[P8-249] Capsanthin, the Main Compounds in Red Paprika Fruit (Capsicum annuum L.), Prevents H<SUB>2</SUB>O<SUB>2</SUB>-Induced Inhibition of Gap-Junction Intercellular Communication

Ji?Sun Kim,Jiyun Ahn,Sun-hye Lim,Suna Kim,Tae-Youl Ha 한국식품영양과학회 2010 한국식품영양과학회 학술대회발표집 Vol.2010 No.10

Benson's Group Additivity Method를 이용한 염화다환방향족 화합물의 열역학적물성치 평가와 생성반응경로에 관한 연구

임지선,박자영,원양수,최성필 嶺南大學校 環境問題硏究所 1995 環境硏究 Vol.15 No.1

도시폐기물 소각시설에서 다이옥신류는 chlorobenzene, chlorophenols, PCBs등의 염소성분이 포함된 방향족화합물과 함께 폐기물의 소각처리시 불완전 연소로 인해 주로 생성된다. 이들 다이옥신 생성에 대한 반응메카니즘의 예측에 필요한 다이옥신을 형성하는 전구물질인 분자 및 radical의 정확한 열역학적 물성치를 평가하기 위해 Benson's group additivity method에서는 고려되지 않는 Cl, F, OH, CH3등과 같은 2개 이상의 치환기가 결합된 방향족화합물에 대한 computer code인 THERM을 이용하여 엔탈피(Hf), 엔트로피(St), 열용량(Cp)을 평가하였다. 또한 이와 같은 열역학적 물성치 평가법의 신뢰성을 검토하기 위해 다양한 방향족화합물에 대한 실험적으로 측정된 문헌치와 평가치와의 절대오차는 para-cresol의 0.02kcal/mole에서 hexamethylbenzene의 3.46kcal/mole로 좁은 범위를 나타내었다. 또한 다이옥신을 생성하는 전구물질들의 열역학적 물성치를 THERM을 이용해 간접적으로 평가함으로써 다이옥신을 형성하는 주요 생성반응 경로에 대해 살펴본 결과는 다이옥신을 형성하는 기초반응(elementary reaction)중 욤소수가 많은 반응물질일수록 반응이 더 잘 일어남을 알수 있었다. Chlorinated dioxins are often observed in effluent from oxidation or incineration such as chlorobenzenes, chlorophenols and PCBs. It would be of significant value to have an accurate and fundamental understanding of the mechanism for dioxin formation, in addition to the knowledge of dioxin thermodynamic properties, in order to assist in the design of stategies to effectively control or reduce emissions of these compounds. Very little has been published on the thermodynamic properties and elementary reactions which lead to formation of dioxins. Benson group additivity method, when used for the estimation of thermodynamic properties of molecules, does not account for all interactions between functional groups or atoms on aromatics, such as chlorines, hydroxyl or ether linkages. Therefore thermodynamic properties of dioxins are estimated by THERM based on Benson's group additivity method corrected by interactions group. Absolute errors between our predictions and literature values range from a low of 0.02 kcal/mole for paracresol to a high 3.46kcal/mole for hexamethylbenzene. We use these thermodynamic calculations to show the feasibility of several elementary reaction pathways leading to dioxin formation, where the presence of chlorine acts to enhance or lower the Gibbs free energy of reactions.

갈근(葛根)으로부터 분리된 puerarin의 항당뇨 효과

임현애,임지선,김정상 경북대학교 농업과학기술연구소 2006 慶北大農學誌 Vol.24 No.-

본 연구에서는 갈근 및 그의 주 이소플라본인 puerarin의 활성을 세포수준에서 분석하였다. 먼저 갈근에 함유된 이소플라본의 양을 분석한 결과, puerarin이 총 이소플라본의 90 % 차지하였다. 다음으로는 puerarin의 항당뇨 활성을 검정한 결과 먼저 탄수화물 및 지방소화효소저해활성에 대해서는 거의 미비한 것으로 나타났으나 인슐린 감수성 및 지방세포의 분화의 유도에 대해서는 농도의존적으로 작용하는 것으로 관찰되었다. 따라서 puerarin은 지방조직내로 포도당의흡수를 촉진함으로서 항당뇨 효능을 발휘하는 것으로 추정된다. In this study we evaluated the anti-diabetic potential of Puerariae Radix and its isoflavone (puerarin) by investigating their inhibitory activities against digestive enzymes, α-amylase, α-glucosidase and lipase and effect on glucose uptake and PPAR γ expression. The activities of carbohydrate digestive enzymes were not inhibited by puerarin. Glucose uptake in differentiated adipocytes was stimulated by puerarin. Furthermore, puerarin enhanced the differentiation of preadipocytes as evaluated by triacylglycerol (TG) accumulation, which is specific for differentiated adipocytes. The effect of puerarin on expression of peroxisome proliferator-activated receptor γ (PPAR-γ) gene, which is associated with obesity and dyslipidemia, was examined by both real-time PCR and reverse transcriptase PCR. The study demonstrated that puerarin increased the expression of PPAR-γ. In conclusion, puerarin showed potential to exert anti-diabetic action by enhancing cellular glucose uptake and thereby TG accumulation in adipocyte tissue.

