A New ent-Kaurane type Diterpenoid Glycoside from Inula japonica Thunb

Jiang Jiang Qin,Jia Xian Zhu,Wei Dong Zhang1,2,Yan Zhu,Jian Jun Fu,Xiao Hua Liu,Hui Zi Jin 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.10

A new ent-kaurane type diterpenoid glycoside, 17-O-β-D-glucopyranosyl-16α-ent-kauran-19-oic acid (1), together with 17-hydroxy-16α-ent-kauran-19-oic acid (2), 16α,17-dihydroxyl-ent-kauran-19-oic acid (3), and 16α-hydroxy-17-acetoxy-ent- kauran-19-oic acid (4) were isolated from the aerial parts of Inula japonica Thunb. The structure of 1 was determined mainly by use of 1D and 2D NMR spectroscopic techniques including HSQC, 1H-1H COSY, HMBC, and NOESY. In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC50 value of 14.3 μg/mL.

ROOM-TEMPERATURE FERROMAGNETISM IN SnO 2 NANOFIBERS AND NANOTUBES PREPARED BY ELECTROSPINNING

JIAN-GUO ZHAO,WEI-YING ZHANG,ZHAO-JUN LIU,ZHONG-LI LIU,YA-JUAN ZHANG,ER-QING XIE,XIU-YUN AN,YONG-FENG CHEN,CHANG-YOU ZHANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2014 NANO Vol.9 No.2

SnO 2 nano¯bers and nanotubes were synthesized by electrospinning method. Magnetizationmeasurement indicates that the SnO 2 nano¯bers and nanotubes annealed in air at 500?C exhibitthe room-temperature ferromagnetism and the ferromagnetism of nanotubes is stronger than thenano¯bers. Selected area electron di®raction, X-ray di®raction and Raman measurements showthat all the samples possess a typical rutile structure and no other impurity phases are observed. The results of the Raman spectra also indicate that there are lots of defects existing in thefabricated samples. The observed room-temperature ferromagnetism in SnO 2 nano¯bers andnanotubes possibly originates from oxygen vacancies. The ¯eld cooled (FC) and zero-¯eld-cooled(ZFC) magnetization curves indicate that the Curie temperature T C is above 300 K.

microRNA profiles of serum exosomes derived from children with nonalcoholic fatty liver

Zhang Jian-Wei,Pan Hai-Tao 한국유전학회 2022 Genes & Genomics Vol.44 No.7

Background: Nonalcoholic fatty liver disease (NAFLD) is a chronic disease caused by excessive fat accumulation in the liver in addition to alcohol consumption and other pathological factors. The incidence of NAFLD is rapidly growing, currently affecting 25% of the world population. Exosomes are extracellular vesicles containing a variety of biological molecules, including microRNAs (miRNAs). Objective: To monitor the expression of exosomal microRNAs in the NAFLD. Methods: In this study, five nonalcoholic fatty liver patients were included in the disease group, and five simple obesity patients were included in the control group. Exosomes from NAFLD patient serum were collected, and exosomal miRNAs were extracted. Exosomes were isolated and then confirmed by electron microscopy, nanoparticle tracking analysis (NTA) and western blotting. High-throughput sequencing methods were used to determine the expression profile of exosome-derived miRNAs. Results: The sequencing results revealed that a total of 2588 miRNAs were identified. The expression of 80 miRNAs significantly differed between the NAFLD and control groups, including 30 upregulated and 50 downregulated miRNAs. miR-122-5p, miR-27a, and miR-335-5p may play an important role in NAFLD. Finally, GO and KEGG analyses were applied to explore the function of miRNA targets. Conclusions: Collectively, this study identified some key exosomal miRNAs and pathways in NAFLD that might be used as molecular targets or diagnostic biomarkers for NAFLD.

Study of oil-particle-aggregation by digital inline holograph

Wei Zhang,Xinsheng Yu,Jian Zhang,Yanyan Wang 한국지질과학협의회 2019 Geosciences Journal Vol.23 No.3

This study was performed to visually analyse the relationship between particles and oil in seawater by digital holograph technology. Two types of particles with different sizes were chosen to form oil-particle aggregates (OPAs) in the laboratory to determine whether these particles may be a good approach to safely and harmoniously recover marine environment after an oil spill. The processes were recorded by a digital inline holographic system, which could facilitate a continuous real-time three-dimensional in situ observation of oil droplets and OPAs without touching these particles. The visual results showed that, in the micro scale, the particles formed two different types of OPA after breaking the oil film and transported oil into the bottom of the water, while some OPAs could be resuspended.

