The Analysis of Agricultural Output in Port SD Province Based on System Dynamics

Jianliang Liu,Junhai Ma,Yi Tian 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.9

In order to know various factors affecting agricultural development in Shandong Province, this paper uses system dynamics model, modeling on agricultural output system in Shandong Province .It analyses how population growth, household consumption, the existing agricultural resources as well as GDP of Shandong Province affect the agricultural output, and uses Vensim software to make algorithm implemented. It analyses the effects of changed factors on agricultural output, and helps for government to make the agricultural development policy.

Metallogeny of the Poyi magmatic Cu-Ni deposit: revelation from the contrast of PGE and olivine composition with other Cu-Ni sulfide deposits in the Early Permian, Xinjiang, China

Yuegao Liu,Xinbiao Lv,Longshuai Yang,Hufei Wang,Yafei Meng,Qie Yi,Bo Zhang,Jianliang Wu,Jian Ma 한국지질과학협의회 2015 Geosciences Journal Vol.19 No.4

Permian mafic-ultramafic intrusions in or besides the Central Asian Orogenic Belt (CAOB) have been the focus of several recent studies, mainly located in Altay, East Tianshan, and Beishan Rift from north to south. Some of them host economic magmatic sulfide deposits. Among those, Poyi is a large magmatic Cu-Ni sulfide deposit related to ultramafic rock in Beishan Rift. Poyi does not have massive ore, but only disseminated ore in hornblende- peridotite, so Poyi is not as rich as the Karatongk Cu-Ni deposit in the Altay area or the Huangshandong and Tulargen Cu- Ni sulfide deposits in Eastern Tianshan. To address these questions, this paper contrasts the feature of PGE (Platinum Group Element) and olivine composition in magmatic Cu-Ni deposits between three regions (Altay, East Tianshan, and Beishan Rift) to provide a view of the metallogenic process of the Poyi magmatic Cu-Ni deposit. The degree of sulfide segregation (DSS) of Poyi is around 0.01%; the value of R (the ratio of the mass of silicate magma to the mass of sulfide that reached equilibrium together) is 500–5000, and is 2333 on average; the R value of Cu-Ni sulfide deposits in East Tianshan is in the range of 100–500, and the degree of sulfide segregation is about 0.013%; Poyi Cu-Ni deposit is not as rich as the magmatic Cu-Ni deposits in East Tianshan, probably because the degree of sulfide segregation of the former (0.01%) is lower than that of the latter (0.013%). From Beishan area to East Tianshan and then to Altay Region, the R value changed from 2333 to 100–500 and then to 100 according to the theory of Naldrett (2011). Poyi does not have the potential to be a PGE deposit. The olivine of Poyi has higher contents of MgO and SiO2 and lower contents of FeO and CaO, which reach sulfur saturation more easily, but due to the lack of sulfur, it is still very difficult to reach sulfur saturation, and therefore the olivine of Poyi has the highest Ni content among the Permian magmatic Cu-Ni deposits in Xinjiang.

Design and Application of a NEW Seven-Dimensional Hyperchaotic System

Duanzeng Liu,Jianliang Zhu,Hao Sun 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.4

MiR-200c-3p inhibits LPS-induced M1 polarization of BV2 cells by targeting RIP2

Zhao Lei,Liu Xiaosong,Yang Jiankai,Wang Xiaoliang,Liu Xiaomeng,Wu Jianliang,Li Chen,Xu Donggang,Hu Yuhua 한국유전학회 2022 Genes & Genomics Vol.44 No.4

Background: Microglia are important immune cells, which can be induced by lipopolysaccharide (LPS) into M1 phenotype that express pro-inflammatory cytokines. Some studies have shown that microRNAs play critical roles in microglial activation. Objective: This study was designed to investigate the role of miR-200c-3p in regulating inflammatory responses of LPS-treated BV2 cells. Methods: The expression of miR-200c-3p in BV2 cells was detected by real-time PCR. Receptor-interacting protein 2 (RIP2) was predicted as a target gene of miR-200c-3p. Their relationship was verified by dual-luciferase reporter assay. The function of miR-200c-3p and RIP2 in microglial polarization and NF-κB signaling was further evaluated. Results: LPS treatment reduced miR-200c-3p expression in a dose-dependent and time-dependent manner in BV2 cells. LPS treatment increased the expression of M1 phenotype markers inducible nitric oxide synthase (iNOS) and major histocompatibility complex class (MHC)-II, promoted the release of pro-inflammatory cytokines interleukin (IL)-1β, IL-6 and tumor necrosis factor (TNF)-α, and enhanced the nuclear translocation and phosphorylation of nuclear factor-kappaB (NF-κB) p65. Reversely, miR-200c-3p mimics down-regulated the levels of these inflammatory factors. Furthermore, RIP2 was identified to be a direct target of miR-200c-3p. RIP2 knockdown had a similar effect to miR-200c-3p mimics. Overexpression of RIP2 eliminated the inhibitory effect of miR-200c-3p on LPS-induced M1 polarization and NF-κB activation in BV2 cells. Conclusions: MiR-200c-3p mimics suppressed LPS-induced microglial M1 polarization and NF-κB activation by targeting RIP2. MiR-200c-3p/RIP2 might be a potential therapeutic target for the treatment of neuroinflammation-associated diseases.

