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Kang, Ji-Houn,Lee, Geun-Shik,Jeung, Eui-Bae,Yang, Mhan-Pyo Cambridge University Press 2007 The British journal of nutrition Vol.97 No.1
<P><I>Trans</I>-10, <I>cis</I>-12-conjugated linoleic acid (t10c12-CLA) has been shown to alter immune function. PPARγ has been shown to potentially play an important role in regulating inflammatory and immune responses by modulating the activity of monocytes and macrophages. Previous studies have indicated that the phagocytic capacity of porcine peripheral blood polymorphonuclear cells (PMN) was enhanced by the culture supernatant fraction from t10c12-CLA-stimulated porcine peripheral blood mononuclear cells (PBMC) but not by t10c12-CLA itself. In the present study, we examined the effects of t10c12-CLA on PPARγ and TNF-α expression of porcine PBMC and the phagocytic capacity of PMN. t10c12-CLA increased TNF-α mRNA expression and production by PBMC. The phagocytic capacity of porcine PMN was enhanced by either culture supernatant fraction from PBMC treated with t10c12-CLA or recombinant porcine (rp) TNF-α. Anti-rpTNF-α polyclonal antibody inhibited the enhancement of PMN phagocytic capacity. t10c12-CLA also up regulated PPARγ mRNA expression in porcine PBMC. Bisphenol A diglycidyl ether, a PPARγ antagonist, not only completely negated the t10c12-CLA-stimulating effects on TNF-α expression and production by porcine PBMC, but also decreased the enhancement of PMN phagocytic capacity by the t10c12-CLA-stimulated porcine PBMC culture supernatant fraction. These results suggest that t10c12-CLA has an immunostimulating effect on porcine PMN phagocytic capacity, which is mediated by TNF-α from PBMC via a PPARγ-dependent pathway.</P>
Transient diestrus-related diabetes mellitus in a dog
Ji-Houn Kang, Ah Young Kim, Mhan-Pyo Yang 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.3
A 10-year-old intact female Cocker Spaniel weighing 15.3 kg presented with dysbasia. The dog had hyperglycemia and glucosuria at presentation. Neurological examination and magnetic resonance imaging on the following day indicated the onset of cervical disk disease. Four days later, the patient returned due to sudden vomiting and anorexia with severe dehydration. Abnormal laboratory findings included severe hyperglycemia with ketonuria. Plasma progesterone concentration was very high at presentation. She was hospitalized for critical care, and insulin administration with fluid therapy was initiated. Mean blood glucose concentration showed a gradual decline, and hyperglycemia with glucosuria disappeared four days after initiation of insulin therapy. This case demonstrated that high plasma progesterone concentration during diestrus can contribute to development of diabetes mellitus in intact female dogs
Acute Renal Proximal Tubular Dysfunction in Two Dogs Associated with Grapes Ingestion
Ji-Houn Kang,Dongwoo Chang,Byeongwoo Ahn,Ki-Jeong Na,Mhan-Pyo Yang 한국실험동물학회 2006 Laboratory Animal Research Vol.22 No.4
Acute renal failure caused by renal proximal tubular dysfunction was diagnosed in two dogs who had ingested grapes. In both cases serum biochemistry revealed severe azotemia, hyperphosphatemia, and hyponatremia. Normoglycemic glycosuria was observed, and the percentage of amino acids that were reabsorbed was reduced. Histopathological examination of the kidneys demonstrated diffuse tubular epithelial degeneration and necrosis manifested by nuclear pyknosis, and cytoplasmic vacuolation. The damage to the proximal tubules was more severe than to the distal or collecting tubules. These findings indicate that grapes ingestion in dogs may induce severe proximal tubular dysfunction, which in turn progresses to renal failure.
Clinical trial of oral administration of Bifidobacterium longum in dogs with atopic dermatitis
Lee, Kang-Il,Yun, Taesik,Ham, Junsang,Lee, Wan-Kyu,Kang, Ji-Houn,Yang, Mhan-Pyo,Kang, Byeong-Teck The Korean Society of Veterinary Science 2020 大韓獸醫學會誌 Vol.60 No.1
This study assessed the effects of probiotics in canine atopic dermatitis (AD). We enrolled 11 client-owned dogs with AD and randomly allocated them to two groups. The probiotics group (n = 7) was prescribed with Bifidobacterium longum while the control group (n = 4) received a placebo powder once a day for 12 weeks. In both groups, the degree of skin lesions was evaluated based on the Canine Atopic Dermatitis Extent and Severity Index (CADESI)-4. We also measured the transepidermal water loss (TEWL). We assessed pruritus severity using the pruritus visual analog scale (PVAS). Alteration of consumed drug doses was converted into medication scores. All the evaluation indices were surveyed every 4 weeks. In the probiotics group, there was a significant decrease in the CADESI-4 score at 4, 8, and 12 weeks compared to that of the baseline score (p < 0.05). There was no significant difference in TEWL, PVAS, and medication score at each time point and between groups. Although these results showed that Bifidobacterium longum did not reduce pruritus, TEWL, and the dosage of drugs for canine AD, it was effective in improving skin lesions, therefore, probiotics could be considered in canine AD with severe skin symptoms.
Comparison of rapid screening immunoassay and intradermal test for canine atopic dermatitis
Yeseul Lee,Ji-Houn Kang,Dong-In Jung,Young-Bae Jin,Sang-Rae Lee,Mhan-Pyo Yang,Byeong-Teck Kang 충북대학교 동물의학연구소 2015 Journal of Biomedical and Translational Research Vol.16 No.3
The intradermal test (IDT) has been developed for confirming diagnosis of canine atopic dermatitis (CAD). Prior to performing IDT, rapid immunoassay (Allercept E-screen 2nd generation; ES2G) can detect allergen-specific immunoglobulin E (IgE) antibodies in canine serum. The objective of this study was to evaluate agreement between IDT and immunoassay in diagnosis of CAD in domestic atopic dogs. Forty dogs were diagnosed with CAD in accordance with Favrot’s criteria. Intradermal testing was performed using 39 selected allergens. ES2G detected IgE antibodies specific for three allergen groups, including indoor allergens, grasses and weeds, and trees. Among 19 dogs diagnosed by IDT, the highest positivity was observed in house dust mites, followed by molds, epidermis and inhalants, house dust, and weeds. A total of 28 atopic dogs were evaluated by rapid ES2G immunoassay. Indoor allergens showed the strongest positive reaction, followed by grasses/weeds and trees. IDT and ES2G were performed concurrently in 17 dogs. The results of ES2G showed slight agreement with those of IDT. Level of agreement was highest for indoor allergens, which showed a predictive positive value of 100% in ES2G. These results indicate that a rapid immunoassay may be valuable for predicting the results of IDT in atopic dogs sensitized to indoor allergens.