Quantitative Investigation into the Relation between Force Chains and Stress Transmission During High-Velocity Compaction of Powder

Wei Zhang,Jian Zhou,Xue-Jie Zhang,Kun Liu 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.74 No.7

High-velocity compaction (HVC), an innovative approach to obtain green compacts with high and uniform density, is widely used in the powder metallurgy industry. In this study, meso force chains, macro stress transmission, and their relation were investigated using the discrete element method. The simulation details of HVC and the quantitative characterization of force chains and stress transmission were shown. Then, the relation between force chains and stress was investigated. The evolution of force chains showed the same change tendency as the stress distribution. They evolved from top to bottom and then reflected backwards in HVC while they did not show this trend in conventional compaction. The strength of the force chains maintained good consistency with the stress magnitude. Meanwhile, the length of the force chains presented a negative correlation with the stress magnitude, and high stress may cause new force chains to shorten. The average collimation coefficient was affected by the transmission of stress, and the short force chains had better straightness. Furthermore, force chains parallel to the direction of gravity were observed in the region with no stress concentration. The directional coefficient of force chains also had the same fluctuation trend as the variation in the principal stress angle.

Seismic Behavior of Low-rise Concrete Shear Wall with Single Layer of Web Reinforcement and Inclined Rebars: Restoring Force Model

Jian-Wei Zhang,Wen-Bin Zheng,Wan-Lin Cao,Hong-Ying Dong,Wan-Di Li 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.3

In order to study the restoring force model of low-rise concrete shear wall with single layer of web reinforcement and inclined rebars, a series of specimens were investigated by quasi-static tests. Based on the fitting of experimental data and theoretical analysis, the restoring force model considering four characteristic points (crack point, yield point, peak point and failure point) and degradation of unloading stiffness was established. The hysteretic rule of restoring force model was determined by analyzing characteristic of hysteresis curve for cyclic loading tests. The results show that skeleton curves and hysteresis curves calculated by the restoring force model are in good agreement with the test curves, which can provide reference for the elastic-plastic dynamic analysis of low-rise concrete shear walls with single layer of web reinforcements and inclined rebars. Shaking table tests of two low-rise concrete shear walls were also conducted to investigate dynamic performance and the seismic damage mechanism of low-rise concrete shear wall with single layer of web reinforcement and inclined rebars. Research on dynamic nonlinear simplified model of SAP2000 shows thatthe proposed restoring force model can be used to analyze the elastic and elastic-plastic dynamic response for the low-rise concrete shear wall with single layer of web reinforcement and inclined rebars.

Relationships of uPA and VEGF Expression in Esophageal Cancer and Microvascular Density with Tumorous Invasion and Metastasis

Jiang, Jian-Tao,Zhang, Lan-Fang,Zhou, Bin,Zhang, Shun-Qun,Li, Shao-Min,Zhang, Wei,Zhang, Jin,Qiao, Zhe,Kong, Ran-Ran,Ma, Yue-Feng,Chen, Sheng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

Objective: To investigate uPA and VEGF expression in esophageal cancer and relations with tumorous invasion and metastasis. Methods: Immunohistochemistry was used to detect uPA and VEGF expression in the normal epithelial tissue of esophageal mucosa and cancer tissue and detect CD34 labeled micrangium and analyze the relationships with clinical pathological features and tumor angiogenesis. Results: Positive rates for uPA and VEGF protein expression were significantly greater in esophageal cancer than normal epithelial tissue (P < 0.05), the two being linked (P <0.05). In addition, uPA and VEGF protein expression of the high microvessel density (MVD) group was significantly lower than in the low MVD group (P < 0.05), with relation to clinical pathological staging, differentiation and lymph node metastasis (P < 0.05). Conclusion: In esophageal cancer tissue, uPA and VEGF proteins are overexpressed and promote tumor angiogenesis, indicative of a poor prognosis.

Association Between XRCC1 Gene Polymorphisms and Risk of Glioma Development: A Meta-analysis