Transcatheter Arterial Chemoembolization Combined with Interferon-α is Safe and Effective for Patients with Hepatocellular Carcinoma after Curative Resection

Zuo, Chaohui,Xia, Man,Liu, Jingshi,Qiu, Xiaoxin,Lei, Xiong,Xu, Ruocai,Liu, Hanchun,Li, Jianliang,Li, Yongguo,Li, Qinglong,Xiao, Hua,Hong, Yuan,Wang, Xiaohong,Zhu, Haizhen,Wu, Qunfeng,Burns, Michael,Li Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1

Objectives: Intrahepatic recurrence is the major cause of death among patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) after curative surgical resection. Several approaches have been reported to decrease the recurrence rate. The objective of our study was to compare the clinical effects of transcatheter arterial chemoembolization (TACE) combined with interferon-alpha (IFN-${\alpha}$) therapy on recurrence after hepatic resection in patients with HBV-related HCC with that of TACE chemotherapy alone. Methods: We retrospectively analyzed the data from 228 patients who were diagnosed with HBV-related HCC and underwent curative resection between January 2001 to December 2008. The patients were divided into TACE (n = 126) and TACE-IFN-${\alpha}$ (n = 102) groups for postoperative chemotherapy. The TACE regimen consisted of 5-fluorouracil (5-FU), cisplatin (DDP), and the emulsion mixed with mitomycin C (MMC) and lipiodol. The recurrence rates, disease-free survival (DFS), overall survival (OS), and risk of recurrence were evaluated. Results: The clinicopathological parameters and adverse effects were similar between the 2 groups (P > 0.05). The median OS for the TACE-IFN-${\alpha}$ group (36.3 months) was significantly longer than that of the TACE group (24.5 months, P < 0.05). The 3-and 5-year OS for the TACE-IFN-${\alpha}$ group were significantly longer than those of the TACE group (P < 0.05) and the recurrence rate was significantly lower (P < 0.05). The TACE and IFN-${\alpha}$ combination therapy, active hepatitis HBV infection, the number of tumor nodules, microvascular invasion, liver cirrhosis, and the BCLC stage were independent predictors of OS and DFS. Conclusions: The use of the TACE and IFN-${\alpha}$ combination chemotherapy after curative hepatic resection safely and effectively improves OS and decreases recurrence in patients with HBV-related HCC who are at high risk. Our findings can serve as a guide for the selection of postoperative adjuvant chemotherapy for patients with HBV-related HCC who are at high risk of recurrence.

Slab analysis of large cylindrical shell rolling considering mixed friction

Suwen Chen,Hongmin Liu,Yan Peng,Jianliang Sun 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.11

Large cylindrical shell rolling is an advanced plastic-forming technique that has unequal speed and radius of both its upper and lowerrolls. A theoretical model for a large cylindrical shell rolling that is based on the slab method is proposed, in which the non-uniform normaland shear stresses that act on the vertical sides are considered. A mixed friction model of combined Coulomb and sticking friction isused to present interface friction, to improve the accuracy of the proposed model. The rolling pressure, rolling force, and torque as well asfriction stress can be rapidly and easily calculated through the proposed model at different rolling conditions. The predicted rolling forceis consistent with the experimental result. The research results provide valuable guidelines for both the design and optimization of rollingproduct, process, and equipment.