일부 성장기 학생 혈중 연농도의 성별 및 연령별 분포

임재언,강은용,최병선,서지영,홍연표,장임원,박정덕 중앙대학교 의과대학 의과학연구소 2000 中央醫大誌 Vol.25 No.2

브랜드 인지도와 광고가 콘택트렌즈의 착용감과 가격만족도에 미치는 영향

임동규 ; 신상준 ; 한지선 ; 이익한 ; 김진숙 김천대학교 2016 김천대학교 논문집 Vol.36 No.-

The purpose of this research was to analyze the effects of brand awareness and brand advertising on price satisfaction and comfort in contact lens. We did a survey with 200 university students (85 male, 115 female) who have experience of wearing contact lens from April to May in 2015. The brand awareness of contact lens influences to purchasing intention of contact lens, it effects women more than men. Many respondents(53%) replied that the reliability is the most important elements of the advertising. This survey indicates that there is no statistically significant correlation between the brand awareness and advertisement with price satisfaction in contact lens. Therefore we could confirm they have dissatisfaction for prices of contact lens regardless to brand awareness or advertisement. The brand and advertising dependence group have more comfort of contact lens than non-dependence group when they are long time wear of contact lens. Therefore, there is statistically significant correlation between the brand awareness and advertisement with comfort of contact lens. As a result, brand awareness and reliability of advertising influences to purchasing intention of contact lens. But there is no statistically significant correlation with price satisfaction in contact lens. Whereas, brand awareness and advertisement have a statistically significant correlation with comfort of contact lens.

한지를 이용한 집단미술치료가 노인의 죽음불안과 삶의 만족도에 미치는 영향

임지향,정명선 한국재활심리학회 2003 재활심리연구 Vol.10 No.1

The purpose of this study was to examine effects of group art therapy by using Hanji(Korean hand-made paper) on death anxiety and life satisfaction of the elderly. From a pool of elderly persons who completed the battery of tests given testing sessions, twenty individuals(10 experimental group participants and 10 control group participants) who scored both above the 60th percentile on the death anxiety scale and below 40th percentile on the elderly life satisfaction scale, were scheduled as participants. Besides the participants were all volunteers, aged sixty-five years and over. This group art therapy program comprised 24 sessions by twice a week. The experiment had a 2×2 factorial design that included one within-subjects variable(test order : pretest or posttest) and one between-subjects variable (group : experimental group or control group). The results obtained are as follows: First, group art therapy by using Hanji had a positive effect on death anxiety with the consequence that participants of experimental group showed a significant decrease in death anxiety. Second, group art therapy by using Hanji had a positive effect on life satisfaction of the elderly. Participants of experimental group who received the group art therapy by using Hanji showed a significant increase in life satisfaction. Then on the basis of the positive emotion, negative emotion, positive experience and negative experience subheads of the life satisfaction scale, I investigated a detailed change. The four subheads of the life satisfaction scale also showed a significant effects, of the four subheads of the life satisfaction scale, the positive experience subhead showed the strongest changes. These results suggest that the group art therapy by using Hanji become effective for the elderly as indexed by decreases in evaluations of death anxiety, and increases in evaluation of life satisfaction. We accordingly must not underestimate the effect of group art therapy by using Hanji. Future research should diversify comparative study of the subject and between Hanji and other art materials.

곡류가루 첨가가 소시지의 품질 및 저장성에 미치는 영향

장선문,임지숙,조은자 동아시아식생활학회 2004 동아시아식생활학회지 Vol.14 No.3

To investigate the effect of cereal powders on the quality and storage characteristics of sausage, Aw, pH, microbial count, TBA value, VBN value, textual and sensory characteristics were examined. Water activity tended to decrease as storage time prolonged and all the samples showed higher Aw's than that of the control. During the storage period, pH values of all the samples decreased. L, a and b values had a tendency to decrease during the storage period. During the four weeks storage at 4℃, TBA and VBN values of all the sample showed increasing tendency and were lower than those of the control. Total plate counts of bacteria, the number of lactic acid bacteria and coliform bacteria counts increased as the storage time prolonged. Texture characteristics of all samples increased up to 1 week storage and decreased subsequently. The sensory scores of all the samples decreased as the storage time prolonged.