Sun, Jian-Ying,Zhang, Chun-Yang,Zhang, Zhen-Jun,Dong, Yan-Fang,Zhang, An-Long,Wang, Zhi-Wei,Mei, Xiao-Long Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Objective: Previous studies of the association between X-ray cross-complementing group 1 (XRCC1) gene polymorphisms and the gliomas risk have yielded conflicting results, and thus a meta-analysis was performed to provide a more accurate estimation. Methods: A computerized literature search of 5 electronic databases was conducted to identify the relevant studies. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots and Egger's regression test. Results: A total of 11 studies (3,810 cases and 6,079 controls), 7 studies (2,928 cases and 5,048 controls), and 4 studies (1,461 cases and 2,593 controls) were finally included in the analyses of the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and glioma risk, respectively. The pooled results showed that GlnGln carriage was associated with moderately increased risk of gliomas in Asians (GlnGln vs. ArgArg, OR=1.490, 95%CI 1.031-2.153; GlnGln/ArgGln vs. ArgArg, OR=1.321, 95%CI 1.037-1.684), whereas a marginal association was revealed in Caucasians. For the Arg194Trp polymorphism, although a significant association was shown in the homozygous genotype comparisons (TrpTrp vs. ArgArg, OR = 2.209, 95%CI 1.398-2.945), no significant link was found on subgroup analysis stratified by ethnicity. With regard to the Arg280His polymorphism, no significant association was found in each comparison. No particular study was found to significantly influence the pooled results, and no potential publication bias was detected. Conclusions: This meta-analysis suggested that the XRCC1 Arg399Gln polymorphism is moderately associated with increased risk of gliomas in Asians, while Arg194Trp and Arg280His polymorphisms demonstrated no significant influence. Due to the limited studies and the potential confounders, further studies are needed to confirm these results.

A novel red-emitting phosphor Ca9Bi(PO4)7:Eu3+ for near ultraviolet white light-emitting diodes

Zhi-wei Zhang,Lu Liu,Shi-tao Song,Jian-ping Zhang,Dongjun Wang 한국물리학회 2015 Current Applied Physics Vol.15 No.3

Red phosphors Ca9Bi1-x(PO4)7:xEu3+ (x = 0.06, 0.10, 0.20, 0.30, 0.40, 0.50, 0.60, 0.70, 0.80 and 1.00) were synthesized by a conventional solid-state reaction (SSR) route. The X-ray diffraction patterns, photoluminescence spectra, ultravioletevisible reflection spectroscopy, decay time and the International Commission on Illumination (CIE) chromaticity coordinates of these compounds were characterized and analyzed. The Eu-doped Ca9Bi(PO4)7 phosphors exhibited strong red luminescence which peaks located at 615 nm due to the 5D0/7F2 electric dipole transition of Eu3+ ions after excitation at 393 nm. Ultravioletevisible spectra indicated that the band-gap of Ca9Bi0.30(PO4)7:0.70Eu3+ is larger than that of Ca9Bi(PO4)7. The results indicate that the phosphor Ca9Bi0.30(PO4)7:0.70Eu3+ can be a suitable redemitting phosphor candidate for LEDs.

Effects of Stellate Ganglion Block on the Peri-operative Vasomotor Cytokine Content and Intrapulmonary Shunt in Patients with Esophagus Cancer

Guo, Wei,Jin, Xiao-Ju,Yu, Jun,Liu, Yang,Zhang, Jian-Ping,Yang, Da-Wei,Zhang, Lei,Guo, Jiang-Rong Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Objective: To investigate the effects of stellate ganglion block (SGB) on the peri-operative vasomotor cytokine content and intrapulmonary shunt in patients with esophagus cancer who underwent thoracotomy. Materials and Methods: Forty patients undergoing elective resection of esophageal cancer patients who had I~II American Society of Anesthesiologist (ASA) were randomly divided into total intravenous anesthesia group (group N, n=20) and total intravenous anesthesia combined with SGB group (group S, n=20, 0.12 mL/kg 1% lidocaine was used for SGB 10 min before induction). Heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP), mean pulmonary arterial pressure (MPAP) and continuous cardiac output (CCO) were continuously monitored. The blood from internal jugular vein was drawn respectively before induction ($T_0$), and 30 min ($T_1$), 60 min ($T_2$) and 120 min ($T_3$) after one-lung ventilation (OLV), and 30 min (T4) after two-lung ventilation. The contents of plasma endothelin (ET), nitric oxide (NO) and calcitonin gene-related peptide (CGRP) were detected with enzyme linked immunosorbent assay (ELISA). Meanwhile, arterial and mixed venous blood samples were collected for determination of blood gas and calculation of intrapulmonary shunt fraction (Qs/Qt). Results: During OLV, ET contents were increased significantly in two groups (P<0.05), and no significant difference was presented (P>0.05). NO content in group S was obviously higher than in group N at T3 (P<0.05), whereas CGRP content in group N was markedly lower than in group S at each time point (P<0.05). Qs/Qt was significantly increased in both groups after OLV, but there was no statistical significant regarding the Qs/Qt at each time point between two groups. Conclusions: Total intravenous anesthesia combined with SGB is conducive to regulation of perioperative vasomotor cytokines in thoracotomy, and has little effect on intrapulmonary shunt at the time of OLV.