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A case of lichen amyloidosis in an adult
( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Lichen amyloidosis is a type of primary localized cutaneous amyloidosis clinically characterized by persistent pruritic, hyperkeratotic papules commonly distributed on the shins. Histopathologically, amyloid deposition in the papillary dermis is the characteristic finding. It appears to be more common in males and most often occurs in people 50-60 years of age. A 49-year-old woman presented with brownish papuloplaques on the both lower legs. Itching sense was severe and the lesion was occurred 2 years ago. Histopatholgic findings showed amyloid deposit in the papillary dermis. D-PAS staining was negative. Based on these findings, a diagnosis of lichen amyloidosis was made. We think this case has typical chracteristics of lichen amyloidosis. Therefore we report a case of lichen amyloidosis for educational purposes.
김태연,유진홍,박성환,김연식,임상현,신완식,강문원,정창훈,최문구,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.2
저자들은 최근 화농성 슬관절염과 병발한 수막구균성 수막염 1예를 체험하였고, 이는 국내에서 아직 보고되지 않은 드문 예로 사료되어 문헌고찰과 함께 보고하는 바이다. We recently experienced a case of meningococcal meningitis associated with pyogenic arthritis in a 37-year old male patient. Pyogenic arthritis developed in right knee joint during treatment for meningococcal meningitis. He was treated successfully by appropriate antibiotics and arthroscopic irrigation. To our knowledge, such a rare case has not ever been reported in Korea, Hence we report this case with a review of related literatures.
Shin, Ji-Yon,Lee, Jung-Min,Shin, Heon-Sub,Park, Sang-Yong,Yang, Jung-Eun,KimCho, So-Mi,Yi, Tae-Hoo The Korean Society of Ginseng 2012 Journal of Ginseng Research Vol.36 No.1
The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside $F_2$ (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with $IC_{50}$ of 50 ${\mu}g/mL$ through apoptosis, confirmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 mg/kg weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.
Anti-Cancer Effect of Ginsenoside F₂ against Glioblastoma Multiforme in Xenograft Model in SD Rats
Ji Yon Shin,Jung Min Lee,Heon Sub Shin,Sang Yong Park,Jung Eun Yang,Somi Kim Cho,Tae-Hoo Yi 고려인삼학회 2012 Journal of Ginseng Research Vol.36 No.1
The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside F₂ (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with IC?? of 50 ㎍/mL through apoptosis, confi rmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 ㎎/㎏ weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.
Relation of Alexithymia, Anger and Binge Eating Behavior
Ji Yon Eom,Mee-Kyung Shin 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.2
Purpose: Purpose of this descriptive research is to examine the correlation of alexithymia, anger and binge eating behavior of university students to prepare the basic data to develop nursing intervention which could be helpful to control anger and binge eating behavior. Method: Study subjects were targeting 412 university students and the correlation between alexithymia, anger and binge eating behavior was analyzed using Pearson‘s Correlation. Results: Alexithymia, anger and binge eating behavior showed significant correlation. Higher the alexithymia is so higher was anger and binge eating behavior. So we must develop nursing intervention for alexithymia.
Silencing of Atp2b1 increases blood pressure through vasoconstriction
Shin, Young-Bin,Lim, Ji Eun,Ji, Su-Min,Lee, Hyeon-Ju,Park, So-Yon,Hong, Kyung-Won,Lim, Mihwa,McCarthy, Mark I.,Lee, Young-Ho,Oh, Bermseok Wolters Kluwer Health | Lippincott Williams Wilkin 2013 Journal of Hypertension Vol.31 No.8
BACKGROUND:: Recent genome-wide association studies (GWASs) have identified 30 genetic loci that regulate blood pressure, increasing our understanding of the cause of hypertension. However, it has been difficult to define the causative genes at these loci due to a lack of functional analyses. METHOD:: In this study, we aimed to validate the candidate gene ATP2B1 in 12q21, variants near which have the strongest association with blood pressure in Asians and Europeans. ATP2B1 functions as a calcium pump to fine-tune calcium concentrations – necessary for repolarization following muscular contractions. We silenced Atp2b1 using an siRNA complex, injected into mouse tail veins. RESULTS:: In treated mice, blood pressure rose and the mesenteric arteries increased in wall : lumen ratio. Moreover, the arteries showed enhanced myogenic responses to pressure, and contractile responses to phenylephrine increased compared with the control, suggesting that blood pressure is regulated by ATP2B1 through the contraction and dilation of the vessel, likely by controlling calcium concentrations in the resting state. CONCLUSION:: These results support that ATP2B1 is the causative gene in the blood pressure-associated 12q21 locus and demonstrate that ATP2B1 expression in the vessel influences blood pressure.
