have less anonymized technical knowledge background, how to configure appropriate parameters for data with different characteristics has become a more difficult problem. In response to this problem, this paper adds a historical configuration scheme resource pool on the basis of the traditional anonymization process, and configuration parameters can be automatically recommended through the historical configuration scheme resource pool. On this basis, a privacy model hybrid recommendation algorithm for user satisfaction is formed. The algorithm includes a forward recommendation process and a reverse recommendation process, which can respectively perform data anonymization processing for users with different anonymization technical knowledge backgrounds. The privacy model hybrid recommendation algorithm for user satisfaction described in this paper is suitable for a wider population, providing a simpler, more efficient and automated solution for data anonymization, reducing data processing time and improving the quality of anonymized data, which enhances data protection capabilities.
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Bernal, Rodrigo A.,Aghaei, Amin,Lee, Sangjun,Ryu, Seunghwa,Sohn, Kwonnam,Huang, Jiaxing,Cai, Wei,Espinosa, Horacio American Chemical Society 2015 NANO LETTERS Vol.15 No.1
<P>Silver nanowires are promising components of flexible electronics such as interconnects and touch displays. Despite the expected cyclic loading in these applications, characterization of the cyclic mechanical behavior of chemically synthesized high-quality nanowires has not been reported. Here, we combine in situ TEM tensile tests and atomistic simulations to characterize the cyclic stress–strain behavior and plasticity mechanisms of pentatwinned silver nanowires with diameters thinner than 120 nm. The experimental measurements were enabled by a novel system allowing displacement-controlled tensile testing of nanowires, which also affords higher resolution for capturing stress–strain curves. We observe the Bauschinger effect, that is, asymmetric plastic flow, and partial recovery of the plastic deformation upon unloading. TEM observations and atomistic simulations reveal that these processes occur due to the pentatwinned structure and emerge from reversible dislocation activity. While the incipient plastic mechanism through the nucleation of stacking fault decahedrons (SFDs) is fully reversible, plasticity becomes only partially reversible as intersecting SFDs lead to dislocation reactions and entanglements. The observed plastic recovery is expected to have implications to the fatigue life and the application of silver nanowires to flexible electronics.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2015/nalefd.2015.15.issue-1/nl503237t/production/images/medium/nl-2014-03237t_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl503237t'>ACS Electronic Supporting Info</A></P>
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