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        Olanzapine May Inhibit Colonic Motility Associated with the 5-HT Receptor and Myosin Light Chain Kinase

        Jiarui Zhang,Ying Qiao,Jingjing Le,Daliang Sun,Yangtai Guan,Zezhi Li 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.2

        ObjectiveaaTo study whether the effects of olanzapine on gastrointestinal motility is related to the serotonin antagonism and myosin light chain kinase. MethodsaaMale Sprague-Dawley rats were randomly divided into four groups. Olanzapine gavage was performed for each treatment group during the course of 30 continuous days, while the same volume of saline was given to the rats in the control group. Defecation of the rats was observed on days 7 and 30 after olanzapine gavage. The effects of olanzapine on contraction of colonic smooth muscles were observed in ex vivo experiments. A Western blot was used to evaluate expression levels of the serotonin transporter (SERT) and MLCK in colon segments of the rats. ResultsaaCompared to the control group, 5–160 μM of olanzapine could inhibit dose-dependently the contraction of colonic smooth muscle ex vivo experiments. The maximum smooth muscle contraction effects of 5-HT and acetylcholine significantly decreased after treatment with 40–160 μM of olanzapine. Constipation was found in the olanzapine-treated rats on day 7 and have sustained day 30 after gavage. Expression of MLCK in olanzapine-treated rats was significantly decreased, whereas the expression of SERT significantly increased on the day 7, then significantly decreased on the day 30 after olanzapine gavage. ConclusionaaSERT and MLCK may involve in the inhibition of colonic contraction induced by olanzapine.

      • KCI등재

        Study on the lubrication film formation and characteristics of different graphite seal composites

        Qili Wang,Jiarui Sun,Mingquan Yu,Yuehu Chen 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.8

        In order to study the formation and characteristics of the lubricating film of graphite composites in solid lubrication, the mechanical properties, micro-structure, friction and wear properties of graphite and impregnated samples are compared and analysed. Results show that the graphite/antimony composites have compression strength of 300.2 MPa and hardness of 98.3 HS, which has excellent friction performance and exhibits the law of full film lubrication. The graphite/resin composites with compression strength of 244.9 MPa and hardness of 87.0 HS exhibit the law of residual film lubrication. Under the condition that the load is 24.1 MPa (heavy load) and the friction pair is 45# (small hardness), the lubrication state of the composite materials are close to full film lubrication. External environmental factors such as load, speed, and pair of grinding pairs have different effects on the friction coefficient and the formation of lubricating film.

      • KCI등재

        Research on Recognition Method of Electrical Components Based on FEYOLOv4-tiny

        Gao Jilong,Sun Haoran,Han Jiarui,Sun Qian,Zhong Tie 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.6

        Recently, electrical component recognition technology is of great signifi cance for fault identifi cation and stable operation of the modern power grids. With the rapid improvement of smart grids, higher requirements are put forward to the recognition methods in detection accuracy and real-time performance. However, the conventional recognition methods are fail to meet the demands since they always have drawbacks in detection performance. To improve the electrical component identifi cation capability, a novel detection method based on Feature Enhanced You Only Look Once v4-tiny (FEYOLOv4-tiny) is proposed in this study. Here, YOLOv4-tiny is employed as the prototype of the proposed network, whereas enhancement module is designed to improve the feature extraction capability. Moreover, frequency channel attention and spatial attention module are utilized to capture the informative and discriminatory features. Experimental results indicate that our proposed method outperforms other lightweight networks in detection accuracy with almost the same real-time performance, especially for the small targets with complex background. Over all, FEYOLO v4-tiny is effi cient in electrical component identifi cation and has signifi cant application prospects in power inspection.

      • SCISCIESCOPUS

        Effective hydrogen gas sensor based on NiO@rGO nanocomposite

        Ren, Haibo,Gu, Cuiping,Joo, Sang Woo,Zhao, Jingjuan,Sun, Yufeng,Huang, Jiarui Elsevier 2018 Sensors and actuators. B Chemical Vol.266 No.-

        <P><B>Abstract</B></P> <P>A NiO@rGO nanocomposite is prepared by a freeze-drying method combined with heat treatment. The morphology and structure are analyzed through X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Raman spectra, and X-ray photoelectron spectroscopy. The results clearly show that NiO nanoparticles are uniformly anchored on the surface of the rGO nanosheet. The gas-sensing performance of the nanocomposite is also investigated to detect hydrogen. The NiO@rGO sensor exhibits good gas-sensing performance with high sensitivity, fast response, good reversibility, and selectivity toward hydrogen. The relative response of the sensor to 1% hydrogen is 0.64, the response time is 28 s, and the recovery time is 142 s. The improved sensing performance is due to the effective electron transfer between the NiO nanoparticles and rGO nanosheet.</P> <P><B>Highlights</B></P> <P> <UL> <LI> NiO@rGO nanocomposite consisting of NiO NPs uniformly anchored on rGO is developed. </LI> <LI> The preparation method involves freeze-drying followed by heat treatment. </LI> <LI> NiO@rGO sensor shows high response and selectivity to H<SUB>2</SUB> at low working temperature. </LI> <LI> High performance is ascribed to the electron transfer between NiO NPs and rGO. </LI> </UL> </P>

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