VECTOR CONTROL OF INDUCTION MOTOR WITHOUT THE DETECTION OF ROTATIONAL SPEED
Yon-Tack Chung,Sa-Young Lee,Chang-Seop Shin,Myong-Ji University 전력전자학회 1992 ICPE(ISPE)논문집 Vol.1992 No.4
In this paper, the vector control of induction motor without speed sensor by means of voltage source power converter is described. Control 1 ing torque through the estimation of input frequency by slip, the speed controller with two control loops of torque control and constant speed operation by the positive feedback of slip is composed of. The pulse width modulation technique is proposed in order to enlarge a variable range of motor driving voltage, and the excel lent characteristic is obtained by vector control .<br/>
Decreases in $Casz1$ mRNA by an siRNA Complex Do not Alter Blood Pressure in Mice
Ji, Su-Min,Shin, Young-Bin,Park, So-Yon,Lee, Hyeon-Ju,Oh, Berm-Seok Korea Genome Organization 2012 Genomics & informatics Vol.10 No.1
Recent genomewide association studies of large samples have identified genes that are associated with blood pressure. The Global Blood Pressure Genetics (Global BPgen) and Cohorts for Heart and Aging Research in Genome Epidemiology (CHARGE) consortiums identified 14 loci that govern blood pressure on a genomewide significance level, one of which is $CASZ1$ confirmed in both Europeans and Asians. $CASZ1$ is a zinc finger transcription factor that controls apoptosis and cell fate and suppresses neuroblastoma tumor growth by reprogramming gene expression, like a tumor suppressor. To validate the function of $CASZ1$ in blood pressure, we decreased $Casz1$ mRNA levels in mice by siRNA. $Casz1$ siRNA reduced mRNA levels by 59% in a mouse cell line. A polyethylenimine-mixed siRNA complex was injected into mouse tail veins, reducing $Casz1$ mRNA expression to 45% in the kidney. However, blood pressure in the treated mice was unaffected, despite a 55% reduction in $Casz1$ mRNA levels in the kidney on multiple siRNA injections daily. Even though $Casz1$ siRNA-treated mice did not experience any significant change in blood pressure, our study demonstrates the value of $in$ $vivo$ siRNA injection in analyzing the function of candidate genes identified by genomewide association studies.
Comparison of uremic pruritus βetween patients undergoing hemodialysis and peritoneal dialysis
( Ji Won Min ),( Su Hyun Kim ),( Young Ok Kim ),( Dong Chan Jin ),( Ho Chul Song ),( Euy Jin Choi ),( Yong Lim Kim ),( Yon Su Kim ),( Shin Wook Kang ),( Nam Ho Kim ),( Chul Woo Yang ),( Yong Kyun Kim 대한신장학회 2016 Kidney Research and Clinical Practice Vol.35 No.2
Background: Uremic pruritus is a common, but unpleasant, complication of endstage renal disease. The uremic burden may differ between hemodialysis (HD) and peritoneal dialysis (PD) patients. This difference may also change the clinical characteristics of uremic pruritus between the 2 modalities. In this study, we investigated the uremic pruritus between patients on HD and PD. Methods: A total of 425 HD and 223 PD patients from the Clinical Research Center registry in Korea were included. Patients were assessed for pruritus intensity, scratching activity, pruritus distribution, and frequency of pruritus-related sleep disturbance using the visual analog scale and questionnaire. Results: The prevalence of uremic pruritus was higher in PD patients than that in HD patients (62.6% vs. 48.3%, P = 0.001). In the multivariable logistic analysis, PD treatment was significantly associated with the prevalence of uremic pruritus (odds ratio, 1.76; 95% confidence interval, 1.20e2.57, P = 0.004) after adjustment for clinical variables. The visual analog scale score, representing a subjective intensity of itchiness, was significantly higher in PD patients (PD 2.11 ± 2.32 vs. HD 1.65 ± 2.28, P = 0.013) compared with HD patients. The intensity of uremic pruritus was independently related with serum albumin levels (β = e0.143, P = 0.006) in HD patients and total weekly Kt/V (β = e0.176, P = 0.028) in PD patients. Conclusion: Our data demonstrate the difference in prevalence, intensity, and risk factors of uremic pruritus between HD and PD patients. These findings suggest that careful consideration for uremic pruritus might be needed in end-stage renal disease patients according to the dialysis modality.