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RISS 인기검색어
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- 저자 : Jianke Li (검색결과 3 건)
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Transcript Profiling of Toll-Like Receptor mRNAs in Selected Tissues of Mink (Neovison vison)
( Mingwei Tong ),( Li Yi ),( Yuening Cheng ),( Miao Zhang ),( Zhigang Cao ),( Jianke Wang ),( Hang Zhao ),( Peng Lin ),( Yong Yang ),( Shipeng Cheng ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.12
Toll-like receptors (TLRs) can recognize conserved molecular patterns and initiate a wide range of innate and adaptive immune responses against invading infectious agents. The aim of this study was to assess the transcript profile of mink TLRs (mTLRs) in mink peripheral blood mononuclear cells (PBMCs) and a range of tissues, and to explore the potential role of mTLRs in the antiviral immune response process. The results indicated that the mTLR partial nucleotide sequences had a high degree of nucleotide identity with ferret sequences (95-98%). Phylogenetic analysis showed that mammalian TLRs grouped into five TLR families, with a closer relationship of the mTLRs with those of ferret than the other mammalian sequences. Moreover, all the mTLRs were ubiquitously expressed in lymphoid organs (spleen and lymph nodes) and PBMCs. Interestingly, the mTLR expression patterns in lung, uterus, and heart showed quite a lot of similarity. Another remarkable observation was the wide expression of mTLR1-3 mRNAs in all tissues. Among the analyzed tissues, skeletal muscle was revealed to being the lowest repertoire of mTLR expression. Additionally, mink PBMCs exposed to the canine distemper virus revealed significant upregulation of mTLR2, mTLR4, mTLR7, and mTLR8 mRNAs, indicating that mTLRs have a role in innate immunity in the mink. Collectively, our results are the first to establish the basic expression patterns of mTLRs and the relationship between mTLRs and a virus, which will contribute to better understanding of the evolution and the functions of mTLRs in the innate immune system in minks.
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Analysis of Operation Characteristics of a Diesel Generator Set with Constant‑Power Pulsed Load
Meng Shi,Puyu Wang,Jinquan Wang,Haichao Li,Ye Xu,Kefeng Huang,Jianke Li 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.6
To improve the power quality of a diesel generator set with a pulsed load in a microgrid, this paper studied the operation characteristics of the system and proposed pulsed load conditions for an actual project based on test data. For a low average pulse power and a high peak power, a new mathematical model of the pulsed load in diferent operation modes was proposed. Then, a simulation model of the microgrid was established in MATLAB/Simulink, and the operation of the system was studied considering changes in various pulsed load parameters (the peak power Pk, output duty cycle D and switching period Ts). It was verifed by tests that the simulation model is efective and can refect the operation of the system. Based on the simulation model, the operation characteristics of the system with a bivariate pulsed load were studied, and qualifcation conditions for the diesel generator set in an actual project were proposed.
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Lichen Zhang,Linlin Wang,Jingwei Cai,Ting Yang,Jianke Li,Guowei Shu 한국식품과학회 2024 Food Science and Biotechnology Vol.33 No.4
Consuming pomegranate juice (PJ) is beneficial for hypertensive regulation because of the phenolic compounds in PJ and their inhibitory activity on angiotensin-I-converting enzyme (ACE). To better utilize bioactive function of food, microorganism fermentation has been adopted to alter phenolic metabolism. This study confirms that even under in vitro digestion, fermented PJ (FPJ) maintains higher ACE inhibitory activity than that of PJ. The main phenolic compounds in PJ were compared either under fermentation or in vitro digestion. This study finds that fermentation promotes antioxidant capacity of PJ. The chemical properties of FPJ are evaluated and the corresponding relationship with bioactivities is analyzed. A sensory evaluation comparison is conducted between FPJ and PJ, furnishing interesting information for consumers. This study highlights the relationship between ACE inhibitory activity of PJ and phenolic composition under fermentation and in vitro digestion, providing novel insights for diet regulation of phenolic-rich FPJ in ACE inhibition therapy.
ScienceON
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