Factors Influencing the Quality of Standardized Treatment for Patients with Post–Cardiac Arrest Syndrome

Jing Lu,Lijun Liu,Jianliang Zhu,Xinying Guo 대한심장학회 2017 Korean Circulation Journal Vol.47 No.4

Background and Objectives: For the present study, we investigated the factors that influence the quality of standardized treatment for patients with post–cardiac arrest syndrome (PCAS) to improve the quality of PCAS treatment. Subjects and Methods: We collected data on patients with cardiac arrest (CA) who were admitted to the intensive care units (ICUs) of 11 hospitals-Class II Grade A or above-in Suzhou from January to October 2013. Indexes of standardized treatment were observed within 72 hrs of CA. We analyzed monitoring techniques, monitoring frequency, ICU human and material resources, and intensivists’ knowledge of PCAS treatment to explore how those factors affected the management of patients with PCAS. Results: The bed/nurse ratio and the frequency with which core temperature was recorded correlated closely with the implementation of therapeutic hypothermia (TH) within 6 hrs of CA. The bed/doctor ratio and intensivists’ knowledge about PCAS correlated closely with high-quality blood glucose control within 6 hrs of CA. Furthermore, the frequency with which core temperature was recorded was an independent factor influencing the quality of TH implementation, and the number times blood gas was analyzed was an independent factor influencing how well partial pressure of carbon dioxide was kept within the normal range in the 6 hrs after CA. Conclusion: The frequency of core temperature measurements and the number of times blood gas is analyzed are the most important factors influencing the quality of standardized treatment for patients with PCAS.

The Research of Quantized Limb Movement Capability Assessment Indicators for the Elderly

Azhen Zhang,Guangchen Yang,Peng Yang,Jianliang Liu 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.10

As the problem of aging population is going to exacerbate, improving the scientific and objective nursing and service for the aged becomes the trend of pension industry. The premise of scientific pension service is assessing the capability of the elderly objectively. Then we can grade the capability of the elderly and provide different types of old-age care for different grades of the elderly. To solve this problem, this thesis puts forward a kind of quantized limb movement capability assessment indicators’ system for the elderly by analyzing human limb movement mechanism and the International Classification of Functioning, Disability and Health. This thesis also puts forward a method of data collection by using Vicon Three-dimensional motion capture system. Therefore, it provides an objective basis of elderly capability assessment method in the scientific pension.

TGF-β1/IL-11/MEK/ERK signaling mediates senescence-associated pulmonary fibrosis in a stress-induced premature senescence model of Bmi-1 deficiency

Haiyun Chen,Jialong Liang,Xin Gu,Jiawen Zhou,Chunfeng Xie,Xianhui Lv,Rong Wang,Qing Liu,Zhiyuan Mao,Haijian Sun,Guoping Zuo,Dengshun Miao,Jianliang Jin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-

To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1-deficient (Bmi-1−/−) mice and determines the major downstream mediator of Bmi-1 and crosstalk between p16INK4a and reactive oxygen species that regulates SAPF, phenotypes were compared among 7-week-old p16INK4a and Bmi-1 double-knockout, N-acetylcysteine (NAC)-treated Bmi-1−/−, Bmi-1−/−, and wild-type mice. Pulmonary fibroblasts and alveolar type II epithelial (AT2) cells were used for experiments. Human pulmonary tissues were tested for type Ι collagen, α-smooth muscle actin (α-SMA), p16INK4a, p53, p21, and TIME signaling by using enzyme-linked immunosorbent assay (ELISA). Our results demonstrated that Bmi-1 deficiency resulted in a shortened lifespan, ventilatory resistance, poor ventilatory compliance, and SAPF, including cell senescence, DNA damage, a senescence-associated secretory phenotype and collagen overdeposition that was mediated by the upregulation of TIME signaling. The signaling stimulated cell senescence, senescence-related secretion of TGF-β1 and IL-11 and production of collagen 1 by pulmonary fibroblasts and the epithelial-to-mesenchymal transition of AT2 cells. These processes were inhibited by anti-IL-11 or the MEK inhibitor PD98059. NAC treatment prolonged the lifespan and ameliorated pulmonary dysfunction and SAPF by downregulating TIME signaling more than p16INK4a deletion by inhibiting oxidative stress and DNA damage and promoting ubiquitinproteasome degradation of p16INK4a and p53. Cytoplasmic p16INK4a accumulation upregulated MEK/ERK signaling by inhibiting the translocation of pERK1/2 (Thr202/Tyr204) from the cytoplasm to the nucleus in senescent fibroblasts. The accumulation of collagen 1 and α-SMA in human lungs accompanied by cell senescence may be mediated by TIME signaling. Thus, this signaling in aging fibroblasts or AT2 cells could be a therapeutic target for preventing SAPF.