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Eui-bae Jeung,Dinh Nam Tran,KangMin Kim,Jimin Lee 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Disruption of the endocrine system can result in various developmental, reproductive, neurological, immune and metabolic diseases. Over the past years, an increasing number of ubiquitous chemicals have been identified to have endocrine disrupting properties to which humans and wildlife are consequently exposed. In which, octamethylcyclotetrasiloxane (D4) is found in the manufacture of detergent products, polishes and waxes, cosmetics, and personal care products. In present study, we investigate the adverse effects of D4 on the brain development. In in vitro, D4 decreased the proliferation of and induce the apoptosis in neuronal progenitor cells in primary cortical neuron cultures. In in vivo, maternal mice were received D4 at dose 10 mg/kg and 25 mg/kg by oral injection from E9 to PND28. At E17.5, D4-treated groups showed decreased in the proliferation of neuronal progenitor in dentate gyrus area. At 6-8 week aged, offspring mice in D4 25 mg/kg group showed impairments in social behavior. Additionally, D4-treated groups showed recognition dysfunction and memory defects. Moreover, D4-treated groups showed motor learning defects and depression-like behavior. This research was supported by a grant (20183MFDS522) from Ministry of Food and Drug Safety in 2021.
Toxicological Mechanism of Endocrine Disrupting Chemicals : Is Estrogen Receptor Involved?
Eui-Bae Jeung,Kyung-Chul Choi 한국독성학회 2010 Toxicological Research Vol.26 No.4
Endocrine disrupting chemicals (EDCs) have been shown to interfere with physiological systems, i.e., adversely affecting hormone balance (endocrine system), or disrupting normal function, in the female and male reproductive organs. Although endocrine disruption is a global concern for human health, its impact and significance and the screening strategy for detecting these synthetic or man-made chemicals are not clearly understood in female and male reproductive functions. Thus, in this review, we summarize the interference of environmental EDCs on reproductive development and function, and toxicological mechanism(s) of EDCs in in vitro and in vivo models of male and female reproductive system. In addition, this review highlights the effect of exposure to multiple EDCs on reproductive functions, and brings attention to their toxicological mechanism(s) through estrogen receptors.
Toxicological Mechanism of Endocrine Disrupting Chemicals: Is Estrogen Receptor Involved?
Jeung, Eui-Bae,Choi, Kyung-Chul Korean Society of ToxicologyKorea Environmental Mu 2010 Toxicological Research Vol.27 No.4
Endocrine disrupting chemicals (EDCs) have been shown to interfere with physiological systems, i.e., adversely affecting hormone balance (endocrine system), or disrupting normal function, in the female and male reproductive organs. Although endocrine disruption is a global concern for human health, its impact and significance and the screening strategy for detecting these synthetic or man-made chemicals are not clearly understood in female and male reproductive functions. Thus, in this review, we summarize the interference of environmental EDCs on reproductive development and function, and toxicological mechanism(s) of EDCs in in vitro and in vivo models of male and female reproductive system. In addition, this review highlights the effect of exposure to multiple EDCs on reproductive functions, and brings attention to their toxicological mechanism(s) through estrogen receptors.