말더듬과 사회공포증의 진단적 연관성 및 효율적 치료전략 제안을 위한 예비 연구

김영기,임기영,조선미,최지원 용인정신의학연구소 1999 용인정신의학보 Vol.6 No.2

Differentiation of Desmoplastic Spitz Nevus from Similar Conditions

( Min-woo Kim ),( Ji Soo Lim ),( Yun Seon Choe ),( Jung Ho Kim ),( Hyun-sun Yoon ),( Soyun Cho ),( Hyun-sun Park ) 대한피부과학회 2016 대한피부과학회지 Vol.54 No.9

The diagnosis of classic Spitz nevus with characteristic histopathologic findings is often straightforward, but unusual variants can cause diagnostic difficulties. Desmoplastic Spitz nevus (DSN) is of particular importance, as its differential diagnosis from other diseases, including desmoplastic malignant melanoma (DMM), is essential but often difficult¹. A 38-year-old Caucasian woman presented with a 6-mm brownish papule of unknown onset on the dorsum of her left hand (Fig. 1A). She did not report any change in the papule size, trauma history, or related symptoms, but she wanted to have the lesion removed. Punch excision of the specimen revealed proliferation of individual spindle and epithelioid cells with scanty pigmentation within dense colla-genous dermal stroma (Fig. 1B, C). The specimen was focal positive for S-100 and HMB-45, positive for Melan-A, and 1% positive for Ki-67 (Fig. 2A∼C). The lesion did not recur after punch excision at the 1-year follow-up. Since its first report in 1975, there have been only a few case series of DSN owing to the rarity of this disease and its under-recognition, except for intermittent case reports^1-3. DSN usually presents as a small red-brown papule on the trunk and extremities. It can occur at any age, but is mostly observed in young adults, with a slight female predominance. The distinctive histopathologic features of DSN―an intradermal growth pattern of large spindle or epithelioid nevus cells embedded in a fibrotic stroma, sparse melanin pigment, no junctional activity, no Kamino bodies, no prominent nest formation―can aid its differentiation from clinical simulators. Additionally, immunohistochemistry is essential for a differential diagnosis. DSN tests positive for S-100, Melan-A, and HMB-45, whereas dermatofibroma is negative for all three³. Hypomelanotic blue nevus shows uniform positivity for HMB-45, whereas DSN shows differential expression in most spindled cells3. The distinction between DSN and DMM is the most important. DMM is more common in elderly patients and tends to occur on sun-damaged head and neck areas. It also shows cellular atypia, strong mitotic activity and Ki-67 expression, less frequent S-100 and Melan-A positivity, and almost exclusive negativity for HMB-45^2,3. Some researchers regarded DSN as an end stage of Spitz nevus that had lost continuity with the epidermis and undergone fibrosis. Paniago-Pereira et al.² also reported that DSNs occurred in patients older than 30 years. These findings suggest that desmoplasia might be an aging process of Spitz nevus. However, Barr et al.1 found no significant difference in patient age, disease duration, or trauma history between patients with DSN and common variants of Spitz nevus, and suggested that desmoplasia may be a tumor-induced reactive stromal induction rather than a regressive phenomenon. The pathogenesis of desmoplasia has not yet been clearly elucidated. Moreover, it is controversial whether DSN should be regarded as a variant of Spitz nevus or whether it belongs to a spectrum of desmoplastic nevus as a distinctive entity^3,4. Some researchers5 suggested strict diagnostic criteria for de-smoplastic nevus, including greater cellularity in the super-ficial portion, and a mixture of melanocytic nevus cells, ovoid and dendritic melanocytes, and spitzoid melanocytes. Further, they mentioned that lesions in which one particular type of melanocyte predominates over others are more likely to represent DSN. Dermoscopic findings can also aid the distinction, because DSN shows dotted vessels and reticular depigmentation whereas desmoplastic nevus demonstrates a delicate pigment network over a pinkish background⁴. Although it is regrettable that we did not acquire dermoscopic image to support the diagnosis, our case overall seems more com-patible with DSN. However, the probability of a morphologic spectrum that embraces DSN and desmoplastic nevus cannot be excluded, and requires further studies. Here, we report an unusual desmoplastic variant of Spitz nevus with a literature review, and propose keynotes for differential diagnosis from its simulators, especially DMM.

병원간호조직의 내부마케팅요인과 간호사의 직무만족, 조직몰입과의 관계연구

김소인,차선경,임지영 고려대학교 2001 간호학논집 Vol.3 No.-